LOCUS AY768549 18009 bp DNA linear PRI 06-OCT-2004 DEFINITION Homo sapiens fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) (FGFR3) gene, complete cds. ACCESSION AY768549 VERSION AY768549.1 GI:53689007 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 18009) AUTHORS Livingston,R.J., Rieder,M.J., Chung,M.-W., Ritchie,T.K., Olson,A.N., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Chambers,S.W., Schackwitz,W.S., Sherwood,J.K., Sherwood,A.M., Leithauser,B.J. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (29-SEP-2004) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..18009 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 30..161 /rpt_family="L2" /rpt_type=dispersed variation 229 /frequency="0.01" /replace="a" variation 271 /frequency="0.11" /replace="g" variation 310 /frequency="0.01" /replace="a" variation 430 /frequency="0.01" /replace="a" variation 436..446 /frequency="0.89" /replace="" variation 549 /frequency="0.02" /replace="c" variation 794 /frequency="0.41" /replace="c" variation 806 /frequency="0.15" /replace="t" variation 932..933 /frequency="0.99" /replace="" gene 1098..16074 /gene="FGFR3" mRNA join(1098..1245,6457..6726,6950..7015,8570..8739, 8823..8946,9038..9228,10895..11039,11533..11723, 12027..12172,12558..12679,12762..12872,12953..13143, 13254..13376,13460..13530,13749..13886,14032..14137, 14319..16074) /gene="FGFR3" /product="fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)" CDS join(1137..1245,6457..6726,6950..7015,8570..8739, 8823..8946,9038..9228,10895..11039,11533..11723, 12027..12172,12558..12679,12762..12872,12953..13143, 13254..13376,13460..13530,13749..13886,14032..14137, 14319..14465) /gene="FGFR3" /codon_start=1 /product="fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)" /protein_id="AAU89726.1" /db_xref="GI:53689008" /translation="MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPG QQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHE DSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMD KKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESV VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCK VYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDA GEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAA VTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPT LANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVK MLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREF LRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT FKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAP PSSGGSRT" variation 1271 /gene="FGFR3" /frequency="0.01" /replace="a" variation 1419 /gene="FGFR3" /frequency="0.02" /replace="c" variation 1535 /gene="FGFR3" /frequency="0.01" /replace="c" variation 1542 /gene="FGFR3" /frequency="0.01" /replace="a" variation 1554 /gene="FGFR3" /frequency="0.05" /replace="t" variation 1590 /gene="FGFR3" /frequency="0.01" /replace="a" variation 1655 /gene="FGFR3" /frequency="0.31" /replace="g" variation 1672 /gene="FGFR3" /frequency="0.01" /replace="a" variation 1750 /gene="FGFR3" /frequency="0.01" /replace="g" variation 1759 /gene="FGFR3" /frequency="0.01" /replace="t" variation 1785 /gene="FGFR3" /frequency="0.05" /replace="t" variation 1907 /gene="FGFR3" /frequency="0.17" /replace="g" variation 2014 /gene="FGFR3" /frequency="0.38" /replace="t" variation 2104 /gene="FGFR3" /frequency="0.13" /replace="t" variation 2111 /gene="FGFR3" /frequency="0.38" /replace="c" variation 2179 /gene="FGFR3" /frequency="0.01" /replace="a" misc_feature 2319..4004 /gene="FGFR3" /note="Region not scanned for variation" repeat_region 3420..3510 /rpt_family="MIR" /rpt_type=dispersed variation 4207 /gene="FGFR3" /frequency="0.07" /replace="c" variation 4211 /gene="FGFR3" /frequency="0.01" /replace="t" variation 4261 /gene="FGFR3" /frequency="0.01" /replace="a" variation 4601 /gene="FGFR3" /frequency="0.99" /replace="" variation 4622 /gene="FGFR3" /frequency="0.01" /replace="t" variation 4633 /gene="FGFR3" /frequency="0.01" /replace="a" variation 