LOCUS CDK4 6663 bp DNA PRI 26-APR-2002 DEFINITION Homo sapiens CDK4: cyclin-dependent kinase 4 (CDK4) gene, complete cds. ACCESSION CDK4 VERSION KEYWORDS . SOURCE Homo sapiens. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6663) AUTHORS Rieder,M.J., Livingston,R.J., Braun,A.C., Montoya,M.A., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (26-APR-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..6663 /organism="Homo sapiens" /db_xref="taxon:9606" variation 224 /replace="T" /frequency="0.01" variation 260 /replace="T" /frequency="0.01" variation 329 /replace="A" /frequency="0.01" variation 342 /replace="C" /frequency="0.08" variation 557..558 /replace="-" /frequency="0.01" variation 667 /replace="T" /frequency="0.03" variation 724 /replace="G" /frequency="0.37" variation 1062 /replace="A" /frequency="0.01" variation 1246 /replace="A" /frequency="0.01" mRNA join(1279..1485,1924..2160,2318..2453,2570..2737, 2895..3004,4156..4206,4343..4478,5043..5440) /gene="CDK4" gene 1279..5440 /gene="CDK4" CDS join(1943..2160,2318..2453,2570..2737,2895..3004, 4156..4206,4343..4478,5043..5135) /gene="CDK4" /codon_start=1 /product="CDK4: cyclin-dependent kinase 4" /translation="MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGG GGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT YLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG LARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEML TFNPHKRISAFRALQHSYLHKDEGNPE" variation 2287 /gene="CDK4" /replace="A" /frequency="0.19" variation 2344 /gene="CDK4" /replace="A" /frequency="0.01" variation 2510 /gene="CDK4" /replace="T" /frequency="0.01" variation 2522 /gene="CDK4" /replace="C" /frequency="0.03" variation 2662 /gene="CDK4" /replace="G" /frequency="0.01" variation 2778 /gene="CDK4" /replace="A" /frequency="0.38" variation 3038 /gene="CDK4" /replace="C" /frequency="0.01" repeat_region 3082..3364 /rpt_family="Alu" /rpt_type=dispersed misc_feature 3286..3421 /gene="CDK4" /note="Region not scanned for variation" repeat_region 3454..3652 /rpt_family="Alu" /rpt_type=dispersed misc_feature 3495..3655 /gene="CDK4" /note="Region not scanned for variation" repeat_region 3653..3942 /rpt_family="Alu" /rpt_type=dispersed variation 3734 /gene="CDK4" /replace="T" /frequency="0.04" repeat_region 3943..4049 /rpt_family="Alu" /rpt_type=dispersed variation 3956 /gene="CDK4" /replace="A" /frequency="0.01" variation 3998 /gene="CDK4" /replace="G" /frequency="0.01" variation 4355 /gene="CDK4" /replace="A" /frequency="0.01" variation 4436 /gene="CDK4" /replace="A" /frequency="0.01" variation 4517..4518 /gene="CDK4" /replace="-" /frequency="0.05" variation 4589 /gene="CDK4" /replace="T" /frequency="0.40" variation 4593 /gene="CDK4" /replace="C" /frequency="0.02" repeat_region 4655..4965 /rpt_family="Alu" /rpt_type=dispersed variation 4712 /gene="CDK4" /replace="A" /frequency="0.01" variation 