LOCUS CES3 17790 bp DNA PRI 26-MAR-2008 DEFINITION Homo sapiens CES3 carboxylesterase 3 (brain) (CES3) gene, complete cds. ACCESSION CES3 VERSION tmp KEYWORDS . SOURCE human. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 17790) AUTHORS Livingston,R.J., Rieder,M.J., Shaffer,T., Bertucci,C., Baier,C.N., Rajkumar,N., Willa,H.T.., Stanaway,I.B., Nguyen,C.P., Gildersleeve,H., Johnson,E.J., Swanson,J.E., McFarland,I., Park,C. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (26-MAR-2008) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..17790 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" repeat_region 29..186 /rpt_family="MER1_type" /rpt_type=dispersed variation 59 /frequency="0.0130" /replace="C" repeat_region 194..362 /rpt_family="L2" /rpt_type=dispersed repeat_region 357..455 /rpt_family="L2" /rpt_type=dispersed variation 424 /frequency="0.0053" /replace="T" repeat_region 545..680 /rpt_family="Alu" /rpt_type=dispersed variation 960 /frequency="0.0053" /replace="T" variation 994 /frequency="0.1263" /replace="T" variation 1075..1078 /frequency="0.0158" /replace="" variation 1096..1099 /frequency="0.0054" /replace="" repeat_region 1198..1501 /rpt_family="Alu" /rpt_type=dispersed variation 1440 /frequency="0.0054" /replace="A" variation 1451 /frequency="0.0054" /replace="T" repeat_region 1551..1599 /rpt_family="MIR" /rpt_type=dispersed variation 1575 /frequency="0.0132" /replace="A" repeat_region 1607..1656 /rpt_family="MaLR" /rpt_type=dispersed variation 1730 /frequency="0.0183" /replace="T" variation 1884 /frequency="0.0185" /replace="T" mRNA join(1945..2099,3889..4093,4201..4339,4512..4645, 5067..5220,5333..5437,6954..7055,7435..7575,10389..10469, 11882..12029,13066..13215,13378..13456,13564..15859) /gene="CES3" /product="ces3" variation 2007 /gene="CES3" /frequency="0.0067" /replace="C" CDS join(2018..2099,3889..4093,4201..4339,4512..4645, 5067..5220,5333..5437,6954..7055,7435..7575,10389..10469, 11882..12029,13066..13215,13378..13456,13564..13759) /gene="CES3" /codon_start=1 /product="CES3 carboxylesterase 3 (brain)" /translation="MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVR GRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVE SMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSY DGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGG DLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIA NTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPF HSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVI DEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAK IKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGD PNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRK AQEDL" variation 2140 /gene="CES3" /frequency="0.0067" /replace="A" repeat_region 2261..2573 /rpt_family="Alu" /rpt_type=dispersed variation 2334 /gene="CES3" /frequency="0.0067" /replace="T" variation 2434 /gene="CES3" /frequency="0.0067" /replace="T" variation 2564 /gene="CES3" /frequency="0.0067" /replace="A" repeat_region 2602..3075 /rpt_family="ERVL" /rpt_type=dispersed variation 2963 /gene="CES3" /frequency="0.0495" /replace="A" repeat_region 3076..3186 /rpt_family="MaLR" /rpt_type=dispersed variation 3105 /gene="CES3" /frequency="0.0109" /replace="T" repeat_region 3187..3318 /rpt_family="Alu" /rpt_type=dispersed repeat_region 3325..3632 /rpt_family="Alu" /rpt_type=dispersed variation 3740 /gene="CES3" /frequency="0.0063" /replace="C" variation 4249 /gene="CES3" /frequency="0.0054" /replace="T" variation 4298 /gene="CES3" /frequency="0.0105" /replace="A" variation 4520 /gene="CES3" /frequency="0.0105" /replace="G" variation 4536 /gene="CES3" /frequency="0.0053" /replace="A" variation 4563 /gene="CES3" /frequency="0.0105" /replace="C" variation 4803 /gene="CES3" /frequency="0.0054" /replace="A" variation 5077 /gene="CES3" /frequency="0.0108" /replace="A" variation 5144 /gene="CES3" /frequency="0.0054" /replace="A" variation 5196 /gene="CES3" /frequency="0.0054" /replace="T" variation 6158 /gene="CES3" /frequency="0.0053" /replace="A" variation 6177 /gene="CES3" /frequency="0.4255" /replace="G" misc_feature 6292..6678 /gene="CES3" /note="Region not scanned for variation" repeat_region 6412..6672 /rpt_family="Alu" /rpt_type=dispersed variation 6783 /gene="CES3" /frequency="0.0054" /replace="A" variation 6968 /gene="CES3" /frequency="0.0053" /replace="T" variation 7074 /gene="CES3" /frequency="0.0526" /replace="A" repeat_region 7639..7745 /rpt_family="MIR" /rpt_type=dispersed repeat_region 7784..8052 /rpt_family="Alu" /rpt_type=dispersed variation 7966 /gene="CES3" /frequency="0.0556" /replace="A" misc_feature 8013..9715 /gene="CES3" /note="Region not scanned for variation" repeat_region 8462..8768 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8882..9175 /rpt_family="Alu" /rpt_type=dispersed repeat_region 9342..9635 /rpt_family="Alu" /rpt_type=dispersed variation 9761 /gene="CES3" /frequency="0.0110" /replace="G" repeat_region 9834..10125 /rpt_family="Alu" /rpt_type=dispersed variation 9970 /gene="CES3" /frequency="0.0500" /replace="T" variation 10228 /gene="CES3" /frequency="0.0054" /replace="A" variation 10348 /gene="CES3" /frequency="0.0054" /replace="A" variation 10425 /gene="CES3" /frequency="0.0053" /replace="T" variation 10454 /gene="CES3" /frequency="0.0426" /replace="T" repeat_region 10708..10806 /rpt_family="MIR" /rpt_type=dispersed variation 10764 /gene="CES3" /frequency="0.0115" /replace="A" variation 10782 /gene="CES3" /frequency="0.0055" /replace="G" repeat_region 10807..11117 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11118..11254 /rpt_family="MIR" /rpt_type=dispersed repeat_region 11259..11387 /rpt_family="MIR" /rpt_type=dispersed repeat_region 11631..11715 /rpt_family="MIR" /rpt_type=dispersed variation 11962 /gene="CES3" /frequency="0.0105" /replace="A" repeat_region 12220..12282 /rpt_family="MIR" /rpt_type=dispersed variation 12261 /gene="CES3" /frequency="0.0105" /replace="A" variation 12414 /gene="CES3" /frequency="0.4368" /replace="A" variation 12415 /gene="CES3" /frequency="0.4368" /replace="G" variation 12416 /gene="CES3" /frequency="0.4368" /replace="T" variation 12417 /gene="CES3" /frequency="0.4368" /replace="T" variation 12418 /gene="CES3" /frequency="0.4368" /replace="T" variation 12419 /gene="CES3" /frequency="0.4368" /replace="T" variation 12420 /gene="CES3" /frequency="0.4368" /replace="A" repeat_region 12421..12503 /rpt_family="MIR" /rpt_type=dispersed repeat_region 12564..12859 /rpt_family="Alu" /rpt_type=dispersed repeat_region 12889..12937 /rpt_family="L2" /rpt_type=dispersed variation 13160 /gene="CES3" /frequency="0.0053" /replace="G" variation 13348 /gene="CES3" /frequency="0.0055" /replace="T" variation 13349 /gene="CES3" /frequency="0.0165" /replace="A" variation 13600 /gene="CES3" /frequency="0.0053" /replace="G" variation 13611 /gene="CES3" /frequency="0.0053" /replace="T" variation 13645 /gene="CES3" /frequency="0.0989" /replace="A" variation 13706 /gene="CES3" /frequency="0.0110" /replace="G" repeat_region 13902..14249 /rpt_family="L2" /rpt_type=dispersed variation 14187..14188 /gene="CES3" /frequency="0.0054" /replace="" variation 14401 /gene="CES3" /frequency="0.0053" /replace="A" variation 14459 /gene="CES3" /frequency="0.0054" /replace="A" variation 14721 /gene="CES3" /frequency="0.0549" /replace="T" repeat_region 14807..16096 /rpt_family="ERV1" /rpt_type=dispersed variation 14874 /gene="CES3" /frequency="0.0053" /replace="T" variation 14953 /gene="CES3" /frequency="0.0474" /replace="T" variation 