4778 /gene="FGFR3" /frequency="0.01" /replace="c" variation 4966 /gene="FGFR3" /frequency="0.16" /replace="t" variation 4971 /gene="FGFR3" /frequency="0.01" /replace="a" misc_feature 5068..5316 /gene="FGFR3" /note="Region not scanned for variation" variation 5532 /gene="FGFR3" /frequency="0.01" /replace="t" variation 5547 /gene="FGFR3" /frequency="0.01" /replace="g" variation 5557 /gene="FGFR3" /frequency="0.01" /replace="t" variation 5559 /gene="FGFR3" /frequency="0.02" /replace="g" variation 5581 /gene="FGFR3" /frequency="0.01" /replace="g" variation 5677 /gene="FGFR3" /frequency="0.03" /replace="a" variation 5680 /gene="FGFR3" /frequency="0.01" /replace="a" variation 5745 /gene="FGFR3" /frequency="0.02" /replace="a" variation 5793 /gene="FGFR3" /frequency="0.09" /replace="t" variation 5846..5849 /gene="FGFR3" /frequency="0.03" /replace="" repeat_region 6047..6328 /rpt_family="MER1_type" /rpt_type=dispersed variation 6540 /gene="FGFR3" /frequency="0.01" /replace="a" variation 6695 /gene="FGFR3" /frequency="0.01" /replace="t" variation 6849 /gene="FGFR3" /frequency="0.01" /replace="c" variation 6987 /gene="FGFR3" /frequency="0.02" /replace="t" variation 7018 /gene="FGFR3" /frequency="0.10" /replace="g" variation 7046 /gene="FGFR3" /frequency="0.01" /replace="g" variation 7086 /gene="FGFR3" /frequency="0.01" /replace="t" variation 7173 /gene="FGFR3" /frequency="0.10" /replace="c" variation 7254 /gene="FGFR3" /frequency="0.01" /replace="g" variation 7269 /gene="FGFR3" /frequency="0.01" /replace="t" variation 7342 /gene="FGFR3" /frequency="0.12" /replace="t" variation 7370 /gene="FGFR3" /frequency="0.04" /replace="g" variation 7455..7469 /gene="FGFR3" /frequency="0.01" /replace="" variation 7479 /gene="FGFR3" /frequency="0.01" /replace="c" variation 7687 /gene="FGFR3" /frequency="0.13" /replace="c" variation 7754 /gene="FGFR3" /frequency="0.22" /replace="g" variation 7795 /gene="FGFR3" /frequency="0.01" /replace="t" variation 7800 /gene="FGFR3" /frequency="0.01" /replace="a" variation 8029 /gene="FGFR3" /frequency="0.01" /replace="t" variation 8712 /gene="FGFR3" /frequency="0.01" /replace="t" variation 8727 /gene="FGFR3" /frequency="0.10" /replace="c" variation 8747 /gene="FGFR3" /frequency="0.03" /replace="g" variation 8783 /gene="FGFR3" /frequency="0.24" /replace="c" variation 8808 /gene="FGFR3" /frequency="0.01" /replace="t" variation 8817 /gene="FGFR3" /frequency="0.01" /replace="a" variation 9180 /gene="FGFR3" /frequency="0.22" /replace="c" variation 9300 /gene="FGFR3" /frequency="0.23" /replace="g" variation 9402 /gene="FGFR3" /frequency="0.01" /replace="c" variation 9446 /gene="FGFR3" /frequency="0.15" /replace="a" variation 9565 /gene="FGFR3" /frequency="0.01" /replace="t" variation 9565 /gene="FGFR3" /frequency="0.01" /replace="g" variation 9752 /gene="FGFR3" /frequency="0.11" /replace="a" variation 9818 /gene="FGFR3" /frequency="0.01" /replace="t" variation 9819 /gene="FGFR3" /frequency="0.01" /replace="a" variation 9853 /gene="FGFR3" /frequency="0.20" /replace="g" misc_feature 9912..10177 /gene="FGFR3" /note="Region not scanned for variation" variation 10372 /gene="FGFR3" /frequency="0.01" /replace="a" variation 10381 /gene="FGFR3" /frequency="0.01" /replace="g" variation 10475 /gene="FGFR3" /frequency="0.01" /replace="a" variation 10772 /gene="FGFR3" /frequency="0.06" /replace="g" variation 10954 /gene="FGFR3" /frequency="0.01" /replace="t" variation 11069 /gene="FGFR3" /frequency="0.03" /replace="c" variation 11148 /gene="FGFR3" /frequency="0.01" /replace="a" variation 11275 /gene="FGFR3" /frequency="0.04" /replace="c" variation 11491 /gene="FGFR3" /frequency="0.01" /replace="c" variation 11516 /gene="FGFR3" /frequency="0.02" /replace="t" variation 11607 /gene="FGFR3" /frequency="0.01" /replace="c" variation 11857 /gene="FGFR3" /frequency="0.01" /replace="t" variation 11995 /gene="FGFR3" /frequency="0.11" /replace="t" variation 12050 /gene="FGFR3" /frequency="0.01" /replace="t" variation 