RAD51 RAD51 NER Pathway CHEK1 CHEK1 CHEK1 RPA complex MDM2 MDM2 GADD45 complex CDKN1A JUN NFkB NFkB BRCA1 BRCA1 Apoptosis Pathway NBS1 NBS1 TP53 TP53 TP53 CHEK2 MRE11A ABL1 ABL1