4797 /gene="CDK4" /replace="A" /frequency="0.03" variation 4819 /gene="CDK4" /replace="G" /frequency="0.01" variation 4918 /gene="CDK4" /replace="C" /frequency="0.01" variation 4949 /gene="CDK4" /replace="G" /frequency="0.08" variation 5179 /gene="CDK4" /replace="G" /frequency="0.01" variation 5345 /gene="CDK4" /replace="A" /frequency="0.01" variation 5505 /replace="G" /frequency="0.03" variation 5572 /replace="G" /frequency="0.03" variation 5575 /replace="C" /frequency="0.01" repeat_region 5619..5915 /rpt_family="Alu" /rpt_type=dispersed variation 5841 /replace="A" /frequency="0.23" variation 5955 /replace="T" /frequency="0.01" variation 6023 /replace="G" /frequency="0.03" BASE COUNT 1640 a 1607 c 1671 g 1745 t ORIGIN 1 caaatgagac actaaccgct ttcctccttt actcccatac ccccaaaggg ctgggagata 61 aagaccttgg agccaataaa acaaagtagg agaaatctac ttgtgtctac ctaggtgtct 121 gggcagaggc catttgggaa caagtgtgtt ctggacagtg ctaagtgcta agaaagcggc 181 actagggaaa aagagggaag cacaataact ccaaatgagt agtcacaagg tttgcagaag 241 ggggcatgtc attttcattc attgtggtgg tctggagggt gcagggggtg tggtggtaac 301 tttcttgcac atgtgcaatc ctgtatccgt cttatatatg atgtgataaa taatatcata 361 tacatacata tatacataga agcatatatg cacacataca aatatcacat aatcatagaa 421 ccttcctact ggaaaaaaaa aaaaaactta aaaggtcaag tattcctgtc tcctgctcat 481 caataacttc tctgccagat ggcctcaggt ctttgcatta acactcccag ggaggtttgg 541 aagttggaaa agtgagagga ttaccttgtc actgagcctg ttggattact gtattaatct 601 gccttccgtc atcctttaat cgtagttttg ccctcaaatg ggcattgttt actccctatt 661 gtagaagacc ccattgttgg ctacatcttt atagatagtc gtaccactac tttaaagggc 721 cagtgacaga caccaaaaac aaaataaaaa cccacataca cactggaagc aagcactcag 781 taaaatgttg tagaattaat gaatgaaaca atgacacaaa tgagagtatg ttttctcatg 841 gtggagcgaa aaggtgacag catcacctct ggtaccccaa ctcccacccc ctccccaatg 901 cagacaggct gaaagaccgg tagtgagact ggagttcagc cttcagaccg gtagtgagac 961 aatccttcag ccgggagttg ggctctgggt ggcctaggtt gccatggcac cgcctcgggc 1021 tccaccctct cttgtccccc tcaccgctcc ccccctgcag cgggggttgt ggcagccagt 1081 cacgtgcccg ccgcgtagcc acacctctgc tcctcagagc aatgtcaagc ggtcacgtgt 1141 gatagcaaca gatcacgtgg ctgccatcgc ccctccgccc ccttacactc ttcgccctcc 1201 tcccagtcga agcacctcct gtccgcccct cagcgcatgg gtggcggtca cgtgcccaga 1261 acgtccggcg ttcgccccgc cctcccagtt tccgcgcgcc tctttggcag ctggtcacat 1321 ggtgagggtg ggggtgaggg ggcctctcta gcttgcggcc tgtgtctatg gtcgggccct 1381 ctgcgtccag ctgctccgga ccgagctcgg gtgtatgggg ccgtaggaac cggctccggg 1441 gccccgataa cgggccgccc ccacagcacc ccgggctggc gtgaggtaag tgcagtccct 1501 tcccaggaat gagaaccagt gcccgccccc ctcacagctt tccacgcgtt cgtttcgcga 1561 gctggttatg gaagggtcgc tcaagggcgg gaagtggggc ctttgtggtc atgggaaagt 1621 ataattttag ggactgaggt gtaggatctt cgatgcaagg catgtgtcat gtgtgatctt 1681 tgtgcggggc gcgattgtcc caaaggaaaa agcgttttct attgcagggc ctcacgtggc 1741 tggaggggtt ggtattgagt cattgtgtta tctctggggc cggccccaag gaagactggg 1801 agcgggggat