LOCUS IGFBP4 16904 bp DNA linear PRI 20-OCT-2003 DEFINITION Homo sapiens IGFBP4: insulin-like growth factor binding protein 4 (IGFBP4) gene, complete cds. ACCESSION IGFBP4 VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 16904) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (20-OCT-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..16904 /organism="Homo sapiens" /db_xref="taxon:9606" variation 177 /frequency="0.48" /replace="A" variation 235 /frequency="0.49" /replace="T" variation 413 /frequency="0.01" /replace="T" gene 715..14939 /gene="IGFBP4" mRNA join(715..1341,10242..10399,11187..11321,13709..14939) /gene="IGFBP4" /product="IGFBP4" variation 727 /gene="IGFBP4" /frequency="0.08" /replace="T" CDS join(993..1341,10242..10399,11187..11321,13709..13843) /gene="IGFBP4" /codon_start=1 /product="IGFBP4: insulin-like growth factor binding protein 4" /translation="MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGC EELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCME LAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNG APREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPA LDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE" variation 1097 /gene="IGFBP4" /frequency="0.49" /replace="G" variation 1910..1912 /gene="IGFBP4" /frequency="0.01" /replace="" variation 1984 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 2004 /gene="IGFBP4" /frequency="0.01" /replace="G" variation 2101 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 2402 /gene="IGFBP4" /frequency="0.02" /replace="G" variation 2603 /gene="IGFBP4" /frequency="0.10" /replace="T" misc_feature 2633..3998 /gene="IGFBP4" /note="Region not scanned for variation" repeat_region 3320..3587 /rpt_family="Alu" /rpt_type=dispersed repeat_region 3591..3901 /rpt_family="Alu" /rpt_type=dispersed variation 4160 /gene="IGFBP4" /frequency="0.01" /replace="A" variation 4554 /gene="IGFBP4" /frequency="0.50" /replace="A" variation 4660 /gene="IGFBP4" /frequency="0.01" /replace="C" variation 4672 /gene="IGFBP4" /frequency="0.01" /replace="C" variation 4900 /gene="IGFBP4" /frequency="0.02" /replace="T" repeat_region 4976..5034 /rpt_family="MIR" /rpt_type=dispersed variation 5078 /gene="IGFBP4" /frequency="0.01" /replace="G" variation 5151 /gene="IGFBP4" /frequency="0.39" /replace="T" variation 5551 /gene="IGFBP4" /frequency="0.02" /replace="T" variation 6313 /gene="IGFBP4" /frequency="0.01" /replace="A" repeat_region 6597..6723 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6724..7035 /rpt_family="Alu" /rpt_type=dispersed variation 6725 /gene="IGFBP4" /frequency="0.01" /replace="C" misc_feature 6886..7033 /gene="IGFBP4" /note="Region not scanned for variation" variation 7212 /gene="IGFBP4" /frequency="0.01" /replace="G" repeat_region 7270..7556 /rpt_family="Alu" /rpt_type=dispersed variation 7720 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 7780 /gene="IGFBP4" /frequency="0.03" /replace="G" repeat_region 7781..8067 /rpt_family="Alu" /rpt_type=dispersed variation 8210 /gene="IGFBP4" /frequency="0.01" /replace="G" variation 8346 /gene="IGFBP4" /frequency="0.01" /replace="A" repeat_region 9066..9390 /rpt_family="Alu" /rpt_type=dispersed