LOCUS MMP8 16340 bp DNA linear PRI 22-JUL-2005 DEFINITION Homo sapiens matrix metalloproteinase 8 (neutrophil collagenase) (MMP8) gene, complete cds. ACCESSION MMP8 VERSION tmp KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16340) AUTHORS Livingston,R.J., Rieder,M.J., Shaffer,T., Bertucci,C., Baier,C.N., Rajkumar,N., Willa,H.T.., Daniels,M., Downing,T.K., Stanaway,I.B., Nguyen,C.P., Gildersleeve,H., Cassidy,C.M., Johnson,E.J., Swanson,J.E., McFarland,I., Yool,B., Park,C. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (22-JUL-2005) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..16340 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 51 /frequency="0.01" /replace="T" variation 56 /frequency="0.15" /replace="C" variation 63 /frequency="0.04" /replace="A" variation 90 /frequency="0.01" /replace="G" variation 256 /frequency="0.01" /replace="T" variation 342 /frequency="0.01" /replace="T" variation 443 /frequency="0.01" /replace="A" variation 462..488 /frequency="0.75" /replace="" repeat_region 588..650 /rpt_family="L2" /rpt_type=dispersed variation 598 /frequency="0.65" /replace="" variation 683 /frequency="0.01" /replace="C" variation 736 /frequency="0.01" /replace="C" variation 856 /frequency="0.02" /replace="" variation 862 /frequency="0.02" /replace="A" variation 896 /frequency="0.15" /replace="G" variation 1087 /frequency="0.01" /replace="G" variation 1170 /frequency="0.15" /replace="T" variation 1190 /frequency="0.34" /replace="T" repeat_region 1192..1434 /rpt_family="MIR" /rpt_type=dispersed variation 1222 /frequency="0.15" /replace="T" variation 1607 /frequency="0.04" /replace="G" variation 1675 /frequency="0.01" /replace="T" variation 1814 /frequency="0.01" /replace="A" variation 2004 /frequency="0.04" /replace="G" gene 2012..14341 /gene="MMP8" mRNA join(2012..2185,4266..4510,5177..5325,5413..5538, 8365..8526,10521..10638,11503..11636,12231..12384, 13083..13186,13483..14341) /gene="MMP8" /product="MMP8" CDS join(2084..2185,4266..4510,5177..5325,5413..5538, 8365..8526,10521..10638,11503..11636,12231..12384, 13083..13186,13483..13592) /gene="MMP8" /codon_start=1 /product="matrix metalloproteinase 8 (neutrophil collagenase)" /translation="MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKIVQDYLEKFYQLP SNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMEKPRCGVPDSGGFMLT PGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINI AFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHE FGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTP KPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYE DFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVN DQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQ RVTRVARGNKWLNCRYG" variation 2091 /gene="MMP8" /frequency="0.02" /replace="G" variation 2178 /gene="MMP8" /frequency="0.34" /replace="C" variation 2257 /gene="MMP8" /frequency="0.12" /replace="A" variation 2262 /gene="MMP8" /frequency="0.01" /replace="C" variation 2282 /gene="MMP8" /frequency="0.01" /replace="G" variation 2412 /gene="MMP8" /frequency="0.01" /replace="T" variation 2455 /gene="MMP8" /frequency="0.02" /replace="T" variation 2535 /gene="MMP8" /frequency="0.35" /replace="A" repeat_region 2893..3103 /rpt_family="MIR" /rpt_type=dispersed variation 2957 /gene="MMP8" /frequency="0.01" /replace="T" repeat_region 3120..3541 /rpt_family="MaLR" /rpt_type=dispersed variation 3213 /gene="MMP8" /frequency="0.01" /replace="A" variation 3226 /gene="MMP8" /frequency="0.02" /replace="T" variation 3243 /gene="MMP8" /frequency="0.02" /replace="A" variation 3294 /gene="MMP8" /frequency="0.33" /replace="T" variation 3501 /gene="MMP8" /frequency="0.12" /replace="A" repeat_region 3578..3654 /rpt_family="ERV1" /rpt_type=dispersed variation 3600 /gene="MMP8" /frequency="0.02" /replace="G" variation 3643 /gene="MMP8" /frequency="0.28" /replace="G" variation 3691 /gene="MMP8" /frequency="0.33" /replace="T" variation 3731 /gene="MMP8" /frequency="0.01" /replace="T" variation 3917 /gene="MMP8" /frequency="0.02" /replace="C" variation 3934 /gene="MMP8" /frequency="0.03" /replace="A" variation 4002 /gene="MMP8" /frequency="0.01" /replace="C" variation 4397 /gene="MMP8" /frequency="0.01" /replace="C" variation 4422 /gene="MMP8" /frequency="0.32" /replace="A" repeat_region 4533..4632 /rpt_family="L2" /rpt_type=dispersed variation 4617 /gene="MMP8" /frequency="0.32" /replace="C" variation 4628 /gene="MMP8" /frequency="0.27" /replace="A" variation 4742 /gene="MMP8" /frequency="0.10" /replace="T" variation 4743 /gene="MMP8" /frequency="0.70" /replace="" repeat_region 4849..5026 /rpt_family="MIR" /rpt_type=dispersed variation 4967 /gene="MMP8" /frequency="0.02" /replace="A" variation 5080 /gene="MMP8" /frequency="0.36" /replace="G" variation 5095 /gene="MMP8" /frequency="0.01" /replace="T" variation 5279 /gene="MMP8" /frequency="0.01" /replace="A" variation 5290 /gene="MMP8" /frequency="0.01" /replace="A" variation 5494 /gene="MMP8" /frequency="0.01" /replace="T" variation 5510 /gene="MMP8" /frequency="0.01" /replace="T" variation 5676 /gene="MMP8" /frequency="0.12" /replace="A" variation 5726 /gene="MMP8" /frequency="0.33" /replace="A" repeat_region 5767..5968 /rpt_family="MER1_type" /rpt_type=dispersed variation 5790 /gene="MMP8" /frequency="0.01" /replace="T" variation 5791 /gene="MMP8" /frequency="0.15" /replace="A" variation 5807 /gene="MMP8" /frequency="0.01" /replace="G" variation 5809 /gene="MMP8" /frequency="0.04" /replace="T" repeat_region 6524..6945 /rpt_family="L2" /rpt_type=dispersed variation 6664 /gene="MMP8" /frequency="0.01" /replace="C" variation 6677 /gene="MMP8" /frequency="0.02" /replace="G" variation 6772 /gene="MMP8" /frequency="0.02" /replace="A" variation 6819 /gene="MMP8" /frequency="0.11" /replace="C" variation 6894 /gene="MMP8" /frequency="0.24" /replace="C" variation 6954 /gene="MMP8" /frequency="0.04" /replace="C" variation 6955 /gene="MMP8" /frequency="0.09" /replace="A" variation 7006 /gene="MMP8" /frequency="0.02" /replace="T" repeat_region 7325..7495 /rpt_family="MIR" /rpt_type=dispersed variation 7325 /gene="MMP8" /frequency="0.15" /replace="T" variation 7470 /gene="MMP8" /frequency="0.16" /replace="G" variation 7591 /gene="MMP8" /frequency="0.01" /replace="G" variation 7785 /gene="MMP8" /frequency="0.02" /replace="G" variation 7790 /gene="MMP8" /frequency="0.01" /replace="C" variation 7872 /gene="MMP8" /frequency="0.01" /replace="T" repeat_region 8066..8120 /rpt_family="MIR" /rpt_type=dispersed variation 8182 /gene="MMP8" /frequency="0.01" /replace="G" variation 8478 /gene="MMP8" /frequency="0.01" /replace="T" variation 8577 /gene="MMP8" /frequency="0.01" /replace="T" variation 8619 /gene="MMP8" /frequency="0.01" /replace="A" variation 8650 /gene="MMP8" /frequency="0.03" /replace="T" variation 8686 /gene="MMP8" /frequency="0.03" /replace="G" variation 8787 /gene="MMP8" /frequency="0.37" /replace="C" repeat_region 8834..9115 /rpt_family="Alu" /rpt_type=dispersed variation 9064 /gene="MMP8" /frequency="0.01" /replace="T" variation 9119 /gene="MMP8" /frequency="0.01" /replace="G" repeat_region 9160..9437 /rpt_family="L1" /rpt_type=dispersed variation 9178 /gene="MMP8" /frequency="0.01" /replace="G" variation 9192 /gene="MMP8" /frequency="0.01" /replace="T" variation 9340 /gene="MMP8" /frequency="0.01" /replace="C" variation 9463 /gene="MMP8" /frequency="0.01" /replace="A" variation 9956 /gene="MMP8" /frequency="0.01" /replace="T" variation 9977 /gene="MMP8" /frequency="0.03" /replace="T" variation 9987 /gene="MMP8" /frequency="0.01" /replace="A" variation 10034 /gene="MMP8" /frequency="0.01" /replace="A" variation 10211 /gene="MMP8" /frequency="0.14" /replace="A" variation 10491 /gene="MMP8" /frequency="0.13" /replace="G" variation 10913 /gene="MMP8" /frequency="0.01" /replace="A" variation 11194 /gene="MMP8" /frequency="0.02" /replace="G" repeat_region 11339..11416 /rpt_family="MIR" /rpt_type=dispersed variation 11497 /gene="MMP8" /frequency="0.01" /replace="T" variation 11500 /gene="MMP8" /frequency="0.03" /replace="C" repeat_region 11757..11889 /rpt_family="MIR" /rpt_type=dispersed variation 11797 /gene="MMP8" /frequency="0.07" /replace="G" variation 11975 /gene="MMP8" /frequency="0.10" /replace="T" misc_feature 11997..12185 /gene="MMP8" /note="Region not scanned for variation" repeat_region 13241..13354 /rpt_family="Alu" /rpt_type=dispersed variation 13431 /gene="MMP8" /frequency="0.17" /replace="G" variation 13464 /gene="MMP8" /frequency="0.07" /replace="C" variation 13495 /gene="MMP8" /frequency="0.01" /replace="C" variation 13536 /gene="MMP8" /frequency="0.01" /replace="T" variation 13567 /gene="MMP8" /frequency="0.07" /replace="C" variation 13648 /gene="MMP8" /frequency="0.03" /replace="A" variation 13746 /gene="MMP8" /frequency="0.01" /replace="A" variation 13822 /gene="MMP8" /frequency="0.01" /replace="A" variation 13991 /gene="MMP8" /frequency="0.16" /replace="T" repeat_region 14096..14531 /rpt_family="MaLR" /rpt_type=dispersed variation 14140 /gene="MMP8" /frequency="0.07" /replace="A" variation 14253 /gene="MMP8" /frequency="0.01" /replace="A" variation 14277 /gene="MMP8" /frequency="0.03" /replace="T" variation 14296 /gene="MMP8" /frequency="0.01" /replace="A" variation 14298 /gene="MMP8" /frequency="0.03" /replace="A" variation 14368 /frequency="0.02" /replace="A" variation 14392 /frequency="0.19" /replace="G" variation 14596 /frequency="0.37" /replace="G" variation 14638 /frequency="0.37" /replace="T" variation 14701 /frequency="0.12" /replace="T" variation 14730 /frequency="0.17" /replace="T" variation 14839 /frequency="0.12" /replace="T" variation 14882 /frequency="0.02" /replace="G" variation 15054 /frequency="0.01" /replace="" repeat_region 15424..15489 /rpt_family="L2" /rpt_type=dispersed variation 15587 /frequency="0.01" /replace="G" variation 15753 /frequency="0.16" /replace="G" variation 15803 /frequency="0.15" /replace="A" variation 15896 /frequency="0.38" /replace="C" repeat_region 15946..16248 /rpt_family="Alu" /rpt_type=dispersed variation 16049 /frequency="0.11" /replace="A" variation 16171 /frequency="0.11" /replace="T" BASE COUNT 4974 a 3277 c 3037 g 5052 t ORIGIN 1 ccctgaaagc aaatgcagta tagccttctc caccactgca ccagggctgg gcctgttggg 61 gggatccaga cccaaccgtt caatttttta acatagcatt tacccaaaca ccaaaaacta 121 agtttaccga agttttagat tctcaactaa atcacttgct gttatgttca gaagaaagta 181 catttataaa ccttgtaagc aagccattgc atcaaaataa ctcaacatag agttagacca 241 atgttaaggc attttcgtgg aggaaaaagc attttttcac caaagaccta atgtaaagaa 301 agccacatta agccatgaac tcaaggagga tgaacatgac cgtgatcttt gaacaatttg 361 gcaggaagct gtcacattta tattaataca aagaatgggt tgctacatct ctgcatgtct 421 acattctacc tcttcatgat ccggttcaaa ttccacctcc ccatgatccg gttcaaattc 481 cacctccctc atgaaacctt ccttgatttc actccctcca caccactgct gtttcctcca 541 aacacccaca gcattttatc caaacctcta ttaatttatc tccaatactc tagcacccat 601 cacagcatgt ggcatgtagt agatgacagg aaatgtttac tgaatgaatg taggaatata 661 catcattaac attaatctgc tgtccagata tgttctaacc caagacacct ttctttggat 721 cattttcaaa gttcctaagt gacctcagga aagatcagaa ctccttatca tagcatctca 781 aatacactct ttacatatta atacatgcta tgtatcatac atgtagacac atgcatttat 841 acacaagaat acctgccttt accaaatatg tatgcatata tgtaaatgag tattcacaaa 901 gactgtgtat gataacaaac tacatgcatg tggactcaga ataagtggga ccaggttaca 961 tgatttgaaa agcatgccca ggggcctctg acaaacagtc tcctatgtag ccatattgtc 1021 tggaaatctc tcagtgtctt actccttgaa gatgtacaac atctcattct ccctctccct 1081 tgtcttctgc ctgtgaatat aagccaaagt atccagctgt tgaaggccta gagctgctgc 1141 tccactatgg cccagccaga gactcaagtg ggagactacc atgcagagcc tatagtagct 1201 cccagctcag tctctctaaa cataccctct ggggttgaat cctggcccct ccacaaatga 1261 aacatgtgac ttaaacaggt catctaaatg tctctggatt tgatttcatc tgtaaaatgg 1321 agatagtaat agcatctccc tcccaaggct atgtgaagat ggattggggt aatatgtgga 1381 acacagtaca aatgtctggg caatcataat tttttagcaa atgttcatta ttatcatcat 1441 cagtattgtt ctctttatct tttccatgga aagtctaact tatagactag ggattttcta 1501 atatgttgat accaaaccac atcctccaga agcagctcta ggccccatac aaagcctgct 1561 ttgtaataac acagtcactc attctctcca catacaatga gggaggataa gtacagagat 1621 tctctagttg ggctccttgg tcccaagata tctaccacaa acctcaaaat attcccctgc 1681 ataagttaat tcaacctcaa catcttacat agtcaaaaaa tgtatccaca taacttcagg 1741 attagtccct tgttcctttt cctcaaccaa ttttgtaaaa ggaaataact aaaacatcca 1801 aaagcaaaga gtagaaagtt ggagttttga aagactgttg aaagactccc ccatttgggg 1861 gtactaaatc acattataaa attgcaaaac tgtcagagtg taattaacct atgttgcttc 1921 atattcctga tgcagcaatt gtttaagaca tggctttaaa gaggactgca agagagctgt 1981 gagtgacaca tgatgctgtg aacctcaggg tgctcgccag ggaagggccc tacccagagg 2041 gacagaaaga aagccaggag gggtagagtt tgaagagaag atcatgttct ccctgaagac 2101 gcttccattt ctgctcttac tccatgtgca gatttccaag gcctttcctg tatcttctaa 2161 agagaaaaat acaaaaattg ttcaggtaaa tgaactatca gttaggtgat gtttgatttg 2221 ctgattatta ggaaatagtg tgggttgttt tctcttgtta attaaaacag cctgaaagaa 2281 attatttggg tgattagttt gagattgaac atctcctttt agtgatttgg agggttccaa 2341 gctggtaagg actaggcctt ttaaaagccg gacatgaaaa caagctgaat tctttaaagg 2401 ctgggaaaat actgctgtag agttacccct agttgggaaa cttttgtaga agaaatggtt 2461 ttatttataa aatggtatca ttttctttct catttaccta aggtttttcc ttccaggata 2521 tctgcaatca agttgctata tgtctggtgc ttccatacag gcattttctt tgccgccaaa 2581 aattccagat atagaaaata atgtgaggat ggtagattac aatgaactag aaatcagtac 2641 acagtaaaat catatttccc agcatcagat tgtggactgt ttataaactc ttggaagcat 2701 tataaaagca gaaccaatag tttttttcca ttgtttcaca gtctgaaagt gaacccaaat 2761 ttttaagaaa cacaagggaa ttctgtcaca aatctctcat gcacagtttt cttagcatta 2821 tagtttggag aaagcattat tattattaag aggttatctc ttaattgtaa cccccgggtt 2881 aatgtaaagt ccattgagtg cttattctat gcaaggcaac tgctacacat ttcacaaata 2941 tctcatttaa tcctcacaag aaccttattg gagcattatt attttcattt cagagacaaa 3001 aatatcttaa atcagataaa taatgtggcc aagtgctcac agttaattca tggcagagtt 3061 aagatttgaa cccaggcctg tctgattcca aagcgtgtga tctggtcagt gtcacctact 3121 gctgtggtta gagtgtgtcc cttgaattta tgtgttaaag atttagtagc ccatgtgaca 3181 gtgggtcctt taagaagtac ttaggtcatt aagaaagatt aatgacactc ttgtgtgact 3241 gggttaattt ttgctggagt gggttctggc tcttgcagaa ctggattagt aatgaataga 3301 atgggtatta taaagagggg ctgccctttg tgttttgccc cttttcacac atgcttgctc 3361 cccttttgtt tctctgccat gttatgacac agcacaaggc catctcagaa gccaaccaga 3421 tgcagccacc tgatcttgga cttcccagcc tccagaattg tgagagaaaa tcagcccctt 3481 ttatgtataa gttacccagc ttcagatatt ctgttatagc aacagaaaat ggactaagac 3541 actgacaagg tgccaggtgt tcacaggcag catgaggtct agttaggtta catttcacta 3601 tgtatgaaga aacttttaag ccaaacttaa aataggtaat ttttaggcta aactctttgg 3661 attttgacta aatttaacac ttccaaagag atactttggt gaataaaatg ctaatatcaa 3721 tgatattgct gttcccctaa aagatatttg aaattatttt gaaattatca gttctcattt 3781 gagaggcaac atggtgagtt aaaatctgaa tcatcacttg gaaaattcct taattctctg 3841 tgcttctgtt tgttcagcag aataaataag ccttttctac agtagtgaag aggataaaaa 3901 agaggaactg cactgatgca acaaatacct caagagaagt