LOCUS CDKN1B 5727 bp DNA PRI 16-DEC-2002 DEFINITION Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B) gene, complete cds. ACCESSION CDKN1B VERSION KEYWORDS . SOURCE Homo sapiens. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5727) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Montoya,M.A., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (16-DEC-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..5727 /organism="Homo sapiens" /db_xref="taxon:9606" mRNA join(230..1169,1680..1809,3895..5228) /gene="CDKN1B" /product="CDN1B" gene 230..5228 /gene="CDKN1B" variation 429 /gene="CDKN1B" /replace="G" /frequency="0.01" variation 616 /gene="CDKN1B" /replace="T" /frequency="0.31" CDS join(695..1169,1680..1801) /gene="CDKN1B" /codon_start=1 /product="cyclin-dependent kinase inhibitor 1B (p27, Kip1)" /translation="MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRD LEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVP AQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDS STQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT" variation 737 /gene="CDKN1B" /replace="T" /frequency="0.01" variation 1020 /gene="CDKN1B" /replace="G" /frequency="0.29" variation 1340 /gene="CDKN1B" /replace="G" /frequency="0.01" variation 1603 /gene="CDKN1B" /replace="C" /frequency="0.04" variation 1894 /gene="CDKN1B" /replace="A" /frequency="0.15" variation 2406 /gene="CDKN1B" /replace="-" /frequency="0.84" variation 2557 /gene="CDKN1B" /replace="C" /frequency="0.04" variation 3029 /gene="CDKN1B" /replace="C" /frequency="0.01" variation 3047..3050 /gene="CDKN1B" /replace="-" /frequency="0.75" variation 3158 /gene="CDKN1B" /replace="G" /frequency="0.46" variation 3226 /gene="CDKN1B" /replace="A" /frequency="0.02" repeat_region 3471..3690 /rpt_family="MER1_type" /rpt_type=dispersed variation 3578 /gene="CDKN1B" /replace="T" /frequency="0.36" variation 3673 /gene="CDKN1B" /replace="C" /frequency="0.47" variation 3857 /gene="CDKN1B" /replace="T" /frequency="0.01" variation 4067 /gene="CDKN1B" /replace="C" /frequency="0.01" variation 4387 /gene="CDKN1B" /replace="A" /frequency="0.01" variation 4496 /gene="CDKN1B" /replace="A" /frequency="0.03" variation 4842 /gene="CDKN1B" /replace="C" /frequency="0.50" variation 5391 /replace="G" /frequency="0.07" BASE COUNT 1602 a 1160 c 1294 g 1671 t ORIGIN 1 agagcaggtt tgttggcagc agtacccctc cagcagtcac gcgaccagcc aatctcccgg 61 cggcgctcgg ggaggcggcg cgctcgggaa cgaggggagg tggcggaacc gcgccggggc 121 caccttaagg ccgcgctcgc cagcctcggc ggggcggctc ccgccgccgc aaccaatgga 181 tctcctcctc tgtttaaata gactcgccgt gtcaatcatt ttcttcttcg tcagcctccc 241 ttccaccgcc atattgggcc actaaaaaaa gggggctcgt cttttcgggg tgtttttctc 301 cccctcccct gtccccgctt gctcacggct ctgcgactcc gacgccggca aggtttggag 361 agcggctggg ttcgcgggac ccgcgggctt gcacccgccc agactcggac gggctttgcc 421 accctctccg cttgcctggt cccctctcct ctccgccctc ccgctcgcca gtccatttga 481 tcagcggaga ctcggcggcc gggccggggc ttccccgcag cccctgcgcg ctcctagagc 541 tcgggccgtg gctcgtcggg gtctgtgtct tttggctccg agggcagtcg ctgggcttcc 601 