12065 /gene="FGFR3" /frequency="0.01" /replace="g" variation 12081 /gene="FGFR3" /frequency="0.01" /replace="a" variation 12310 /gene="FGFR3" /frequency="0.04" /replace="g" variation 12529 /gene="FGFR3" /frequency="0.04" /replace="g" variation 12898 /gene="FGFR3" /frequency="0.01" /replace="t" variation 12954 /gene="FGFR3" /frequency="0.02" /replace="t" variation 13187 /gene="FGFR3" /frequency="0.01" /replace="t" variation 13370 /gene="FGFR3" /frequency="0.04" /replace="g" variation 13391 /gene="FGFR3" /frequency="0.01" /replace="c" variation 13398 /gene="FGFR3" /frequency="0.05" /replace="a" variation 13761 /gene="FGFR3" /frequency="0.01" /replace="a" variation 13867 /gene="FGFR3" /frequency="0.01" /replace="a" variation 14027 /gene="FGFR3" /frequency="0.01" /replace="t" variation 14039 /gene="FGFR3" /frequency="0.01" /replace="t" variation 14198 /gene="FGFR3" /frequency="0.01" /replace="t" variation 14470 /gene="FGFR3" /frequency="0.01" /replace="g" variation 14501 /gene="FGFR3" /frequency="0.01" /replace="g" variation 14649 /gene="FGFR3" /frequency="0.05" /replace="t" variation 14671..14672 /gene="FGFR3" /frequency="0.01" /replace="" variation 14678 /gene="FGFR3" /frequency="0.01" /replace="g" variation 14752 /gene="FGFR3" /frequency="0.01" /replace="t" variation 14825 /gene="FGFR3" /frequency="0.01" /replace="a" variation 14963 /gene="FGFR3" /frequency="0.01" /replace="a" variation 15032 /gene="FGFR3" /frequency="0.01" /replace="c" variation 15125..15126 /gene="FGFR3" /frequency="0.01" /replace="" variation 15263 /gene="FGFR3" /frequency="0.04" /replace="c" variation 15579 /gene="FGFR3" /frequency="0.01" /replace="g" variation 15754..15757 /gene="FGFR3" /frequency="0.01" /replace="" variation 16491 /frequency="0.01" /replace="c" variation 16645 /frequency="0.04" /replace="g" repeat_region 16661..16689 /rpt_family="L2" /rpt_type=dispersed variation 16693 /frequency="0.01" /replace="t" variation 16753..16754 /frequency="0.01" /replace="" variation 16935 /frequency="0.99" /replace="" variation 16968 /frequency="0.01" /replace="g" variation 16980 /frequency="0.05" /replace="c" variation 16992 /frequency="0.01" /replace="a" variation 17323 /frequency="0.03" /replace="c" variation 17338 /frequency="0.03" /replace="" variation 17562..17563 /frequency="0.92" /replace="" variation 17617 /frequency="0.02" /replace="t" variation 17806 /frequency="0.09" /replace="t" variation 17946 /frequency="0.01" /replace="a" ORIGIN 1 tgccccagac ctgcggcgca cacgggaggc tcagcctgga atgccgtcct gccctcctcc 61 acctgaggaa ttgccgctca caccacaggg ttcagctccg cggcatctcg gcgaagcctc 121 ctgacatccc gacccccgcc gagacctccc ctctgagctc ctgagcacag ccccagggga 181 cccgagctgc gcgctatgca aacacaggcc tgccctcgcc ctcggtgcgc cccgtgcccg 241 ccgccccctg ggccgccccg cggtgcgact aggggcctag cccgcctgcc ccggctccca 301 cgccctcgag accgccgggc gcccccgccc ggccacgccc cctcggatgc cccgctccgc 361 cccgaggggg cgtgccctgc gcccccgcga gccgggcggg gaccgggcgg gagcggggcg 421 gggccggggc ggggccgggg cggggcgcgg accgtccccc actggctgcg gcgcgcgggg 481 cagcccaggc tcagtgcgcg gtggcggcgg cgtcgcgggc agctggcgcc gcgcggtcct 541 gctctgccgg tcgcacggac gcaccggcgg gccgccggcc ggagggacgg ggcgggagct 601 gggcccgcgg acagcgagcc ggagcgggag ccgcgcgtag cgagccgggc tccggcgctc 661 gccaggtccg tgcttggggc cgggcaggct cgcggagggg tccaacggtg ctcgcggagg 721 ggtcggggcg cggctgtcgc ggaaccacag aggtccctgc agcgggccgg gccggggcgc 781 gggcttcccg ctcaggaaag tttgccgccg ccgccgccct gggagggctt tgcagcagcc 841 agggagggaa gggggaggag ggagggaccg cggcggggag gaggcggccg gcgccaggcg 901 gcccgggagc cctgggcggc ggcggcggcg gccgcggggc ggctgggggt cggaggggtc 961 gggacgcagg agccggccac cgccgctttc gtccctgtcc gcccctctaa cgagctgcct 1021 tcctcctcct gcagtctccc gagcggcgcc cgcctcccgc cggtgcccgc gccgggccgt 1081 ggggggcagc atgcccgcgc gcgctgcctg aggacgccgc ggcccccgcc cccgccatgg 1141 gcgcccctgc ctgcgccctc gcgctctgcg tggccgtggc catcgtggcc ggcgcctcct 1201 cggagtcctt ggggacggag cagcgcgtcg tggggcgagc ggcaggtaag aagggaccca 1261 ctaggcacgg gagaggccgg cccgtgcggg