LOCUS MTHFR 15835 bp DNA linear PRI 07-JUL-2003 DEFINITION Homo sapiens MTHFR: 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) gene, complete cds. ACCESSION MTHFR VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 15835) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (07-JUL-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..15835 /organism="Homo sapiens" /db_xref="taxon:9606" gene 9..14601 /gene="MTHFR" variation 539 /gene="MTHFR" /frequency="0.04" /replace="G" repeat_region 590..885 /rpt_family="Alu" /rpt_type=dispersed variation 747 /gene="MTHFR" /frequency="0.09" /replace="T" variation 863 /gene="MTHFR" /frequency="0.08" /replace="G" repeat_region 886..988 /rpt_family="Alu" /rpt_type=dispersed variation 1151 /gene="MTHFR" /frequency="0.01" /replace="T" variation 1221 /gene="MTHFR" /frequency="0.12" /replace="A" variation 1559 /gene="MTHFR" /frequency="0.01" /replace="A" variation 1848 /gene="MTHFR" /frequency="0.04" /replace="T" mRNA join(1940..2187,3669..3907,4746..4856,8669..8862, 9720..9970,10205..10339,10530..10710,10979..11161, 12689..12790,13742..13861,14170..14601) /gene="MTHFR" /product="MTHFR" CDS join(1952..2187,3669..3907,4746..4856,8669..8862, 9720..9970,10205..10339,10530..10710,10979..11161, 12689..12790,13742..13861,14170..14388) /gene="MTHFR" /codon_start=1 /product="MTHFR: 5,10-methylenetetrahydrofolate reductase (NADPH)" /translation="MVNEARGNSSLNPCLEGSASSGSESSKDSSRCSTPGLDPERHER LREKMRRRLESGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLYIDVTWHPAGDPG SDKETSSMMIASTAVNYCGLETILHMTCCRQRLEEITGHLHKAKQLGLKNIMALRGDP IGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGSFEADLKHLKEKV SAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQLVKLSKLEV PQEIKDVIEPIKDNDAAIRNYGIELAVSLCQELLASGLVPGLHFYTLNREMATTEVLK RLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQEWDEFPNGRWGNS SSPAFGELKDYYLFYLKSKSPKEELLKMWGEELTSEESVFEVFVLYLSGEPNRNGHKV TCLPWNDEPLAAETSLLKEELLRVNRQGILTINSQPNINGKPSSDPIVGWGPSGGYVF QKAYLEFFTSRETAEALLQVLKKYELRVNYHLVNVKGENITNAPELQPNAVTWGIFPG REIIQPTVVDPVSFMFWKDEAFALWIERWGKLYEEESPSRTIIQYIHDNYFLVNLVDN DFPLDNCLWQVVEDTLELLNRPTQNARETEAP" variation 2068 /gene="MTHFR" /frequency="0.11" /replace="T" variation 2154 /gene="MTHFR" /frequency="0.01" /replace="A" variation 2190 /gene="MTHFR" /frequency="0.01" /replace="G" variation 2347 /gene="MTHFR" /frequency="0.04" /replace="C" variation 2582 /gene="MTHFR" /frequency="0.10" /replace="" variation 2603..2604 /gene="MTHFR" /frequency="0.01" /replace="" variation 2793 /gene="MTHFR" /frequency="0.04" /replace="A" variation 2794 /gene="MTHFR" /frequency="0.04" /replace="T" variation 2911 /gene="MTHFR" /frequency="0.26" /replace="G" variation 2962 /gene="MTHFR" /frequency="0.09" /replace="T" repeat_region 3015..3072 /rpt_family="L2" /rpt_type=dispersed variation 3048 /gene="MTHFR" /frequency="0.01" /replace="C" variation 3078 /gene="MTHFR" /frequency="0.11" /replace="A" repeat_region 3121..3423 /rpt_family="Alu" /rpt_type=dispersed variation 3270 /gene="MTHFR" /frequency="0.15" /replace="C" variation 3338 /gene="MTHFR" /frequency="0.01" /replace="A" repeat_region 3437..3570 /rpt_family="MIR" /rpt_type=dispersed variation 3461 /gene="MTHFR" /frequency="0.01" /replace="T" variation 3777 /gene="MTHFR" /frequency="0.01" /replace="A" variation 3849 /gene="MTHFR" /frequency="0.02" /replace="A" variation 4002 /gene="MTHFR" /frequency="0.01" /replace="C" variation 4134 /gene="MTHFR" /frequency="0.02" /replace="A" variation 4282 /gene="MTHFR" /frequency="0.18" /replace="T" variation 4318 /gene="MTHFR" /frequency="0.12" /replace="A" variation 4441 /gene="MTHFR" /frequency="0.02" /replace="T" variation 