gggatgctgg tggtgttctt tgcgcttttt ttttgggagt ccctttgttg 1861 ctgcaggctc ataccatcct aactctgtaa gcgacttttg gtgataggag tctgtgattg 1921 tagggtctcc cttgatctga gaatggctac ctctcgatat gagccagtgg ctgaaattgg 1981 tgtcggtgcc tatgggacag tgtacaaggc ccgtgatccc cacagtggcc actttgtggc 2041 cctcaagagt gtgagagtcc ccaatggagg aggaggtgga ggaggccttc ccatcagcac 2101 agttcgtgag gtggctttac tgaggcgact ggaggctttt gagcatccca atgttgtccg 2161 gtgagaaggt ggtggagggt tgggcgtggg gagtaaaggg aaaagacagc ctataggtgg 2221 ggtgtgatga tctgtagaga agtggggacc ctgaggaaat aatgagaggc catgttgggt 2281 taaaggggat tgaaaagtga gcatttactc tggtcaggct gatggacgtc tgtgccacat 2341 cccgaactga ccgggagatc aaggtaaccc tggtgtttga gcatgtagac caggacctaa 2401 ggacatatct ggacaaggca cccccaccag gcttgccagc cgaaacgatc aaggtgagtg 2461 gggttggtag gcattgagag gtggattggg acctttgtag tagaaccttc tgggatttca 2521 ggtatggtgc ctagtttcca gtgcatctgt acctcccctt tgaaactagg atctgatgcg 2581 ccagtttcta agaggcctag atttccttca tgccaattgc atcgttcacc gagatctgaa 2641 gccagagaac attctggtga caagtggtgg aacagtcaag ctggctgact ttggcctggc 2701 cagaatctac agctaccaga tggcacttac acccgtggtc agtagaaaga tggtaccaaa 2761 atgggttctg gttgggagta ggagagtgat tgcccgtagc aattgagaag tcatgtgctt 2821 catgtgttca gtcaagcaag ttgtgtttca tggtaaccca tggggtcccc atccattctt 2881 cctattccct ttaggttgtt acactctggt accgagctcc cgaagttctt ctgcagtcca 2941 catatgcaac acctgtggac atgtggagtg ttggctgtat ctttgcagag atgtttcgtc 3001 gaaagtatgg gacccacata ccctggacta ccttgaattc cccaaatcgc ttgttcataa 3061 accacatcca taccttgccc attctttttt tttgagacca gggcttgctg tgttgcccag 3121 gctggattgc aatggcatga tcacagctca ctgcagcttc aacctcctgg gctcaagtga 3181 tcctcccatc tcagcttccc aactagctga cactacaggc acgcacctcc atgcttggct 3241 agtttgttaa tatttttata gagatggggt ctcagtatat tgcccaggct ggtcttgaac 3301 tcttgcactc aagcaatcct cccaccccta cctcccaaag tagcataagc tactgcatct 3361 ggccccattc ttttacttgc gtactactaa cttgcccata gcagaaagct ctgaaatgtt 3421 ctggaattag gaacttcata tccctttatt ctctttattt tttatttatt tatttattta 3481 tttatttatt tatttattta tttattgaga taaggtttca ctctgtcacc caggctggag 3541 tgcagtggcc caattacagc tcactgtagc ctctacctcc tgggctaaag caatcctccc 3601 atctcagcct cttgagtagc tgagactaca ggtgcacgcc accatgactg gctttttttt 3661 tttttagatg gagtcttgct ctgtcgccag gctggagtgc agtagtgcga tctctgctca 3721 ctgcaacctc cacctcccag attcaagcaa ttctcttgac tcagcctccc aagtagctgg 3781 gaccacaggt gcacgccacc atgctcagct aatttttgta cttttagtaa tgacagggtt 3841 tcaccatgtt ggccaggatg gtctcgatct cttgacctca tgatccaccc acatcagact 3901 cccaaagtgc taggattaca ggcgtgagcc gctgcacctg gcatttcttt ttttttaaaa 3961 aaagagacaa ggtcttgctt gcccaggctg atctagaact cctgggctca agcagtcctc 4021 tcacctcagc atcccaaagt gctggaattg ttggccttta ttccctatac ttcctatttt 4081 gagccactaa gcagtaacca ttcaactaag atatctttga aaatgactgc taccttatat 4141 cccttctcac cttaggcctc tcttctgtgg aaactctgaa gccgaccagt tgggcaaaat 4201 ctttgagtaa gtgaccaaca tgggagaaaa agattttcta