LOCUS DQ847413 5324 bp DNA linear PRI 23-SEP-2006 DEFINITION Homo sapiens fibroblast growth factor 21 (FGF21) gene, complete cds. ACCESSION DQ847413 VERSION DQ847413.1 GI:114731553 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5324) AUTHORS Livingston,R.J., Rieder,M.J., Shaffer,T., Bertucci,C., Baier,C.N., Rajkumar,N., Willa,H.T., Stanaway,I.B., Nguyen,C.P., Gildersleeve,H., Johnson,E.J., Swanson,J.E., McFarland,I., Park,C. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (12-JUL-2006) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..5324 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" misc_feature 1..496 /note="Region not scanned for variation" repeat_region 13..481 /rpt_family="ERVK" /rpt_type=dispersed repeat_region 560..1028 /rpt_type=tandem /satellite="satellite" variation 671 /frequency="0.03" /replace="c" variation 691 /frequency="0.03" /replace="g" variation 884 /frequency="0.44" /replace="a" variation 900..950 /frequency="0.44" /replace="" variation 1051 /frequency="0.01" /replace="c" variation 1213 /frequency="0.01" /replace="t" repeat_region 1497..1645 /rpt_type=tandem /satellite="satellite" variation 1590 /frequency="0.01" /replace="c" variation 1812 /frequency="0.03" /replace="g" gene 1835..4074 /gene="FGF21" mRNA join(1835..2219,2674..2777,3679..4074) /gene="FGF21" /product="fibroblast growth factor 21" variation 1855 /gene="FGF21" /frequency="0.01" /replace="t" variation 1863 /gene="FGF21" /frequency="0.01" /replace="a" variation 1866 /gene="FGF21" /frequency="0.02" /replace="t" CDS join(1985..2219,2674..2777,3679..3969) /gene="FGF21" /codon_start=1 /product="fibroblast growth factor 21" /protein_id="ABI75345.1" /db_xref="GI:114731554" /translation="MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQV RQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFL CQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRG PARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS" variation 1996 /gene="FGF21" /frequency="0.01" /replace="t" variation 2020 /gene="FGF21" /frequency="0.25" /replace="a" repeat_region 2237..2572 /rpt_type=tandem /satellite="satellite" misc_feature 2329..2635 /gene="FGF21" /note="Region not scanned for variation" variation 2887 /gene="FGF21" /frequency="0.01" /replace="g" repeat_region 2942..3032 /rpt_family="MIR" /rpt_type=dispersed variation 3016 /gene="FGF21" /frequency="0.01" /replace="t" variation 3119 /gene="FGF21" /frequency="0.06" /replace="a" variation 3124 /gene="FGF21" /frequency="0.07" /replace="a" misc_feature 3156..3422 /gene="FGF21" /note="Region not scanned for variation" repeat_region 3303..3626 /rpt_type=tandem /satellite="satellite" variation 3530 /gene="FGF21" /frequency="0.29" /replace="g" variation 3610 /gene="FGF21" /frequency="0.02" /replace="a" variation 3759 /gene="FGF21" /frequency="0.06" /replace="t" variation 3760 /gene="FGF21" /frequency="0.01" /replace="a" variation 3855 /gene="FGF21" /frequency="0.01" /replace="g" variation 3860 /gene="FGF21" /frequency="0.18" /replace="t" variation 3960 /gene="FGF21" /frequency="0.06" /replace="t" variation 4105 /frequency="0.05" /replace="a" variation 4130 /frequency="0.27" /replace="t" variation 4146 /frequency="0.37" /replace="c" variation 4175 /frequency="0.22" /replace="t" variation 4193 /frequency="0.17" /replace="t" variation 4194 /frequency="0.01" /replace="c" repeat_region 4204..4512 /rpt_family="Alu" /rpt_type=dispersed variation 4207 /frequency="0.01" /replace="c" variation 4254 /frequency="0.28" /replace="g" variation 4273 /frequency="0.01" /replace="c" misc_feature 4559..4915 /note="Region not scanned for variation" repeat_region 4588..4916 /rpt_family="Alu" /rpt_type=dispersed variation 4992 /frequency="0.35" /replace="g" ORIGIN 1 cacagcacag caggatgact gcgggcaggc ctagataata cccagcctcc cacaagaagc 61 tggtggagca gagtgttccc tgactcctcc aagaaaagga gattcccttt cgtggtctgc 121 tgagtaacgg gtgccttccc agacactggc gttcccgctt gaccaaggag ccctcaagag 181 gcccttatgc cggtgtgaca gaaggctcac ctcttgcctt ctaggtcact tctcacaatg 241 tcccttcagt acctgaccct atacccaccg gttgtttcct ggttatatta gttatacaac 301 aaagaataaa agtaatagct aatgattaat aatgtttaca ctaatgattg atactgtcca 361 tgatcatctc tatatctaat ttgtatgata actattctta ttctaactat tttctttatt 421 atactgaaac agtttgtgcc ttcagtctct tgcctcggca cctgggtaat ccttccccac 481 agactgaccc tcccattcaa gatacatcaa tgtcaaagac tcaggagttt gacttgattc 541 ccagaagttt aaccatcatc tccccaggct cgggactccc agcacccaga cccttctgct 601 cacacccagc agtccaggcc cccagaccct cctccctcag acttaggagt ccaggctccc 661 ggcccctcct tcctcagacc caggagtcca agccccctgc ccctccttcc tcagacccag 721 gagtccagga ccccagcccc tccttcctca cacccacgag tccagatccc tagcccctac 781 tccctcagac ccaggagtcc agaccaaagc tccctcctcc ctcagaccca ggagcccaag 841 ttccccagcc cctcctccct cagatccagg agtacaggcc cagcccctcc tccctcagac 901 ccctcctccc tcagatccag gagtacaggc ccagaccctc ctccctcaga cccaggagtc 961 caggcccccc acccctcctc cctcagaccc aggagtccag agccccagcc ctcctccctc 1021 agacacagaa ggcctaccct tgcaccctta ggggctccag gaaattagcc aacctgtctt 1081 ccctctgggt gcccactcca gggcctggct tggctgccaa ctccagtcag ggactttcag 1141 ccacccctcc ccccaggtta tttcaggagc acctgcctgg gcctgggatg gcttctctgg 1201 tgaaagaaac accaggattg catcagggag gaggaggctg ggatgtccag ggtctgagca 1261 tctgagcagg gacagatgag gttgaggttg gcccacggcc aggtgagagg cttccaaggc 1321 aggatacttg tgtctcagat gcggtcgctt ctttcataca gcaattgccg ccttgctgag 1381 gatcaaggaa cctcagtgtc agatcacgcc ctccccccaa acttagaaat tcagatgggg 1441 cgcagaaatt tctcttgttc tgcgtgatct gcatagatgg tccaagaggt ggtttttcca 1501 ggagcccagc acccctcctc cctccgactc aggtgcttga gaccccagat ccttctctct 1561 gagactcagg aatgtgggcc cccagcccct ttcacctggg tcccagctaa cccgatcctc 1621 ccctccctca tcccctagac ccaggagtct ggccctccat tgaaaggacc ccaggttaca 1681 tcatccattc aggctgccct tgccacgatg gaattctgta gctcctgcca aatgggtcaa 1741 atatcatggt tcaggcgcag ggagggtgat tgggcgggcc tgtctgggta taaattctgg 1801 agcttctgca tctatcccaa aaaacaaggg tgttctgtca gctgaggatc cagccgaaag 1861 aggagccagg cactcaggcc acctgagtct actcacctgg acaactggaa tctggcacca 1921 attctaaacc actcagcttc tccgagctca caccccggag atcacctgag gacccgagcc 1981 attgatggac tcggacgaga ccgggttcga gcactcaggg ctgtgggttt ctgtgctggc 2041 tggtcttctg ctgggagcct gccaggcaca ccccatccct gactccagtc ctctcctgca 2101 attcgggggc caagtccggc agcggtacct ctacacagat gatgcccagc agacagaagc 2161 ccacctggag atcagggagg atgggacggt ggggggcgct gctgaccaga gccccgaaag 2221 tgagtgtggg ccagagcctg ggtctgaggg aggaggggct gtgggtctgg attcctgggt 2281 ctgagggagg aggggctggg ggccttggcc cctgggtctg agggaggagg ggctggggat 2341 ctggactcct gggtctgagg gaggaggggc tggggatctg ggcccctggg tctgagggag 2401 gaggggctgg gtctggaccc ctgggtctga gggaggaggg gctgggggtc tggactcttg 2461 ggtttgaaga aggaagggct ggggtcctgg actcttgggt