LOCUS CCNE1 13456 bp DNA PRI 04-JUN-2002 DEFINITION Homo sapiens CCNE1: cyclin E1 (CCNE1) gene, complete cds. ACCESSION CCNE1 VERSION KEYWORDS . SOURCE Homo sapiens. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 13456) AUTHORS Rieder,M.J., Livingston,R.J., Braun,A.C., Montoya,M.A., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (04-JUN-2002) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..13456 /organism="Homo sapiens" /db_xref="taxon:9606" variation 112..133 /replace="-" /frequency="0.09" variation 267 /replace="A" /frequency="0.36" variation 481 /replace="C" /frequency="0.13" variation 514 /replace="-" /frequency="0.18" mRNA join(690..812,1006..1074,5175..5320,5444..5579,8740..8886, 9760..9855,10034..10168,10278..10389,10484..10641, 11693..12350) /gene="CCNE1" /product="CCNE1" gene 690..12350 /gene="CCNE1" CDS join(747..812,1006..1074,5175..5320,5444..5579,8740..8886, 9760..9855,10034..10168,10278..10389,10484..10641, 11693..11815) /gene="CCNE1" /codon_start=1 /product="CCNE1: cyclin E1" /translation="MKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGS QPWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVW KIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDR YMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMI MKALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDC LEFPYGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHF RGVADEDAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGP EMA" variation 844 /gene="CCNE1" /replace="-" /frequency="0.44" variation 1148 /gene="CCNE1" /replace="T" /frequency="0.01" repeat_region 1322..1438 /rpt_family="MIR" /rpt_type=dispersed variation 1514 /gene="CCNE1" /replace="G" /frequency="0.01" variation 1515 /gene="CCNE1" /replace="C" /frequency="0.01" variation 1613 /gene="CCNE1" /replace="C" /frequency="0.21" variation 2271 /gene="CCNE1" /replace="G" /frequency="0.01" variation 2522 /gene="CCNE1" /replace="-" /frequency="0.16" variation 2579 /gene="CCNE1" /replace="T" /frequency="0.04" variation 2814 /gene="CCNE1" /replace="A" /frequency="0.17" variation 3008 /gene="CCNE1" /replace="A" /frequency="0.01" variation 3025 /gene="CCNE1" /replace="T" /frequency="0.19" variation 3536 /gene="CCNE1" /replace="G" /frequency="0.03" variation 3575 /gene="CCNE1" /replace="G" /frequency="0.01" misc_feature 3619..3747 /gene="CCNE1" /note="'Region not scanned for variation'" repeat_region 3660..3882 /rpt_family="Alu" /rpt_type=dispersed variation 3822 /gene="CCNE1" /replace="T" /frequency="0.01" repeat_region 3911..4211 /rpt_family="Alu" /rpt_type=dispersed misc_feature 4042..4262 /gene="CCNE1" /note="'Region not scanned for variation'" variation 4469 /gene="CCNE1" /replace="A" /frequency="0.09" variation 4487 /gene="CCNE1" /replace="G" /frequency="0.03" variation 