caattaatgt tagtcctaat 3961 ttttttgtaa aaacaagaag acagtctcct gactgtagag tagcactttg cctgtgtgat 4021 gtgatcctca tcccttatga gacacccttt tttatgcata accattaact ggagcactga 4081 gtggaggaac tgttctttct aaaaagagtt gttctctcaa agccaaccta caaattaatt 4141 tgtgttattg ttcctgtggc tgtcaagtta tcagacctct gtagtaactt agaaagggtt 4201 gcaaaatgac cagagaactg gaggtccttt cacagcaaga cccctatgtg cttgtctttg 4261 tccaggacta cctggaaaag ttctaccaat taccaagcaa ccagtatcag tctacaagga 4321 agaatggcac taatgtgatc gttgaaaagc ttaaagaaat gcagcgattt tttgggttga 4381 atgtgacggg gaagccaaat gaggaaactc tggacatgat ggaaaagcct cgctgtggag 4441 tgcctgacag tggtggtttt atgttaaccc caggaaaccc caagtgggaa cgcactaact 4501 tgacctacag gtgatatctc tagggtttca ggatacactc atttatccag tatggactgg 4561 gctcttatat gacagacact gttcttggga tacactagga acaagtagat aaatatacct 4621 gcctttgtag agtgtgagta gtgaatgaat atgagaatga aaatgttgag ataccgtggg 4681 ttctttccac tccaaggctt cccgttttag tcttccttct ccaacaatct aaagaggact 4741 accagcaatg ttaggctgtc tctctaagca cttactttag gacccaacaa aggcttaatc 4801 attgctggag agagtcaagt ccctcctttc atacatctta ataataataa taatatctaa 4861 tatttgtgga atattattac tatttgacaa gtaatgaact aaatgcttta tatgtattta 4921 atccccacgg cagccctatg agagggatac tatattagta tcctcatttt atgaatagga 4981 aactgaggtt taaagacatg tattaacttg ttcagaaccc acatctgtcc tccaccctga 5041 gacctgcact ccctccttat cctctccagt ggtagcacac catgatgcaa ctcacttcaa 5101 aacagaacaa ctcatcagtt gatggactac tgttctaaat aacatttaac tcttcataca 5161 tcctctcatt ttgaaggatt cgaaactata ccccacagct gtcagaggct gaggtagaaa 5221 gagctatcaa ggatgccttt gaactctgga gtgttgcatc acctctcatc ttcaccagga 5281 tctcacaggg agaggcagat atcaacattg ctttttacca aagaggtagg tacaaagcag 5341 tcatgctcag ttttgctttc tttggctaac ctgaaacttg gcaaggatct aatacaaatg 5401 ttcttatttc agatcacggt gacaattctc catttgatgg acccaatgga atccttgctc 5461 atgcctttca gccaggccaa ggtattggag gagatgctca ttttgatgcc gaagaaacat 5521 ggaccaacac ctccgcaagt aagttaatca agattatgtc cacacacagc ttctgaatta 5581 accttttaca gattagaata cacacacaca cacacacaca ataaaggtaa cataatattt 5641 caaactcaca aaaagtgatc atttgaaatt tttgctacct catgatacta agtcaatttg 5701 ggattttttt aaaaaaaaga aagaagaaga catgctgaat ctgattactg accttacttc 5761 ttaggtcaga gatcagaaaa tacagactac ggccaaatcc tgcctgaccc ctgtctgtat 5821 aaataaagtt ttattgaaac agggccacat ttatttgttt ctatatcata aatggctgct 5881 ttcactctac aatggcaagc tgagtaattg caacatggat catttggctt acaaagccta 5941 aaatatttgc tatctggttc tttacagata ctgctttaga atatctttat tttaatattc 6001 ccaaatttag tgatgtttga aaagagccta tttttccatt tttggaaatt catttagaaa 6061 ttataatttc tataattaga aattagccta tttttccatt ttttggaaat tcatttagaa 6121 attataattt ctataattag aaattagtct attgagaaaa gaacagacac cttccctctc 6181 atctagttag ttcatctcct tggagctctt cttcagtggt atgcttctgt acagcaagcc 6241 actcctttca ggagaaggct cctattaaga aggactgggc tgcttgaagg gaagaaatga 6301 ggctgaggac aggtataccc agaccatgtg gtacttcaca aaatatgggg taacaatatg 6361 ccagagagca cttttagaaa ataatcagaa aggcaccttt tacctttgct tggcacctgt 6421 tcctcctgcc attttctcaa catgggtatg ttacgagggt ctattctacc taagtccata 6481 tgctaggagc tgtgtgtagc caaagatagg taataaccct cagctcctct ccattccctg 6541 ttgccctcct cactagttcg gatgatcatt acctcttacc tgaacgaatg atctagattc 6601 ctaactggac tctccatctc cagtatgtgc tccctctaat ttttcctacc attgcagcag 6661 ggtttgtttt tggaagccca tcttggatca catcactctc atgcttaaaa gtttcaatgt 6721 ttacacattc tgcaccaaat aaggtccaaa tacttccact tggtattgaa ggctcttggt 6781 gcttgttcat ccttgtcttt cttggcttgt cttcttattt cacgtattcc attcacatcg 6841 ggctaacacc cacattgtac attcactgtt tctaggtcac accctatgct ttttatcttc 6901 ctcacatttg cttgaattgc ttcctctccc tgaaatactc ttcccatgcc ccaagcacca 6961 ccttttaaaa tctctctcat cttgccatgc tatgtatgtc aaaggccacc ttctgtcttg 7021 ccttgtcctg gaaatgagaa cttcctctgc agaattctga