14985 /gene="CES3" /frequency="0.0053" /replace="T" variation 14986 /gene="CES3" /frequency="0.0053" /replace="A" variation 14999 /gene="CES3" /frequency="0.0105" /replace="A" variation 15026 /gene="CES3" /frequency="0.0106" /replace="A" variation 15264 /gene="CES3" /frequency="0.0106" /replace="T" variation 15459 /gene="CES3" /frequency="0.0053" /replace="T" variation 15603 /gene="CES3" /frequency="0.1543" /replace="C" variation 15693 /gene="CES3" /frequency="0.0054" /replace="A" variation 15810 /gene="CES3" /frequency="0.1526" /replace="T" variation 16056 /frequency="0.0105" /replace="C" variation 16116 /frequency="0.0053" /replace="C" repeat_region 16153..16476 /rpt_family="Alu" /rpt_type=dispersed variation 16256 /frequency="0.0054" /replace="T" repeat_region 16626..16940 /rpt_family="Alu" /rpt_type=dispersed variation 16920 /frequency="0.0161" /replace="T" repeat_region 17030..17096 /rpt_family="L2" /rpt_type=dispersed variation 17104 /frequency="0.1585" /replace="T" repeat_region 17190..17494 /rpt_family="Alu" /rpt_type=dispersed variation 17421 /frequency="0.0556" /replace="T" variation 17465 /frequency="0.0127" /replace="T" variation 17556 /frequency="0.0230" /replace="T" repeat_region 17669..17787 /rpt_family="L2" /rpt_type=dispersed BASE COUNT 3942 a 4947 c 4751 g 4150 t ORIGIN 1 ccagggtcta gtgtccatgg gtaggtccca gagctgggac tagagcaaga caagcaagtg 61 taaaatttag aaggcattca ttctcaggtg ccgaccctct actggtatga ccccgggggt 121 gagtgactct ttaactttta tgccctgggc gccttgctgg cctgtctcac cctagtcctg 181 gccctggtag gcccatccac aatgctagga gggaaggcag acctagctgc agggagttgg 241 gaaacgtggc cttgggagca gatggagagc tctcctggca gcatctatac ccgaagatgg 301 aaggtaagat tgtgggcgga gaagagatcc aggtgccttg atgtgagtgt tgaaggtgga 361 aagcatgcca gagccaggtg ctaaaatctt cagcaaatga tcaagggggt gtggctgggg 421 ggtggcaggg ctgtgatggc aacaagaaga ggaaggtgga atagggaagg acaaagtctg 481 gaggcagctc tgaaaaggag accccacccc aggctgccgg ggaagattca ggaagctgca 541 atggtttttt atgaattttt ttttagagag agagtcttgc tatgttgccc aagctggcct 601 caagctcctg ggctgaagca atcctcctgc ctcagccgcc tgagtagctg ggactacaga 661 cttgtgccac aatgcccagc tggcactagt tatttttggc agaagggaag tttcatccta 721 aagcctgtct cttcagctct gggtgccagc tggagccccg gaagaggatc tggcatcgtg 781 tttaggcaca accctcactc tgtctttcac tgggccagca aatatctatc catcctccca 841 ccgcctactc ccagccagcc atgttcctga cactgaggcc cagaagtgag tcctgccctc 901 cctgggggtg ggagcctcct aagccagcag agagacagat gccctgcaga tccccgcccc 961 ggtcaagagc aggcttccat cagttctggt tcccagactc tcctctcctc aggcttccat 1021 gagttctggt tccaagcccc tcccctcctc tcccctcccc tccctccctc cctccctctc 1081 tctctttctt tctctctcta tttttctttt ttctcttttt gtttctttct ctttttctgt 1141 ctctttttct ttctctctct cctttctctc tctccttctt tctctctctc ctttctttct 1201 tctctctctc tctttctctc tttctttgtc ttgctctata gcctagccta gagtgcagtg 1261 gcattatcac agctcactgc agtctcgaca acctgggctc aagtgatcct ctcacctcag 1321 cctcccaagt agctgggacc acaggcatgc accatcacac ctggctaatt ttttttattt 1381 tttctagaga cgtgtctccc tgtgttgccc aggctggtct caaactcctg ggctcaagcg 1441 atcttcctgc cccatcctcc taaagcactg ggattacagg tatgagccac cacacccagt 1501 cccaagcctc atgttttcac acacacactc acacacacat gcaaacatgt accctcactt 1561 caatgctatg aggtgggtcc tattatcatc actgttttat tttctttcac attttaacat 1621 gagatttgga ggggacaaaa catccaaacc atatcaagcc ctcacctcag gctgggttgc 1681 ccactcggag tggcacccca gggtcactgg ccaccacttc ctagggtcag tgatgtggtc 1741 accttgggat gaacgcacag gatttcatgg agatcaccaa gtcaggagag ctggaatttg 1801 aaaacagtgg gacggggagg gctgtcatat caaccaggcc tctgcagggc actcatctag 1861 ccctgcctct ggctcagcct gagcatgggg ctggccacca gctaggtggc gctgtccttg 1921 gaggttctat atcacagccc tttagagatc ggtggtgctg aagggcaggg atcttattcc 1981 accttctgaa gcttctgtcg aaccagttgt aaggagaatg gagagagcag tgagagtgga 2041 gtccggggtc ctggtcgggg