4582 /gene="CCNE1" /replace="A" /frequency="0.09" repeat_region 4742..4897 /rpt_family="L1" /rpt_type=dispersed variation 5516 /gene="CCNE1" /replace="C" /frequency="0.02" repeat_region 5715..5895 /rpt_family="MER1_type" /rpt_type=dispersed variation 5766 /gene="CCNE1" /replace="C" /frequency="0.01" variation 5775 /gene="CCNE1" /replace="A" /frequency="0.04" misc_feature 5863..5971 /gene="CCNE1" /note="'Region not scanned for variation'" repeat_region 5896..6064 /rpt_family="Alu" /rpt_type=dispersed variation 6045 /gene="CCNE1" /replace="A" /frequency="0.10" repeat_region 6065..6363 /rpt_family="Alu" /rpt_type=dispersed misc_feature 6082..6803 /gene="CCNE1" /note="'Region not scanned for variation'" repeat_region 6364..6497 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6498..6685 /rpt_family="MER1_type" /rpt_type=dispersed repeat_region 6686..6801 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6802..7100 /rpt_family="Alu" /rpt_type=dispersed variation 6850 /gene="CCNE1" /replace="T" /frequency="0.03" variation 7029 /gene="CCNE1" /replace="A" /frequency="0.01" repeat_region 7101..7281 /rpt_family="Alu" /rpt_type=dispersed misc_feature 7134..7351 /gene="CCNE1" /note="'Region not scanned for variation'" repeat_region 7282..7336 /rpt_family="MER1_type" /rpt_type=dispersed repeat_region 7337..7619 /rpt_family="Alu" /rpt_type=dispersed variation 7433 /gene="CCNE1" /replace="A" /frequency="0.26" variation 7589 /gene="CCNE1" /replace="C" /frequency="0.01" repeat_region 7620..7754 /rpt_family="MER1_type" /rpt_type=dispersed variation 7624 /gene="CCNE1" /replace="G" /frequency="0.01" variation 7689 /gene="CCNE1" /replace="G" /frequency="0.03" repeat_region 7915..8017 /rpt_family="MER2_type" /rpt_type=dispersed variation 8010 /gene="CCNE1" /replace="G" /frequency="0.10" repeat_region 8010..8306 /rpt_family="MER2_type" /rpt_type=dispersed variation 8126 /gene="CCNE1" /replace="A" /frequency="0.01" variation 8263 /gene="CCNE1" /replace="C" /frequency="0.03" repeat_region 8307..8610 /rpt_family="Alu" /rpt_type=dispersed variation 8379 /gene="CCNE1" /replace="A" /frequency="0.03" variation 8503 /gene="CCNE1" /replace="T" /frequency="0.10" repeat_region 8611..8652 /rpt_family="MER2_type" /rpt_type=dispersed misc_feature 8902..9116 /gene="CCNE1" /note="'Region not scanned for variation'" repeat_region 9158..9448 /rpt_family="Alu" /rpt_type=dispersed variation 9285 /gene="CCNE1" /replace="T" /frequency="0.01" variation 9295 /gene="CCNE1" /replace="T" /frequency="0.03" variation 9347 /gene="CCNE1" /replace="T" /frequency="0.01" variation 9411 /gene="CCNE1" /replace="A" /frequency="0.01" variation 9481 /gene="CCNE1" /replace="T" /frequency="0.03" variation 9713 /gene="CCNE1" /replace="A" /frequency="0.01" variation 10005 /gene="CCNE1" /replace="T" /frequency="0.09" variation 10413 /gene="CCNE1" /replace="T" /frequency="0.01" variation 10475 /gene="CCNE1" /replace="C" /frequency="0.11" repeat_region 10700..10994 /rpt_family="Alu" /rpt_type=dispersed variation 10707 /gene="CCNE1" /replace="T" /frequency="0.22" variation 10734 /gene="CCNE1" /replace="G" /frequency="0.22" variation 11203 /gene="CCNE1" /replace="T" /frequency="0.03" repeat_region 11300..11621 /rpt_family="Alu" /rpt_type=dispersed variation 11502 /gene="CCNE1" /replace="A" /frequency="0.09" misc_feature 11557..12116 /gene="CCNE1" /note="'Region not scanned for variation'" variation 12147 /gene="CCNE1" /replace="T" /frequency="0.12" variation 12243 /gene="CCNE1" /replace="A" /frequency="0.29" variation 12307 /gene="CCNE1" /replace="G" /frequency="0.01" variation 12361 /replace="C" /frequency="0.02" variation 12401 /replace="G" /frequency="0.37" repeat_region 12459..12775 /rpt_family="Alu" /rpt_type=dispersed variation 12685 /replace="C" /frequency="0.01" variation 12865 /replace="A" /frequency="0.10" variation 13015 /replace="A" /frequency="0.03" variation 13186 /replace="-" /frequency="0.89" repeat_region 13188..13452 /rpt_family="Alu" /rpt_type=dispersed variation 13215 /replace="C" /frequency="0.02" variation 13280 /replace="G" /frequency="0.01" BASE COUNT 3261 a 3063 c 3305 g 3827 t ORIGIN 1 taaatgtccc gctctgagcc gggcgcagga gcagccggcg cggccgccag cgcggtgtag 61 ggggcaggcg cggatcccgc caccgccgcg cgctcggccc gccgactccc ggcgccgccg 121 ccgccactgc cgtcgccgcc gccgcctgcc gggactggag cgcgccgtcc gccgcggaca 181 agaccctggt gagtctactg ccgcgggctg cggacaggga ctcctggggc ccagaccgcg 241 ccggggagct gggtgggggc ggggtgcggc cgggtcgcgg gtccccgggc ggcgtcgcgg 301 ggcgcccggg agggtgctga gagcgcggcg gggtggggtg gaggggacac tgaggcagcc 361 cgggccccgg gaggcgacgg gccggtgagg gcggcggggg cggcgggacc ccgggtcggg 421 ggtcggcggg tgcccgggtc gcgggtgaca ggccaccccg ccatcggcca tcttcctggc 481 tcgcccggcc gcccgcgcgc aaagggggaa ggggtactgg gcccgcggcc tgaccccgcc 541 gccgcctcac cccgcgccgc cccgcaggcc tcaggccgga gcagccccat catgccgagg 601 gagcgcaggg agcggtgagt gcccgcgccg cggggccgga cgggacggga cgggacggga 661 cgggtggcgt gggggagggg cggccgcggg tgctcacccg gcccggtgcc acccgggtcc 721 acagggatgc gaaggagcgg gacaccatga aggaggacgg cggcgcggag ttctcggctc 781 gctccaggaa gaggaaggca aacgtgaccg ttgtgagtac aaaagagaca ggttggggag 841 catccccccc catctcacct gggtacccga cttggctctg cctacggggg cgggggtccc 901 ttgggcagga acggagctca taacctgatc agctttctct tcttctctct gtttttgtct 961 tgtttggtgt gtttccttgg ggtcatgggg gtggcttcat gttagttttt gcaggatcca 1021 gatgaagaaa tggccaaaat cgacaggacg gcgagggacc agtgtgggag ccaggtaggt 1081 ccgcccgggg ttgggcctct gtggaggtcc ttctccccct gggtcacatg gggtttcatg 1141 ctgtcttgtc tcttgctgga gacactctgg tgagagtgaa cttctctaat gcagccacag 1201 cccatatggc