4442 /gene="MTHFR" /frequency="0.21" /replace="A" variation 4467 /gene="MTHFR" /frequency="0.01" /replace="T" variation 4477 /gene="MTHFR" /frequency="0.01" /replace="T" variation 4594 /gene="MTHFR" /frequency="0.01" /replace="C" variation 4654 /gene="MTHFR" /frequency="0.01" /replace="G" variation 4660 /gene="MTHFR" /frequency="0.03" /replace="C" variation 4667 /gene="MTHFR" /frequency="0.12" /replace="A" variation 4670 /gene="MTHFR" /frequency="0.02" /replace="A" variation 4960 /gene="MTHFR" /frequency="0.01" /replace="T" variation 5005 /gene="MTHFR" /frequency="0.20" /replace="A" variation 5008 /gene="MTHFR" /frequency="0.11" /replace="C" repeat_region 5139..5437 /rpt_family="Alu" /rpt_type=dispersed variation 5217 /gene="MTHFR" /frequency="0.03" /replace="A" variation 5248 /gene="MTHFR" /frequency="0.02" /replace="A" misc_feature 5431..6017 /gene="MTHFR" /note="Region not scanned for variation" repeat_region 6027..6339 /rpt_family="Alu" /rpt_type=dispersed variation 6044 /gene="MTHFR" /frequency="0.02" /replace="A" variation 6083 /gene="MTHFR" /frequency="0.03" /replace="C" variation 6168 /gene="MTHFR" /frequency="0.15" /replace="G" variation 6178 /gene="MTHFR" /frequency="0.01" /replace="A" variation 6178 /gene="MTHFR" /frequency="0.01" /replace="T" variation 6178 /gene="MTHFR" /frequency="0.98" /allele="G" variation 6541 /gene="MTHFR" /frequency="0.03" /replace="G" variation 6575 /gene="MTHFR" /frequency="0.12" /replace="A" repeat_region 6673..6787 /rpt_family="Alu" /rpt_type=dispersed variation 6722 /gene="MTHFR" /frequency="0.03" /replace="A" variation 6801 /gene="MTHFR" /frequency="0.11" /replace="T" variation 7089 /gene="MTHFR" /frequency="0.19" /replace="C" variation 7093 /gene="MTHFR" /frequency="0.01" /replace="T" variation 7174 /gene="MTHFR" /frequency="0.47" /replace="A" variation 7199 /gene="MTHFR" /frequency="0.13" /replace="T" variation 7200 /gene="MTHFR" /frequency="0.13" /replace="T" repeat_region 7231..7455 /rpt_family="CR1" /rpt_type=dispersed variation 7337 /gene="MTHFR" /frequency="0.12" /replace="T" variation 7414 /gene="MTHFR" /frequency="0.04" /replace="G" repeat_region 7456..7775 /rpt_family="Alu" /rpt_type=dispersed variation 7549 /gene="MTHFR" /frequency="0.04" /replace="G" variation 7599 /gene="MTHFR" /frequency="0.07" /replace="T" variation 7600 /gene="MTHFR" /frequency="0.46" /replace="T" variation 7715 /gene="MTHFR" /frequency="0.23" /replace="T" repeat_region 7776..7842 /rpt_family="CR1" /rpt_type=dispersed repeat_region 7843..8151 /rpt_family="Alu" /rpt_type=dispersed variation 7885 /gene="MTHFR" /frequency="0.40" /replace="G" variation 7918 /gene="MTHFR" /frequency="0.02" /replace="A" repeat_region 8152..8364 /rpt_family="CR1" /rpt_type=dispersed variation 8278 /gene="MTHFR" /frequency="0.04" /replace="T" variation 8304 /gene="MTHFR" /frequency="0.08" /replace="C" variation 8747 /gene="MTHFR" /frequency="0.22" /replace="T" variation 9041 /gene="MTHFR" /frequency="0.02" /replace="T" repeat_region 9145..9326 /rpt_family="MER1_type" /rpt_type=dispersed variation 9228 /gene="MTHFR" /frequency="0.04" /replace="G" variation 9237 /gene="MTHFR" /frequency="0.01" /replace="G" variation 9258 /gene="MTHFR" /frequency="0.39" /replace="C" repeat_region 9435..9552 /rpt_family="Alu" /rpt_type=dispersed variation 9678 /gene="MTHFR" /frequency="0.01" /replace="A" variation 10087 /gene="MTHFR" /frequency="0.05" /replace="A" variation 10199 /gene="MTHFR" /frequency="0.01" /replace="G" variation 10229 /gene="MTHFR" /frequency="0.13" /replace="T" variation 10370 /gene="MTHFR" /frequency="0.41" /replace="C" variation 