tggtctgtct gctcctggca tgccctgcca cagccactgg 2101 taagacacac ctgctgggcc tgcagaggta cttggtgtgg aggagtcaag agtgagacag 2161 ggacagggag cagtgggccg accgctcagg aaacagtcct gtttggaggc agaccagggg 2221 ttgtgcattc tctctgggca ggcgctctgc tcttgctgta tttgtttcgt tgtttttgtt 2281 gttgttgttt gagacagagt tttgctcttg ttacccaggc tggagtgcaa tggcgcgatc 2341 tcggctcact gcaacctccg cctcctggat tcaagcgatt ctcctgcctc agcctcctga 2401 gtagctggga ttacaggcac ctgccaccat ggccggctaa tttttgtatt tttaggagag 2461 atggggtttc accatgtggg ccaggctggt ctcaaactcc tgacctcagg tgacccacct 2521 gcctcggcct cccaaagtgc tgggattaca ggcgtgagcc accgcacctg gcctgtcttt 2581 atgtcttaag ggggcctgag atttgtttta atgaagtata gtaagacaag cagatatgca 2641 aatgactatc atgagggaag gagtttgctc gtagttccct gtgaacagga agcaggccat 2701 gccacatagg gccacagagg gaagcaccag gtggcatcag ccaggaggca gagggagcag 2761 ggggaaaatg tgggcaagcc cctttgacac ggttgccacg ggaaggaata ggcaaggcag 2821 gctaaagagg tttacgattg gcagcaggct ctggggaaag gggctgtccc cagccagctt 2881 cctggtaccc ggctctgtgg tgattatggc tggtggatgg cagccaggag ctgagagctg 2941 tataaaggag gtggttgggt atggctctgg actggtttgc ctttgctccc tagagagatg 3001 cctgccaatt ccacctcccc agagagctgc ctcctatctc taggaattgt ctagcctggg 3061 agaggcagtc ctccagtctt agtctgtttg tgttgttgta aaagaataca ggaagctggg 3121 taattcacaa agaaaagaag tttagttagg ccacagttct gcaggccgta caagaaacat 3181 ggtgccagct gggcatgatg gctcacacct gtcgtcccag cacttgggga ggctgaggtg 3241 aaaggattgc ttgagcccag gggtttgaga ccagcctggg caacataatg agaccccatc 3301 tctacttttt aaaaaataat tcagggctgg gcatgatggc tcatgcctgt aatgccagca 3361 ctttgggagc cccaggtgga tggattactt gaggtcagga gttcgagacc agcctggcca 3421 acatgatgaa accccgtctc tactaaaaat acaaaaatta gccaggcgtt gtggtgcaca 3481 cctgtaatcc cagctacttg ggaggctgag gccctggagt cgcttgaact cgggagtcag 3541 aggttgcagt gagccaagat cgtgccactg cactccagct tggtcaacag agctagaccc 3601 tgtctcaaac acaaaaaata aaaacaaaga aatgggcaag tggctggccc caaggcacaa 3661 ggccctagtg gcaggcccgg tctggcctgg agtggagtgg tagtgactct caggcaggca 3721 gggaggagga agttgggcgt caacctaaga ccaggctcac cggcttgctg ggaaggttac 3781 caagatgctg tgtggtaagt actgagaaca gcctgagggt ttgtctttca ctccttcccc 3841 tcatgggggc tgcaaactca ccccgtggcc tttctgtcct tccctcaggg cccgaagttg 3901 ctcagcctga agtagacacc accctgggtc gtgtgcgagg ccggcaggtg ggcgtgaagg 3961 gcacagaccg ccttgtgaat gtctttctgg gcattccatt tgcccagccg ccactgggcc 4021 ctgaccggtt ctcagcccca cacccagcac agccctggga gggtgtgcgg gatgccagca 4081 ctgcgccccc aatgtgagta gtgctggtgg aggcgggcaa acaggcaggt tgcaggagaa 4141 tcctgctgct ggggcttgtg gggctgaaca gctggacctc aggcccaccc ttggccacag 4201 gtgcctacaa gacgtggaga gcatgaacag cagcagattt gtcctcaacg gaaaacagca 4261 gatcttctcc gtttcagagg actgcctggt cctcaacgtc tatagcccag ctgaggtccc 4321 cgcagggtcc ggtaggccgg taggcacccc agagggccct gtccacctga tccagctcca 4381 ctatgcctac ctgtcccctc cccgtccctg tttccaaagc accctagcgg tcctgagact 4441 gcctgggctg gcaggtgggc agctaaggtc tcaggagctt gggggtcagt gccccatggc 4501 cacctctgca ggtcatggta tgggtccatg gaggcgctct gataactggc gctgccacct 4561 cctacgatgg atcagctctg gctgcctatg gggatgtggt cgtggttaca gtccagtacc 4621 gccttggggt ccttggcttc ttcaggtgag acgacaggca tggccagagc actgcctgca 4681 ccggggagag gccagctcac cagagcaact ggggatctag gttggggtcc ggaacctgaa 4741 gggagggccc cttacccatg atgtctgagg cagagaaggg caccccccaa gcctccaccc 4801 tgggagaggg gtccagccaa agccagaatt atacagtgaa cttggtccct tgggcagagg 4861 gcattgattc ctgggctgaa gcccaggttc cagcaggata tgggacaaag agcaacaggc 4921 tgtggagatg ccaaccacgg ctcccagaca ggccagacct ggggagcaga gaagggtctg 4981 gcatcctggt ggctaattca aagcaaacct gcagaggctg gcgaggagcc aggctgaact 5041 aaccgttgcc ccaacactgc ccccagcact ggagatgagc atgcacctgg caaccagggc 5101 ttcctagatg tggtagctgc tttgcgctgg gtgcaagaaa acatcgcccc cttcgggggt 5161 gacctcaact gtgtcactgt ctttggtgga tctgccggtg ggagcatcat ctctggcctg 5221 gtaagtcact