cagaggcgtt ggggacggga accggccccg 1321 ggtcggaggg gccgccgggt gtgagtgacg ccccggggtt agagcccgga ttccgctgcc 1381 tccttgccgg agagcgcggc cagagctagc gcggcgactt gtggtgcgcc cggagccgca 1441 gctaccctcc aagtgcgagg ccaccacggg gagccaggct gggggttggc gtccgcagcc 1501 ccgatcccct gcgactccct agccctggcc tgtcgggagg gcgcgggggg ccccatttcc 1561 acgattcccg ctgttgttat tcgggttctg cgcagacgga aagttcccat tgttggcgtc 1621 cccctccccc gggccccagt ttgtggccag cttcagccaa ggcgagagac cggacttcta 1681 agggtgggtg tgcgcgtcag cgaagcccgg cccctgcccg cccgaagagg cagcagcctc 1741 cagcgtcccc gctgccgacc ctgcccctgc ctgggggccg agggcgcttc cccgtgggtg 1801 cgcgccgagc tccaggcaag cgaggggcgc gtgtcccagc gtcgcgggcc ctagactggg 1861 ctggcggtcc aggtcccgcg ggacgtcgag ggtctgaagg gaggtcccaa ggggcgaggg 1921 gaggggaagg ggcgcccggc cggacctgca cacgcgccgc ggttcctcgt gggccgggcc 1981 gagagctccg gtgccgccgc cgcgtacacc cgcagccggc tccggacggg cgaggggggc 2041 gcgcacagct cagcccggcg gccgcgcgga gggaggcctt ggcccggtga gctcgcgccc 2101 cacccgggcc gaggcccgaa cagccgcttc tttgtacctc gacgcggcca cagaccgcgc 2161 attgatggcg gctcggcggc tcgcggggag gtgtgagcga ccgcgggcgc ggcgggccgg 2221 ggagggcgcc tggagggccg aggcagatgg cgtccgcccc gcccgcgccc ccgcgcccct 2281 ttctccgtcg gcggctgcag cctcccggaa caatgtcatt ttttttatga atgaaagtgg 2341 cccggcgctt gaatgtgcgt gtcattcagc ggcgtgacag gggccgtcgg gaggtcagcg 2401 cgcgctttta gcgtctgctc gggcggcccc gcttccaggg gtgccggagg ggcggccgcg 2461 gggggagctt ggctttcgca ttctcattca gataaagata ttactcccta cggcccggga 2521 atgtcagcca gccccgggga agggcggcgg ccaggctgcg gagcctctcc tggaccccct 2581 gcgggcgcgc ggggcctccc ccagtcgctc ctggaacgcc ccgcccaccc ctcccccggg 2641 gcggcgcccc cgcccgcact ggagctggtg aaacaggtag tgagttgatc ggtcaataaa 2701 cttaatccgg ttccttaaca agatgggccg ggcagtaaaa atacaaagac ctcgtgaaat 2761 ggactgaggt ctaggctggc gcttgcccgg gaacataaat tatggagcct tggctcgcag 2821 gggtcaaggg cggtgggaaa ggttttggcc actggactgc cctggccacc ccaggccctg 2881 ccaggacagc ccccatctcc ccagggggcc gtattcctgg ttgggacctg gagtgacccc 2941 ccagggtgca gggaggtaca caaggtcggc tctcccacag tcccacccca cccagcaggg 3001 gtctgggggt gcagggcctt tcccgaaggt gctggctgca acctccccca ctcctcctct 3061 gcagggctgg actttgagcc gcgtgggcct ctgggtggtt cattaacctg ggctgagcct 3121 ggcctccagg tccttgtgtg agcctaggaa ccccttgtta cccacccccc agctccccag 3181 ccctcaggtc tcacttgggg ctagatctgg ggctgtggca ccccttgtta cagctgagct 3241 tgagtgggag cccaggggct tggggtctcc tggaggacgg ggatctaaag tcacctcatc 3301 tagggaggca tgcagccctc acctgagtga ttcaggagtg aatgagccag gagtggagcc 3361 acctttggtg gggtaggggt cagcctggac ctctaggctg ccagctcagg ctcgggtgcc 3421 ctcttcgaac ctcagtttcc ttacctgtcc aagagaaccg ataatggcag gctgtttgaa 3481 ggattaggcc agataaccct ggcaagccct ctttagcctg cccagcctcc agatcccttt 3541 tttccggact ttattgtgaa actccaggtg gggagacagg gaggctggac ttttgggggc 3601 cccctcctct taggctattt tatagctcct acctggcaat acctcctgta ccccagagag 3661 ctgcagagaa cttcatgtgc atccgaaacc agaatgtgtt gtttcctgac cccaggccct 3721 catctcaccc caaaacccaa ataaacccct ggggcagcca gctccggaag cgagtctgga 3781 tttgatcctt gttctctggg gtcaacccga ggggcttatg atggagcaag gctcccccat 3841 cctctcagcc atgctccctc acatgcactg ggcctccact gcagagaccc agagcctgga 3901 gaaaggttcc ccaggccaga gtttggccgt ccccagcacc ctgcctaatg gacatcagtc 3961 ttggggccag agacccaggg cagggagcgc ctctcacccc taccctcact cctgcagcca 4021 tttcagggcc tggtgccctc cctgagctcc tgggcctgtg gggtgggatt tttactttgt 4081 gccacagtgg gggaaactga ggtacaggac cagtgagtgg cagagttgtg gagactctgg 4141 gacacagcag agggctgtcg ttggcatgtg gagcccaagt tgaggtcggc actgtgtggg 4201 gttggggcgc cggcaggagc acgtgttgtg ggatccatag aagggtggga ggtgggacgc 4261 gttgcctcct accccgcctt gggtacagca ggagttttgt ctccaacgtg tttgggcacc 4321 agtgtctgtg tggtgtcagt ggggcctccc ttttgtggat caagaaagaa agaacccttc 4381 ctagggctgc tggggggcta tagctctccc catgcctggc agctgggtgg ggtatggggg 4441 ctccacccaa ctgctgactt cccagtggga gtcagaccct gaacttatag cacccactca 4501 tgccccgtgt cacactgtcc ttcacctggt gctcgccacc cagcccctgc tggggtaccc 4561 tggcctctgc tggcacctag caggcaggca gtgggggggg gcagtcaggg ctgcaccctc 4621 cccaccacac acgggcagat ggccactggt gtggctggcc