10454 /gene="MTHFR" /frequency="0.24" /replace="T" variation 10627 /gene="MTHFR" /frequency="0.01" /replace="A" variation 10649 /gene="MTHFR" /frequency="0.27" /replace="C" variation 10668 /gene="MTHFR" /frequency="0.08" /replace="C" variation 11200 /gene="MTHFR" /frequency="0.01" /replace="T" repeat_region 11338..11619 /rpt_family="Alu" /rpt_type=dispersed variation 11445 /gene="MTHFR" /frequency="0.01" /replace="T" variation 11526 /gene="MTHFR" /frequency="0.04" /replace="C" repeat_region 11622..11926 /rpt_family="Alu" /rpt_type=dispersed variation 11776 /gene="MTHFR" /frequency="0.01" /replace="T" variation 11816 /gene="MTHFR" /frequency="0.01" /replace="T" repeat_region 11940..12086 /rpt_family="MIR" /rpt_type=dispersed variation 11979 /gene="MTHFR" /frequency="0.01" /replace="G" variation 12152..12153 /gene="MTHFR" /frequency="0.01" /replace="" repeat_region 12153..12256 /rpt_family="MIR" /rpt_type=dispersed variation 12156 /gene="MTHFR" /frequency="0.02" /replace="A" variation 12227 /gene="MTHFR" /frequency="0.01" /replace="G" variation 12506 /gene="MTHFR" /frequency="0.01" /replace="T" variation 12574 /gene="MTHFR" /frequency="0.01" /replace="A" variation 12609 /gene="MTHFR" /frequency="0.02" /replace="A" variation 12619 /gene="MTHFR" /frequency="0.01" /replace="C" variation 12713 /gene="MTHFR" /frequency="0.01" /replace="T" variation 12822 /gene="MTHFR" /frequency="0.01" /replace="T" variation 12825 /gene="MTHFR" /frequency="0.24" /replace="A" repeat_region 12830..13149 /rpt_family="L2" /rpt_type=dispersed variation 12884 /gene="MTHFR" /frequency="0.03" /replace="C" variation 13015 /gene="MTHFR" /frequency="0.12" /replace="A" variation 13175 /gene="MTHFR" /frequency="0.02" /replace="G" repeat_region 13176..13473 /rpt_family="L2" /rpt_type=dispersed variation 13178 /gene="MTHFR" /frequency="0.01" /replace="T" variation 13198 /gene="MTHFR" /frequency="0.02" /replace="A" variation 13506 /gene="MTHFR" /frequency="0.01" /replace="T" variation 13872 /gene="MTHFR" /frequency="0.01" /replace="T" variation 13906 /gene="MTHFR" /frequency="0.02" /replace="A" variation 13908 /gene="MTHFR" /frequency="0.01" /replace="C" variation 14007 /gene="MTHFR" /frequency="0.07" /replace="T" variation 14122 /gene="MTHFR" /frequency="0.28" /replace="G" variation 14144 /gene="MTHFR" /frequency="0.01" /replace="A" variation 14198 /gene="MTHFR" /frequency="0.09" /replace="A" variation 14375 /gene="MTHFR" /frequency="0.01" /replace="T" variation 14429 /gene="MTHFR" /frequency="0.01" /replace="T" variation 14760 /frequency="0.37" /replace="A" variation 14931 /frequency="0.06" /replace="A" variation 15042 /frequency="0.01" /replace="G" variation 15458 /frequency="0.01" /replace="A" variation 15678 /frequency="0.04" /replace="T" variation 15755 /frequency="0.01" /replace="T" BASE COUNT 3585 a 4148 c 4339 g 3763 t ORIGIN 1 aatcagaggg tttacaggtg gttcagcttc ctcctactct aggttctgtt ccagcaagca 61 attaacgagg tgcgccctta aacgctggag gaaagccaac tggctgctct tgctgttact 121 cctccccccc gcccccgttc ctcactcccc acagccatcc ccactgagaa tctggagttt 181 gaggtcagaa tgaaagagag cagccctaga gggagaaagc tttggcccag ggttcttagt 241 ctggaatcaa ctccttgtct ttggatgtat ccccgtgtag tctgtgcacc tgtgtgtgta 301 tttcagggga agggagcagt gcatttaatc agattgtcaa aagagtctaa gaccccaaat 361 ggttaggtac acagggttag tggtggacag tctgaaagaa atgaacctca cctgggcttt 421 cctctgttgt gccatgtcac cacacaccca ttcactactg tgtgtttgcc cattgctgtg 481 caagtgtttt gtttgttttt aagtgtttgt cttattttct taaccagact gccagatgac 541 cctatgccct ctgttggcct gtctgtgccc tggtggctct gattacttgt ttctgttttt 601 tgtttttgtt tttttttttg agatggagtt ttgcttttgt cgcccaggct ggagtgctat 661 ggcacaatct tggttcactg caacctctgc cttccgggtt caagcgattc tcctgcctca 721 gcctccagag tagctgggat tacaggcgcc cgccaccaaa cctggctaat ttttatattt 781 ttagtagagt cgggatttca ccatgttggc caggctggtc tcaaactcct ggcctcaggt 841 gatccaccca cctcggcctc ccaaagtgct gggattacag gtgtgttttt tgttttttta 901 agagatggag tctcgctatg ttgcccaggc tggccttgaa ctcctgggct caggcaatcc 961 ttctgcctca gccttcccag tagctgggtc actgtgatga tttgaattga attctgtgat 1021 gtgtaagaag agcagcctgc aaggcaagca cagatggggc agcttttgtt ctgagaaatt 1081 cgtgccctta ctgaacttgg gtctggctat ttttggaaca tggccagcat caagttctaa 1141 cccacaacac ggtctttttg gagtagcatg aattcaggag aaatctggct gcatagtcaa 1201 gccctcaccc cttccatcct gtgcacgaac tgtttcaagt aacagatgtt ccaggcagag 1261 ccagccagag tgagctgttc cttctctgga gggtgatctg gtatccctga acgcctgttg 1321 gcctcatctc caccaacccc tgcagtctct gcccctgagt ccccctcctt ccatccgcct 1381 ccccttacta gagcctcagc cctccctcct cgcctggaag ccttgccccc gcccccttgt 1441 gctggctgga gctcaagcct cttcctttgt cgcagctccg cccagttgaa cacacccgct 1501 ggggaaggtg cctctgttcc ctccccacgc actctgggcc tgagctgaca gagatggacc 1561 atcgaaaagc cagggtcctc ccagctgggc actactgccc ctcgctagga atatgggcct 1621 cgcaggtcgg cagcgtgagg tcctctgtgc caccttccat caggtagctg tcaccgagga 1681 gcatgttgca gtgccgggtg ggggctgcct tgcatgcaag gagcctggca gcagcggagg 1741 gcaaggcttt gagtgaggcg gcccggacag ccatagctga ggagcatgga gccactggga 1801 gggggcagtg tcaccttttt tggccttctt cctgtgtgga aatacagcgc ctccggcttg 1861 aacctgccac tcaggtgtct tgatgtgtcg ggggtgtggc tgcctgcccc ctgatgctcc 1921 ctgccccacc ctgtgcagta ggaacccagc catggtgaac gaagccagag gaaacagcag 1981 cctcaacccc tgcttggagg gcagtgccag cagtggcagt gagagctcca aagatagttc 2041 gagatgttcc accccgggcc tggaccccga gcggcatgag agactccggg agaagatgag 2101 gcggcgattg gaatctggtg acaagtggtt ctccctggaa ttcttccctc ctcgaactgc 2161 tgagggagct gtcaatctca tctcaaggta aactcatgca aggttaaggt gggaggcggg 2221 agtggtggtg cctggggagc aaactgtcag ccctgaggct gggctgccct ttaacccggc 2281 agaaaaaagc agccggaggg ggcaggaagg agaaggcaga gtgggtcatc tgatctgcaa 2341 cttctctgtt gcctgtaaaa gtccctccac agtgtcaagg tattttagac acactcttca 2401 atgggttaaa aatgttgatt ctcacactgt attctttgag ggaacttggg ggctggatca 2461 cgagtgcagt ttaggaagtc acaaagcagt gagattgttt tcagcaagtt agaaatttgg 2521 attatgcttc ttgaactcta gaaatgccaa ctgaattaca ttagcacttc atgaattgca 2581 gttttttttt taagtttatg ccttttactg tatgcacgtc tcacgtgtca ctcccaagtt 2641 tttgaagttt aaatgcacaa ggatgtttaa atacaccgtt gatagcttgt aacacaagta 2701 ctcgtgcaca tccaggcttt tttttgagtc tcgtttcgga acttggcctt ggtctgcata 2761 actgtaagct gctgcacagg gcttgggggg tggcatgaaa gaaagtgagt ctgctgaccc 2821 tctttctaac tgttcctaca gcgaggctgt gcttgccaca gttaggattc ccctaactct 2881 caatcatgat gtcttaactc acctgagata ataaacaggc aagcgctgtg aaaagtctga 2941 agtgctgctc tcacacaaaa tgatagcgct gttgttgtgt cttacctctg taatagtgat 3001 tataacggca cctcacatat actgagtatt cggtttgtac accaggcact gttctaagtt 3061 ctgtggaacc agctgccgtc atattctcct agtgttatgg ttttttgttg ttgttgttgc 3121 tttttttttt tttttttttt ttttgagaca gagtctcatt ctgtggccca ggctggagtg 3181 cagtggtgtg atcttggctc attgcaacct ctgcctcctg gctcaagcaa ttctcctgcc 3241 tcagcctctc aagtagctgg gattacaggt gcccaccacc acacccagct aatttttgta 3301 tttttagtag agatgaggtt tcactatgtt ggccaggcgg tctggaactc ctgacctcaa 3361 gtgatccact cacttcagcc tcctgaagtg ctgggattac aggcgtgagc caccacgccc 3421 agcatcctag tgttattatg aagtgggtac tactatctgc cgtgtcttat aaataaggaa 3481 acagaactca cagagattaa gtaatgtacc caagatcaca cagctataag tagcaaagcc 3541 aggatatgaa cgctgattgg tctgtctcca accttcattg atgcttctct aactcccggg 3601 ccccatggga aggcagtgac ggatggtatt tctcctggaa cctctcttca gaaacaaacc 3661 ccctacaggt ttgaccggat ggcagcaggt ggccccctct acatagacgt