NIEHS Exome Variant Server
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Nomination of Candidate Genes to the Environmental Genome Project Re-Sequencing Efforts
Experimental studies in molecular genetics, toxicology and other biomedical fields have shown that genetic differences between two individuals can determine the relative sensitivity of each individual to environmental chemicals or agents. Some human-inherited disease susceptibilities are caused by a single inherited trait, and other disease susceptibilities are likely determined by multiple genetic traits. For many diseases, the genetic blueprint of each individual does not in and of itself cause disease; instead, disease is the outcome of a complex interplay between multiple genetic and environmental factors.
The rationale of the Environmental Genome Project (EGP) is that certain genes have a greater than average influence over human susceptibility to environmental agents. By identifying and characterizing the polymorphism in those genes, we will increase our understanding of human disease susceptibility. This knowledge can be used to protect susceptible individuals from environmentally induced disease by identifying genetic factors related to susceptibility and by reducing environmental exposures.
Environmentally responsive genes tend to fall into eight broad categories of genes:
The EGP, in consultation with the NIEHS scientific community, generated a list of environmentally responsive genes (http://www.genome.utah.edu/genesnps/cgi-bin/query.cgi?FunctionClass=NIEHS). The first phase of resequencing, now complete, extended from 1998 to 2003 and focused on polymorphic variants in approximately 200 DNA repair and cell cycle genes. The second phase of resequencing will include genes in other categories, prioritized on the needs of the NIEHS scientific community.
To nominate a gene for resequencing, please provide ALL of the following information: