LOCUS FGF23 15399 bp DNA linear PRI 03-MAR-2004 DEFINITION Homo sapiens fibroblast growth factor 23 (FGF23) gene, complete cds. ACCESSION FGF23 VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 15399) AUTHORS Livingston,R.J., Rieder,M.J., Chung,M.-W., Ritchie,T.K., Olson,A.N., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Sherwood,A.M., Leithauser,B.J. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (03-MAR-2004) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..15399 /organism="Homo sapiens" /db_xref="taxon:9606" variation 72 /frequency="0.03" /replace="G" repeat_region 324..558 /rpt_family="MIR" /rpt_type=dispersed variation 520 /frequency="0.07" /replace="C" variation 616 /frequency="0.03" /replace="" variation 805 /frequency="0.03" /replace="T" variation 825 /frequency="0.01" /replace="A" repeat_region 841..982 /rpt_family="L2" /rpt_type=dispersed variation 1040 /frequency="0.01" /replace="C" variation 1205 /frequency="0.01" /replace="A" variation 1477 /frequency="0.01" /replace="C" variation 1601 /frequency="0.01" /replace="T" variation 1629 /frequency="0.17" /replace="G" gene 1970..13472 /gene="FGF23" mRNA join(1970..2326,9002..9105,10916..13472) /gene="FGF23" /product="FGF23" CDS join(2116..2326,9002..9105,10916..11356) /gene="FGF23" /codon_start=1 /product="fibroblast growth factor 23" /translation="MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYT ATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNI FGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSR RNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSP MASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI" variation 2999 /gene="FGF23" /frequency="0.18" /replace="T" variation 3056 /gene="FGF23" /frequency="0.01" /replace="A" variation 3267 /gene="FGF23" /frequency="0.10" /replace="G" variation 3285 /gene="FGF23" /frequency="0.03" /replace="A" variation 3317 /gene="FGF23" /frequency="0.02" /replace="A" misc_feature 3408..4634 /gene="FGF23" /note="Region not scanned for variation" repeat_region 3760..3825 /rpt_family="L2" /rpt_type=dispersed repeat_region 3969..4275 /rpt_family="Alu" /rpt_type=dispersed variation 4713 /gene="FGF23" /frequency="0.01" /replace="G" variation 4735 /gene="FGF23" /frequency="0.01" /replace="T" variation 4822 /gene="FGF23" /frequency="0.01" /replace="C" repeat_region 4880..5168 /rpt_family="Alu" /rpt_type=dispersed variation 4902 /gene="FGF23" /frequency="0.01" /replace="A" variation 4960 /gene="FGF23" /frequency="0.11" /replace="A" variation 5042 /gene="FGF23" /frequency="0.01" /replace="C" variation 5107 /gene="FGF23" /frequency="0.12" /replace="C" variation 5363 /gene="FGF23" /frequency="0.01" /replace="C" variation 5506 /gene="FGF23" /frequency="0.01" /replace="A" variation 5529 /gene="FGF23" /frequency="0.01" /replace="A" variation 5537 /gene="FGF23" /frequency="0.01" /replace="T" variation 5582 /gene="FGF23" /frequency="0.01" /replace="A" variation 5613 /gene="FGF23" /frequency="0.09" /replace="G" variation 5664 /gene="FGF23" /frequency="0.01" /replace="C" repeat_region 5887..6009 /rpt_family="MIR" /rpt_type=dispersed variation 5951 /gene="FGF23" /frequency="0.01" /replace="A" variation 6061 /gene="FGF23" /frequency="0.01" /replace="T" variation 6066 /gene="FGF23" /frequency="0.01" /replace="A" variation 6077 /gene="FGF23" /frequency="0.01" /replace="T" variation 6123 /gene="FGF23" /frequency="0.01" /replace="A" variation 6335 /gene="FGF23" /frequency="0.01" /replace="T" variation 6405 /gene="FGF23" /frequency="0.15" /replace="A" repeat_region 6487..6654 /rpt_family="MIR" /rpt_type=dispersed variation 6660 /gene="FGF23" /frequency="0.01" /replace="G" variation 6885 /gene="FGF23" /frequency="0.03" /replace="A" variation 6888 /gene="FGF23" /frequency="0.26" /replace="C" misc_feature 6930..7034 /gene="FGF23" /note="Region not scanned for variation" repeat_region 7030..7330 /rpt_family="Alu" /rpt_type=dispersed variation 7061 /gene="FGF23" /frequency="0.01" /replace="T" variation 7062 /gene="FGF23" /frequency="0.44" /replace="G" variation 7233 /gene="FGF23" /frequency="0.02" /replace="A" variation 7381 /gene="FGF23" /frequency="0.01" /replace="T" variation 7671 /gene="FGF23" /frequency="0.01" /replace="C" variation 7725 /gene="FGF23" /frequency="0.06" /replace="A" variation 7748 /gene="FGF23" /frequency="0.01" /replace="T" variation 7811 /gene="FGF23" /frequency="0.09" /replace="G" variation 7891 /gene="FGF23" /frequency="0.06" /replace="A" variation 7997 /gene="FGF23" /frequency="0.01" /replace="G" variation 8320 /gene="FGF23" /frequency="0.08" /replace="C" repeat_region 8350..8449 /rpt_family="L2" /rpt_type=dispersed variation 8763 /gene="FGF23" /frequency="0.01" /replace="T" variation 8898 /gene="FGF23" /frequency="0.04" /replace="G" variation 8965 /gene="FGF23" /frequency="0.91" /replace="" repeat_region 9279..9343 /rpt_family="MIR" /rpt_type=dispersed variation 9301 /gene="FGF23" /frequency="0.24" /replace="G" repeat_region 9360..9778 /rpt_family="L1" /rpt_type=dispersed variation 9461 /gene="FGF23" /frequency="0.01" /replace="C" variation 9494 /gene="FGF23" /frequency="0.18" /replace="G" variation 9721 /gene="FGF23" /frequency="0.24" /replace="G" variation 9821 /gene="FGF23" /frequency="0.16" /replace="T" repeat_region 9904..10011 /rpt_family="MIR" /rpt_type=dispersed repeat_region 10177..10262 /rpt_family="L2" /rpt_type=dispersed variation 10388 /gene="FGF23" /frequency="0.01" /replace="A" variation 10721 /gene="FGF23" /frequency="0.01" /replace="T" variation 11023 /gene="FGF23" /frequency="0.01" /replace="T" variation 11183 /gene="FGF23" /frequency="0.01" /replace="T" variation 11316 /gene="FGF23" /frequency="0.17" /replace="T" variation 11379 /gene="FGF23" /frequency="0.03" /replace="G" variation 11744 /gene="FGF23" /frequency="0.01" /replace="A" variation 11878 /gene="FGF23" /frequency="0.01" /replace="A" variation 12405 /gene="FGF23" /frequency="0.01" /replace="T" variation 12435 /gene="FGF23" /frequency="0.02" /replace="G" variation 12785 /gene="FGF23" /frequency="0.24" /replace="T" variation 12891 /gene="FGF23" /frequency="0.01" /replace="G" variation 13128 /gene="FGF23" /frequency="0.01" /replace="A" variation 13159 /gene="FGF23" /frequency="0.01" /replace="T" repeat_region 13496..13805 /rpt_family="Alu" /rpt_type=dispersed variation 13496 /frequency="0.01" /replace="C" variation 13576 /frequency="0.01" /replace="G" variation 13610 /frequency="0.01" /replace="T" variation 13657 /frequency="0.01" /replace="A" variation 14074 /frequency="0.01" /replace="T" variation 14093 /frequency="0.01" /replace="A" variation 14319 /frequency="0.01" /replace="T" variation 14372 /frequency="0.01" /replace="A" repeat_region 14541..15052 /rpt_family="L1" /rpt_type=dispersed variation 14648 /frequency="0.23" /replace="G" variation 14696 /frequency="0.01" /replace="C" variation 14919 /frequency="0.01" /replace="C" variation 14932 /frequency="0.34" /replace="G" variation 14982 /frequency="0.01" /replace="A" repeat_region 15054..15397 /rpt_family="L1" /rpt_type=dispersed BASE COUNT 4479 a 3407 c 3324 g 4189 t ORIGIN 1 agggcaaatg ttcctaagtg atttgcatct caattctgaa agctagctat ttcttcaatt 61 agctaagacg tagcattata tttataatcc attctgtggc tattagtaaa gaagactgtt 121 ttacatataa acatttcatg tcatacttct tccactcaac cctggggaga caagcaccat 181 gtgtcctaga gattcatcct gggtaaaagc ctgggttttt agagaataac agaggactgc 241 tttgccacct gcactttttt accaagctcc tggctctcat ggctttagct ctaacatgtt 301 gtatgggttt ggacaccttg aaaagtgctt aggaggtctt ggggccagac ctggattcaa 361 atccaacctc ttccacatgt tacctttcta tctctaggca agttacttaa actgtgtgca 421 tagatcagtt tcctgatcta tataaagaaa ataacagcat ctcctcaaag agttattctg 481 aagatgaaat gggttactac aagtaaagca cttagagcag taagtggaac agtaagctct 541 ccatgagcgt tagttcttgc tgtgattctt tggagaagca gcctagggaa ggagaagacc 601 ttgtcctggc tctaccattt atttgctttg tgcctttgga catggaaaca ctaagatttc 661 catttcttca tgtaaagtat taaaatcttg ataatgcatg gagtgcctat ctcacagagt 721 ggcagtgagg ttcaaataag ctaatagatg tgaaaatgct ttgtaaacta taaaaaaaaa 781 ctgtacaaat gtagggtaac aaatgccatc tctttctgtc tatacctgta agcttgcact 841 cattttgtat tatagttact tatttttatc tgcctcctgc attagatttg agctcctcaa 901 gataggaatc acatcttgct gtctcctata tcaacctgta catgagtcta gcttgatgcc 961 tgtacatggc atatactcag tacagggaaa ctggaagaat agcaaactcc ttgtgtgttt 1021 tttcgggtgt gtgttccagt agcttgctcc cctttagact gtatgtgcca ggactattcc 1081 acccgacatc aggtgtagct tcccagaggg ctcactgtga acagcatctg caggcaggca 1141 tccaacacca agctgagcac tcatgtacag acactaaatg tggggacacc ctgtcctgag 1201 gctcggatcc ccagtgctca gccagcagct gttccaatcc ccatgaggtc tctgaatgag 1261 tctccttact actggagaga ctactagttt agttgccctc gatagtccaa actagggaaa 1321 ttgagaaatt gaaccttggc atattcagtg aagtccagac taaggaagct gagaaactga 1381 accttggcat gttcactgac ctcaaggcct tacttctttt tcttccattt caaaatcttc 1441 ccaaaatggc aactttggct tttgtgcccc tgctcctagc tcccatcttt catgaagtgg 1501 gtgttcttag aggatgccat ctgcctgatg gtgtcatgta tctctatatc ctgcaagcta 1561 cccaccaaat cctgctcaca gattaagcac tggatacata cttgctgatt ggaatttaaa 1621 gaaaaccaaa ataagtaaac tcgacaggag attaattgcc taggagtcgg ttgactgctt 1681 gactgaagct ggattttttt tgggaaccgc tggctgcctt cacatttcct gatggaagtg 1741 ggacaggtca acagacagcc cagagtggca gataactttt gcccacacgt cattcatttt 1801 ttggagcgtt ggcttgaaat tgaggggtgt gtgtgtctgg aaccgacgtg ccttccgtgc 1861 gcctccgggg tctttgcact ttctttcaat gggctgatta caacacagag gatgtggaca 1921 gtggagtttt tcctgtttga tgtcacactg ctacccttta aaagtctgac ggcaaaaagg 1981 agggaatcca gtctaggatc ctcacaccag ctacttgcaa gggagaagga aaaggccagt 2041 aaggcctggg ccaggagagt cccgacagga gtgtcaggtt tcaatctcag caccagccac 2101 tcagagcagg gcacgatgtt gggggcccgc ctcaggctct gggtctgtgc cttgtgcagc 2161 gtctgcagca tgagcgtcct cagagcctat cccaatgcct ccccactgct cggctccagc 2221 tggggtggcc tgatccacct gtacacagcc acagccagga acagctacca cctgcagatc 2281 cacaagaatg gccatgtgga tggcgcaccc catcagacca tctacagtga gtagggcttc 2341 aggctgggaa gaaggggagc acccttgttg tccatctaca ggaggcttgg ggaggttggg 2401 gactagactg gagggctaat ccaaccctcc tagctttctg cccaggaacc acttattgtc 2461 tttgtgtgtg tgtgtgtttg tgtgtgtgtg tgtgtgcgtg tgtatttaaa acttagggga 2521 agattctgtc actctcctaa ttagcatttg ctggtttttc tcaatatgaa taatttttat 2581 ttcaactaaa acccttccca cagtaggagc catgttccct ttgccccgtc aaaagattga 2641 aaaaatgtac agaaagaaag gcaaggagtc taagagaaaa agaagccagg cagatcaaca 2701 gacactaagt ttcagctcat ggactttgga ctgggttaac tagggaggtt gtaaagattc 2761 ctgggtcata cccagattgt tatagataaa tctgggggct ctttccaact ctggccttat 2821 aaaaattctt ggaaaaatgt attaaagaca gactgtccat gtatgttgtc ttggtgagaa 2881 tggccaagta tacaacccat ccacccattc atttgtccat gcatccatcc atccatccat 2941 ccatccatcc atccatccat ccatccatcc atccaacagg tttaatgggt gtttcagaca 3001 cccaggtacc caggtaccca gtatgagttg gtgattcttc tctgtggaac tgaaaggtgt 3061 ccagtcagta gcaagtcaag ctagttagaa acttattggc aacatgagac aactggaatg 3121 tttttaaaga tcaggtttgt ggagaattgg atcacaatcc acaataatca atccattagc 3181 aatgattcaa atgagggtcc ctttgtgtgc acctatataa ggggtaatgt ggtgaaagca 3241 gggatagata ttgaaaaaga ctggatcttc tattttaaga aaacgtgaga aaacacctca 3301 aagcatacag aaaaatgcaa actgatccaa tatagctcaa attaaaggaa agaaaaatta 3361 gttagacaat ctctaactaa agaaaacata ggaattatga tttgcccttt attgttgtaa 3421 taaataaatt aattattttt gctgtgacct tgctgtgtgt gaggcattta ttcttctagg 3481 ctccaaaggt ccttaaacct ggttgcaaga tatacaacat gcaaaattaa gttgcaagat 3541 atataacatg cgaaattgac agtttaacct cttcaagtac taaatgcata ttgacaggag 3601 ataaaaggag agaggaaagt tctctccgaa taccaaacag gttccagaac tccagagaat 3661 atagtaagac tcaggagtca acatcttgga aaccaagttt gagtctcatg gcaaaaattt 3721 caattaaatc tggatacact tgatgcaccc gaagtgttgt tcattttatt caatggatat 3781 ttaataggat ctaccatgtg cctggcattc taccaagcgc tgtggctgaa aactaagaca 3841 caacccttca aggacctcat ggtctgtcgt cctaccttgt cagccagctc actaccagac 3901 tttcaggaaa tgcaattttg catgtctcat ggaggggaca cccttactct aattcaagac 3961 tatatgtggg ccaggtgtgg tggctcacgc ctgtaatccc agcactctgg gaggccgagg 4021 caggcagatc acgaggtcag gagattgaga ccatcctggc taacacagtg aaaccccatc 4081 tctactaaaa atacaaaaaa ttagccaggc gtggtggcag gcgcctgtag tcccagctac 4141 ttgggaggct gaggcaggag aatggcgtga acccgggagg cagagcttgc agtgagccga 4201 gattgcgcca ctgcactcca gcctgggtga cagagcgaga ctccatctca aaaaaaaaaa 4261 aaaaaaaaaa aaaaagacta tatgtgattt aaaatgcaga atagtagatt atggtaaatt 4321 attttgattc tcttagatgg aaagggctgc atccaactag agaatgttta tacaacttgt 4381 ctcgaatcct ggaatcccgt tgctgaaagg aactccttaa agacgtttct tcctgaacaa 4441 gaattagggt agaacagaac aggccggcta cggtggggag tgagtgtgaa gagtcaacct 4501 cctgggctgg cagtctgaac ttagaccttt tccttgaaag cccacctcgt atcaggcccc 4561 aagggatcac tgagtgctag ttagagtgaa ttaaaatgac tgagaagcag caaaataaat 4621 tgaactgact tcagattttt aaaaatagaa atgtgatttt gtttccttag acataggcac 4681 tagctaaaca ttgcatcttt aaagagttaa acatgaatgc ggggagggga acttcgggtc 4741 agggtagtgg gagggagatc tacttttcct agtctatgta gataactttt tgtactgttc 4801 aatgagttgt catgtgtatt atgggaaaaa aaaagtgcag gaaaaaatta cacactacaa 4861 ttaaaagtta cccaaaagag gccagatgcg gtggctcacg cgtataatct cagcactttg 4921 ggaggccgag gtgggaggat cacttgaagt caggggttcg agaccagtct ggccaacatg 4981 gggaaaccct gtctctacta aaaatacaaa aattagtggg gtgtggtgcc tgcctgtagt 5041 cacagctact tgggaggctg aggcagaaga atcgcttgta ccccagaggt ggagcttgca 5101 gtgagctgag atcgcaccac tgtgctccag cctgggtgac agagtgagac tccgtctcaa 5161 aaaaaaaacg ttacccaaaa gaaagaggaa agattaatgc atgtagataa gaagcacaac 5221 taattaaatg tctggtgaag gatttgtaat gacctcatca gtgactgtta agcaatgttt 5281 ttacactgat ggaaacctaa aatgtgaggg gtattttttc ccctcctaat tatccatttc 5341 tattgaattc tggtttatct tattactttg ctgtaagaaa ttcttaagag ttgagtgcac 5401 aacccatctt tgggtcactg gacttgacaa aatgaagtta tctcctgcct accagattct 5461 tcaagctccc ttaggactca caagcgctgc tgccaggtac ccctctggtg tccttatcac 5521 ccgttccatg aacaaggcca tcctctgact cccctttatc cttattatat ggaaacagca 5581 agagagagat gcttattgtc cctggtaata tcatttccta gatcctgcta ttttcacttc 5641 ctccatcttc cccataggaa ctatctttat tgaagctgaa ttaccgctga gctccttcag 5701 cctttttcat acgtttttct tttgaggtgc tcaaagcact tcactgctat catcttattt 5761 atcacttact ggccacaaga gtagaatgga gtagataatt ttctacttct ataagcagag 5821 gttgaagcaa agtggtaata gtaaaaatta ctagcactta ggaagtgctt tctaaaggat 5881 aaaaacatta tctcattatg tcttcaagat gaccaaatga ggtaaatgtt tctgctgtcc 5941 tcattttata tgtgaaaaaa caagagttaa agaacttaaa taactggctg aaggtcagac 6001 aggtagtaaa agacctagag gacaccttga ccccaaatcc caagctgttc caaggtcaca 6061 cgcacggaga cacctccgtc attgaaggca aagtccatta agcctgctca gctccaacag 6121 gcggggctgg ttgctccggc agtccatggt ttgttccttc cttctgcaaa attctccctt 6181 gaatctgtgc agactgcgaa aagatgcctt ttgaaagcac aaaggaaaga aactctgact 6241 ctctcacatt ttctaaactt tcacattggc tcacactgtt tgatggaaga gtctgtgtgc 6301 cctccgtagc agcttctcac agttcctcaa ccaccgccgg atgttttcta gggggactgg 6361 ctctggaaac caggagcgtg tgtgccatac acactgccca cactgacccc aagcatcaag 6421 ccagcacacc tgtcaaggca tgggcccggc ataaacagca ggtcagaaca cgccacgtga 6481 tgtcctctgt ttgctcgaca ctttcgagtc acttttacca ccattatccc cttcgatcat 6541 caccctatga agtaggcagg acagccattg ttctatttca cagctgagga aactgaggct 6601 agtgcaaggt cagcaagtgg cacaattggg accaaaatcc aagtcccctg gttcttggca 6661 cctggctcag tgccccttcc ccgagccctt agtgctgctg tgactccttg tcctcactgc 6721 ctgcagcatg tattttagca tttgatattg tcttctcaga ctcttagtga tttctgctgg 6781 aggcttgtta ccgggtggtg ggaagatgtc tctgacctga gtttcaatcc tgtcttagtt 6841 tccttatcac ttaaattagg atattgctgc tactactact actactaata ataataatca 6901 gtactaacaa tataaaattt gttttgagaa tttaaaatat gtaaagtgct tagagtgcaa 6961 ccgctcaaag accattacta aatgtaattt tttcccaatt agactgaaaa gtcaccagaa 7021 cagaaaccat ttcttttttt ttttttttga gacggagtct cactctgtcg cccaggctgg 7081 agtgcagtgg tgcaatctcg gcttactgct agctccgcct cccaggttca tgccattctc 7141 ctgcctcagc ctcccgagta gctgggacta caggtgccca ccaacacacc tggctaattt 7201 tttttgtatt ttagtagaga agaggtttca ccgtgttagc caggatggtc ttgatctcct 7261 gacctcatga tccacccgcc tcagcctccc agagtgctgg gattacaggc atgagccacc 7321 gcacccagtc gaaaccattt cttacacgtt ccttatattt ctccaaaggt ttaccacaaa 7381 actagccata catttgagac acataggcag acaccactgt ggaggaattt aagcatcctt 7441 tgcgcctgtc ataccccagt ccactttctg ggaagctttc ctcaaggttc ccctcagcca 7501 aactttgaaa caaattaact tctctctttg gccctcttcc tttctcacct ttctggggct 7561 tgtctccacc ctcattccct ctgttccgcg tcagtccaat ttcagtccct atcatgattt 7621 ctactcagct agtacctaat tattgctgct tattttcctc aaaggtcctt gtattgagcc 7681 tgcatgggat aggagaagag ctttggcctt taaatcaccc ccacgaggct ccatcacttg 7741 ctaggcacaa acattgggca tttacaacct ctccaagcta cagttgcaga agaggaatta 7801 gaatccctgc atgggattct agctgcctcc ctggaggcta tgaggtcaga tgagatgcac 7861 ctagaaattc tgtgataggc aactggaagt ggccccaaag acctaaagta atgattttta 7921 acagaaaatg tcaggtaatt aaataacatg tggggaagaa atctcgctga attatcacgc 7981 atgttacacc agtatatgat ctaattgtgc ctttgccaca aaacagtaat ttaaagccat 8041 tatcaattac ttaagaggta ggtcgtgtga atgggtttca ggcccttgtc ggagactagt 8101 ttttgagagg ggacactgaa agtccatgag gggctgcacc tggagaggtc accaccaagt 8161 gagaaaatga caaagaacca acccaagaag agccaagaag aaaattccat ccgtcactta 8221 tattgattca acataaacag ttataccctc tgctcctaag cagctcactc taaggaacgc 8281 actggatagg taaactcagc taaagcaagt taaatggaat acatgctgta atagaggtga 8341 aggcattgtc ctgaggagct gagaaggaag aacaactgat tttgaatgga aagatgagga 8401 aagtcttcat agagatggtg acgcctgagc ctggtcttga agagtgagtg acttcaataa 8461 gtagagaagg aagagggaga tcaactctac taccattctg tacacatact gggtgttgac 8521 tgatgtatta gacaattaca cagacatcca ggaggagaat cagactctat ggcaagctgg 8581 atccttgaaa gacatctcag catagattta aaaatcacaa agtagaaggc atggaagaat 8641 gtgactatca ccacaaacat tcaaaggtat tagtaaggca aaagggaaaa taaagacggt 8701 ccaggtagag agagagaaac atgtgttcag cacaggtaga agaattccag gagctcagag 8761 tgccccatac aggcaacaag atgaagcagg aggtgaatga ctgtatgtgt gttgggggca 8821 agagaggatg tcagaagaaa cgctgaatat gcagaaatga ggctgaattt aagagtgctg 8881 aagttatcac cacccttaaa atcaatccag ggaggtttca tgaaggtagg ttttcaggag 8941 gtgcttgaag gtgggaattg gatgcgcaat gagtctttgc cctgcctgtt tttctccata 9001 ggtgccctga tgatcagatc agaggatgct ggctttgtgg tgattacagg tgtgatgagc 9061 agaagatacc tctgcatgga tttcagaggc aacatttttg gatcagtgag tttctttttt 9121 gtgttggtca ccatttgcaa acaattaacc taatttcttt gacacgacat agacttttct 9181 agcttaacaa ttccatttgc agtgtaccct ggtgacctgt ttccactgat acttcatgca 9241 gtctaagtat gaattaaacg tgaatgctca cgtttaatag ctggggtttg aactcaggca 9301 atctggctcc agatcccagg ctctcagccc ctagtctgca ctgcccattg gaacccactt 9361 ttttttttta ttattatact ttaagtttta gggtacatgt gcacattgtg caggttagtt 9421 acatacgtat acatgtgcca tgctggtgtg ctgcacccac taactcatca tctagcatta 9481 ggtatatctc ccaatgctat ccctcccccc tccccccacc ccacaacagt ccccagagtg 9541 tgatgttccc cttcctgtgt ccatgtgatc tcattgttca attcccacct acgagtgaga 9601 atatgcggtg tttggttttt tgttcttgcg atagtttact gagaatgatg gtttccaatt 9661 tcatccatgt ccctacaaag gacatgaact catcattttt tatggctgca tagtattcca 9721 tggtgtatat gtgccacatt ttcttaatcc agtctatcat tgttggacat ttgggttgtg 9781 gaacccactt ttgaatctag cacaggccct ggtatgtagt cgtaggtcct caagtcatgt 9841 caattcacgt tgtaaagtac attagaaagg gtgaaaagcc attggtgtct tcttgattct 9901 gggactagct gtgactttgg gtaaatctcc tcacttctcc aaacttcagc attttcactt 9961 ggaaaaagcg aagtggaata gaccacgtga cctgtggagc tccctccagt taaagatttt 10021 taattaataa cccctgcccc aattgtgata gctattcatt cggattggta agcaaaggat 10081 ttcccaaact aaaggctgct ggcctctttt ggaggatttt