gacctggcac 3721 ccagcaggtg accctggctc agacaaggag acctcctcca tgatgatcgc cagcaccgcc 3781 gtgaactact gtggcctgga gaccatcctg cacatgacct gctgccgtca gcgcctggag 3841 gagatcacgg gccatctgca caaagctaag cagctgggcc tgaagaacat catggcgctg 3901 cggggaggtg tggagccagc actcccctac actctgggtt ctggctttcc cggaggccac 3961 ttggtagcct gaacttggtt cctgaaatgg tcctttactt cttcctgggc cccacgctga 4021 ggatccgcag gatcccatcc ccgccagtag tgtcagtagg cattgtgggt agtgagtcat 4081 cctgggcacc acacacaggc agccacctct tccacctctt gacctcgaca taggagttcc 4141 gtcaggaatg cagtcgcggc ctgataaccc tctgccttgc ctacaccact gcatcgattg 4201 ctggctgcac ccagcacttg gcccaatcac agagtaacag agtatccagg agtgagaata 4261 gccggtcagg cctctggtgc ccgctgttgt caggccacct aagagtggga agagggagcc 4321 tgatgggtgg gatcctatgg cctcgtgctc cctaccacaa gaccccttca cttgagatga 4381 gtagaaaatt ctcccaggag gcaggagccc caaggccgtg ggatgggaga gggtggcagg 4441 cgtgcccagg tagaagtagg gaagggctct ccaatcctcc aggcacggtg agaagcagcg 4501 gtggtctcct attctccacc gccagcacag ggtcagcatg cagtgaatat tgaactggtg 4561 ggctgctttt ttccctcctg ctgtcttacc aagtgctaga aagagacgaa ccaaacctaa 4621 ataatatgaa gtttctgcct tccagggact cgcagtcctg ggtgtcgggg ctaggtagag 4681 ggaacagaaa gggtctctgg aggttgggtg agacccagtg actatgacct ccaccaaccc 4741 tgcagaccca ataggtgacc agtgggaaga ggaggaggga ggcttcaact acgcagtgga 4801 cctggtgaag cacatccgaa gtgagtttgg tgactacttt gacatctgtg tggcaggtga 4861 gtggctggat catcctggtg gcggggatgg agctagggag gctgagatgc ccagagagcc 4921 tgtcggtgtt cggttcagga cacagtgatc aggggcactc atgggtccat gctggatgaa 4981 ggacatgcag aggtgaactg caccgtgtcc ttgctccttt tgtatcaccc actcccctcc 5041 tgggcctgcc accatcgacc cctagctttt tgttcctctg cctggctgtg cccttagcct 5101 gcttggcctt attcttttct ttaaaacgaa agaggggtct gggcgcggtg gctcacacct 5161 gtaaccccaa cactttggga ggccgaggca ggcagatcac ctgaggtcag gagttcgaga 5221 cctgcctggc caacatagcg aaaccccgtc tctactaaaa atacaaaaat tagccaggtg 5281 tggtggtgca cggctgtagt cccagctact caggaggctg agccaggaga atctcttgga 5341 cccaagaggc ggaggttgca gtgagccgag atggtgccgc tgcagtccag cctcagtggc 5401 agagcaagac tccatctcaa aaaaaaaaaa aaaacaacac cccacaaaag agggatattt 5461 actaacagga ttccagaggg cagggaaccc aagatcagga gatggcctca gacctcacaa 5521 ggcactggaa gaggtcaaaa agcaaggccc tccctcattc cctctggggc cacagggtcc 5581 cccatctccg cttcccactg cacatctgtg cttcatctgg gagacctgat acccatgctt 5641 ttccacacac ctggcctgct cctgagtgtg cagagtgtca gttccagcca gttccccagg 5701 ctaatggaca ggcctccgtt ccaaattccc aggaaagaga atcaccattg gccacagcca 5761 caagaccagg ttcccccaac agaaatgggt gggttggact tctctcccac ccttgaagct 5821 gaaggctggc attgagccct cagcgtctca gacagcgctc aggtatggca agacagtgtg 5881 caccagggac aggaagtccc gggattggca cattttctgg gatgacagtt tttttgccaa 5941 tattctggga gaaatcctac catttttata ttaaacatgg ctatgttatg gagtagcatc 6001 taaagtgata tgaactaaaa aaaaaaggcc aggtgcggtg gctgaagcct ataatcccag 6061 cactttggga ggccaaggcg ggtggatcat gagatcagga gtttgagacc atcctgtcca 6121 acatagtgaa accccgtctc tactaaaaat acaaaaatta gccgggcatg gtggcgcgtg 6181 cctgtagtcc cagctacttg gtaggctgag gcaggagaat cgcttgaacc caggaggcgg 6241 agcttgcagt gagccgagat cgcaccaatg cactgtagcc tgggcaacag agccagactc 6301 cgtctcaaaa aaaacaaaac aaaaaaccca aaaaacaaac cacgtggctt caagaaaatt 6361 acatgttgtg agtaactttg gccttgtccc taacccccga tggacatgtc cattctgtca 6421 acaggggtgt ttaggtgcta agtctgggaa gcgctgatta ggagtcagag aacagacatt 6481 tccaactgtt aaattgtcat cgcttgtatc agccattata tagtcagtta ctgggggaat 6541 atgcacccgt gatgggcgtt aggtgataat gattggaaac tagtgaagct gtgagctcac 6601 agttgctgaa tggtttctta ctttgcttat caagtgggta atgaagatga gtggattaga 6661 aaacaccaac ctgttgggca tggtagctca tgcctgtaat cccagagctt tgggagactg 6721 aggcaggaga tcaagaccag cctgggcaac acagtgagac