ccagcactgt acctgtcagt gggcactggc ctctgccagt cctgggattc 1261 caggaagctt ggtgttcctg actggcaccg tctgagatta cagatatgtg cctagcctgg 1321 aagaaccaga atggacatca cagtattcag tcctcccctt ctgcccagga ggaaactgag 1381 actcagttag aggaagaaag taacccagag tcctgtgcca tccaggggca aagttgggct 1441 ctcggccttg tctgtaaaag ctggtgaact gggggagggt tcctgggtgt ttataagcaa 1501 caactttccc cctatctaca cctatttttc ttgtcatggt gtttaaggac ctcctccgtc 1561 ttctgtaggt cagatttcaa attcttctcc tctttctggc cctggaagtt cttatagccc 1621 ctccagcaat tacctgcatt gatccccagc tcagcctgac ctcagcaaga gtatcagtgg 1681 aacattcagt gtaatgatag gtggtgtctc aatacatttt tttttgactg cttttctttt 1741 ctctccttaa ggagttcctg ccaaatttcc tgcatgcagt gtgataatca ttataatatc 1801 agaagtttct tgcagaaaaa gcttgtacta tctctttact ttcagaaatg gctggagact 1861 gtagttatgg ctccagtggg ggaagcagcc tatctctaaa ctagctggtc aggccttctg 1921 actctatcac agataaacgc tgaacagaaa cagtgttcga cctgagtgca gggatcccag 1981 ctaggttagc agagaagccc ctcactttgc agagcagcag ccagggtagt tcatctggaa 2041 gcgtgaaggg tttcaacgca gtgcgccgtg ttctaaatag cagttgtcac tgcatgtaag 2101 gtcccccgaa ataagcattt ctgaggaggg tccactgact attgaagaaa gggttgctga 2161 tttccttttt cattcaaaga aatcatttca gagacggaaa tgagacggca tatccccagt 2221 tttttttttc ttcccttaaa gtacattcaa atcaagcaag ttgatttttt aggtattata 2281 aaatgaattc tgactttgtg aaattcagga ctgtttattt tcccagctgt gttttgaata 2341 gaaaagaaac ttccagctga agatgaagca gggccgtccc tgttgcattc ttggagtttt 2401 agaagcatgt ctgttctcaa ggatagcctg agcagtgacg agggtgcctc ctgggacgga 2461 ttgtggctct gtcccctggc cacagtgtgg atagctgtgc tgccggaata gccataccat 2521 ttcccactag aaggcatttt cgtggttatc cagagattaa tggcgacaga tttctatacg 2581 ttttgtagag tagatagctt aaacattagc tgtctatgta tggagcagta tctttgttat 2641 ttctttgtgg agcttcatga aactagaact tgggggtaca acagaacctt tttccctgct 2701 cacatacaga atttttctct ggagttatca taattccccc cagtacgaca gtcttgagct 2761 acttggagcc attgtgccaa actcttgtgt aactgcttca tcgagaccac atggaagctt 2821 tttaattttc atcttaggct gttcttaatg aaaagaatac ccttttatct aagatctact 2881 taacacgtcc attttgttgt ttaatttttt tgcacaagac tcaatctttc tattgaagtg 2941 gaatcctgga ctgttacttt tcagaaaata atcctatgta aggaaaaaag tggtatgagg 3001 agttggagtg gttaggaatc ccgtgggtct cttattgtta tctcattctt tcctaaataa 3061 agtcagacag atcttgcttt gaaacttggt gtacactcaa ggacatagac ttaattattc 3121 tacctcatcc actggtccct aaaaaggcca actttggaaa ccatttgtct gctgatggtt 3181 cacctagttt gggaactgct gctggactca tctatgtcca aaggcctgct ctcagatgtg 3241 ccagccatct ggctgtagag ggtggcaccc agcattatgc cttcaagact agaattcatt 3301 cttcctgaat gaagaacaac ttacagcggt tgtaatgtga ccctttttga gttaaggaaa 3361 tgccacccgc acatggtact agaactgaaa ggaagcagcc ttgctcgcac agctgttggc 3421 aggagctgtc atggataatt tgcatgccca attctttgta cattgggtgg ggaagagctt 3481 tatctggctt tgctcttcta actgaaagtg cttgggcttc ctctgaaggc ggccaatgtg 3541 ttgtggtcgc caccatgtgc