LOCUS GPX4 5055 bp DNA linear PRI 16-JUN-2003 DEFINITION Homo sapiens glutathione peroxidase 4 (phospholipid hydroperoxidase) (GPX4) gene, complete cds. ACCESSION GPX4 VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5055) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (16-JUN-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..5055 /organism="Homo sapiens" /db_xref="taxon:9606" variation 91 /frequency="0.46" /replace="G" variation 108 /frequency="0.46" /replace="A" variation 116 /frequency="0.46" /replace="A" variation 152 /frequency="0.46" /replace="C" variation 188 /frequency="0.46" /replace="A" repeat_region 213..508 /rpt_family="Alu" /rpt_type=dispersed variation 233 /frequency="0.47" /replace="A" variation 251 /frequency="0.01" /replace="C" variation 300 /frequency="0.45" /replace="G" variation 303 /frequency="0.04" /replace="A" variation 481 /frequency="0.01" /replace="T" variation 705 /frequency="0.02" /replace="C" repeat_region 996..1306 /rpt_family="Alu" /rpt_type=dispersed variation 1107 /frequency="0.01" /replace="A" variation 1207 /frequency="0.43" /replace="A" variation 1210 /frequency="0.43" /replace="G" misc_feature 1306..1597 /note="Region not scanned for variation" repeat_region 1328..1618 /rpt_family="Alu" /rpt_type=dispersed misc_feature 1678..1791 /note="Region not scanned for variation" variation 1835 /frequency="0.99" /replace="" variation 1843 /frequency="0.02" /replace="T" gene 1941..4757 /gene="GPX4" mRNA join(1941..2104,3163..3257,3343..3487,3636..3787, 4220..4244,4378..4437,4518..4757) /gene="GPX4" /product="GPX4" variation 1949 /gene="GPX4" /frequency="0.02" /replace="T" CDS join(2021..2104,3163..3257,3343..3487,3636..3787, 4220..4244,4378..4437,4518..4550) /gene="GPX4" /codon_start=1 /product="glutathione peroxidase 4 (phospholipid hydroperoxidase)" /translation="MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEF SAKDIDGHMVNLDKYRGFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPC NQFGKQEPGSNEEIKEFAAGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNA IKWNFTKFLIDKNGCVVKRYGPMEEPLVIEKDLPHYF" variation 2025 /gene="GPX4" /frequency="0.04" /replace="A" variation 2056 /gene="GPX4" /frequency="0.22" /replace="A" variation 2129 /gene="GPX4" /frequency="0.04" /replace="G" misc_feature 2211..2873 /gene="GPX4" /note="Region not scanned for variation" variation 3077 /gene="GPX4" /frequency="0.01" /replace="T" variation 3288 /gene="GPX4" /frequency="0.02" /replace="C" variation 3340 /gene="GPX4" /frequency="0.01" /replace="T" variation 3502 /gene="GPX4" /frequency="0.01" /replace="T" variation 3601 /gene="GPX4" /frequency="0.78" /replace="" variation 3819..3824 /gene="GPX4" /frequency="0.12" /replace="" variation 4086 /gene="GPX4" /frequency="0.14" /replace="T" variation 4092 /gene="GPX4" /frequency="0.02" /replace="C" variation 4137 /gene="GPX4" /frequency="0.01" /replace="G" variation 4456 /gene="GPX4" /frequency="0.33" /replace="C" variation 4594 /gene="GPX4" /frequency="0.41" /replace="T" variation 4798 /frequency="0.02" /replace="C" variation 