ctgagttggg agggggcttt 2521 ggcttgggct tctcctgggt ctgagggagg aggtaggctg tgggcttgga ctcccagggc 2581 tgggacagag ccggatggtg ggacagagtc gggtggtggg acagtcccgg gtgggagagg 2641 tcctcgaacc accttatcgc tttcacccct taggtctcct gcagctgaaa gccttgaagc 2701 cgggagttat tcaaatcttg ggagtcaaga catccaggtt cctgtgccag cggccagatg 2761 gggccctgta tggatcggtg agtttccagg accctcctca ccacccacca tgctcctcct 2821 atatgtcgcc ctcacagcct ggggtgcctt gtcttgctca tcccccccgg agccagactt 2881 gattctattt gctctgcacg cccccagctg caacatttgg aggttgaagt tgtcatcagt 2941 gtttgcaaga tgaggaaact gaggcccagg ccggggcgcc agtgacctca atcatgtgat 3001 gtgtggatgc tggagcggcc tgaggctcag gttattggga gtctcgtgat tcagtaaccc 3061 ctgctcctgc ccacacggcc cctgtgtgca cggctcatgc tgggcacagg gacactcggg 3121 gaagccatgg ccagtaaagt gaccaggacc ttgagtgcta gggagacacc ccgcctggcc 3181 tgagagagca ctgatggctc cgagggctgg aatgttctct gtgaagtctg aactgggagg 3241 caggtccctg caggagagcc ctggggtaaa aaacaaaacc tgccttgctg ttttgtttcc 3301 tagaggaggg gctgggggcc tggactcctg ggtctgaggg aggaggggct gggggcctgg 3361 acccctgggt ctgagggagg aggggctggg ggcctggaac cccgggtctg agggaggaga 3421 ggctggggcc tggaaccccg ggtctgaggg aggagaggct ggggcctgga accccgggtc 3481 tgagggagga ggcgctgggg gcctggactc ctgggtcgga tggaggagaa actagggtct 3541 ggacccctgg gtctgaggga ggaggcgctg ggggcctgga cccctgggtc tgagggaggc 3601 agggctgggg cctggatcct gggtcttaca tcaggaaaac agaggaaccc tgtctctgat 3661 cctgtttttg tcccctagct ccactttgac cctgaggcct gcagcttccg ggagctgctt 3721 cttgaggacg gatacaatgt ttaccagtcc gaagcccacg gcctcccgct gcacctgcca 3781 gggaacaagt ccccacaccg ggaccctgca ccccgaggac cagctcgctt cctgccacta 3841 ccaggcctgc cccccgcacc cccggagcca cccggaatcc tggcccccca gccccccgat 3901 gtgggctcct cggaccctct gagcatggtg ggaccttccc agggccgaag ccccagctac 3961 gcttcctgaa gccagaggct gtttactatg acatctcctc tttatttatt aggttattta 4021 tcttatttat ttttttattt ttcttacttg agataataaa gagttccaga ggaggataag 4081 aatgagcatg tgtgagtgtc tgagggaaga catggcagct gttttgtctc ccttggcccg 4141 gacaatcccc tctacacctc ccctcacgtg gtccgagggt cctggcttcc cactgggcct 4201 cacttttttc ttttcttttc tttttttttt tttgagacgg agtctcgctc tgtcacccag 4261 gctggagtgc agtggcgcga tcttggctca ctccaacctc cgcctcccag gttcaagcaa 4321 ttctcctgcc tcagccaccc gagtagctgt gattacaggc gtgcgccacc acacccagct 4381 aattttgtaa ttttagtaga gacagggttt cgccatgttg gccaggatgc tctccatctc 4441 ttgacttcat gacctgcctg ccttggcctc ccaaagtgct gggattacag gcttgagtca 4501 ctgtgcccag cccagcctca cttttctact ctgctaaagt gtccccaggg actgtggact 4561 atccctgctc tctgaaagga caagactggc cgggagtggt ggcttacgcc tgtaatccca 4621 gcactttggg aggccgaggc aggtggatca cgaggtcagg agattgagac tatcctggct 4681 aatacgatga aaccccgtct ctactaaaaa tacaaaaaca aaattagctg ggcgtggtgg 4741 cgggcgcctg tagtcccagc tactccggag gctgaggcag aatggcgtga atgcgggagg 4801 cggagcttgc agtgagccga gatcgcgcca ctgcactcca gcccaggcca cagagcgaga 4861 ttccatctca aaaaaataaa taaataaata aataaataaa taaatataaa aataaaatga 4921 aagagcagga cttctttcta caacccctca acttgtgtga gcgttgtgta actatttcat 4981 agagctacct caataacagg ggagctttta cgaggtgaca cagcacactc acatcctcat 5041 gggagatgta gttttctggc atcatttagc agcaggaatg agatctgttg ggcctcaaat 5101 ctgggacaag gactcctggg tcctggagta ggtttggggc tagtgtaaca cccaagttct 5161 ggggaatcag tgggctggac atctggacac ctggatcaca ggagaactgg ggactgcaga 5221 cttaggcatc ctggtctgag aaaaaagggg ctggagggtg ggagtttggg ttctcaggaa 5281 aaggagctga aacctggaat tcttccatct gggtccttat gaac //