tggggctgct gtgtcccccg 4681 tccccccgtg ctggaccagg ctgaagcaaa tacttgtgtg gatggcttga cctgttgtcg 4741 ccactcagac caaaccggaa ccaaccggct gttgcccttg ggccagggcc tgcagctgag 4801 gctgccataa ccagcctgtt ctcggccttc tggggggcct cgagcagctc ccagctctgg 4861 gtggtcccca caagacactg gccaggaccg gagggctgga ggtcaggcca ggagcccccc 4921 tgactgcggg gtccctacag gggcagtcct tgagctgtgg gtcccggtgg ggcgagggct 4981 ccttcggatg cttcagggga tgagtgtggg cccttctggc tggcagggtc accctgggca 5041 ctaggcgtgt gtggctggat caggtgggtt gggcagaaga gggcctggcc gggcagccag 5101 ggactggtgt ggccagagtg ggcagctggg cccccgaatc taggccacgc gtctgcagaa 5161 tgacaagtga tggcgcaacc cgcccagctg ggtctgaaga aggaggctgc ctgggggacc 5221 acccaccccc gtcccggccc caagcccggg acgcctgcct gcatgcattg tctggccctg 5281 gcagggaagc ctaggggcga ttgtcccccc agccctgccc atggtgtgtc cttgggtcac 5341 aggctttggt ggctctgggg agctgggcag ctactgggga gggacccagg ggccacctgc 5401 acatctgccc ctgtgggtgg gcccccaccc cagcttctca gcccccaggg aggggccagg 5461 gctgctgacc tgccctggct ctcacagctt cctgccccca gcctggtcgt cctctgtgag 5521 ggggccccag tccccctgca ggcagcagga ctccaccccc cggccccctt gagggcccgc 5581 ctgggcctcc ccactccccg gcctgtgaga cccacttggc cggacccagc gccgtgtttg 5641 tactttgctc ttctcggtat gttttccgtc atgaccgccg tgtggagctt ccataggagc 5701 tgcaggatac agaaccttgc ccaccccaag gagcccccac ccccgccccg gccccctcgc 5761 gctgctccgg cctgtgctct gaccggtgaa cccgcgcatc gccccccaga ccgtccacac 5821 ggccacgtga ccctgcacct ccttccttct cgcctgttct gttccctggc tgtccatctg 5881 aactgctttt caggctcata tggggtgcgg gggctactga ggacggaccc ctcctggggt 5941 gaatctgcac cacgaggggg ctggctggcc aaccctggca ccccctctga gctccatttc 6001 agtcagaggc cagcaaaggg cagcctgtcc cctttgcccg cagcacctgc ccgtcgtggt 6061 gccgcctgtg agacaagcat ggattttatg tttccaagca attgaacaaa ttaaaagaac 6121 gaagagtcac attttgtgac actttgagat ttgaattctc cgtgtccatg agtgaagcat 6181 catggggcca ctgctgtggg gttggctgca ggttgtgtgg ggaaggcggc tgtcacaccg 6241 aggcagaccg gagtccttgg gacagactgg ttggcaaagc tgaagataga gacctttggc 6301 ccttttggga cacagtttcc agcccctggt ctggtgggac cctggatctg ggtcagagcc 6361 ttcctcactc agggccgccg aggcttccac tgctgtgtct gtaaacggtg ccgggtttgg 6421 gggtgcctgc ctcatggttg cccatcttcc ccacagaagt cccgggccca gagcccggcc 6481 agcaggagca gttggtcttc ggcagcgggg atgctgtgga gctgagctgt cccccgcccg 6541 ggggtggtcc catggggccc actgtctggg tcaaggatgg cacagggctg gtgccctcgg 6601 agcgtgtcct ggtggggccc cagcggctgc aggtgctgaa tgcctcccac gaggactccg 6661 gggcctacag ctgccggcag cggctcacgc agcgcgtact gtgccacttc agtgtgcggg 6721 tgacaggtga gctctggggc cacgccagct acagaaagga gccgagtgcc gggctccctg 6781 agtccctgcg tgggtcagga gcggctgggg gtctctctgg tcattggtgg agaggagggc 6841 acccccagga agtgctgccc aaatggggga ccctgcccca tctgggaggg gcacctgggg 6901 gcctcctggg gcaggttggg cattggttgc ggccatctct gccttgcaga cgctccatcc 6961 tcgggagatg acgaagacgg ggaggacgag gctgaggaca caggtgtgga cacaggtagg 7021 agcagggtcc agggttcagg ccagccgggg tggggcccgc tgccaccgcc aagccctgcc 7081 cttcacaggc agctgaggga ctaaggcccc ggaacaacct ccctggggtc accccgaagg 7141 tctggtcccc tcaggataca ggaggggctg ggtcactgac atggctctag atgccccacc 7201 ctggtggcag ggctggggtg caaggggaca ccgtgttgct gatggggaga ctgaggcaca 7261 gggccctggg ggttccagga gcaggaggag gccagggctg gcctgtgggg ctctggtgtt 7321 ggctataggt gaggtggacc ccgcagacat tagcgcagca gggcagggca ctcaggtggc 7381 tgccgtgggg tggatggacc cggggtgagg gcgccggggc acctgccaca accagtggcg 7441 ggcagggtgg ctggcaggag ggtggctggt gggtgggctg cggctgtgag agagcagtcg 7501 gggacgatgc ctggcgtccc ggcctggaac ggtggcaggt ggactttgcc aagttgtagg 7561 gtggggaggt ggggcttctg gttttggagg gagctctgag gggagtgcgt gcaggtgagg 7621 gtcatcgtgg cacagacatg gggggcagtt acgacttgcg gactgatggt gtgtgcgctg 7681 ggtccctggg ccagtggggt aagcaggtga ggaagggagg ctgagtccat gagagaaaca 7741 gctgggggaa ctcaccctgg gggtctccag gaggcctggg agggagctca gcaccgtggg 7801 gtgcctcttt ccagcctgtg tccacactgc tgcttgctgg gcctcagtgc ccctgatggg 7861 cgtgtgcctg gagggggctg gcagtgagct cactgagggg agggctgctt ccctcctggg 7921 gaatgccagc ccatccttgc ctggagtccc ggcaggaagg cagcaccagc cctgaggaag 7981 gagaaaaacc agttgggctg tgagaggggt ggtgggagcc ctggacatcg