ttctgagtcc tctttctgct 4261 gaacccagga tggcaactgg ctctgcccat ggggatggga actggaggac cctcctgacc 4321 agagttctcc tgtcccccac agcctgattg ggctgcctcc agaggatgac tggcctcgag 4381 atgtatccct gccccgtgga gcctttcccc ccagagggcc ccgcccagtg cagtcggtgg 4441 tacctgagat ggaggagtcg ggagcacagc tgctgctggt actggagatg gctgtgggca 4501 cagggaaaga aatagagact ggggaaagaa atagagcagt atgcagggcc ctggccactg 4561 tggttaatga aacttggttg gtagatgggc tgtagttttt attacagctg caaatagcca 4621 cccacagaga aggatataga agagaaccca tcctggctgg gcacggtggc tcacgcctgt 4681 aatcccagca ctttgggagg ccaaggtggg cgtatcacct gaggtcagga gttcgagacc 4741 agcctggcca acatggtgaa acctcgtctc tactaaaagt acaaaaataa gccgggggtg 4801 gtggcacacg cctgtaatct cagctacttg ggaggctgag ataggagaat cacttcaact 4861 caggaggcgg aggttgcagt gagctgagat cataccattg cactccagcc tgggtgatag 4921 agcgagactc cgtctcaaaa aaaaaaaaaa agaaaaaaga agaaagctca tcccaggtat 4981 tgttgtgggt gggcagaagt ctgttttctt catggttttc tgacctttgc ctctcccctc 5041 aggaaatgct gacttttaac ccacacaagc gaatctctgc ctttcgagct ctgcagcact 5101 cttatctaca taaggatgaa ggtaatccgg agtgagcaat ggagtggctg ccatggaagg 5161 aagaaaagct gccatttccc ttctggacac tgagagggca atctttgcct ttatctctga 5221 ggctatggag ggtcctcctc catctttcta cagagattac tttgctgcct taatgacatt 5281 cccctcccac ctctcctttt gaggcttctc cttctccttc ccatttctct acactaaggg 5341 gtatgttccc tcttgtccct ttccctacct ttatatttgg ggtccttttt tatacaggaa 5401 aaacaaaaca aagaaataat ggtctttttt ttttttttaa tgtttcttcc tctgtttggc 5461 tttgccattg tgcgatttgg aaaaaccact tggaagaagg gactttcctg caaaacctta 5521 aagactggtt aaattacagg gcctaggaag tcagtggagc cccttgactg acaaagctta 5581 gaaaggaact gaaattgctt ctttgaatat ggattttagg cggggcgtgg tggctcacgc 5641 ctataatccc agcacgttgg gaggccaacg cgggtggatc acctgaggtc aggagttcga 5701 gaccagcctg actaacatgg tgaaaccctg tctctactaa aaatacaaaa ttagtcaggc 5761 gtggtggtgc acacctgtaa tcccagctac ttgggagact gaggcaggag gatcgcttga 5821 acccgggagg cagaggttgc ggtgagccga gatcatgcca ttgcactcca gcctgggcaa 5881 cagagcaaga ctctgtgtca aaaaaaaaaa aagaatatag atttttaaat ggcttttact 5941 tttatattcg ctaaactttc tcaaactgga tcctgcttat tacaggaaag agttcttggt 6001 tgttttctcc ttggccctat ccctgattta cccttagagc cacaccaggg tatgttgagg 6061 tgatccagta tatggacaga ggaagggaaa cagctaagaa tgactccagc ccccatccta 6121 tgcactcaca gaagcttccc atatcctctt ggagagagag gaagaaagtt tttcctttta 6181 ttccttatag tctggctccc actaaaatat gtcaaggcat aaagtcttgc tattccatca 6241 attttagagg atgtgacaag gggcctttcc tttttctcaa accaaaacgg ttacagaccc 6301 tagatattcc ctaagggagg aagagaaagc ttagagagag cagaagaaaa gtcagaagga 6361 tccaaagtct catagaaagg cactggggtt ggctctagga tccttctgat tccgaaatct 6421 cattgctagc caaacaccaa ggatctgtag gaacaaaggg agagagataa gtatcaatta 6481 attctcagtc tcaaaaagga tgtgtgtgag ggaactggag aatgttacct ctgtaaagct 6541 aaagaagagt ccaacacccc ctaggatttt cagggcttcg tctgaatgct taagaaactt 6601 ttctccacac atctggcatg tggggctctg gctcttgcag atctgaggat aaaacgtgaa 6661 gaa //