atagggggct agtgatggtg gccaggaggg ctccggtggt ctcagaactc 5281 ccagctcctc tgccctcctc tgacagccac ctcctctctc caatgcaccc aggtcctgtc 5341 cccagtggct gcagggctgt tccacagagc catcacacag agtggggtca tcaccacccc 5401 agggatcatc gactctcacc cttggcccct agctcaggtc tgtatttcct tccctctctt 5461 actctatgtg tgcctcccat accccactct gtgctggccc tggggtctca gagtagcggg 5521 gtttgctggc agggagctcc ctgttagcaa agagaagccc aataagacga aggagcatca 5581 gaggaaacaa ctgctgcatt ccagcatatt ggcactcagg gagggcttcc tgaaggaagc 5641 caccctgaag catatcattg ttggcccttt ctccagggtg gggtcttcag gagcacccct 5701 ctctgcccca ggcagcatgg tggagggggt ctccattgcc agccacctgc tgcctgcgag 5761 ctctccattc aggctccaga tccccaccct agatcctcat tgtaaggcct tgtgaagaaa 5821 atccagggga agccacagtg ggaactgcat ctgcaaaggc tgcaggtgtg ggagagagtg 5881 acaggtcctg caggagcaag ctcgcaggtt agggaacagg gcaggaagtg aaggtgctgg 5941 agaagtgggg gccatgcctg ggaatctgga ctttctccag agggcaggaa gaagttgggc 6001 aatgacaagg ttgagctacc tggagtagaa ggtgggttgg agggagccgt cctgaagatc 6061 aagacaccag tgaaatgacc agggcagagt ccaggagaaa gagacaggat ggaataggga 6121 tagagccatc ggggagagag ggggcaaatg tgagcaggat ttggaagact gggtcaattc 6181 cctcacctgg ccccagatgg tggccaaggc agtgtgggct gggcatttta accactgtgt 6241 acaagatgat tctggaacct ctgcgtgggc atgttgactc ttgtatggac aacagcatcc 6301 tcctctcaac ctccccatcc catcctctcc ccatggccag gagagatttt ctcaaccaca 6361 gacttgaggt cattccctgt ctctcctgtg tccaaagaaa aacacagctc aaggctgagg 6421 ttggcggatc acaaagtcag gagatcaagg tgatcctggc taacatggtg aaaccccatc 6481 tctactaaaa atacaaaaaa ttagccgggc atggtggcag gtgcctgtag tcccagctac 6541 tcaggaggct gaggcagaag aatggtgtga acccgggacg cagagcttgc ggtgagccaa 6601 gatcatgcca ctgcactcca gcctgggcga cagagcgaga gtctgtctca aaaaaataat 6661 aataaaagat aatgacacta ttcttagagg gcaatgagga ctcagtgccc ccattccccc 6721 agataataaa attatggtat aataggggac gcaagggggc ccttgggacc acccaagctg 6781 acgggcaggg caggcttctc aggagtggtg acaagtctgt gaccagtctc gaggccgatc 6841 tgtgacatca catccagctg tcctacagat gcaccctctc tgtgggaggc agaaggctgc 6901 aaggtggggc tgagtggctg agagggaggc atgactcttt catttgtccc cagaaaatcg 6961 caaacacctt ggcctgcagc tccagctccc cggctgagat ggtgcagtgc cttcagcaga 7021 aagaaggaga agagctggtc cttagcaaga agctggtatg gccacccttt tggggatggt 7081 gccgggcaat ggcacagagg gggttctatc catcccctgc aggagcagag gggcagtcta 7141 cccccaggtg gggctgggga cagcagctca tgaggggaag gggctgaggg cttggagaca 7201 gaaatggagg gccatctcca tccccacagc aggcctgtct tctaggaaag aaactggacg 7261 catctgttgc cctgatctcc tggttccccc gaccccctta accctggtga tcttcatccc 7321 ttcactttcc ctccaggctc agacactcag gcctgcagct cagtggctgc tggggtccta 7381 gcctttgagg cttggcccta acttgggagc ctcctgcatt gctttctcct gcagaaaaat 7441 actatctatc ctctcaccgt tgatggcact gtcttcccca aaagccccaa ggaactcctg 7501 aaggagaagc ccttccactc tgtgcccttc ctcatgggtg tcaacaacca tgagttcagc 7561 tggctcatcc ccagggtgag ttgctcccac ccctgtgccc ttcaaggccc tgccccagcc 7621 agtacctgcc accccagcat caacactaca gccttgtgaa cggagcactc ccgttactcc 7681 catttgataa gtgagaaagc agaggcccag aaaggtttga gggacttgcc caaggtcacc 7741 cagctttgtt ttgttgtgtt gttgttttgc tttttttttt ctgtttttgt ttgtttgttt 7801 gtttgttttt gagacagagt ctcgctctgt cacccaggct ggagtgcagt ggtgcgatct 7861 cagctcactt caacctccac ctcctgggtt caagagtttc tcctgcctca gcctcccaag 7921 cagctgggat tacaggcaca tgccaccaca cccagctttc accacgttgg ccaggctggt 7981 ctcaagctcc tgacctcaag taatccatct gctttggcct tccgaagtgt tgggattaca 8041 ggcgtgggcc acttcaataa agcaaatgtt ttcttttggg gaacaaggtt tttgcacaaa 8101 ctggccttct gggcactgct gatctgggca gcatattcct gccttggcgt ctggtttata 8161 catcaggctc tatgagactg gttagtgtga ctctgtgcca gagcaattga ctaaaactct 8221 caggttttag atatcaagcc accggggact tcatgagcca agtcccttcc attcctttcc 8281 aggtgcatag aacttcccac aagagtgtca gcactgtgct ttcatcccga gcatcttgtt 8341 tctgtcattc ttattcttct acccatcttc acagcaatca ttttcttcac ttttcttttt 