agatgggagg 8041 aggcagggcc tccagggtgc caccgtctct gggtgcccgc cagacttgga gctctgcaga 8101 gggtggtgta gggtcttgat ttccgtgggc ccatgctgcc cagctgcctc caaggctcct 8161 ggctctgcag gcgactgggc tcctctcctg gtaaactgct cccaggtcct ggcttgtcca 8221 ctagatgggc ctgccccctg ggtcttcagt ctccccgttg gtgggcctgg ccctggcacg 8281 cctctctggg caggtgggct cccctggaca atgccctgtg ccctgtgact tcacaggtcc 8341 gggcagagca ccctggaggg gaggggaggg gacacacggc ccagctctga gaaagccccg 8401 gggaggggac aagatgtgga ggctcctggg aacctcatcc cgccctcttc ctacacagga 8461 cgggaaactg aggctgggga tgggcagggg cagctctggg aagggggttg ttcagagggg 8521 cctctgctcc cactcgggtc atggccttca cacgcacctc ggcccgcagg ggccccttac 8581 tggacacggc ccgagcggat ggacaagaag ctgctggccg tgccggccgc caacaccgtc 8641 cgcttccgct gcccagccgc tggcaacccc actccctcca tctcctggct gaagaacggc 8701 agggagttcc gcggcgagca ccgcattgga ggcatcaagg tgggcgcggc ggggtggctc 8761 tgggcctggc aggcgcggtg gttgctgcct ccgctcactc acccgcccgc gtcccggtgc 8821 agctgcggca tcagcagtgg agcctggtca tggaaagcgt ggtgccctcg gaccgcggca 8881 actacacctg cgtcgtggag aacaagtttg gcagcatccg gcagacgtac acgctggacg 8941 tgctgggtga gggccctggg gcggcgcggg ggtgggggcg gcagtggcgg tggtggtgag 9001 ggagggggtg gcccctgagc gtcatctgcc cccacagagc gctccccgca ccggcccatc 9061 ctgcaggcgg ggctgccggc caaccagacg gcggtgctgg gcagcgacgt ggagttccac 9121 tgcaaggtgt acagtgacgc acagccccac atccagtggc tcaagcacgt ggaggtgaat 9181 ggcagcaagg tgggcccgga cggcacaccc tacgttaccg tgctcaaggt gggccaccgt 9241 gtgcacgtgg gtgccgccgc tggggctcct gggctggccc caagggtgcc ccttggctgc 9301 gggttgcgtg aggatttggg tctaggggtt ggagcttcgg gggcagaagc tgtgggggtg 9361 cttgtggggc caagtctcag ccaccccaca cctcagggcc ataggcagct gcgttgggac 9421 ccgtttccgt gtctgcagag ggccagcctc agccactgaa gtccctgaca tggagctgcc 9481 cacgggcttc ttgggggtgg gtgcggcttg ggcagcagtg gtgccccagg acaggagggc 9541 agtgtggcca agccctccag gccccctctg ggcctcagag gcggtggctg agccccgacc 9601 tggccgattg gctctcgtca gctgtgtgca gtggggcccg agctcactgt ctgcccgcct 9661 cctgaagccc ttagctttgt tcccatggct gccgggtggg ggccactgaa ttgggacggt 9721 tgcgacactc aaagcccaaa gagaaacatc tgttcagaga gaagacggtc tcttgggggc 9781 ggggagcagg cgcagggcga gggtggagtc cagaccccgc ccagagaggc cgcctcgggc 9841 cctgtccagg gtacaggttc tgcaagagcc cgggggaggg caggccagtg accagaggtt 9901 gtctgagggt ctgggctggg ttgttggggt ggaggcagag acgtgcatcc tgtgaaacca 9961 cagccaccgt gaagtgcctc cacgcctcct ccaggcagcc tttggggctg acgcagccca 10021 gcctcgatct gtaccttggg ggtctcccac atcctgcctc gtgcccggcg gggctgcctc 10081 gggggcgtgc ctgagccggg tctcttgtcc ccgcagtcct ggatcagtga gagtgtggag 10141 gccgacgtgc gcctccgcct ggccaatgtg tcggagcggg acgggggcga gtacctctgt 10201 cgagccacca atttcatagg cgtggccgag aaggcctttt ggctgagcgt tcacgggccc 10261 cgagcaggta acgactctgt cccatgccgg ccggcacaag agctccagct ccaaggccct 10321 ggccgcgcgc cctgcacgcc ccgcacgccc agccctgctc gctcccgccc cggctcgcgc 10381 tccactcggg gccgcctcgg caaggctggc agctccagcc tccacggtga ccgcccgctt 10441 cgagccctgt ggcctgcgcc gacccttccc gcacgcctgc gacccccaca ggaggtgccc 10501 ggtgcccacc gggccggctc cgtgccgtct gtgagcaccc ctttgcgcct ctctccaccc 10561 ctgcccgctg cctgctcgct tccgcagcct gtgtgtccct gtgtccatcc tccacctgca 10621 cccgcccggc tctgcgctaa cccgcatgct gcctgcccgc ctgccgctca cctgggacag 10681 aggactcgcc ggtggagggg cctggcttcg ggctcagtac cggtgtacca ggcggagggc 10741 cctcagccgc gtggcggtga ccaagttggc gatggctgag gagttggtgg tggcggcgtt 10801 ttccttgcag cggctggatc ctgccgtgtg gactctgtgc ggtgcccgca gggcggtgct 10861 ggcgctcgcc tatcgctctg ctctctcttt gtagacggcg ggcgctaaca ccaccgacaa 10921 ggagctagag gttctctcct tgcacaacgt cacctttgag gacgccgggg agtacacctg 10981 cctggcgggc aattctattg ggttttctca tcactctgcg tggctggtgg tgctgccagg 11041 taccggcttc tgctgctgct gctgctccgc actgtctggg ggacgctggc tcgggacacg 11101 ccaaagctgc caggacggac gggaatcctg tgacttacgg ccgtcccgct tcttgagccc 11161 tcactcctgg ccctgtgccc agtgtgggga caaagttggc ctggcccggt cctggtccca 11221 gaggggcccc ctcagccccc tcgagcccac ttcccatctg ggtccccaaa ggcctctcct 11281 gtggctctgg tgtctcccgg gcgcctggtg gcggtgtggg actggctggc tctgctgggc 11341 tccttctctc cagggtctgg ccctctagac