4824 /frequency="0.38" /replace="T" BASE COUNT 940 a 1505 c 1722 g 888 t ORIGIN 1 ctcagggatc cttgcttcac tgcctctgcc accaaaccat ccatgacgcc tctgtgctgc 61 atctggcagg cctgagtcgg gggcagtggc cggggcaggc tcatagcgcc ccccaggtca 121 acccggccct gagtctgtct ctgaagaaat attcagtgca gggtcagaaa aggttaagac 181 cttgagggca acatacaaat cccaagcacc taggcggggt agagtggctc acgcctgtaa 241 tcccagcact ttgggaggcc gaggcaggcg gatcacctga ggtcgggagt tcgagaccaa 301 cctgaccaac atggtgaaag cccgtatcta ctaaaaacac aaaaattagc tgggcgtggt 361 agcacatgcc tgtaatccca gctactcagg agactgaggc aggagaatca cttgaacccg 421 gaaagcggag gttgcagtga gctgcgatgg agccactgca ctccagcctg ggtgacagac 481 caagactcct caaaaaaaaa aaaaaaaatc caaacccctg cctgtacagg ggtcaaagtc 541 caatcacggt gactcagttc ccaagtatga gatgagtgtt tctgttgcca catgtccaag 601 ccacgaagtg aaaaacagag ttggaagcca agatgtgggg cagtatgggc tcgggtgtgc 661 ccataccttg taatgttaga agtgtaagaa aaccctccag acttgtgttt attttctgag 721 cacataccgc gcgtccctgc gtgggcagct gcccctgggg gtgggagccc aggaaactcc 781 aggttctcag ttaagtggta actgtcttga tgactctcag gtctcagtgc ccacattata 841 caagcggctc agcaaccaga cccaggatgg ggagtcactg accccctgcg cccatggcag 901 gggtgagggt agggacaccc ccataagatg gagctgtgat gagaagcaaa cccaactcag 961 tttggtttca tttacattaa aaaggcaaat cccttggccg gatgcggtgg ctcacacctg 1021 taatcccagc actctgggag gcctaggcgg gcagatcacc tgaggtcagg agttcgagat 1081 cagcctggcc aacatggtga aaccccgtct ctactaaaaa tacaaaaaaa ttagctgggt 1141 gtggtggctc gctcgtgtaa tcccagctac tcaggaggct gagtcaggag aatcgcttga 1201 acccgggggc tgggtggagg ttgcagtgag ctgagatagc gccactgcac tccagcctgg 1261 gcaaaagagc aaaaaaactg tgtctcggaa aaaaaaaaaa aaaaaaggca aatcccggcc 1321 gagcctttgg ctcacgcatg tgatcccagc acttttggga agctgaggct ggaggatcac 1381 ttgaggtcag aagtttgaga ccagcctagg caacatagcg agacccccat gtctacaaaa 1441 caataattag ccaggaatgg tggatgagcc tgttgtccca gctactcggg aagcagagac 1501 gggaggttcg cttgagcctg ggaggtcgag gctgcagtgt gccctgatcg tgccactgca 1561 cgttagcctg ggcaacacag caagaccccg tgtcttaaaa aaaaaaaggt aaataagagt 1621 tggggacact tttctgcgag ttggagaaac caaaccccct cgacgagtct taagtagtat 1681 tctcaggttg tctggcctgc ggccgcgctg ctgtcaacca gccggataac tgcgctgcct 1741 cccgacgcgc cgccagccag gccacggcct cctagacaca agcgagcatg cgcagtcgcc 1801 aacaacaagt ccgcacgtcc ggtcccgccc cccccttccc cgccttcttc ccactccggc 1861 ctcccattgg ctgacgtcgg cgcgagcgct caacaccgac gcgtctgacc aatgagcgct 1921 ctggagggcg tggccgtggg aaaggaggcg cggaaagccg acgcgcgtcc attggtcggc 1981 tggacgaggg gaggagccgc tggctcccag ccccgccgcg atgagcctcg gccgcctttg 2041 ccgcctactg aagccggcgc tgctctgtgg ggctctggcc gcgcctggcc tggccgggac 2101 catggtgagc tagcgccgcg gccgttgccg gcccggtgac cgttggggcg ggcgcgcgat 2161 ccctgcctcc gctcgccggc gtggggaacc ctcaggctcc agtgaccttg gtggggggcg 2221 tctgggggct ccccctcccc acccccggcc gggcacggac gcgggtgacc gtactgcgac 2281 gcgctccgcg gccctccagg ccgttgtagg cgcgcgggct ggggtcgggg aaggggaagg 2341 ggttgttcca cgcgcgcggg tcgtggtcgg ggaaggggcc gtccaggccg ttgcaggcgc 2401 gcgtgccggg gccggggtcg ggggtccagg cttgcagggg gcggggtccg ggacggctgg 2461 ggcggagctg gaccgttgag ggccacggcg gggcgtctcc