gagatagtaa aatagtagga 10141 ctgcttatct caggagtctc tgaccaccac acatgcccac tagaaactcc acaagaacag 10201 agactttctg ttttgctttc tgctgcatcc cagcccctac aatagtgtct ggctagagta 10261 ggtaaacaaa caaacaaaaa atctgttgaa ccactattga aatatagata actaactaaa 10321 catccgttaa cccctctagg catgtagata gtcctgatct gtaaactgct tactttgtgg 10381 agcttgagga ttaaaagaaa taacaggcaa aggccttcgt ggggcactca gtaaaaccca 10441 gtactagtgg tagaggattc aaacccagct catctgtcag caaagttcat gtctccaatc 10501 ccgtcagtgc tctcattcat gtttgaccct ataaactcca tcccctctcc tttctccagt 10561 aaagagacaa acccaagcca attttcagcc agcagaggct tggaaaagat agagggcagg 10621 aaggacaagg tggtgcctac tccaggaaaa ccacaggcca ggccagcccg ggcctccagg 10681 cagtaagcgg aggccccagt agtcgtagtc tctgaaaggg cgaactatat agtcagggct 10741 tgagcattaa tcaaaaccac tctaccccag cagggaacaa aggggtgaag gctcaacgcc 10801 ctaagaactg cagagcttca ggccggctgg cacaagcatg tggccccagg aggagctggg 10861 gagtgggtgg ggcccccact gccagccttc acgtggttcg ctcttgtcct tccagcacta 10921 tttcgacccg gagaactgca ggttccaaca ccagacgctg gaaaacgggt acgacgtcta 10981 ccactctcct cagtatcact tcctggtcag tctgggccgg gcgaagagag ccttcctgcc 11041 aggcatgaac ccacccccgt actcccagtt cctgtcccgg aggaacgaga tccccctaat 11101 tcacttcaac acccccatac cacggcggca cacccggagc gccgaggacg actcggagcg 11161 ggaccccctg aacgtgctga agccccgggc ccggatgacc ccggccccgg cctcctgttc 11221 acaggagctc ccgagcgccg aggacaacag cccgatggcc agtgacccat taggggtggt 11281 caggggcggt cgagtgaaca cgcacgctgg gggaacgggc ccggaaggct gccgcccctt 11341 cgccaagttc atctagggtc gctggaaggg caccctcttt aacccatccc tcagcaaacg 11401 cagctcttcc caaggaccag gtcccttgac gttccgagga tgggaaaggt gacaggggca 11461 tgtatggaat ttgctgcttc tctggggtcc cttccacagg aggtcctgtg agaaccaacc 11521 tttgaggccc aagtcatggg gtttcaccgc cttcctcact ccatatagaa cacctttccc 11581 aataggaaac cccaacaggt aaactagaaa tttccccttc atgaaggtag agagaagggg 11641 tctctcccaa catatttctc ttccttgtgc ctctcctctt tatcactttt aagcataaaa 11701 aaaaaaaaaa aaaaaaaaaa aaaaaaaagc agtgggttcc tgagctcaag actttgaagg 11761 tgtagggaag aggaaatcgg agatcccaga agcttctcca ctgccctatg catttatgtt 11821 agatgccccg atcccactgg catttgagtg tgcaaacctt gacattaaca gctgaatggg 11881 gcaagttgat gaaaacacta ctttcaagcc ttcgttcttc cttgagcatc tctggggaag 11941 agctgtcaaa agactggtgg taggctggtg aaaacttgac agctagactt gatgcttgct 12001 gaaatgaggc aggaatcata atagaaaact cagcctccct acagggtgag caccttctgt 12061 ctcgctgtct ccctctgtgc agccacagcc agagggccca gaatggcccc actctgttcc 12121 caagcagttc atgatacagc ctcacctttt ggccccatct ctggtttttg aaaatttggt 12181 ctaaggaata aatagctttt acactggctc acgaaaatct gccctgctag aatttgcttt 12241 tcaaaatgga aataaattcc aactctccta agaggcattt aattaaggct ctacttccag 12301 gttgagtagg aatccattct gaacaaacta caaaaatgtg actgggaagg gggctttgag 12361 agactgggac tgctctgggt taggttttct gtggactgaa aaatcgtgtc cttttctcta 12421 aatgaagtgg catcaaggac tcagggggaa agaaatcagg ggacatgtta tagaagttat 12481 gaaaagacaa ccacatggtc aggctcttgt ctgtggtctc tagggctctg cagcagcagt 12541 ggctcttcga ttagttaaaa ctctcctagg ctgacacatc tgggtctcaa tccccttgga 12601 aattcttggt gcattaaatg aagccttacc ccattactgc ggttcttcct gtaagggggc 12661 tccattttcc tccctctctt taaatgacca cctaaaggac agtatattaa caagcaaagt 12721 cgattcaaca acagcttctt cccagtcact tttttttttc