variation 9370 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 9385 /gene="IGFBP4" /frequency="0.01" /replace="C" variation 9404 /gene="IGFBP4" /frequency="0.01" /replace="" misc_feature 9503..10081 /gene="IGFBP4" /note="Region not scanned for variation" variation 10192 /gene="IGFBP4" /frequency="0.28" /replace="A" variation 10212 /gene="IGFBP4" /frequency="0.28" /replace="C" variation 10642 /gene="IGFBP4" /frequency="0.01" /replace="A" repeat_region 11478..11601 /rpt_family="MIR" /rpt_type=dispersed variation 11672 /gene="IGFBP4" /frequency="0.45" /replace="G" misc_feature 11804..12285 /gene="IGFBP4" /note="Region not scanned for variation" variation 12363 /gene="IGFBP4" /frequency="0.01" /replace="T" repeat_region 12368..12574 /rpt_family="L1" /rpt_type=dispersed variation 12423 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 12559 /gene="IGFBP4" /frequency="0.01" /replace="T" repeat_region 12577..12745 /rpt_family="Alu" /rpt_type=dispersed variation 12601 /gene="IGFBP4" /frequency="0.99" /replace="" repeat_region 12746..13031 /rpt_family="Alu" /rpt_type=dispersed variation 12941 /gene="IGFBP4" /frequency="0.01" /replace="" variation 12954 /gene="IGFBP4" /frequency="0.01" /replace="A" variation 13085 /gene="IGFBP4" /frequency="0.01" /replace="C" variation 13224 /gene="IGFBP4" /frequency="0.01" /replace="G" variation 13961 /gene="IGFBP4" /frequency="0.01" /replace="C" variation 13996 /gene="IGFBP4" /frequency="0.01" /replace="T" variation 14123 /gene="IGFBP4" /frequency="0.01" /replace="C" repeat_region 14169..14220 /rpt_family="L2" /rpt_type=dispersed variation 14872 /gene="IGFBP4" /frequency="0.01" /replace="A" variation 15094 /frequency="0.02" /replace="C" variation 15349 /frequency="0.01" /replace="C" misc_feature 15367..15536 /note="Region not scanned for variation" variation 15733 /frequency="0.01" /replace="A" variation 15880 /frequency="0.01" /replace="C" variation 15977 /frequency="0.02" /replace="G" variation 15980 /frequency="0.01" /replace="G" variation 16435 /frequency="0.01" /replace="A" variation 16802 /frequency="0.01" /replace="T" BASE COUNT 3600 a 4506 c 4576 g 4222 t ORIGIN 1 aatgggcctg agaggcaaac atccaagaag gaggaagagg ctcggcggca cctccctccc 61 cgggagttct gctgattcca tcttggggaa gcagggtgga ccagggccca aatgcgccct 121 ggggagattg cgggggcggg agaggttgca aggggcaagt ggcaagagcc tgttaacgtc 181 ttagggcctc caggcctttc tgtgccccta gctgtgcctg tacgctttac cccacctcag 241 gaggcttggt ctccagcggt tgaggctgga agcaccgggg tgcggtggaa agggctctgt 301 ccaggaagac cggatccgca gagccgggag tccgggctag gaagtccctt tctcggtggg 361 agactgaggc cgccttggcg gggcgggacg agactcctcc gaggtcggga aagggggccc 421 cgcagcagcc ccttggcttc ccttctccct tgcctcccct ccggggctcc ggttcagagg 481 cactctgggc gcctgctaca gcttccaaac tgcgccgctt ccttcttcgg cagaaaagga 541 ctttcagatg cggcggcggc ggcggcggcg actcaggaca gcgccccctc cccctaacgg 601 ccgcctctcc ctctccccct cgcccgcccc ggctccccca cctctgggaa ggcgctgggg 661 gtgtggccag ggaccggtat aaagtccggg ggagccggtc ccgggcagcc gctcagcccc 721 ctgcccctcg ccgcccgccg cctgcctggg ccgggccgag gatgcggcgc agcgcctcgg 781 cggccaggct tgctcccctc cggcacgcct gctaacttcc cccgctacgt ccccgttcgc 841 ccgccgggcc gccccgtctc cccgcgccct ccgggtcggg