8401 tttttttttt cgtcttggcc cattgcacac cctaagacaa agcaatccat ttttgttgtt 8461 gttgttgttt gtgtgtttgt ttgttttttg agacagagcc tcgatccatc atccaggctg 8521 cagtgcagca gcgccatcat gactctctac tgcctcaacc tctcaggccc gagcaatcct 8581 cccagcttcc tgagtagctc gggcctcagg tctgtgccac catactctgc taactttttt 8641 tttcttccgt gtatagtcag gtctccctct gttgcccaag ctggtctaga gcacctggcc 8701 tcaagcaatc ctcttgcctc gacctcccac agtgctggga ttacagacat gagccacagc 8761 acccagccaa caaccacttt taatggctgc aaatcttcca caaatggagc gtctcgttac 8821 attgttcttt catcttggca tttgggcatc ttctagtttt tttgtttgtt tgtttgtttt 8881 gtttttgaga tggagttttg ctcttgttgc ccagggtgga gtgcaatggc gcgatcttag 8941 ctcaccgcac tgcaacctct gcctcccagg ttcaagcgat tctcctgcct cagcctcctg 9001 agtagctggg attacaggca tctgccacca tgcctggcta atttttgtat tttttttagt 9061 agagatgggg tttctccatg ttggacaggc tgatctggaa ctcctgaact caggtgatcc 9121 accagccttg gcctcccaaa atgctgggat tacaggcatg aggctgcacc cggtcctggc 9181 aacttctagt ttttaccact gaggctaata gcgcagtgaa tgtcttcatg tccatggctt 9241 ttgtcctctg acttagccct ttggaatcaa tcccctcata ttggtccctt ggtatgtgag 9301 agagaggctc atgcaatctt gacattcaaa gacaaagctt aagccgggtg cggtggctca 9361 tgcctataat cccagcactt tgggaggctg aggtgagtgg gtcacttgaa gtcaggagtt 9421 cgagaccagc ctagccaaca tggtgaaacc ccatctgtac taaaaataca aaaattagct 9481 gggcgtggtg gtgcatgcct gtaattccag ctactcagga ggctgaggca cgagaatcac 9541 ttgaacccag gaggcagagg ctgcagtgag ccgagactgt cccactatac tccagcctgg 9601 gtgacagagt gagacactgt ctcacaaaat acaaagcttg taaaagtttt caggtcaatg 9661 ccctcaactc tggcaggcag cctttacccc acaccatcaa cttacagttg tatgagtgaa 9721 accaagggaa ccccaacctg gctgtgcccc aggacctggg tagatctgcc tggcgtggaa 9781 ggctgtgccc aggacttgtt gctgagaatg tttcttagaa gttgggtgac tcaggctggg 9841 cccggcggct catgccttta atcccagcac tttgggaggc caaggcaggc ggatcactca 9901 aggccaggag tgtgagacca gcctggccaa catggcataa ccccacctct actaaaaata 9961 caaaaattag ccaggcacgg tggtgcacgt ctgcggtccc agctactcgg gaggctgagg 10021 caggagaata gcttgaaccc aggaggcgga ggttgcggtg agccgagatt gcgccactgc 10081 actccagcct gggcaacgga gtgagtctct gtctcaaaaa aaaaatgttg aagaaatttt 10141 tcattctcta cagttgcctt taaccacttg cctgttgtat ttggggctgc tctccccatc 10201 cacaccaacc acctcccacc aatttgcggt ttatcttttt ggatctgtgg acttttcggc 10261 cccattttgg ccaagtgctc catgatgagt ttctggcctc aggaccgtga acactctctt 10321 gcccagggct gggagtcggg gtgagccggt ggtcaggctc cactgagagg gccttggtgt 10381 ccacacaggg ctggggtctc ctggatacaa tggagcagat gagccgggag gacatgctgg 10441 ccatctcaac acccgtcttg accagtctgg tgagacaaga ggcaggaggg aggaagctag 10501 ggcaggaggg aggaagctag tgggtatccc atccaacagc acagtctctg cccctacctt 10561 ccgacaccca cagctaccca cctaccacca agcccctttg tctaactgat caattttact 10621 tccactccgg aatctcctta gatatgagcc agtgtggttc tcaaaggaaa accatcatca 10681 ccatcatcgt caacatgaaa ctgcccgtta atgagcacat attacgtgcc agggactatg 10741 gtgcactgag cgccgggaga gggtttcatc tccttcaatc ctcactgcaa ctctgttttc 10801 ttttcttttc ttttctttgt tttttttttt ttttttgaga cagagtcttg ctctgtcgcc 10861 aaggctggag tgcagtggcc cgatctcggc tcaccgcaac atccacctcc ctcattcaag 10921 cgattctcct gcctcagcct cccgagtagc tgggattaca ggcccctgcc accatgcccg 10981 gctaattttt gtgttttagt agagacaggg tttcaccatg ttggccaggc tggtctcaaa 11041 ctcctgacct caggtgattc acccgcctcg gcctcccaaa gtgctgggat tgcgagcgtg 11101 gagccaccgc gcccggcgct gcaactcttt acagaggaat tctcgctagc cccattttac 11161 acatgaggaa actgaggctt gaggtgtcat gctggggaag gggcagaggc agagtttaag 11221 ccagttttgt ctgaccctag agcctcagct gtcagatgtg gagctagata gacctggggc 11281 caaatcccag ccctgggcac ttgcccagtt atcctatccc ctctaagccc atctcttcat 11341 ctacacatgg ggatgacact gcccactcgc ctgggctgtt gtaaggagac tagacgttgc 11401 atttgaagag tctacctggg atctcaatac caggggctgt tcaatctttg tccatttccc 11461 ttctttggaa gccccagaac ccttcccatt cacgcaatct catcactgcc ctctggagct 11521 gaggggagcc cctatcattt