cgtgtctcta caaaaaataa 6781 aaacatttta aaaaagaaag ccctcagctg ttcatgatag aaaaatagag taaatagcaa 6841 aatctatacg taatcaaatg ctagatttgt tcggtgatat ttaggtattg tagctatact 6901 tttcagctat taaaaagcct tgttgtttct gaaattccta ctgggaaaat agctttgtta 6961 ttgcaagtgt gaagccccat tgctttatcc cccactccct taccccttga aacaatagtt 7021 tttatattca ttttttgatg actctgggtt tcttaagaac ggaactgcct tatcagagca 7081 aagcagcttg gccttccgcc tggctcagag tcctgccctg ggcttgggct gatgaaacca 7141 gcactccatg tagtttcatg aaggcctatg gtcgtcctgc ttgcctgacc gagcaaggcg 7201 gctagtaagt ttagtcattg aggaaagggg tcagagagtt cacagagcca gtaaggagcc 7261 tatgggacat ctgatcccac ctcctaagca attctggaat cttgtcttca gcatccactg 7321 cccctgtgtt ttcagactcc aggagctcat tgttttgtga gtggcttata gtactctagc 7381 cagctctctg aaccggatgc tggttctgcc attagaaaca acacagaata tgactaataa 7441 agaacttcac tagggggctg ggtacagtgg ctcatgcctg taatctcagc actttgggag 7501 gccaaggtgg gaggattgct tgagcccaga agttccagac aaacctggac aagatagcaa 7561 gaccccatct ctaaaaaata aataattaat taaaaaaaaa ttttttaatt agccagatgt 7621 ggtggcttgc atctgtagtc caagctactc aggagactga agtgggagat cacttgtgcc 7681 cgggagttca aggctacagt gagccatgat tgtaccactg cactctagcc tgggtgacag 7741 agcgagaccc tgtctctgaa acaaaacaaa acaaactcac ctatggtgga tcctttttcc 7801 ccaggacaga cctttggaca tttgaaagga gtttctgtat tcttttcatt cttttttttt 7861 tttttttttt tgagacggag tttcactctc gttgcccagg ctagagtgca atggtacgat 7921 ctcggctcac tgcaacctct gtctcgtggg ttcaagcaat tttcctgact cagcctcctg 7981 agtagctatt acaggcatac accaccacac ctggctaatt tttgtatttt tggtagagac 8041 ggggttttac catgttggcc aggctggtct cgaactcctg acctcaggtc atcctcctgc 8101 cttggcctcc caaagtgctg ggattacaga catgagccac cgcaccctgc catccattat 8161 tttctttgaa gaaaacatca ctttcttcag ttcttccttg tgtaacttgg tttttagctt 8221 ttcactatct tggacccctg agtaatttca gtgttacatt aaaaacaatg tttaatccgg 8281 tgcctagaga aaagtcaagc ttagtacccc agatgctgcc cagccagtgc taactgtagc 8341 attttctctt ttctatggcc accaagtgca ggcctgattt gcttggctgc tcaaggcagg 8401 acagtgtggg agtttggagc aatccacccc cactcttgga actgggctct gagccacctc 8461 ccctgagagt catctctggg gtcagaagca tatcagtcat gagcccagcc actcactgtt 8521 ttagttcagg ctgtgctgtg ctgttggaag gtgcaagatc agagccccca aagcagagga 8581 ctctctctgc ccagtccctg tggtctcttc atccctcgcc ttgaacaggt ggaggccagc 8641 ctctcctgac tgtcatccct attggcaggt taccccaaag gccaccccga agcagggagc 8701 tttgaggctg acctgaagca cttgaaggag aaggtgtctg cgggagccga tttcatcatc 8761 acgcagcttt tctttgaggc tgacacattc ttccgctttg tgaaggcatg caccgacatg 8821 ggcatcactt gccccatcgt ccccgggatc tttcccatcc aggtgagggg cccaggagag 8881 cccataagct ccctccaccc cactctcacc gcaccgtcct cgcacaggct gggggctctg 8941 ggtggagtgc tgagttcgct gagttcttcc cagatctcct ctcaggtcca gaacttgcac 9001 agcgttgctt ggccacccca ttttggttac ctctaatttt ccccccaaaa cccagcaaca 9061 gtgtctgttg aggggtttgt tgtactttgg ccaacaagca tcaccaaaag ggattctaat 9121 tctcattaca aatcctgctt aaatcagtgt ttcccaaagg tggctgtcat cagaaccact 9181 tgataagctt tttcaaaaag tggatctcca ggtcccaccc ctggaggttc tcactcagta 9241 aatctgaggg aggtccttgg aatgtgtgtt ttacttcttg agcttggcag gtgattcgga 9301 tgatcagtgc agcatgggaa cagctgggtt agatgacacc atgttaccaa cagacacatc 9361 tagggctaaa aggctggctc aacccaaggc tggaatgctt agggcagctg ctctactctg 9421 taaaaagtgg gaaagctggg catagtggca cgtgcctgta gtcccggcta cttgagaagc 9481 tgaggcagga ggatggcttg agccctggcg tttgagagca gtgagactca gtctctaaaa 9541 acagaaaaaa gaggagaaaa cggcaggcca agcccaggtg tgctcctaga atatgatcgg 9601 actttcgtgg gtccctctgc ctgacactgt ggttggcatg gatgatggaa gggggagaag 9661 tatttagggt gggagacggg ctggccagca gccgccacag cccctcatgt cttggacagg 9721 gctaccactc ccttcggcag cttgtgaagc tgtccaagct ggaggtgcca caggagatca 9781 aggacgtgat tgagccaatc aaagacaacg