tcctccagga gcgccaggcg 901 ctgccgccgt gtgccctccg ccgctcgccc gcgcgcccgc gctccccgcc tgcgcccagc 961 gccccgcgcc cgcgcccagt cctcgggcgg tcatgctgcc cctctgcctc gtggccgccc 1021 tgctgctggc cgccgggccc gggccgagcc tgggcgacga agccatccac tgcccgccct 1081 gctccgagga gaagctagcg cgctgccgcc cccccgtggg ctgcgaggag ctggtgcgag 1141 agccgggctg cggctgttgc gccacttgcg ccctgggctt ggggatgccc tgcggggtgt 1201 acaccccccg ttgcggctcg ggcctgcgct gctacccgcc ccgaggggtg gagaagcccc 1261 tgcacacact gatgcacggg caaggcgtgt gcatggagct ggcggagatc gaggccatcc 1321 aggaaagcct gcagccctct ggtaaggtac ccctggcctc ccaattccct cctgagtgcg 1381 ctcccttccc agcggcttct tccccattcc agccgccctg gaaggccctt aaaaatcccc 1441 tatgagttga agagaaggca ggtacgtggc agggcccgac tggcatggga caggctcatc 1501 aaggaaactg ctaccgagtc cctagcagcc tgttgccacc accaagggag actgtcccat 1561 cgctccatct caaacctcca agggttgtct gtttgataag ggggtcccag tgggaggcct 1621 ggctgctggt gcaggagtgg cagattaagg tccagttaag tcagctgtct agggccagag 1681 aactggagga tggtggtggg gtgtgtgttg gggaggatga gggagtgggg aaagctttct 1741 gttcctgatc caggccgagg gtgaaatccc agtggtctgg ggagccaggg cctgaacttt 1801 ttttttacat ggtccagtgg tggagtggga catacaaatt agagggactt tggcgttgag 1861 gggcattaga cttgcccttc cccaaagccc agagccaggt caccttgttg tttgagaggc 1921 agtgggaaga caggggtccc tctgccaggc ctggacacct ctgcctgccc tggtatacag 1981 gccccctgtt cttttctcca ggcaggtagg atttgaggtg gtagaaaagt cttggctcct 2041 agccgagagc tgcaggagcc tcatgtgtgt gggataggga atagagaagg ggccagggcg 2101 ccaggggaga gaaacagaga gagagagaga gagagagaga aacacacaca cacacacaca 2161 cacacacaca cacacacaca cacagagaca gagagagaga gagagagaga gagagagaga 2221 gagagagaga gagagagaga gactctgaga aggcccttgc cctaacctca ttcttacact 2281 ttcttttttt gtttctcagt ttctccttag actctcagtc tcttttcctt ctttctcttg 2341 ctcttttgtt cttcctgatt tgtctctcaa cctctagttt cactagtcat gctctcgagt 2401 tctgttttcc tcagtgtctt ctgcccatcg tgcgtttctt tctccacctt attctgtgtt 2461 tctgtttcag ttgctctgct tctctccctc tctttctgtt gctgtttctc tgtgtctctg 2521 tcactgttgg tctttccctg ttactttggg aatctctctg tctgtctttc tgtatctatg 2581 cctctgtttc tcattccatc tccgaccctg ttttgctctc ctgtgcctct gtctgtctct 2641 gtctcttttc ctggtgcttg aagcttccat tgttgcagtc cggatgctgg gactccagcc 2701 ccaagcttcc tgtcctggga cccaaaccct ccacttcctc aatcctctgc agcttgtcag 2761 ccgaggagag caggatgcag ggaaaacagg aaggaggtgg actccagggg tctgggcctc 2821 gggcctctct gcccttcctg cccctgggta gggagagatg ggtcagcaga aaacattcta 2881 ggagaaatgc cagcctggca cccagcatat ctgggaaggg gggtcctggg ggagaaagtc 2941 gctaatcttg gggcagagat gccagtggca atggtagagg aggggtactg agactgggag 3001 ggagcaaggg ccgagccctt gggttcgcgg ggtacaacag agtcacgttc cctttgaatc 3061 tccatcctcc accagccaga gggtatctgg caccagataa ggatggctgg tagcctcctc 3121 ctctctcagc actttgaatg caagacagaa gagccctcaa agggctgggt aggaatacct 3181 catcctctgg ttgggtagga atactccatc ctgtagtgga ggaaaataag atcccctagg 3241 ggtttgggga gggcatggca tgagaatttt gtggttgtcc tctggatata atgcaaactg 3301 gcctccagga atatctaggg gctgggtgtg gaggttcatg cttgtaatcc cagcactttg 3361 ggaggattgc ttgaggccag gagttcgaga ccagcctgag caatatagcc agacccccgt 3421 ctctacaaaa aaaaaaaaaa aaaaataggc aactgcagtg gctcatgcct gtagtcccag 3481 gtatttggga gtctgagatg agaagttcaa ggttacaatg agctatgatc acgtgattgc 3541 actccagcct gggcgactct atttcgtaaa