tgtgtcttcg aggtagcact tacagcccga gtttccactt 3601 tcatttatag tgaccccagt tgtctatttt gttctttagt caatgttaat ggtctctgct 3661 tttttttttt tttttttggg ggggggacag agtcttgctc cgtcacccag gctggagagc 3721 aatggcgcga gctcggctcc ctgcaacctc cgcctcccag gttcaagtga ttctcctgct 3781 tcagcctccc gagtagttgg gattacaggc gcccgctacc acacccggct aatttttgta 3841 tttttagtag agacggggtt tcaccaggtt ggccaggctg gtggtctctg ctttaaaaaa 3901 aaaaaaaaat gccaggtgcg gtggctcagg cttgtaatcc cagcactttt ggaagacaag 3961 gcaggaggat ggcttgagtc caggagttcg agaccagcct ggacaacatg gcaaaacccc 4021 atctctacaa aaaaatacaa aaattagctg ggtgtgctcg ctgcatgcct gtagtcctag 4081 ctgctcagga ggctgaggca ggaggatcgc ttgaccccag gaggcagagg ttgtagtgag 4141 ctgagattac accactgcac tccagcctgg ggaacagagg gagaccctct ctcaaaaaaa 4201 aaaaaaaaaa agccaagtct cagactttca tatggcttcc atgctagtag gattgttacc 4261 tgcctaatat ctttagcaaa gttactattt tataacttta aaaatcaaac agacttctta 4321 gagtaggaat agctttaaaa atgaaaatat tctaaatgga ctttagtgtt tttcagatat 4381 tgaaaattga atacatatct gaaaccttta aaagaaaagc atagtgcttt ggtttctaat 4441 agttccttat tttatcaggt atttgaatta ccctgcaaga ctcaggagat tcagaggtct 4501 taaggagtgt ctaggctagc ttcctgtaga cttcatagta tgacctgtga ccatcacttg 4561 atttggtttt aactaggtgg atgttcattc tgtttgtttc gagttaagga aaagaaaaag 4621 tcctttatta tttaacatat ttggctagtc ctgcaacaaa aagaaaatgt cacatttgat 4681 gagtttttgt tttaaactga ggggacttta atacatatgg cagccaaatt tacatttttg 4741 atcttttttt tattatactt ttaagtttta gggtacatgt gcacaacgtg caggttagtt 4801 acatatgtat acatgtgcca tgttggtgtg ctgcacccat taactcatca tttaacctta 4861 ggtatatctc ctaatgctat ccctcccccc tcccccccat ttttgatctt ttatactaat 4921 gaatgtgaag tgcttatgta aatattttta ttgacagttc tgttttactt ttaagaaatt 4981 ttagtagatg cattgtactc attaaaaaaa tctttgagtt gtgacaaaaa atatcataat 5041 gtatcttttt ggaagcactt tcagaagtca tgcctagtat cttactgagt tgcaggtgaa 5101 tttgtaatgt ttttgggtaa tgtaagagct gtttgcatct tatctcacct ctcctgtgta 5161 tttttcattt acagccttgg gacaataatg cagtctgtgc agacccctgc tccctgatcc 5221 ccacacctga caaagaagat gatgaccggg tttacccaaa ctcaacgtgc aagcctcgga 5281 ttattgcacc atccagaggc tccccgctgc ctgtactgag gtcagtgccg actctgccac 5341 atggcttcca ggtctcttac tccatgctcc cctttatccc tcatagcatg gacgcattct 5401 tacccctttg tgggcctcat ttttgttgtg tgttttgttg tagctgggca aatagagagg 5461 aagtctggaa aatcatgtta aacaaggaaa agacatactt aagggatcag cactttcttg 5521 agcaacaccc tcttctgcag ccaaaaatgc gagcaattct tctggattgg ttaatggagg 5581 tgagcttgag tcttcctgtt cgcttcatga aagcactgag catttccagc atttttgtgt 5641 attaggacct ctgtgtggtt tattccctcg acatgttctc catctctgaa gctatatggt 5701 atatttttac tgtggtggtc tttctgtttt gcttgtattc ttagcaagaa tttctgaaat 5761 ctttttatcc ttcagatgtt ttaaaattgg catctaattt tttccatcca agtttaaata 5821 attgttaaga ttgtattttc cagtaaattg taactgttaa catttgagct ttgttcatta 5881 tgttcattaa attgcttttt