gggccgagcg gggctgctgc 2521 gcccgagcgg ttgggggcgc ggagggctgg aaatcccgga tcacgcgccc ccgggcgccg 2581 ccccgccccc gcaccttggc ctagcgcggt ggcgtcacag tcgcgcagtc ctgactacgg 2641 cctccgggcc ctttgtcccc gctagcggcg ctcggggtgg gggagccagg aggggcggga 2701 gacgggcggg tatgggccgc gcgggcgcag gctcccccgg gcgccgcagg cagcggtgcc 2761 agagccgggg caggcggcgg ccgcgagccc ctcggcggcg gaaggcccca gcgtgcaggc 2821 gcaggagggc gcggcgccgg cggaagaagc cctgtccccg cagcttgcga ccggagatcc 2881 acgaatgtcc caagtcccag gacccggtgc gcgcggggcc cccacaccgg ctaatgtggc 2941 acattttggg gttggaaccc tctcccggcc tccgggtctc cggtaaaacc ggaccagaag 3001 tacaaggggg cgtgtgcgtt taaggaggag gagcgttcag gtcttcaggg ccgcagggcc 3061 tcggtgtccc cgccaccgac ccgctcccga tcccttcctg cctcagggtc ccgggctcag 3121 cctcccgtcc acgctccctg ctcagcttcc tttgccttgc agtgcgcgtc ccgggacgac 3181 tggcgctgtg cgcgctccat gcacgagttt tccgccaagg acatcgacgg gcacatggtt 3241 aacctggaca agtaccggtg ggcgctcgcc tggggtgggg cgcggggtcg ggccctggga 3301 gggggccgtg ttcttctgcg ctgacgccgc cgatcctcgc aggggcttcg tgtgcatcgt 3361 caccaacgtg gcctcccagt gaggcaagac cgaagtaaac tacactcagc tcgtcgacct 3421 gcacgcccga tacgctgagt gtggtttgcg gatcctggcc ttcccgtgta accagttcgg 3481 gaagcaggtg ggctgctgcg tccccggggc ccgcagaggc gggtgggtgg gggtcggggt 3541 gggctccagc ctggagaggg cctgggagtg tgcagggggc ccggactgag ggggtgccag 3601 gcccccgact cactcacaca ccttggccgc cacaggagcc agggagtaac gaagagatca 3661 aagagttcgc cgcgggctac aacgtcaaat tcgatatgtt cagcaagatc tgcgtgaacg 3721 gggacgacgc ccacccgctg tggaagtgga tgaagatcca acccaagggc aagggcatcc 3781 tgggaaagtg cgtgacctct ggggacagta cggctgctgg ggtgggggtg ggggggctgc 3841 tgggatgctc acacctccct ggggcagaat ggctcatggc tcggggggcg gttgcgggga 3901 ggtgctggga ctctcacatc gcgtggcctc ctgggggtaa gatggctcag ggggacatag 3961 agggctgtgg aggcagccag ggatgcccac acctttgtgg cctcctgggg acaggatggc 4021 tcgggggcct gtggggggct gttgggactc tcacactgca tggcctcctg gggtaagatg 4081 gctctggggg ggcttggggg cactgtggct gtggaggcag ccggggaagc tcacaccctt 4141 gtggcctcct ggagacagga cagcttgggg actgtggggg gctgctgggg acgctcacgt 4201 ccatgtgctt cttttccagt gccatcaagt ggaacttcac caaggtaagg gggctgtggg 4261 gggtagggga ccagcttccc ctggccacag ccgtggccca gatgggcagc ggacaggaag 4321 ggcagcctca gccccttgca ggggtggccc cacagtttgg acaccgtctc tccacagttc 4381 ctcatcgaca agaacggctg cgtggtgaag cgctacggac ccatggagga gcccctggta 4441 ggtcctctct agggagcccg cttgaggctc gggggcttgg gaggtagctg ccctaaccca 4501 gctttcctcc ccgacaggtg atagagaagg acctgcccca ctatttctag ctccacaagt 4561 gtgtggcccc gcccgagccc ctgcccacgc cctcggagcc ttccaccggc actcatgacg 4621 gcctgcctgc aaacctgctg gtggggcaga cccgaaaatc cagcgtgcac cccgccggag 4681 gaaggtccca tggcctgctg ggcttggctc ggcgccccca cccctggcta ccttgtggga 4741 ataaacagac aaattagcct gctggatctt tctgcgtagg ggcttggggg gcccttttgc 4801 caggggcccc tccatgtcag ggccagttgc cgtcagctgc caggctgggg gtgccatgga 4861 ggtggcgtgt tgttgccccc tcttcctcca ggctcggggg gctgtgctgg ctgcagtgct 4921 ggggtgcagt gagatctggg cccgttggac acccagccct ggctcttaat ccgtgcagcc 4981 ccacctgctg tgcacaggca gggcctggtg tagtgccgag tcttggagga gataattcta 5041 agtggctgtg cttcc //