aaaaaaaaaa aaaaaaagta ggccgggtgc 3601 agtggctcac acctgtaatc tcagtatttt gggaggctga ggagggtgaa tcacctgagg 3661 tcaggagttt gagaccagcc tggtcaacat ggtgaaacct cgtctctact aaaaatacaa 3721 aaattagctg ggcatggtgg tgcgtgcctg tagtcccagc tacttgggag gctgaggcag 3781 gagaatcact tgaacccggg aggtggaggt tgcagtgaac caagattgtg ccactgcgct 3841 ttagcctggg tgacagagcg agactctgtc taaagaaaac aaaacaaata aacaaaaaaa 3901 acaaaaaacg gtgtcttgga atggggtggc tttaggtccc ctttggatga cacagccaag 3961 gtctgtaatg cccctccccc tttcctcctt gccttgtcct ccagcctcca gccatgcaat 4021 ggatgcaggt atctggagag agacgaggga agcctggagg tacctactga gcaagctatg 4081 cccgtgccct cccacacctc ctagtcatca tagaagtaat cccttgctgt gacctgggcc 4141 acatggcacc atgtaaaagg cactctctag agttctgctg cagccctgca gggtctgtgg 4201 gtgagataag acgaccaagc ccctacccac ccatcttttt agccttacac agtcagtagg 4261 ccactgtctg ctttaggtcc caaggtttgg gcccactggc ccgcgaatag cttggtcgag 4321 ggtacctgtc tattttttct gccttttcct tttggggctg agtgtcagca ggtggctggg 4381 ggagggtggc cacttggcat gcccccttct ttggctgcta tggtccagct gcctcctgtt 4441 tgccccaggg gcagatctcc cctttccgtc tccagccacc cctgcctgcc ctcctgtcac 4501 agctttccat gtgctggcca ggttgtggct taacaccact gaggccacca gaggtgaggc 4561 ggggcgtgtg catcaaaagt ccacacctct gcatcctggt actgatccta gactcatgga 4621 atctggggga gtggacagcg gaaagatcag cgtttggacg gggagttcct aagctgggct 4681 ctcagtccct ttgggacagg gttagggaac aggcaggctg ggttaatttt tagtcaatgc 4741 agcaaattct gcccccctac ttcagtactg ggaatccagt tatgtcatgg gaacaagggc 4801 attcccagaa attctgtgcc ttgtggggag ggggagggag gagcatggcc gcttcccatt 4861 tttaatttag tactggcaaa gctagcagta ttggtgcctc gggtatcagg agtctttcca 4921 cttaaagaca gagtgctgca gagctaagtc tctcctcctc cccttccacc cagtctactt 4981 cattttccta atttttaaag tggggagggc aacaggacct gcctcacagg gttggggcgt 5041 ctggcatcgg gtaagagctc aataaattga agtgatgagg aagatggtga tgaagaagct 5101 gatgctggga cttagggaag cggtaggacg agggagcaaa tttggggcaa cattcagagg 5161 agttgagagg ggtggggtgg cctttggtgc attttgctgc tgtcaacatg ggaagaacag 5221 gccaagttgc cttatctgtt ttttattctg aggctggcag catgacacag ctgttggggg 5281 tgatacccct tgagccagac ctcagagaaa gggcctggta cccagcacca gcggtcttgg 5341 cttctccagc tagagtctag gggaagaggg aaaagacctt tctagcagga caggtgggtg 5401 accctctgga tcacagctga aacttctggt cgggatggct gggcccactc agttcatagc 5461 ctaggtgtct ctcgagggcc aggggctggc gttggggaga aattgtgagg gtaaaatcag 5521 gcaacaggaa agaggaaatc ctctggcttt cgccacaaac tttgcagccg gtggtgccaa 5581 agccgtgtgg cctcttctct ggcgccttcc cttcctctgc tgctggagca aagaccgagg 5641 tttcccctat agtcagatgt caactggctt agctccaagc tgggcgctgt aggaggacca 5701 agcctacttg gaagtcccat ctcccaaaca agctttttgg aggtcagact tttcagggga 5761 ataggtctga ctccactcct gctcagaggg gaacccacag gcattggaat ttctccagag 5821 ggcactacca ggatgagtag caccaggtgg ctggaactct tgtgtgagca gggaaatagc 5881 aagtatttag ccagttttgg agatgagaag gttaacgtta tcaagagact caatgctata 5941 acccttaccc ccacaaaaac ctggtgctta ggggtggatc ctggggtggc tcttcagtct 6001 gccagttaag cagggttggg caaggaaaag ttacagatta catggaaagt caacaaacca 6061 cggtgcagag aagctgttga agtcagcgtg ccctgccctg gctctgtgtc tctgaccagg 6121 gcagggtcag agtgcccaag tgcatgtggg taaggcacat gtggatgaat gtgtgtctgg 6181 acacgtgatt gtttgtgtac acttgcagtt cttgagcctg agcctgtctg tgtgagtagg 6241 caaatacgga tttaccctgt