tcactgccat cacatactaa 12781 ccttatactt tgatctattc tttttggtta tgagagaaat gttgggcaac tgtttttacc 12841 tgatggtttt aagctgaact tgaaggactg gttcctattc tgaaacagta aaactatgta 12901 taatagtata tagccatgca tggcaaatat tttaatattt ctgttttcat ttcctgttgg 12961 aaatattatc ctgcataata gctattggag gctcctcagt gaaagatccc aaaaggattt 13021 tggtggaaaa ctagttgtaa tctcacaaac tcaacactac catcaggggt tttctttatg 13081 gcaaagccaa aatagctcct acaatttctt atatccctcg tcatgtggca gtatttattt 13141 atttatttgg aagtttgcct atccttctat atttatagat atttataaaa atgtaacccc 13201 tttttccttt cttctgttta aaataaaaat aaaatttatc tcagcttctg ttagcttatc 13261 ctctttgtag tactacttaa aagcatgtcg gaatataaga ataaaaagga ttatgggagg 13321 ggaacattag ggaaatccag agaaggcaaa attgaaaaaa agattttaga attttaaaat 13381 tttcaaagat ttcttccatt cataaggaga ctcaatgatt ttaattgatc tagacagaat 13441 tatttaagtt ttatcaatat tggatttctg gtcattctaa ccctaaagtg ttttctttct 13501 ttctttcttt cttttttttt tttttaagat ggagtcttgc tctgtcaccc aggctggagt 13561 gcagtggcgc gatctcggct cactgcaacc tctgcctccc aggttcaagc gattctcctg 13621 cctcagcctt ccaagtagct gggattacag gcacctgcca ctgcgcctgg ctaatttttg 13681 taattttagt agagacaggg tttcaccatc ttggccaggc tggtctcgaa ctcctgacct 13741 cgtgatccac ccacctcaga ctcccaaagt gctgggatta caggcatgag ccaccgcacc 13801 cagccgtgtt ttctttaaag agggaatttt tatttggaaa atacacacca tcacaaccac 13861 gtcagtatct cagtaaacca aatgctatgc actaaacaca tacacagtgt taccgtcccg 13921 tgagatttga tagcaggaca ccaagataat gaatctacat tctgagactg gtgttcccag 13981 agttccttct ttcagaagga actatgaaaa ggagagactt tacatatggg catgagcatt 14041 cactacaggt ccttcgccaa agactgggta gcacatgcac gaggtaagat acggtgagtc 14101 ctacaaaggt cacctgctac agcagcagga gatagatagt gagtgatacc agatgctatg 14161 caatgttgaa acacgttaga aattcaacca cacctgggtg aagagacctt actgagtgcc 14221 tcagaactca aaaggctgtt cttataagac taagccccag aggcaggggg tatatcctaa 14281 aactaaattc aaaactgaaa cagacttgct ctaagtgaga attataccaa tcctggcaaa 14341 ctacaaggat ctaccaataa tgtaactgac cgccagaaga gaacttaaca ccttttaaag 14401 gaagaggaca tgattcagac ttaatacatg gtatcctaca caatcagtaa tagtaaaata 14461 actggacatg agaagaaata ggaaaaaaac atgtgcacaa tcaagagaaa atgcagtcac 14521 tagaaactag taaggtgatc taaagataga gctaatataa attatcttat ctgagtaaca 14581 gagaagaaat aagttttttg aaaatgagta gaacctcaat gatctgtgag accttattaa 14641 gctgtccaac atatgagtaa gttgagtccc agaaggaaag gagcacaaag aactggggag 14701 taaaaaatat ttgaagatat ggtggctgaa aatttcccaa ttattggtta aaaataagtg 14761 tactaataca agaagctcag aaaactccaa gcaagacaaa tgcaaagatc acagttatgt 14821 atattgcagt caaactgtta aaaatcaaaa atcaacagaa aatctgaaag ctactgtaga 14881 caaatgacac tttatatata gaggaacagc tataatagta gtggatttct tctcataacc 14941 atggaaacta gaagacaatg gaatgatgta ttgaaaaggt tgaaagaaaa taaaaagcta 15001 cctacccaga attacacata cagcaaaaat gtccttcaaa attaagatgg aataaaaatg 15061 gagagaaatt attgccatgc tgaaaaggag taacaccaga tggacattta gaattacaga 15121 aagaaaacca tcattaaatg tgtgaataca tttaaactat atatattgta taccttcttc 15181 cctgatttca ctaacaggct gcttaaggca aaaattataa cactgtatgc aggttttgta 15241 acatatatag atgtaatata taaggcaaaa ctcccacata ggatgggagg gataaatgaa 15301 acaatatggt tacaagatga taacactgta tgtaaaaatc ttacaatatt aactctagac 15361 tgtgataaat taaggatgca tattgtaatc cccaaagtg //