cagcttttgt atctccttct 7081 ctgtcatcac tcactgtgtg ctttcaagtt gtttgcacac atctctcctc ttctagacta 7141 tgcactccct gtagagcaga gaaccacaac aaattgccca cagttccttt cacggtattc 7201 caagcattca aagatatttt tctgaaatgc actcatgaat gcataattaa aaggatgtga 7261 tgataagaaa caattcttag agcatgggta gaattttagc aggctaatta tcaacaggaa 7321 gttgaacatt gcagtaagag catggatctt gccattatac ctgggtttga ccccaatctg 7381 tcacttacta gttgagggac caagtaccag ctattcaaaa tctatgggca tcagtcactt 7441 tactataaaa atattgttaa taaaacttca gaaaaatgtt atgaggattg cataacatta 7501 gattgcctag tatgttgtag gtactctaca attatggctt tttttaaaag taggcatata 7561 caaaaatgca tcagtgtgtt tgtgaggcag catgtagact ggctggactg aaggattcat 7621 gttaaaaggc aagcactcaa atatctgctg gagccaagtg gaggaggtct tgaaggccag 7681 gcaaaagagg ttgggcttta tttgatagga agtgagatcc tgggaaggtt ttaagtctcc 7741 agttgtgaac ggcactatgc tcatggaagt taaaacatgg agaaagagag caataagggt 7801 aggatttgtc tctctccagt agagaattcc tagagcatct tagaaagctc agaaacagag 7861 aagagctggt gctaagctgt gggtgatgag ggagccaaca tgagccagcc ctccatctga 7921 ggctgctcca ctgctgggct ggcttctctt ctaactactt gctcacaggg actctactcg 7981 tgaggctgag tgtctgggac agtggagatg gtgattgtgg gaatgcaaga gaagaggggt 8041 tcccaaagtc atgacggctc tgccattact tctccaagtc tcagatgcac atttgtaaaa 8101 tgtgagaatt ggaataaatg cagcttttct gggttctaag agtttataag aagttcatac 8161 tcacctagtc gccatctatg accactatct tgattcttct caatgtccac tttctcaggt 8221 atctgaaaga aagatgaaaa agacagccat gggaagggct atttccctga gcagttttga 8281 cttggaggtt gcattccttg agatcatgtt tctgccaccc tgggatccac actgagctgt 8341 ttaccacccg tgtttgcatt tcagattaca acttgtttct tgttgctgct catgaatttg 8401 gccattcttt ggggctcgct cactcctctg accctggtgc cttgatgtat cccaactatg 8461 ctttcaggga aaccagcaac tactcactcc ctcaagatga catcgatggc attcaggcca 8521 tctatggtaa ggtcttctca agagagtcat agtacatggt aggacctggg aataggcgaa 8581 cactcccaga atctgaatat ctcttccttt gcacttctgc agtttccata aaactgaact 8641 ctgaatttcc ccagtaataa agcattaaca aagaaggtgt gagggactga gcctctattg 8701 ctgccctaaa agaaaaaaag tttaagaaga aatgcactac agtgcttccc agttattgtc 8761 tttggatggt ggggattttt ttcttctttt ttaggctttc caaatttcca attttaaatt 8821 ttttttgggg ggggggatgg agtctcactc tgttgcccag gctggagtgc agtgacgcga 8881 tcttggctca ctgcaacctc tgcctcccaa gttcaagcaa ttctcctgcc tcagcctctc 8941 aagtagctga gattacagat gcccaccacc acacttggct aatttttgta ttttcagtag 9001 agaggtgatt tcaccacaat gaccaggctg gtcttgaact cctgacctcg agtgatctgc 9061 ccacctcagc ctcccaaaat gctgggatta caggcgtgag ccattgcacc tggccccaat 9121 tttaaatatt ctaaaaagac atgactattc tttttcctac agcaatcctg ctcccagatg 9181 tatctatcaa agaaattctc atgtagatcc ataaggggac atgtacaaat catgccaaag 9241 atgttcactg cagtcttgtt tgtggtaatg gaagttggaa gacacctggg agtctattag 9301 gagaagacta tacagataaa atgtggtagc tgcacaccat gaagtgatgt gcagcagtga 9361 gaaacatggt actagatgca catatggcaa cagtacagat gggtctttaa aacttggtac 9421 tttgtgaaaa agaaacagaa tgagatatat tgcacaatgt attaattaaa ttacacaata 9481 tataagtcta tgtaaattta aaatgtatat aaacaaagca aggcattttt caagaagaag 9541 aaagggaatg gtagtggagt atggagagaa aaaaagaaac ttttttaagg catcactgat 9601 acatttcaag gataagtata ggggcctttt gccatattgc ctggataaga ccattacatc 9661 tctcttcacg cttgcccttc tgttccctag ttggctgtga ataaaaacaa gaaaccaata 9721 agggatttac tgctctctaa aaaagtgtgg aatggaatgg aatagtggat tggagtgaaa 9781 tataattgaa tggagtggaa cagagtggag tggaattggg gaaagccctt ttctgtctct 9841 ggtgggacag cactataaaa tcaagcaagc atgccagggt gccacaacca gggaactttt 9901 ttgtgattgc agatatttca gaaatgttga gcctatccta actgcctcta ttccccaatt 9961 tcttcctcct gcccacccca acaacacccc tttattttgt tcaccaatgt ttttatctta 10021 actattatta tagcctttca ttccacagtg agaaaacaca tgaaaattca aatacttata 10081 gaaaaaatat tgctaaaatt tgacttaggt gtatgctata gcgtaaaaga ctaatatcat 10141 tctttcctga aagtggattt tggtgaggag agaggcaata