gtccccatga gactaaggag ggagctactc tccctatctg 6301 gtgggtgcta ctccgtgtag acatgaactg gggataagta ggatggctag tggggaacct 6361 aacaagggag aagccaggca gtttgctggc ttagcttttc gtaggtaacc ctctgatgtg 6421 acatggggcc ataccaaccc aagagcataa gccatgcctc tggactcacc ctgtgcccca 6481 tgcagcccta ggcttcagtg agcataccta atcctcctta atggtaaaca tcccaaatat 6541 ccattaataa tcctctgagg gttagttatt tgtgaacttt gactcgtaaa agctcagcac 6601 tgtggctcac gcctgtaatc ctagcacttt gggaagtcta ggcaggagga tcacttgagg 6661 ccaggagttt gagaccagcc tgggaaacac agtgacaccc tgtctcttaa aaaaaaaaga 6721 aaaggccggg cgcaatggct catgcctgta atcccagcac tttgagaggc cgaggcaggt 6781 ggatcacgag gtcaggagat cgagaccatc ctggctaaca cggtgaaact tcatctctac 6841 taaaaataca aaaaaattag ctgggcatgg tagcgggcgc ctgtagtccc agctacttgg 6901 gaggctgagg caggagaatg gcgtgaacct gggaggtgga gcttgcattg agccgagatc 6961 gcgccactgc attccagcct gggcgacaga gcgagactcc gtctcaaaaa aaaaaaaaag 7021 gagagagaga gagaaaaaga aactcagcat ggaaagcata gttgtggtca tgcttctatt 7081 ccatatctct tgagattttt gaggctgcta ccaccctaat tctccacact tccagggtgg 7141 gagctcacta cctcctgaaa actcttcctc actccttgaa ctcctgaaaa accttcctca 7201 ctccttgaac caaagaatat tctacccatt tactgagagg aatgaatcat tgtacaaaat 7261 agtgcttgct tttttaaaat tttgagacag ggtctcactt gttgcacagg ctagagtgca 7321 gtggtgtgat cactgctcac tgcagcctcg acctcctggg ttcaggtgat cctcccacct 7381 cagcctccca agtaggtggg actacacctg tgcatcacca caccaggcta attttttgta 7441 gagatagggt ttcactatgt ttcctaggct ggtcttgaac tcctgggttc aagcgatcca 7501 cctatttcgg ccttccaaag tgttgggatt acaggcgtga gccaccccag ctggccccta 7561 gtactttctt ttatggtcat taaaagaaag caaactcagg aaaaacaaag gctttccagg 7621 ttggaagggt gccccctggt gttagtgtcc tgggctgtgg caaacaagtc caggtgatct 7681 ccagccctac ttaagtaaca gggtggggcc tttgtccaca tctcagctca gcctctgtcc 7741 ttctgacatt tggttctaat tctttaattc ttgaattttt tttttgtttt tttgtttttg 7801 tttttgtttt aagagacagg gtcttgctct gttacccagg ctggagtgca gtggcacaat 7861 catagctcac tgtagccttg atgtactggg gtcaagcgat cctcctacct cagtcttcta 7921 agttaggacc acaggcaggt ctgactaatt tttttttttt tggtagagac agggtcttgc 7981 tatgttgccc aggctagtct tgaactcctg gcctcaagtg atcctcccac ctcggcctct 8041 caaagcactg ggattacagg cgtgagcacc cagcctggtt ctaattcttt gaggtcttcc 8101 atttcctttt tctctccact ccccagttcc agcttacacc cctgaaacac ggtgactcca 8161 tcctcaagcc ttatggcttt gtgcaaggtg ggggtgtgga gggaggtgat cactggggca 8221 gcttaggttt ctttggctgg aggaattcct tgggagggtc tcaaaggaag ggcctggatc 8281 ccagatcttt ctctggttcc taaccgaggg ctcaggatcc atctccttat ggtccccttg 8341 gcacagtcct cgtcttctga agtttatgtt tcttcttttg ctgcctacct tggccagggg 8401 gtcttgctat agtgtcttct ctttggttga ctcttaggaa cttgatgtag gactggagtc 8461 ccctctggac tgtccttctt gggattttaa atgtgcagaa ggatggatta tatctgtcta 8521 ctctatttat ttcttccctt ttattcctct tttctaagcc agctctccac cgtaacaaaa 8581 tcttcttcca tccttggtga attttattaa taacctttgg tgtggaaggt tattgataaa 8641 gactttctgg ttagattcct ccttgcctgg tttgccttta tccacatatt tctccccaca 8701 ccccccaaac caggagaatg aaaagagaac caaccccccc agctttggct aggcagaaaa 8761 ataccatttg acccagaggc agctctggga tcgctgccac gcatggagga acctgctaac 8821 tcctcaggaa aaaaaaaacc ctgacgcaaa ccagatgtaa cctcctgtcc ggctgccaac 8881 atctggaatg ctggcagggg ctttgcactc aggccggcag cgagctgcca agcctgagca 8941 