tcactggcgt tactgactgc gagaccctcc 11401 agacaaggcg cgtgctgagg ttctgagccc ccttccgctc ccagtggtgc ctgcggctct 11461 gggccagggg catccatggg agccccgtgg gggggggggc caggccaggc ctcaacgccc 11521 atgtctttgc agccgaggag gagctggtgg aggctgacga ggcgggcagt gtgtatgcag 11581 gcatcctcag ctacggggtg ggcttcttcc tgttcatcct ggtggtggcg gctgtgacgc 11641 tctgccgcct gcgcagcccc cccaagaaag gcctgggctc ccccaccgtg cacaagatct 11701 cccgcttccc gctcaagcga caggtaacag aaagtagata ccaggttctg agctgcctgc 11761 ccgccaggcc tcctggagcc ccacctcggc ccacgctggt cctgggctgt gtgagccctc 11821 tctgcagcca ggcgggctcc cctctcctcg tctctgctca ccatgtagag cctagggtac 11881 tttggggcac gaaacattct aaaaatcttc attcaatgct ggtggaagtc agaacgcccc 11941 cccttctggc ccagcactga cccccggctg tacctccacg ccctgtcgcc cacgcggcgc 12001 caacctgccc ctgctgaccc aagcaggtgt ccctggagtc caacgcgtcc atgagctcca 12061 acacaccact ggtgcgcatc gcaaggctgt cctcagggga gggccccacg ctggccaatg 12121 tctccgagct cgagctgcct gccgacccca aatgggagct gtctcgggcc cggtcagtgg 12181 tgctgagggc cagcgttggc tgtagggggc ttggtggtgg gggtgaaaca gccaccagtc 12241 agaggcccgg ctgggtttag gggccgtcag ggatgtggcg gatgttgggt gtggctgggg 12301 ttctgtggac atgctcctgg gacgggtgta tggcagggac tgcccctctc aaggtgccct 12361 gtctggaggg gcagcaaggg cgggaggctg tgggtgacac tcttcgtcct tacgagcagg 12421 ctgtaggggg agcatggagg gcttcctgga ggtggtggct ctgggcctca agggctgggc 12481 caggctgggg tggggaccgt ggtgggctga gagtgggcga gtttgcacac tcatggtccc 12541 tctgcctcca ctgccaggct gaccctgggc aagccccttg gggagggctg cttcggccag 12601 gtggtcatgg cggaggccat cggcattgac aaggaccggg ccgccaagcc tgtcaccgta 12661 gccgtgaaga tgctgaaagg tgaggagggg gcggccaggg gtgcagagca gggctggggg 12721 cgccgccgcc gcctgacaca ggccccccgc tccgtgcaca gacgatgcca ctgacaagga 12781 cctgtcggac ctggtgtctg agatggagat gatgaagatg atcgggaaac acaaaaacat 12841 catcaacctg ctgggcgcct gcacgcaggg cggtaggtgc ggtagcggcg gtggtgccgg 12901 ctgggcggcc ctcctgggcc tggcagcccg tctgaggagc ccgtgtcccc agggcccctg 12961 tacgtgctgg tggagtacgc ggccaagggt aacctgcggg agtttctgcg ggcgcggcgg 13021 cccccgggcc tggactactc cttcgacacc tgcaagccgc ccgaggagca gctcaccttc 13081 aaggacctgg tgtcctgtgc ctaccaggtg gcccggggca tggagtactt ggcctcccag 13141 aaggtgggca gggcggcagg tgtgggtgga gtaggctggg ccctgccctg agatgctggg 13201 agcagcgggg agaggtggag aggcttcagc cctgcctccc accccttccc cagtgcatcc 13261 acagggacct ggctgcccgc aatgtgctgg tgaccgagga caacgtgatg aagatcgcag 13321 acttcgggct ggcccgggac gtgcacaacc tcgactacta caagaagaca accaacgtga 13381 gcccggccct ggggtgcggg ggtgggggtc atgccagtag gacgcctggc gccaacaccg 13441 ccttcccaca ccctcccagg gccggctgcc cgtgaagtgg atggcgcctg aggccttgtt 13501 tgaccgagtc tacactcacc agagtgacgt gtacgtgtcc tgcagagctc aggcttcagg 13561 ggtggaggcg ggaactgggc agagccagga ccccagctgc agtccccagg cctgtgccct 13621 ggagctcctg ggtgtggttt ctacccctcc ctgggggcag cagcgcagcc ctggcctatt 13681 cccctggtgc ccgcccaggt gtctgtcctg ggagtctcag gacagcctga cctcaccttc 13741 ccctgcagct ggtcctttgg ggtcctgctc tgggagatct tcacgctggg gggctccccg 13801 taccccggca tccctgtgga ggagctcttc aagctgctga aggagggcca ccgcatggac 13861 aagcccgcca actgcacaca cgacctgtga gtggcatccc tggccctcca ctgggtcctc 13921 aggggtgggg gtccctccgg ggctgggcgg gggagggact ggcagccctt caggctgttc 13981 ccgaataagg cgggaagcgg cggggctcac tcctgagcgc cctgcccgca ggtacatgat 14041 catgcgggag tgctggcatg ccgcgccctc ccagaggccc accttcaagc agctggtgga 14101 ggacctggac cgtgtcctta ccgtgacgtc caccgacgtg agtgctggct ctggcctggt 14161 gccacccgcc tatgcccctc cccctgccgt ccccggccat cctgcccccc agagtgctga 14221 ggtgtggggc gggccttctg gggcacagcc tgggcacaga ggtggctgtg cgaagagggg 14281 ctcggtggca cagcgctcac cccgcctccc gccagcagga gtacctggac ctgtcggcgc 14341 ctttcgagca gtactccccg ggtggccagg acacccccag ctccagctcc tcaggggacg 14401 actccgtgtt tgcccacgac ctgctgcccc cggccccacc cagcagtggg ggctcgcgga 14461 cgtgaagggc cactggtccc caacaatgtg aggggtccct agcagcccac cctgctgctg 14521 gtgcacagcc actccccggc atgagactca gtgcagatgg agagacagct acacagagct 14581 ttggtctgtg tgtgtgtgtg tgcgtgtgtg tgtgtgtgtg tgcacatccg cgtgtgcctg 14641 tgtgcgtgcg catcttgcct ccaggtgcag aggtaccctg ggtgtccccg ctgctgtgca 