gatactgagt gaccaaaaaa 10201 gcagaaagag gaactgaaaa gtcagagaag aattagttta gaatttaaaa gggaaggaag 10261 gagcatagaa ttcaaatttc tttacttcac agcttgacct ggaacttacc ctgaaaacca 10321 tcattactct tattaaagaa acaaaaactt taaaaggatg aaatatacaa ttactttaat 10381 actttatggt atagtctggt agcacttacc ttcacatgaa gacccttcac ctttctgaga 10441 agtctctgat gtacccaaga gtcacaccgg acttactctc ataagaaaga cctttttttt 10501 tttttttttt ttttttccag gactttcaag caaccctatc caacctactg gaccaagcac 10561 acccaaaccc tgtgacccca gtttgacatt tgatgctatc accacactcc gtggagaaat 10621 acttttcttt aaagacaggt ataaaattga aatatttctt cctttgattc ctcttactga 10681 cataccttaa aactggattc aaattaagtc acacgttagt caccttttcc ttgaattcta 10741 tacttgtgct tctcatcgga attttttata ggttctgggg caccactagg attatcatag 10801 ccccctgagc ttaactttat catcttcgtc ttttaaagac tatttgtacc atttttgtgt 10861 ctatactgaa tttatgcaat tgagtatttt ctgggtaact caagacatcc aggagaaaaa 10921 aaaaacatga aaacattcac aaacattcag atgcctttgg tgatgtaaac agacatgggc 10981 tacagctgct tgggaacccc atagctgaaa caccaaagca ccatccagtt ccatccaaaa 11041 tcagtcaagt aaatggaacc tgcgcttagc tagctgtgca gcaaatcatc aaactgagcg 11101 aaatttttat ttgtccattg gctattttgt gagtgtgcaa tcacaggctg agggtacatg 11161 ctgttgcttt tatcaatatg ttcacagcat ttactgggag caataatgaa agatgctaca 11221 aagtaagatt tttcaatgtc caaggcagga caatgccaaa tgtaatcaaa taagatcact 11281 cccataacct tccctgaaag ctgtgaagta cttgccagat ggacaatatc actataaagc 11341 ttcgccatat gctggtcact gtgctaggaa ctttgcattc gttcgattgt tatattctcc 11401 cagcaatcct acaaggacca tcactagcct aaaagtcaca ggaactgcct acttagactg 11461 ttatgtataa gtgtgtgtgt gtgtttcctt atgttccgtt aggtacttct ggagaaggca 11521 tcctcagcta caaagagtcg aaatgaattt tatttctcta ttctggccat cccttccaac 11581 tggtatacag gctgcttatg aagattttga cagagacctc attttcctat ttaaaggtaa 11641 cttcctaaag ttttcatctt atgttagttc tgcctgaagg gagggggcag gacttctttg 11701 tggtcccttt caggttcatg gtgagctaat gacagcatta agctggccag gcttttgcca 11761 gaagactagg gttgggcccc atcaggacca ctaactactg tgtgaacctg agtgggttat 11821 ttgcttttca gccctcagtt ttctcaccaa caaaatgaga ccacactaga ctgtcgttag 11881 cattctttca tcctcatccc agatacaatt ctctaagact cctcaagctg taatttggtt 11941 tctgcataaa agtcacacaa actaaggcat ccaactgtgg ggccttgaat gtcttgctca 12001 gaagttttta ttttttatag gctctgggga accattaagg ctctcacagc ccccctgaac 12061 ttaactttat catcttcatc ttttaaagac tatttgttcc attttcatat ctatgtgcaa 12121 gaccaagaag tggtatatat atatatatat atatatatat atatatatat atatataatt 12181 ttgtaaaaat ggaaaagtcg tatttaacac ttaacctgaa tcattgacag gcaaccaata 12241 ctgggctctg agtggctatg atattctgca aggttatccc aaggatatat caaactatgg 12301 cttccccagc agcgtccaag caattgacgc agctgttttc tacagaagta aaacatactt 12361 ctttgtaaat gaccaattct ggaggtaacg taaactattt tttcaattat aggttgaaat 12421 ctgtgtttct ctaccctgct tacaaacctt caagcatttc aaggtttaaa acaatctaga 12481 tagtctctaa taggttttac cgagaatata ttctttttta caggatgatt gatgttacca 12541 tggcttttga aatttttcat ttctataaaa ttaaaatgtc tatgcaatag tattgaggat 12601 tctgcatcaa gaaacaaaga aaaccttaac aaagcactag ggtgagatac aaagaaagat 12661 ttaagctaat tctcacttat gagttcaact cagacatatg caagcaaatg ttatccagat 12721 agcctgcaga atttggttcc caagttgaac ctattatgta tgtttatata tctatataca 12781 cacacaaggg agttatacta tataccaatt aagtaaaagc cttgaaaata taagcttact 12841 ttgggtaata acagtgtgtc agccatcaag cctgttttag aattaatgat aaccatatgt 12901 tttataaatg tgtaccctta ggtagagaaa ttaaccattc ttaatcctag taaacagggc 12961 attgtgagaa ctgaatgaaa aaatatgtgt gaggagactt tgtaaattat atacaataaa 13021 aaaaattttt ttcgttatat tctgtattgg tgttaaatcg gatgacattt tgtttttacc 13081 agatatgata accaaagaca attcatggag ccaggttatc ccaaaagcat atcaggtgcc 13141 tttccaggaa tagagagtaa agttgatgca gttttccagc aagaacgtaa gtaggaaaaa 13201 aaaacctaat aaatgtgttg tttgtttgtt tattatagag gagacagggt cttactatgc 13261 