tttcagaggt ggctctgatc tgcagagagg tcttccaacc tctttctcca gctcagccct 9001 gtattctggt tttgactgct tggagggagg agcagtggtt acagttctgg gactcaagca 9061 tggggttttt cttttttaaa aaaatgtatt ttattttatt ttattttttt agagacaggg 9121 tcttgctctg tcacccaggc tggagtgcag tggtgtgatc atagctcact gttaacctcg 9181 aattcctggg ttcaagtgat gctcccgcct cagcctcctg agtagctagg actacaggca 9241 catgccacca tacccggtta atttttaaat tttttgtgaa gatggggtct tgccatgttg 9301 cctaggctgg tctcgaactc ctggccttaa gtaatcttcc ctcctcagcc tcccaaagtg 9361 ttgggattac aggcatgagc cacaatgccc catttggatg gagtttttct tgagctcaga 9421 tagagccttc aggagatccc acagaggggt tgaaggtcca gcctcatcac tcccgtctcc 9481 agatccctgg tgccctggtt ctgggcaacc cctatggact ttggatggag tctgaagtct 9541 aagaatggga aacttcgagg tgggggactg aaggaatgtg tgaggctgtt cttgtggtcc 9601 tggggccaca caggttgtgt tacacacaca ctcacacaca cactcactct tcctcatgca 9661 ggcggataca ctaactccca cttctctccc actcagccaa tggggagagc cttttgggct 9721 agagttctca ttgctcatgg aaactctgat tcaggccatt tggaagaggg cgagcagagt 9781 ccacagccct ggggatcccc tggctggctc agccagacac cgaaaaaatc aggagaggca 9841 acagggagaa cgatcagatg gagaggggaa tggtgggagc tgaatggaaa ggggacagga 9901 tccagcaggg ggtccccctg cctgcctcag acctccctgc agggcccagg ggaccctcct 9961 gccatctggg cagctgcagc tggtgactca tctgagcgct ggcctgagtg gggtgaggga 10021 caagtcaagg acttcaagag gaatattctc ctgagagatc caggggagag gggaggaggt 10081 agggggctgc tcttgtttct tcccgctccc caggccccct gctcttctcc agcgccaagc 10141 cgaagaatcc ccaggaagga gaacgtgggt gggaggctgg gttggtgtga cgctctgacc 10201 tcttccggtg ctgacctctc cttatcgcta cctgaataca gacaaggacg agggtgacca 10261 ccccaacaac agcttcagcc cctgtagcgc ccatgaccgc aggtgcctgc agaagcactt 10321 cgccaaaatt cgagaccgga gcaccagtgg gggcaagatg aaggtcaatg gggcgccccg 10381 ggaggatgcc cggcctgtgg taaggacctc cgatgcacaa atgtgcatgt gcatagacac 10441 acacacacac acatgccccc tgccccccac atgcacgcac ccacacacac catcaccacc 10501 agatctgggg cgtgttcatt cagcacacat tctagggtga ctactgtgtg caaggtgcaa 10561 ctagtgtgag tcatcaggac ccagagaaag cactcattcc cttccttggg attcctttcc 10621 tgcccatcag ttatatacat cggggcagct taagtgatta ttaaatactg aaaaacttct 10681 ataccaattg gtaaaaagca gttacccaaa gcgccctggg gtttcttggc cttttttgga 10741 ttccccaccc cagaccttct cagtaaccaa agggtaatgc tggccatagc agggggcctg 10801 ggaccctgct ccagggtctg gctaatttcc cttctgaagg tcttacaagt tgtcagttgg 10861 aagttttatc tgtcccttct gcatagaaat caccccctcc ctggctttct gcataggttc 10921 ccacagcccc tttccccaca gtgtcccctc acttcccacc cctcctttga agaagctctt 10981 tggctcgaga ccctttcctc cacgtctcta ccctcccagt gtgtcctcca gacccaggcc 11041 tctctcttca cctcactggg tcctgcccag cccctggggc tcaggcctcc tttcggggcc 11101 ttcagttctc acttagctct gaccccaggc ctgggcctcc tgcctctctt ccttctgctg 11161 agcaattttg tcttcccctc ctccagcccc agggctcctg ccagagcgag ctgcaccggg 11221 cgctggagcg gctggccgct tcacagagcc gcacccacga ggacctctac atcatcccca 11281 tccccaactg cgaccgcaac ggcaacttcc accccaagca ggtgggtctc tgtctcccgc 11341 tggcttggcc ctggactcag ctctggggca tttccggcct ctccgcagga tggtcctgga 11401 tggagatctc aggaagggga aactcctcaa ccccaaccca accccttgga gcctccctaa 11461 acctacctca gcgtcagaac ctcactcatt ttggagatga ggagactgtg atccagagag 11521 gagtaaaagc gccgggctag tccagagtca tagaacaagt taacagcaga tcttgcctcc 11581 ctatccaggg caatttccct cacccctgga