gagaggggtt cgggccgcgt aggggcgctt tgttttgttc ggttttgttt ttttgagagt 661 gcgagagagg cggtcgtgca gacccgggag aaagatgtca aacgtgcgag tgtctaacgg 721 gagccctagc ctggagcgga tggacgccag gcaggcggag caccccaagc cctcggcctg 781 caggaacctc ttcggcccgg tggaccacga agagttaacc cgggacttgg agaagcactg 841 cagagacatg gaagaggcga gccagcgcaa gtggaatttc gattttcaga atcacaaacc 901 cctagagggc aagtacgagt ggcaagaggt ggagaagggc agcttgcccg agttctacta 961 cagacccccg cggcccccca aaggtgcctg caaggtgccg gcgcaggaga gccaggatgt 1021 cagcgggagc cgcccggcgg cgcctttaat tggggctccg gctaactctg aggacacgca 1081 tttggtggac ccaaagactg atccgtcgga cagccagacg gggttagcgg agcaatgcgc 1141 aggaataagg aagcgacctg caaccgacgg taatgaccct ttcccaacca tagaatgtgt 1201 ttggggcccc gctttgcctg ctggagggtg ttaaccttag cttgcttttc ggcgtattct 1261 gatttagctt tgggagagct aactttattg gtcttaggtg ttcagtgcta cctggcccac 1321 tgcttgtctg tttgtgactt ttaagtcaga aactggagat ggtaagatcc gataatttcc 1381 ctaacttaat acatcgcggt ccctctcact agcaactcct aggtatgtga caaagttggg 1441 atgtttatca acggtccgcc tcctggctag ggaaagagct ctggggcgga gaatgcactt 1501 tctgtttttt gaaaacaacc tcattttgtg cccttaaaag ccactgggga tgacggatcc 1561 aggattgtgg gtggaggtag tgggtttttc atcccctgac tatggggcca acttctgcca 1621 gccattgttt tttctaataa agattgtgtg ttctttttaa aaatttcccc tgcgcttaga 1681 ttcttctact caaaacaaaa gagccaacag aacagaagaa aatgtttcag acggttcccc 1741 aaatgccggt tctgtggagc agacgcccaa gaagcctggc ctcagaagac gtcaaacgta 1801 aacagctcgg tgggttgatc actaaaggag cacgcactgg aacccggggc cttcagacct 1861 cacgatacct gatcttactg gttgctggca aattaaaagc ttatggggtt ttgttttgtt 1921 tatacttcgt gaggtcaaaa aagtagcaat ggggaaggct ggggatacgg taattcctca 1981 gagtttctat gcccagagat actttctctt caaactgttg accagagcag ctacttgtaa 2041 cccaggcccc atcgggtagg aaggtcgttt ccctgtgagt cccactaaaa cgtgttggga 2101 gcaataggtt ctttgcccat ccgaacaaga actagggtac tccctcagtc cgaattaatg 2161 agaattaatt tcctagaggt tcagcttgag tcggtaacag attttgagcc atacatggaa 2221 aaatggcaaa tacatgatta agtttcaatt ttgaggggga atgtttggta gaaattgctc 2281 atctttggtt atgcaaggga ttagagatgt gaataggatg gtatgttgtg ttctttgaca 2341 ttttaataaa ctgtcacttt ccctgttgtc tcctaagttt ggagagagaa ggaaccagta 2401 tttgcaaaaa accaaatgga aagataaaaa agttactaaa gtttctacag aatttctggt 2461 aacactgaag ttgcaaagca gaagttaaat taactcttgt cagtaagcaa tccaggaaca 2521 cgtcagccag tgtatgctaa ttgtgccgta acagggtgat ttggatattt gtaggggaaa 2581 tgggtagtaa atatcaagac tggtgaccgt aggtcagccc agcacaaagg aagtggagat 2641 ttttccatgc acaagaatct gatcactgta aatagctaat ttgaataatt cagtccccag 2701 ataaccaaca tgggttggtt attcataata aactacatat tttaatagtt tattagcttc 2761 ctttagacca agactgtgac ctctttattt tctaaagcac acacgtagtt tagcatatga 2821 ggcgataaaa tattgatgtt aactttttaa atccccagtt ataaaaattt taaaataaca 2881 gggattaagg tgagattcag gtttgttgtg tctttaaatt gtatatgtga cttcacatat 2941 ctttttcagc gcttatacaa aacggcacta tagaacctcc attttacagc accatatgaa 3001 gtgggaaaat taggtgaaaa ttttcctgaa gcaaccttaa catgcgcagc cagccttgtt 3061 ggtttgtgac ttgtggccta gctcatcaga tgagccacga gaatcagacc tggattttga 3121 tctggccctg ttctgacatg caatgaggca tttgtagcat ttagtaatat