tgaccaggtt agtgtcaaac tcctggcctc aagcaatcct cccacctcag cctcccagag 13321 ttctgggatt acaggcatta gccaccgcac ctggtgttta aattttttaa atagcatgtt 13381 tgcatttgaa tgttatgttg gaacaggggc agggttttct aactgaagac atctgagata 13441 ttctataagc taattcaata aattatctct ctttttttat agatttcttc catgtcttca 13501 gtggaccaag atattacgca tttgatctta ttgctcagag agttaccaga gttgcaagag 13561 gcaataaatg gcttaactgt agatatggct gaagcaaaat caaatgtggc tgtatccact 13621 ttcagaatgt tgaagggaag ttcagcatgc attttcgtta cattgtgtcc tgcttatact 13681 tttctcaata ttaagtcatt gtttcccatc actgtatcca ttctacctgt cctccgtgaa 13741 aatatgtttg gaatattcca ctatttgcag aggcttattc agttcttaca cattccatct 13801 tacattagtg attccatcaa agagaaggaa agtaagcctt tttgtcacct caatatttac 13861 tatttcaata cttacatatc tgacttctag gatttattgt tatattactt gcctatctga 13921 cttcatacat ccctcagttt cttaaaatgt cctatgtata tcttctacat gcaatttaga 13981 actagatttt ggttagaagt aaggattata aacaacctag acagtaccct tggcctttac 14041 agaaaatatg gtgctgtttt ctacccttgg aaagaaatgt agatgatatg tttcgtgggt 14101 tgaattgtgt cccccataaa agatatgttg aagttctaac cccaggtacc catgaatgtg 14161 agcttaccag ggtctttgca gatgtaatta gttaagttaa ggtgagatca cactgaatta 14221 gggtgggctc taaatccatt atgactgttg ttcttataag aagaagagag gcatagccac 14281 ctaggggagg aggccgtgtg aagacagagg cagagattgg agtgacgcat ctccaagcca 14341 aggaattcca aggactgtaa gccaccagta gaagctttga agaggcaagg aaggattccc 14401 tccaatagcc ttcaagtgtg accctgctga cacctgcaga attcggactt ctatcctcca 14461 aaaccgtgag ggaataaatt tcctttgttt taagccacca actttgcaat actttgttac 14521 agcaacccta gacatgaggt actagacaca gtacatctac acatatgaaa atgaatcaac 14581 acagaatgca gaagtagaac ccttgctaag gactactggg catcttccca ggacagcagc 14641 caaaagagaa ccaccacttc ctctcctgcc tcctccttgc tctctcctag agtccaaacc 14701 caaatgggcc agttggatct gatgttcgtc agttctttac ttctatttcc tggggtactc 14761 aggagggcac acactataga taacttgggt tagctgcata aaattcaatg tctcattaag 14821 ttgcattaaa ctgagcttag atgtgtaagt ttgctaacgg atgggttttt ttgttaagaa 14881 ctataggatt tatgggacca agtctagcga gtccagatat caaaatcatt ataatgttat 14941 atttgctgtt attagaatat aatatagctt attatacaat aaatatgtag actgtaaaat 15001 atatttctca ctagtacctc ctattttctt tctctgttga agtttttaaa tcccacagat 15061 aattaaattg gcacctttat gcttgttcaa aaattaaaat aatctattaa ataagttcaa 15121 attaaagatt tttacttcaa atgactgatt tgtgatttgc ttttaatttc ttaaaatgtt 15181 accacataat tcatctaaag tataaaaagg aatagcaaat tttagatgtt gtgcagatat 15241 ataatgcttg tgtcagaatt attataatat tgataataaa ctttagatat tgcttcagag 15301 tgtgtgaaat attttataaa tatttgaggt cctcaaaaat ttcctcaagt atgttaatac 15361 attattctca aattatttta caaaataaga aaactgaaac aagtatatat tatcattcca 15421 ttcattgatt tattcagcaa gaattaacta cctacctact attaattatg tttcagggac 15481 tgtgctaaga aaagtgagag agatgtataa gcgattcatc atatcaacgt aacaaatgca 15541 aaaggatcta taagaattga atattccatt tttaatagta gcatcaattt cagactatca 15601 tgtttcctaa aactttctat aatgccagtt atgaaagttt taggaaaatg caggcatgaa 15661 aatgagtgtc ttatcttctc agaacacctg ctagttgtgc tggctatgat agactcttgg 15721 ctcaaacctc atctatacat ctttgagatg agaactgatc tcatactatt ttttaaccac 15781 atttgacaga gtcatagaca gtgaactgta atatgaagtg taataaagaa ttcagagtta 15841 ttccttttaa aaaaattatc ttgttgacaa catgtagtat tttccagcta ttacattgat 15901 attttgaatg ggcacaagag atataaagac ctaagcttag aatgcattta tttatttttt 15961 gtttatttat ttatttttga gacagggtct tgctctgtca cccaggctgg tgtacagtgg 16021 tgcaatcaca actcactgca gcctcaaacc cctggcctca agcaatgccc caccttagcc 16081 tttcaagtat ttgggactac aggcacacac caccacactc agttattttc ttttgtaaag 16141 gtggggtccc actacatttc ccaggcttgt ctcaaactcc tgggctcaag tgatcctcct 16201 gcctcggcct cccaaagcgc tgggattaca ggcttgagcc accatgccac cctgcctaag 16261 ctagaattta aacaatgaga ttcatgttta tcttaggttg agattcttca aaagcaaagc 16321 ctaagtcaag acattggtgc //