tttcaccatc tgtggtgcag acctagcaac 11641 cctgacaacc tctggctccc aacactctct cattcactct actctattcg tatgagtaat 11701 tcctcctgtc actgagtgag gtttcttctg ggaatggagg gccaaagtca tgaggagtca 11761 gggaggaaac tcagcctacc cctccctgca aggcgagtag caaaaccacc tggggtacag 11821 caagagtgaa ggtaaaacca gattggacgg ttggagacag gcactttggg tagaagcaga 11881 ggaaggagtg gggcaggaga gaagacacaa aggcagcaac ttccctattc cttcctgccc 11941 ttggaagctg gggtcctctg acaagcctcc aggaggctgg gatggtcagc agggttggcc 12001 tcttccagtc tatctctggc ccatcagaat gggtggcctg tctgggcagg gctctggtgt 12061 gcctcctgct gggtgttgcc tggggaaccc tagcctggag ctctttgtcg acgtagacag 12121 acccatttcc ctgctccatg agctatagac aaatccacaa tttgagctgc cactctgcca 12181 gcagaagtct agatagaagg acaaaggttg ccctgagtct gtgcatccca ggatggcatg 12241 aaaagggtat gagtgaaggg acagagaggg caccccaaaa ccaatgccca gcctatttct 12301 aacctttatc ctaacacgaa ttttatcctt gtcccaattt aaaaaacttt ttctcttaat 12361 ttaaaaaaaa caattaatag ctttattttt tagagtagtt ttaggtttac agaaaacttg 12421 agcaagagta cagggtttca atgtactgtc atccacccca gtttcctcat tattaacatc 12481 ttacatttgt tgcaattgat gaacgaatat tagtatatta ttattaatta gtggtttata 12541 ttagggttca ctttttgtgt tgcaaaattc tatgcatttt cttctcctga tttttttttt 12601 taaaggcagg atctcagtct cccaggctgg agtgcagtga tgcgatcaca gctccctgca 12661 acctccacat cctgggctca tgtgatcctc ctacctcagt ctcctgagta gctgggacca 12721 caggcacaca actatgtcag gctaattttt tttttttttg agacagagtt tgtctcttgt 12781 tgccgaggct ggagtgcaat ggtgggatct cggctcactg caacctccat ctcccgggtt 12841 caagcgattc tcctgcctta gctcccgagt agctgggatt acagttgcct gccaccacac 12901 ccggctaatt ttttgtattt ttaggagaga tggggttttg ccatgttggc caggctggtc 12961 tcgaactccg gacctaaggt gatccaccca cctcggcctc ccaaagtgct gggattacag 13021 gcttgagcca ctagcttctt cctctgattt ttatcccatt gaaagttctg acacttgaac 13081 tttatcccca gaccagttct gatccttaag ctatccttca ctccaagatt aattctcaca 13141 ctgaaatata catttgcgcc ccctgaacct tctactatct aattttgacc caaaatttag 13201 cttaacttta gttattctga ccttgacctc tgtctttatc ccaattgtgt ttttacctgg 13261 gctttaaccc tcacccaact catccagctc aacttttagt catatttcct cattcaactg 13321 caactcttac cctggtccta ccttaatccc agcttggatc cacctcataa ctataatccc 13381 attcttaaag tcccaaccca atcagaatat gtacccaaaa catctccaac ctgaacccag 13441 cctttcaaat ccagctgtgc ctttaaaccc gagggctttc ttaaggtcct gccttccaga 13501 actctctgga cctttccttc ttgaccatgt tctccctgct ccagtgagct cagaagaccc 13561 atgctcaaaa aagagtcacc accctcagag gccatcttga agcagcgacc gtctgacttg 13621 ggggctgggc tgggctggga ttggggtggg tcacttgggg tctcttttcc tgcgtcggaa 13681 ctgacccctc atgtccttct cttggcagtg tcacccagct ctggatgggc agcgtggcaa 13741 gtgctggtgt gtggaccgga agacgggggt gaagcttccg gggggcctgg agccaaaggg 13801 ggagctggac tgccaccagc tggctgacag ctttcgagag tgaggcctgc cagcaggcca 13861 gggactcagc gtcccctgct actcctgtgc tctggaggct gcagagctga cccagagtgg 13921 agtctgagtc tgagtcctgt ctctgcctgc ggcccagaag tttccctcaa atgcgcgtgt 13981 gcacgtgtgc gtgtgcgtgc gtgtgtgtgt gtttgtgagc atgggtgtgc ccttggggta 14041 agccagagcc tggggtgttc tctttggtgt tacacagccc aagaggactg agactggcac 14101 ttagcccaag aggtctgagc cctggtgtgt ttccagatcg atcctggatt cactcactca 14161 ctcattcctt cactcatcca gccacctaaa aacatttact gaccatgtac tacgtgccag 14221 ctctagtttt cagccttggg aggttttatt ctgacttcct