atgctgccat ccgcaactat ggcatcgagc 9841 tggccgtgag cctgtgccag gagcttctgg ccagtggctt ggtgccaggc ctccacttct 9901 acaccctcaa ccgcgagatg gctaccacag aggtgctgaa gcgcctgggg atgtggactg 9961 aggaccccag gtgagggcag tggcccagag atccccagag gagggtccaa gagcagcccc 10021 ggctgcagtg ctggctcccc acggtggtac agatggatgt ctgtgccatg gctagctggg 10081 cacatcgaag gctccagtct cagagggcat cagatggaag aactcagcct caggggtgct 10141 cccctgcttc cggctccctc tagccaatcc cttgtctcaa ttctctgtcc ccatcctcac 10201 ccaggcgtcc cctaccctgg gctctcagcg cccaccccaa gcgccgagag gaagatgtac 10261 gtcccatctt ctgggcctcc agaccaaaga gttacatcta ccgtacccag gagtgggacg 10321 agttccctaa cggccgctgg tgagggcctg cagaccttcc ttgcaaatat atctttgttc 10381 ttgggagcgg gagggcagaa gaagtttgca tgcttgtggt tgacctggga ggagtcaggg 10441 gcagaattta caggaatggc ctcctgggca tgtggtggca ctgccctctg tcaggagtgt 10501 gccctgacct ctgggcaccc ctctgccagg ggcaattcct cttcccctgc ctttggggag 10561 ctgaaggact actacctctt ctacctgaag agcaagtccc ccaaggagga gctgctgaag 10621 atgtgggggg aggagctgac cagtgaagaa agtgtctttg aagtctttgt tctttacctc 10681 tcgggagaac caaaccggaa tggtcacaaa gtgagtgatg ctggagtggg gaccctggtt 10741 catcccctgc ccctggcctg accccagctg caggccaggc tgcggggctg tgacttcccc 10801 atcctgtgcc ctcccctcca tgctgtggac atggcaaagg gagaagggta agttgggaga 10861 cctccacctg gaagggctta gggaggcaaa gacaggctgg gtctttgttg ggggccgtga 10921 gagggactca gggtgccaaa cctgatggtc gccccagcca gctcaccgtc tctcccaggt 10981 gacttgcctg ccctggaacg atgagcccct ggcggctgag accagcctgc tgaaggagga 11041 gctgctgcgg gtgaaccgcc agggcatcct caccatcaac tcacagccca acatcaacgg 11101 gaagccgtcc tccgacccca tcgtgggctg gggccccagc gggggctatg tcttccagaa 11161 ggtgtggtag ggaggcacgg ggtgcccccc tctcttgacc ggcacccgtg ggttccccag 11221 agcttagggc agagcagcct gcctctcctg ggctcttaaa ttttgaatga gcatggattg 11281 gagcggatgg gagctcatgc tttaagtcag atagacctgg ctgggcacgg aacccggcca 11341 gcactttggg aggccaaggc gggtggatca cttgagccca ggagttcgag accagcctgg 11401 gcaacatggt gaaacccatt ctctacaaaa aatacaaaaa tgaccgaggc atggtggtgt 11461 acacctgtag tcccaggtac ttagggggct ggggtgagag gatcgcttga gtccgagagg 11521 ttgaggctcc agtaagccat atttgtgcct ctgcactcca gcctggccca caaagtgaga 11581 ccctgtctca aaaaaaaaaa aaaaaaaaaa aaaaaaagat tggctgggct tggtggctca 11641 tgcctgtaat cccagcactt taggaggcca aggtgggcag atcacaaggt caggagttcg 11701 agaccagcct gacaaacatg atgaaacccc atctctacta aaaatacaac aattagccgg 11761 gtgtggtggc gggcacctgt agttgcagct acttgggagg ctgaggcagg agaatcgctt 11821 gaacccggga gacggaggtt gcagtgagct gagatcatgc cactgcactc cagcctgggc 11881 aacagagcaa gactccatct caaaaaaaaa aaaaaaaaga tagaaatcag acctatggag 11941 gcaggtcact cgacctctct gagcctggtt ttctcgtctg taaaatggga tgtagcttgt 12001 gttctgggca tgaaacctaa caaagcatgt aacgtgcttg gcacatggta agagcaggaa 12061 gcactccctg aaaggcagct gctgttacta tcctgagttg acacctttct cccagggctg 12121 ctggagttaa cattatgttc tgatctaagg cccacgggcc ctggagcaga aagacctgag 12181 tttaaggacc agctctactg tttactgtca gagtagccaa cgtgctcaac ttccctgaac 12241 ccactttcct cacgtggggc tcactgtgcc cagcctcccg tattatcagc attctagcaa 12301 atgagtttga gtaaacccag cttaatccct gataggcact ggttctagag gagatgtcaa 12361 tgtcattgtc agcttgcact ggggaggatg gaatgtgtgg ggcctctctc ccatgactcg 12421 gcctgtcaaa ccagttgctg ctgttcagaa atggcttctt cgtggagtct tccctgactg 12481 attgggagag gggtggctga tagccctcag acctgtccag actgagaaac tcacgtcccc 12541 actcccctca ccctttgctt atggacgtgc caacgccaca gttcattatt ccgcccacat 12601 ggctgccagt agtcctgata ccttaggtgt ctgcgaaagg gcgtctggca gggctggggt 12661 tggtgacagg cacctgtctc tcccacaggc ctacttagag tttttcactt cccgcgagac 12721 agcggaagca cttctgcaag tgctgaagaa gtacgagctc cgggttaatt accaccttgt 12781 caatgtgaag gtaggccagg ccccagggtt cccacagagt accaggccct