tttttttttt ttttttgaga tggagtcttg ctttgtcacc 5941 caggctggag tgcagtggca caatctcagc tcactgcaac ctctgcctca cgggttcaag 6001 tgactttcct ggcctcagcc tcctgagtag ctgggattac aggcgcacgc catcacgccc 6061 agtatttttt tttttttttt ttgagacgga gtcttgctct gtcacccagg ctagagtgca 6121 gtggtgcgat ctcagcttac tgcaagctcc tcctcccggg ttcatgccat tctcctgcct 6181 cagcctcccg agtagctggg actacaggcg cccgccacca cgtctggcta attttttgta 6241 tttttagtag aaatggggtt tcaccgtgtt agccaggatg gtctcgatct cctgacctcg 6301 tggtttgccc gccttggcct cccaaagtgc tgagattaca ggcgtgagcc accgcaccct 6361 gcctaatttt tgtattttta gaagaaacgg ggtttcacca tgttggccag gctggtcttg 6421 aactcctgac cttgtgatcc acccacctcg gcctcccaga atgctgggat tacaggtgtg 6481 agccaccatg cccagctaaa ttgcttttaa atgtattcac tgggatgcat atatcacctg 6541 ttttatagct actgtcataa attgtaaaca tatatgaaca agcttatctt aaacaggtct 6601 gacattgctc ctttttaact tcttggaatc cattcccttt tccaccattc ccatttattc 6661 taataaaata tattgttcaa atcctggctg ggcacagtgg ctcatgtctg taatcccagc 6721 actttggaag gccaaggcag aaggatccct tgagcccagg agttagagac tagcctgggc 6781 aacatagcga gaccccatgt cttttttttt tttttttgag acggagtttc gctcttgttg 6841 cccaggctgg catgcaatgg tgtgatcttg gctcaccaca acctctgcct cccgggttca 6901 agcgattttc ttgcctcagg ctcccgagta gctgggatta caggcatacg ccaccacgcc 6961 cggctaattt tgtattttta gtagagacgg ggtttcctcc atgttggtca ggctggtctt 7021 gaagtcccga cctcaggtga tccgcccgcc ttggcctccc aaagtgctgg gattacaggc 7081 gtgagccact gcgcctggcc cttgagaccc catttcaaca aaaaataaaa aattgtcagg 7141 gtatagtggc tcaggcttgt agtcacaact actggggagg ctgaagtggg aggattgctt 7201 gagcctggga gttggagctt gcagtgagct gtgatagcgc cactgcactc cagcctaggt 7261 gaccatgaga ctctgtctca attttttttt taagcatatt tttaaagata tttggaccat 7321 tggagtggct tctgtgtttt gagacagagt tgctctgtca cccaagctgg agtgtagtgg 7381 tgcagtcacg gctcactgca ggctccaatt cctgggctca agcagtcctc ccgcctcagc 7441 ctccgcagtc cttgggacta caggcatgag ccactactcc ctgccgattt tttatttttt 7501 gttgagttgg ggtcttgcta tgttgccccg gctggtctcc aactcctggg atcaagggat 7561 ccccatgcct tggcctccca aagtgctggg attgcaggtg tgagctacag cacccaactc 7621 aaatcttttc ttggtccaca ctattttatt tctctttaac agttaatcaa aagaacaagt 7681 ataacaacat ttgatagata atggttaaac ataaaagatg agattttatt ggttgtatat 7741 cttactggga tgaactgcgg tagcttatag tttcttgatt aagggaagct tcctagacaa 7801 ccttgtaaga cttgaatggg tgagaagtgg gcttttcttc tgaagtggaa ggacatctca 7861 ggcagacctg cttcatgaaa acatgtagaa gttgagtgtg taactacaga agtacccctc 7921 atcctcgggg gtacatccca agacccgcag gagatgcctg aagccacaga tagtactgag 7981 ctctagatat gccatgtttt taatcctcta ctttcatgtt ttcacttaaa gaaagcactt 8041 cacggcttct ctttggcatt tccaaatagc cagcatcact actcttgccc tgtggggcca 8101 ttattcagtc aaataagggc tgcttgcttg aacaccagca ctgctgtgct gtgacagtcc 8161 atctgatgac ctgtgtgcta gtgagtgact aacaggcagg tggcctactc cacggggatg 8221 tgcgggcaag gggatgattc acatcctagg