ctgattttgg catgtggaga 14281 cactcctata aggagagttc aagcctgtgg gagtagaaaa atctcattcc cagagtcaga 14341 ggagaagaga catgtacctt gaccatcgtc cttcctctca agctagccag agggtgggag 14401 cctaaggaag cgtggggtag cagatggagt aatggtcacg aggtccagac ccactcccaa 14461 agctcagact tgccaggctc cctttctctt cttccccagg tccttccttt aggtctggtt 14521 gttgcaccat ctgcttggtt ggctggcagc tgagagccct gctgtgggag agcgaagggg 14581 gtcaaaggaa gacttgaagc acagagggct agggaggtgg ggtacatttc tctgagcagt 14641 cagggtggga agaaagaatg caagagtgga ctgaatgtgc ctaatggaga agacccacgt 14701 gctaggggat gaggggcttc ctgggtcctg ttccctaccc catttgtggt cacagccatg 14761 aagtcaccgg gatgaaccta tccttccagt ggctcgctcc ctgtagctct gcctccctct 14821 ccatatctcc ttcccctaca cctccctccc cacacctccc tactcccctg ggcatcttct 14881 ggcttgactg gatggaagga gacttaggaa cctaccagtt ggccatgatg tcttttcttc 14941 tttttctttt ttttaacaaa acagaacaaa accaaaaaat gtccagatga ttgtgtttgg 15001 ttgatttatt ctcagttaga cacagggatg caccaggggt ggagagacgg ggacagattt 15061 tgggaggtga gtattgtgtg gtccccagac ctgtctgtat ggtaagggac tgcagaagga 15121 cggccaatcc accttcctct tccctgcaac ggaagtttcc tagggaactc cttggcttca 15181 aagtctgcgc tgtctttact tagactcctg gtgggcaaac aatggctcct gaaagggggg 15241 catgaccaag gacagccctg tgggggcaga gctgtctctg ggatcagctg gcatgtgggg 15301 ctggggcatt tcctagggca tcgggcggac tgggcttgca tctggatttg atttattaat 15361 ttgttgggga ggggcaggga cactgccctg catttgagga aagggggtag atgcttcagc 15421 acattccaca gctctgactg ccgagatctc tgactcgggc attgtgctga gattggattc 15481 tgaggttggg aggggttgac tttgctgtag actcagtgcc agccacagct tcagagattg 15541 tgctcacatg gtatgcctgg actcttggcc atcctccaaa tgcccctccc ctcccacacc 15601 tctgtgcctt gtgtgtgtgt gtgcacgcat gtgtgtggca gggggtggag ggtccgggag 15661 cagaagctga tctctcggtg ggggcctttt tccaggaggt tgcaggcagt ctggagacgc 15721 tgcattgagc ctgccgcccg ctgcgcgggc tccctcctat ctagctgtgt cctggattct 15781 cagccccctc cccagctcca gaggcgcttc caggcttctg atttcactgg gccccaactt 15841 tgttggcacc tgtcccgtct gcatcttgag gctgggtctg cagttctgtc tctctagctc 15901 tgccccagca gcaaagtcct gcagccatct ggtctccctg aggcaccacg gcggctgcca 15961 gcagcaggag ataaagaaca aagtggtgtt gagggttgct tcctcagccc cagccactct 16021 tcacagagtc ccctccttct ggagcccagg ccaaggcctg tggggatggg aggtggtgca 16081 cgctgaagat taagttttag gtttcaagtt tagggaaagt atctctttcc ctaaggcatc 16141 tttttcaacc cccttgtctc tagtcccctt cccgatgctc taggcttgca cccttggcag 16201 tggtggtagg aggtcctttt tctttcatgg gcctcccaaa aaagccaaat tggcttggaa 16261 gtagctgtgt gcatggcctg ggtgtaactt cgtgacatac gtgcatttgt ggagtatgtg 16321 tgtgtgcatg catgtgagta tgacgcagtg acacctgaaa cgtgagtgta tgggcttttt 16381 gggggtgtgc atgcctgttt gatgtgtgaa gggaaggtgt gccatttgtg tggtgtgtat 16441 atgtggtgtg tgcatttgtg tggtgtgcat ttgtgtggtg tgtatatgtg gcgtgtgcat 16501 ttgtgtggtg tgtatatgtg gcgtgtgcat ttgtgtggtg tgcatttgtg tggtgtgtat 16561 atgtggcatg tgaacacgtg tgcgatgtga ggagagaggg agtgagacat tcacggagca 16621 cgcctgtctc tcctggctgt ggatgactgg actctcgctc attaggtgat cccacctcag 16681 ggtttgtggg gagatgtctg acactagaga atgaacatgt gctttgggga gaggactttc 16741 acatcccaca gaaacactgc cctgtccagg cttcatgccc acaggatcct ggagccaggt 16801 cctaagtacc aaaaagcaaa taaaagcagc ttcttgtttg cagctaggcc ctcccaccct 16861 tgaaacggtg ggaataccca aatggtctct ctagttgcca cagg //