tcgttgagca 12841 aacacccagc acctagcctg ggctaggcat tgtgcaagac agagagatac aggcagaact 12901 ggggccctgc tcttaaggag ctcccagcct agagtgaggg aggcagatca atgtgtgacc 12961 accagccagt gtaagtggga aaatcaagtt caggagagga tgctgtcggg tccagaggag 13021 ggatatctca cctgggaggc cagggaaggc ttctcagagg gtcatctgtg ggaatcactg 13081 aggacaaaga ggagttggcc aacaggagag aagggtattc ctgggacagg gcagaggaca 13141 ggcagaggca gtgagctgca ccatctgggg aaaccgggaa catgagcagg aggaggcggg 13201 agtgttaagc aggggccagg cccgcagaga tcatggttgt cctgctggaa tttgagtttt 13261 ccctcaatgc aagggaagcc tttctccagc agtggggtgg cttggttcct gctttatttt 13321 aggcaaatca cagtggatag tcatacggat gagagagatt ggggacggct agagccgggg 13381 aggccagtga agagacccct ggagtgaccc aagccaaaca cactcctgga ggtgggctag 13441 acaagaggga atggatcaga gagtgagcag ggggtgctca aggaggagag gggaagtggc 13501 caggacgcct ctaggttcag gcttgtgtgg ggagagatat cattcacaga tgcaggcaga 13561 ggaggccagg agcggaggca cagggagagg ggagtggagg cgcagggaga gtggaggccg 13621 ggagtggagg cgcaggcaga gggtattgag cccagacagc ctcattgagt caaggctgtc 13681 caggcagtgg gactccagtt gttcttggcc caggtcttac ccccacccca catcccctca 13741 gggtgaaaac atcaccaatg cccctgaact gcagccgaat gctgtcactt ggggcatctt 13801 ccctgggcga gagatcatcc agcccaccgt agtggatccc gtcagcttca tgttctggaa 13861 ggtaaaggag ccgggggcaa gcttgccccg cccacctgga aaaccgtggg gagggattgg 13921 gaccaagtcc caagcgtgtg ctgaaggcca cactggaccc agccttcagg gcacacccag 13981 ctctgactca cccatgtcac tgctgacgca gggtgtttat ttctgggcag gggtgggaag 14041 tgatactggc agtgggcctt gttctattcc gggaaatgtc ctgttgagca gagcccttgg 14101 agagccctgt taatcttgcc tctgtgtgtg tgtgcatgtg tgcgtgtgtg cgggggtatg 14161 tgtgtgtagg acgaggcctt tgccctgtgg attgagcggt ggggaaagct gtatgaggag 14221 gagtccccgt cccgcaccat catccagtac atccacgaca actacttcct ggtcaacctg 14281 gtggacaatg acttcccact ggacaactgc ctctggcagg tggtggaaga cacattggag 14341 cttctcaaca ggcccaccca gaatgcgaga gaaacggagg ctccatgacc ctgcgtcctg 14401 acgccctgcg ttggagccac tcctgtcccg ccttcctcct ccacagtgct gcttctcttg 14461 ggaactccac tctccttcgt gtctctccca ccccggcctc cactccccca cctgacaatg 14521 gcagctagac tggagtgagg cttccaggct cttcctggac ctgagtcggc cccacatggg 14581 aacctagtac tctctgctct agccaggagt ctgtgctctt ttggtgggga gcacttgcgt 14641 cctgcagagg accacagtgg gtggcacctc ctgagaaggc gaggagagtg gttgttgcca 14701 actaagccct cgaaccaagg cagcctccag agccagcctg ggactcccag tgaacttacc 14761 cttggagccc gtgcagtaca ggcaaaacac gcaagggcat caggcactgg tggcatcgta 14821 gaagagatgt ggcaaagtgc tgtacccttc cacctcctag aggtgggcag ctgggcccca 14881 cctacttgtg actgaagggg cacaccactg ccctgcctgc ccacttagcc gtccatggca 14941 ccagccccct ggatgggcat tgggctgaca cctaccatgc tgctttttgg cacagttgtc 15001 tattctgagc cttgagagaa aaagtgcccc ttaagggttg aaggcagtct gaacccttgt 15061 gcttggtggg gctcgtggcc ttcccctttt gcctggctgt ggaggcctga tgctgccccg 15121 ttccctgtca gaggctaaga tgagatttgc cagcacaggg gccccagatc tgcctgggcc 15181 tgtgcagcag cccagcttcc tggtgtattt ttcaggtagg cccttgtcct gccagctgcc 15241 ttcctcatcc cctcgtcctg tcccagaggt tatctgcctg gcctggctcc ccacgagtca 15301 cctgcaagcc ccagggcctg ggggcagtga ctggcaggtg cagatgggct gtttcgtgta 15361 gtggaagagc agcctgatgg ccaagggggt ggacgcaatt gtgggatgtc ctctttactc 15421 ccttcctggc ctcactggct ggggcagagg ggcagccgct aggagagact gaaagcagca 15481 gctaggactg aggagtgggt tttattgtcc ttcagagctc ttcaagctgt cccctctgtc 15541 atcactccct ggatgtgtgg ggcatggttc cttccctggg aaggctaagt tcagttctgt 15601 tttttattct atgagaacaa gtcacagctg cagctgggcc ccatgctctg ccccaagccc 15661 ccaaccccgc ggtgctccgg cggcttcctg tccactctcg gggcccttgg ggcctggctt 15721 gctccagggt cttgggctac tggcagctcc tctccttggg ctcctggctg ccaggcgttg 15781 gtgccacttc ttaaaggcct ggaaccaggg aggagaggaa atgctattgt tgtgg //