caggtgaggg tgggacaggc cagaagggcc 8281 cctcatttaa aacctatcag ttgttaggct gggcacagtg gctcatccct ataatcccag 8341 cactttggga ggccgaagca ggtggatcac ttgaggccgg gagttcaaaa ccagcctggc 8401 caacgtggtg aaataccatt tctactaaaa atacaaaaat tagctgggca tggtggcggg 8461 tgctggtaat tccagctact cgggaggctg aagcaagaga atcgcttgag cctggaagtt 8521 ggaggttgca gtgaaccaag atcacaacac tactttccag actgggtgac agaataaggc 8581 acctcaaaaa aaaaacaaaa aaacaaaaaa ctatcaattg ttgagttcag gaactttgca 8641 ttttatattt tccttcacca aagtcattac aagttttttt tttttcccct ccctcaagta 8701 aaacttactt gtgctaaaac ttactaaata tgttttcagg tgtgtgaagt ctataaactt 8761 cacagggaga ccttttactt ggcacaagat ttctttgacc ggtatatggc gacacaagaa 8821 aatgttgtaa aaactctttt acagcttatt gggatttcat ctttatttat tgcagccaaa 8881 cttgaggtaa ataattttca aatatttgtt ctataatgtg tgttatttct cgagctccac 8941 tgagattggg ggaagaggtt ggcgcttagc ctatagcact catcctaaat ttttctgatt 9001 tgctaccctg taaagttaag acacatgcca aaaagaaaaa aaggctggaa agtgaccagg 9061 aagagaaaag tagtgagggt atggaagacc taggttcatg tagttacatt gagccaaaaa 9121 aaaaaatgaa ctttgaacta agataataat tttgggcccg ggttggtggc tcaagcctat 9181 aatcccagca ctttgggagg ccaaggcagc tgggtcactt gaggccagta gtttgagaca 9241 tggtgaaata ccatttgtac taaaaataca aaaaattagc caggcgtggt ggcacgtgcc 9301 tgtaatccca gctattcggg aggctgaggc aagagaattg ctggagccca ggtggccgag 9361 gttgcagtga gtcgagatcc taccactgca ctccagcctg ggcaacagag ggaaattctg 9421 tctaaaagaa aaaagaaaag attaaaaatt tgtgtatgat tatcaaaggg tatatgggcc 9481 caactttcaa atgtgttaaa ggtactgaaa aggggatatt tcaagagtac ccacaatgag 9541 tcaaagttcc atccatttat ttaatggtgg gtgggagttg tgttcttttt tttttttttt 9601 ttttttttta caaccattgg tgtggcttct gtgttaattc catcagtgcg ccctctctct 9661 ttccatgcca gggtactgag aagtcatttt ggatgcatta taaattgaga ctgttagaga 9721 ttggctttgg tgctagtgcc atcttttatt tcctttcagg aaatctatcc tccaaagttg 9781 caccagtttg cgtatgtgac agatggagct tgttcaggag atgaaattct caccatggaa 9841 ttaatgatta tgaaggtggg ttccagtgaa ttttccggcc attttttaaa tgcgtacggc 9901 agatcttttc cacctgaagt gtgagtgcct ctgggaggtg ttctccagct ggacacattg 9961 tggcatggaa catggctgca ttttgaactt cttttctcaa tcatcggtct cttttctctc 10021 tgttttcctt taggccctta agtggcgttt aagtcccctg actattgtgt cctggctgaa 10081 tgtatacatg caggttgcat atctaaatga cttacatgaa gtgctactgc cgcagtatcc 10141 ccagcaaatc tttatacaga ttgcagaggt aagtggctcc atcacgtccg tggggccacc 10201 ttccctgcag ctggagtgag gaactctaga ataggcgtgt ggtggcatcc atctcagcgt 10261 tcttttcttc tccgtagctg ttggatctct gtgtcctgga tgttgactgc cttgaatttc 10321 cttatggtat acttgctgct tcggccttgt atcatttctc gtcatctgaa ttgatgcaaa 10381 aggtttcagg taagttggct ttccagtgca tgcacaaaca aggtgtacta agcttacatc 10441 cagttgtcag cctcagatta agcccacgat gtcttcactg cagggtatca gtggtgcgac 10501 atagagaact gtgtcaagtg gatggttcca tttgccatgg ttataaggga gacggggagc 10561 tcaaaactga agcacttcag