14701 acggtctcct gactggtgct gcagcaccga ggggcctttg ttctgggggg acccagtgca 14761 gaatgtaagt gggcccaccc ggtgggaccc ccgtggggca gggagctggg cccgacatgg 14821 ctccggcctc tgcctttgca ccacgggaca tcacagggtg ggcctcggcc cctcccacac 14881 ccaaagctga gcctgcaggg aagccccaca tgtccagcac cttgtgcctg gggtgttagt 14941 ggcaccgcct ccccacctcc aggctttccc acttcccacc ctgcccctca gagactgaaa 15001 ttacgggtac ctgaagatgg gagcctttac cttttatgca aaaggtttat tccggaaact 15061 agtgtacatt tctataaata gatgctgtgt atatggtata tatacatata tatatataac 15121 atatatggaa gaggaaaagg ctggtacaac ggaggcctgc gaccctgggg gcacaggagg 15181 caggcatggc cctgggcggg gcgtgggggg gcgtggaggg aggccccagg gggtctcacc 15241 catgcaagca gaggaccagg gctttttctg gcaccgcagt tttgttttaa aactggacct 15301 gtatatttgt aaagctattt atgggcccct ggcactcttg ttcccacacc ccaacacttc 15361 cagcatttag ctggccacat ggcggagagt tttaattttt aacttattga caaccgagaa 15421 ggtttatccc gccgatagag ggacggccaa gaatgtacgt ccagcctgcc ccggagctgg 15481 aggatcccct ccaagcctaa aaggttgtta atagttggag gtgattccag tgaagatatt 15541 ttatttcctt tgtccttttt caggagaatt agatttctat aggatttttc tttaggagat 15601 ttattttttg gacttcaaag caagctggta ttttcataca aattcttcta attgctgtgt 15661 gtcccaggca gggagacggt ttccagggag gggccggccc tgtgtgcagg ttccgatgtt 15721 attagatgtt acaagtttat atatatctat atatataatt tattgagttt ttacaagatg 15781 tatttgttgt agacttaaca cttcttacgc aatgcttcta gagttttata gcctggactg 15841 ctacctttca aagcttggag ggaagccgtg aattcagttg gttcgttctg tactgttact 15901 gggccctgag tctgggcagc tgtcccttgc ttgcctgcag ggccatggct cagggtggtc 15961 tcttcttggg gcccagtgca tggtggccag aggtgtcacc caaaccggca ggtgcgattt 16021 tgttaaccca gcgacgaact ttccgaaaaa taaagacacc tggttgctaa cctggccctg 16081 tgctttctgt ctccagttct gggatagggg agggaggggt cactttgcca ggtggtccca 16141 gttgcgcggg atggatgctg gcagcagcac cgaaagtcac tggtgggctg ggagccccaa 16201 gagcaaggaa tgtttatggg aggggcctgg cggaagggag cagggtgcct gggggtgcac 16261 tgccctggct gctcccagct tgtgggttcc tgaggtggtg gtggtggtgg ggagggtcct 16321 ttctcactag ctctgaggca gaccttctct catcacccca ctcctggcat ccgccttccc 16381 agtcagctgg ggagctttct gggcatccct ctatggagcc aaaagcaagc aaagccctca 16441 tggggccctg ggggctacac aggcggtcac tctcctccag atcagctctc tgccctccca 16501 ggccgggcaa ccagtgcccc cactgccttg ggctccatca gggtccccta cagtgataaa 16561 gcacctttgg gcagatgagg tgctgagaac ccagagatgg aaccaggccc ttgcccaagt 16621 tcatagccct agcagggtgg gaggacaaca tggtgagagc aagtctggga aggcttcctg 16681 gaggaggtgt gccgtctctc ctgactcccc accaccctct ttgctgtcct cccttctgct 16741 atcctccctc tcttgtcctc ccgtttttcc catctctgct gtccccacct ctgtcgtcct 16801 cctcctgctc tcctcccccc atcccctctg ctctccctac ctctgctgtc ccctctgccg 16861 tcctccctct gctctcctcc cctctgctgg ctcaagagca gggtttccca accatgagct 16921 gcatgaactc tagcattcta aaatgctctg gctacaaact cacctttcag gtcagggggt 16981 actgctggcc cgtttcctgg gcaggcaagg gtttaactca accccattca gggaagcacg 17041 tgtgggcgca ggcctggtgg aagtggcctt acaagggact ctgcatccct aatgccccca 17101 cttgcccaga aaccctatgc tgggccccag aggcaggcct ggccatggga cgcctggtga 17161 cagtggcagg atggggaggc ccacatgggc ctgaaggctg aggcctgcag ggcagtgggg 17221 ggaccaggcc aacaggcagg cagtgccagc atccacacca aggcaggcag agcatggggc 17281 tcgaagcgcg ggccgggagc gccccctagc gctggctggg cagtgtccct gctacaaacc 17341 caaggcccct ctcctgtcag ggctctggtg gacctctggt gggcacagtg ggatcctgaa 17401 tgggtgctgg ggaccaaagg gctgggccac cgggagaaca gtggcccatg aaggtgctgg 17461 tgggccagcc ccctcctcct cagcgtgctt ccttagcgac cccagatggc agggcacagt 17521 ccctgaagct gccccaccag gggctccctg gctgcctccc cctgtcccat aaggtgagcc 17581 catgagagac cccagctgtc agcacaactg aacctccgcc atcagggtgc cctctagtgg 17641 ttgggtgtgc tctaggctgg cagggtcccc gcccttgctg tctgctgatg gctgaggggg 17701 acatgtctca tgggaggccc agcttccagg acacaactgg tggctcctgg ggtcaccaag 17761 ggcacctggt ttgttcacag ctctttgggc tgctgtcccc atgagggagc acctcccacc 17821 ccagctgtgg gtccatcatt tcctctgatt aattagggcc taggggtcaa gggaggcccc 17881 gagggaggac tctcagtgtg aacaaaccag cagccagggc cgcagagaag cctgtgaggt 17941 gcccacaggg cctggtccca gtgtgggcag agcacctaag ggatggcttc tgtccactga 18001 gaagggtcg //