ctgctctcac ttacttccca gttaacttca accgagcacc 11581 tgcttccagg ccagaccctt tgctggggac ttcacatagg ctgccaggca gagactgact 11641 ttcagagagg tttagccacc tgtctgcgat cacacagcca agcagtggtt gcagagctaa 11701 gatctgactc caaacctgag cttatgccaa actcccaggg aggcagagag gcagctggct 11761 gtcccctgga ccatcagccc tgggatttga gggaagctat gctggagagt ttggggcttc 11821 ctgggatggt ctgccacatc tgtgcaccct gagcagggct gagcctggcc tcttgcccca 11881 ggatgtgccc cctgagatga tgcccaccgt catagatgaa tacctaggaa gcaactcgga 11941 cgcacaagcc aaatgccagg cgttccagga attcatgggt gacgtattca tcaatgttcc 12001 caccgtcagt ttttcaagat accttcgagg taagcctgtc cctggccacc tgcccaaccc 12061 ctcccacttg ggcccaggag ctgggtcatc acaggtgaca tggcatgata gggtgctggt 12121 tccctcaatg ccttgcaccc cacaccccac tgccccccac caaacctatc tttctctggg 12181 atgcagtgtc atagtaatga gaggtatctc cagcaggaaa ctatgcagag gagaaaacct 12241 cagactcaga gaggtacaat gactcaccaa aggtcaccca gcagggccta tcactaattc 12301 tcagggattc actcaaatgg gtgatttcat cctctttcag cacttctggg gggaaagtct 12361 tgcttccttc aagcctagta gctaatccct gatgcagacc cagaacagtt ccagacccag 12421 aactttgtga ccttgggcaa gatacctacc ccctctgagc ctcagtttcc tcctttgtaa 12481 aatggaaata ataatagaat ctaatctatt aattctatta atacagaatc tattgtgatg 12541 gggattcaat aaatgatgac actggccagg cgcggtgggt ggctcaatct tgtgatccca 12601 gtactttggg agaagcggga ggatcgcttg agcccaggag ttcaagacca gcctgggcaa 12661 catattgacc ccaatctcta cacaaatttt ttgaaaatta gccgggcatg gtggtacaca 12721 cctgtagtcc cagatacttg ggaagctgaa gtgggaagat cacttgagcg cgggagtctc 12781 aggctgcagt gagctgtgat catgccactg cactccagcc tggtcgacag caagaccatt 12841 tcagagatta aaataaaaat attaaattaa attaaaatga tgacacaaag cacacagaat 12901 ggtgcctgtc acctagcaag cgctcagtaa atgtttgcag ctagtcattt tatcatcatc 12961 atcatcatca tcatggaaat tggtgttatt atgagcatgt gctgccaaag gcagcatcga 13021 atcaggccat gagtgcctaa ctcccatccc atcctttctc tgtagattct ggaagccctg 13081 tctttttcta tgagttccag catcgaccca gttcttttgc gaagatcaaa cctgcctggg 13141 tgaaggctga tcatggggcc gagggtgctt ttgtgttcgg aggtcccttc ctcatggacg 13201 agagctcccg cctgggtgag gacagacaga cagacatgtg atccctaggc tgccagactc 13261 caaggggcct gggcagggct tgcaggaaca cgggtctcca gtcagcactg aggatccttg 13321 ggtcccttcc aggtcccacc tgactctcgt tcagttctgt ccctctcacc tttccagcct 13381 ttccagaggc cacagaggag gagaagcagc taagcctcac catgatggcc cagtggaccc 13441 actttgcccg gacagggtga gtgagtgaca gggcatagct cgctttgggc ctgggatgct 13501 caggtcggcc cctctggggg acagcacagg aagccttggt cctcattcat tcctcccacc 13561 cagggacccc aatagcaagg ctctgcctcc ttggccccaa ttcaaccagg cggaacaata 13621 tctggagatc aacccagtgc cacgggccgg acagaagttc agggaggcct ggatgcagtt 13681 ctggtcagag acgctcccca gcaagataca acagtggcac cagaagcaga agaacaggaa 13741 ggcccaggag gacctctgag gccaggcctg aaccttcttg gctggggcaa accactcttc 13801 aagtggtggc agagtcccag cacggcagcc cgcctctccc cctgctgaga ctttaatctc 13861 caccagccct taaagtgtcg gccgctctgt gactggagtt atgctctttt gaaatgtcac 13921 aaggccgcct cccacctctg gggcattgta caagttcttc cctctccctg aagtgccttt 13981 cctgctttct tcgtggtagg ttctagcaca ttcctctagc ttcctggagg actcactccc 14041 ccaggaagcc ttccctgcct tctctgggct gtgcggcccc gagtctgcgt ccattagagc 14101 acagtccacc cgaggctagc accgtgtctg tgtctgtctc cccctcagag gagctctctc 14161 aaaatgggga ttagcctaac cccactctgt cacccacacc aggatcgggt gggacctgga 14221 gctagggggt gtttgctgag tgagtgagtg aaacacagaa tatgggaatg gcagctgctg 14281 aacttgaacc cagagccttc aggtgccaaa gccatactca ggcccccacc gacattgtcc 14341 accctggcca gaagggtgca tgccaatggc agagacctgg gatgggagaa gtcctggggc 14401 gccaggggat ccagcctaga gcagacctta gcccctgact aaggcctcag actagggcgg 14461 gaggggtctc ctcctctctg ctgcccagtc ctggcccctg cacaagacaa cagaatccat 14521 cagggccatg agtgtcaccc agacctgacc ctcaccaatt ccagccctga ccctcaggac 14581 gctggatgcc agctcccagc cccagtgccg ggtcctccct cccttcctgg cttggggaga 14641 ccagtttctg gggagcttcc aagagcaccc