tgctagttca 3181 aagaatacta gaaatattag taagaaccta ttcaaaagta ttcatgagta ttttctgcat 3241 atgaatcagg aattagaata ttttgaaaat gatgttaata aaattttcct ctggaaggcc 3301 tttataattt ttattcccaa tcatttttca aatttagaaa gtttaatctg tcacaggaga 3361 aaaaaaatta aaaattttca aaaatttaga aaatttttac ccgtaagtat tacagtttcc 3421 taattatcct atttatttcc cacttgcctt tgacctagat tatttagagt agggtttctc 3481 agcctctgca ctaatgacat tttgggccga ataattctgt tgtaggaggc tgtcctgtgt 3541 gttttagatt gtttggaatt atccctggcc tctcacacta gatgccagca gtatcctcct 3601 cccccagtgt gacaacctaa aatgtctcca gacattgcca aatgttccct gtggggcggg 3661 ggcaacattg cctactgtta agaactactg ctctagacca aagaacacag cacagaggaa 3721 aggaaaaaaa aatccagtta agagaatgtt aggtggagat gactatagtc atcaaacttt 3781 tttccccatc aagtatttcc aagctaacat agtgacaaaa taattcctgt actctactgg 3841 taacgttaat ctagtgctct tcctttaatt cttccgtttt gttttctttt gcagaattaa 3901 gaatatgttt ccttgtttat cagatacatc actgcttgat gaagcaagga agatatacat 3961 gaaaatttta aaaatacata tcgctgactt catggaatgg acatcctgta taagcactga 4021 aaaacaacaa cacaataaca ctaaaatttt aggcactctt aaatgatctg cctctaaaag 4081 cgttggatgt agcattatgc aattaggttt ttccttattt gcttcattgt actacctgtg 4141 tatatagttt ttacctttta tgtagcacat aaactttggg gaagggaggg cagggtgggg 4201 ctgaggaact gacgtggagc ggggtatgaa gagcttgctt tgatttacag caagtagata 4261 aatatttgac ttgcatgaag agaagcaatt ttggggaagg gtttgaattg ttttctttaa 4321 agatgtaatg tccctttcag agacagctga tacttcattt aaaaaaatca caaaaatttg 4381 aacactggct aaagataatt gctatttatt tttacaagaa gtttattctc atttgggaga 4441 tctggtgatc tcccaagcta tctaaagttt gttagatagc tgcatgtggc ttttttaaaa 4501 aagcaacaga aacctatcct cactgccctc cccagtctct cttaaagttg gaatttacca 4561 gttaattact cagcagaatg gtgatcactc caggtagttt ggggcaaaaa tccgaggtgc 4621 ttgggagttt tgaatgttaa gaattgacca tctgctttta ttaaatttgt tgacaaaatt 4681 ttctcatttt cttttcactt cgggctgtgt aaacacagtc aaaataattc taaatccctc 4741 gatattttta aagatctgta agtaacttca cattaaaaaa tgaaatattt tttaatttaa 4801 agcttactct gtccatttat ccacaggaaa gtgttatttt taaaggaagg ttcatgtaga 4861 gaaaagcaca cttgtaggat aagtgaaatg gatactacat ctttaaacag tatttcattg 4921 cctgtgtatg gaaaaaccat ttgaagtgta cctgtgtaca taactctgta aaaacactga 4981 aaaattatac taacttattt atgttaaaag atttttttta atctagacaa tatacaagcc 5041 aaagtggcat gttttgtgca tttgtaaatg ctgtgttggg tagaataggt tttcccctct 5101 tttgttaaat aatatggcta tgcttaaaag gttgcatact gagccaagta taattttttg 5161 taatgtgtga aaaagatgcc aattattgtt acacattaag taatcaataa agaaaacttc 5221 catagctatt cattgagtca aattgtaatg tgctttacca aacaaggtat ttgacctggc 5281 attctagtca tatttacaca aatgtaaatg tgaagtggca aatacctagg taattcaggc 5341 ccacaactca gatgatgttt tatgtagtcc gaatgtagtt agcagttact attttccact 5401 tagctctgtg tgggaggaca aaactttaga aggtgaaaat ggaaaagcta cattttcata 5461 tgaataaggt tgtcaaaagt ctgcattagt aaaaatattt atgtcttcta ggatatgaat 5521 gtgtcaaaac caaagaatcc ttacataagt gtacactgac acatttgcag gattgaaaat 5581 gaaagtaaca tggtgacttc tctaaattct gtatttacac atgagaagtg tgaggaatta 5641 aagcaattgt ttggaccatc taatgtataa atcttgttta aaatattcaa acatatgggc 5701 ccttaagaaa ttggtgtgca ctctacg //