accaagacac agcaggacag gccaggggag 14701 ggcatctgga ccagggcatc cgtcgggcta ttgtcacaga gaaaagaaga gacccaccca 14761 ctcgggctgc aaaaggtgaa aagcaccaag aggttttcag atggaagtga gaggtgacag 14821 tgtgctggca gccctcacag ccctcgcttg ctctccctgc cgcctctgcc tgggctccca 14881 ctttggcagc acttgaggag cccttcaacc cgccgctgca ctgtaggagc ccctttctgg 14941 gctggccaag gccggagcca gctccctcag cttgcgggga ggtgcggagg gagaggggcg 15001 ggcaggaacc ggggctgcgc gcagcgcttg cgggccagag tgagttccgg gtgggcgtgg 15061 gctcggcggg gccccactca gagcagctgg ccggccccag gcagtgaggg ccttagcacc 15121 tgggccagca gctgctgtgc tcgatttctc gctgggcctt agctgcctcc ccgcggggca 15181 gggctcggga cctgcagccc tccatgcctg accctccccc caccccccgt gggctcctgt 15241 gcggccggag cctccccaag gagcgccgcc ccctgctcca cagcgcccag tcccatcgac 15301 cacccaaggg ctgaggagtg cgggtgcaca gcgcgggact ggcaggcagc tccacctgct 15361 gccccagtgc tggatccact gggtgaagcc agctgggctc ctgagtctgg tggggacttg 15421 gagaaccttt atgtctagct aagggattgt aaatacaccg atgggcactc tgtatctagc 15481 tcaaggtttg taaacacacc aatcagcacc ctgtgtctag ctcagtgttt gtgaatgcac 15541 caatccacac tctgtatctg gctactctgg tggggacttg gagaaccttt gtgtccacac 15601 tctgtatcta gctaatctag tggggatgtg gagaaccttt gtgtctagct cagggatcgt 15661 aaacgcacca atcagcaccc tgtcaaaaca gaccacttga ctctctgtaa aatggaccaa 15721 tcagcaggat gtgggtgggg cgagacaaga gaataaaagc aggctgcctg agccagcagt 15781 gacaaccccc ctcgggtccc ctcccacgcc gtggaagctt tgttctttcg ctctttgcaa 15841 taaatcttgc tactgcccac tctttgggtc cacactgcct ttatgagctg taacactcac 15901 cgcgaaggtc tgcagcttca ctcctgagcc agcgagacca cgaacccacc agaaggaaga 15961 aactccgaac gcatctgaac ctcagaagga accagttccc gacacgccac ctttcagaac 16021 tgtaacactc accgggaggg tccgtggctt cattcttgaa gtcagtgaga caaagaaccc 16081 accaattccg gacacagaag taaacatttc ttgctttgag gatcaatgta ccactacctt 16141 aaaacacctg ggtttatttt tgtttttgtt ttagagacag ggtccactct gctgtgcatg 16201 ctggactgaa gtggcacgat tgtagctctc tgcagccttg aactcctcga actcactgca 16261 gcctcgaact caatcaagcg attctccccc ctcagcctcc caagtagcgg ggactgcaag 16321 tgagtgtcgc catgcctgga taattttttt agtttttgta gggacagggt atcaccatgt 16381 tgccgagact ggcctcaaac tcctggcctc aaatgatctt cccggctcgg ccttccaaaa 16441 cactgggatt gcaggtgtgt cccactgtgc ccagccaaca cctggatttc aatacatatc 16501 ccagagtctt ccctgccccc gttatgccat cctaccagct ccagtcgcac aaatgccctt 16561 cctcagtcag actgagctgc tggctgctga tgggtgggtg aaaagcattt tcattttctt 16621 ttttctttct tcctttcttt ctgtcttgtt tttttgagat ggagtttcac tcttgttgcc 16681 caggctggag tgcaatgaca cgatctcagc ccactgaaac ctctacctcc caggtccagg 16741 caattctcct gaatcagcct cccgagtagc tgggattaca ggcgcccacc atcatgccca 16801 gctaattttt ttgtattttt agtagagaca gggtttcacc atgttggcca ggctggtctt 16861 gaactcctga cttcagatga tccacccacc tcggcctccc aaagtgctgg gattacaggc 16921 gtgagccacc gcgcctggcc agcattttca tttccaactg gaaccagctc tgttctggga 16981 agtccatttt ggggaggaag gagagacaga aagccagaag ggctctgagt catatcattc 17041 tcctgctcga aagctcctgg tgactccctg tctccctgaa gacaagtcca agttctccac 17101 gtgccactga agtcctgcta ttctcatcca cttccttcca ccagggaagt tcatccccac 17161 aagctggtag agcttgacaa gtaggccctg gccgggcacg gtggctcacg cctgtaatcc 17221 cagcactttg ggaagccgaa gcgggtggat cacctgaggt caggagttcg agtccagcct 17281 ggccaacata gcgaaacctt ctctgtatta aaaaatacag aaatcagcca ggcgtgctag 17341 tgtgcacctg tagtcccagt tactagagag gctgagccag gagaatcaca tgaacccggg 17401 aggcagaggt tgcagtgagc cgagatcacg ccactgcact ccagcctggg tgacagagtg 17461 agaccttgtc tcaaaaacaa aacaaaacaa aacaggcccc aataatacag tgtgtaactg 17521 ggacacgaag ggctgtgagg acacagagac gtagaccagc ccagacttgg gagacaggga 17581 aggagggaca tctcagctga gacccgagga ataaacagag gttactcaac cgtgcagacc 17641 agcgtagaag actggaaggg tggggagcgg gggaagggcg tgcctggcag agggaacaac 17701 agcagcaaag gcctgaagga tgcaatgtgt ggaggaatcg cggctctgca gggctggaga 17761 ggtcagcaaa gagcagacgt gagaggactt //