gggcgtcgct gatgaagatg cacacaacat acagacccac 10621 agagacagct tggatttgct ggtcagtgct gctccttctt tcagtccttc ttggccaaat 10681 tcttaaaact gcctaaatag gccagccgcg gtggttcagg cctgtaaacc cagcactttg 10741 ggaggccgag gtgggccgat cacttgaggc caggagttca agaccagcct ggccaacatg 10801 gtgaaacctt gtctctacta aaaataaaaa aattagccgg ctatggtggt gggcacctgt 10861 agtcccagct actcgagagg ctaaggcagg agaatcatct gaacccggga ggcggaggtt 10921 gcagtgcgtt gagatcacgc cactgcactc cagcctgggc aacagagcga aactatgtct 10981 caaaaaaaaa aaaactgcct aaataacctg ttcacttttc ttcaggcagg ccccaaatat 11041 ccttgaaaaa ctccaatttt aattaattga aaaagaaaaa tcctggcaaa ttgatgctgt 11101 atctcactat catatagact atagagtttt aaagtgctct ttgatatttt tttttctttc 11161 actcacctcc gtagaaaaag acatagtggc cagacacagt ggcttttgga ggccaaggca 11221 gaaggactgc ttaagctcag aagtttgaga ctagcctgga caacataggg agaccctgtc 11281 cctaaaaaat ttaaaaacta gccaggcatg gtggcacatg tctgtagtcc cagcactttg 11341 ggaggcggag gcgggcagat cgcctgatat caggagttca agactagcca ggccaaaatg 11401 gcgaaaccct gtctctatga aaaatacaaa aattagctgg acatggtggc gggtgcctat 11461 aatctcagct actctacttg ggaggctgag gcgggagaat cggttgaacc ctggaagtgg 11521 aagttgcagt aagccgagat cccaccactg tactacagtc tggatgagaa agcaagtctc 11581 catcttgaga aaaaaaaaaa atttaaaaat taaaaaagaa aaagcctatg gtaattgaag 11641 cccaaggata tgttctactc taatgtgttg tcccttttat tcttaccaac aggacaaagc 11701 ccgagcaaag aaagccatgt tgtctgaaca aaatagggct tctcctctcc ccagtgggct 11761 cctcaccccg ccacagagcg gtaagaagca gagcagcggg ccggaaatgg cgtgaccacc 11821 ccatccttct ccaccaaaga cagttgcgcg cctgctccac gttctcttct gtctgttgca 11881 gcggaggcgt gcgtttgctt ttacagatat ctgaatggaa gagtgtttct tccacaacag 11941 aagtatttct gtggatggca tcaaacaggg caaagtgttt tttattgaat gcttataggt 12001 tttttttaaa taagtgggtc aagtacacca gccacctcca gacaccagtg cgtgctcccg 12061 atgctgctat ggaaggtgct acttgaccta agggactccc acaacaacaa aagcttgaag 12121 ctgtggaggg ccacggtggc gtggctctcc tcgcaggtgt tctgggctcc gttgtaccaa 12181 gtggagcagg tggttgcggg caagcgttgt gcagagccca tagccagctg ggcagggggc 12241 tgccctctcc acattatcag ttgacagtgt acaatgcctt tgatgaactg ttttgtaagt 12301 gctgctatat ctatccattt tttaataaag ataatactgt ttttgagaca gctggtttta 12361 tgagctatgt ctggtaactt aaggtagcag tcagctttaa ttgtggttat atcaacttct 12421 gttttttgac ttcatacttc ttgaggctca agtctttctt tttttttttt tttttttttt 12481 tttttttgag acagggacag ggtctcgctc tgtcaccaag gctggagtgc aggggcacaa 12541 tcttggctca ctgcagcctc tgcctcccgg gtttaagcga ttctcctgcc tcagcctcct 12601 aagtagctgg gactacaggc gtgtgccacc acacccagct aatttttgta tttttagtgg 12661 agatggggtt ttgccatgtt ggccaggctg gtctcaaact cctgacctca ggtgatctgc 12721 ccatctcagc cttccaaagt gctgggatta caggtgtgag ccaccacacc cagccttgag 12781 tcttaactct tttggtcaaa tacatttttc aatgtatttg atggaaagga aactttagac 12841 gtgggcttca ggtgcagcct gtctgcctcc tggtgccccc tgagctggaa gtgaggagtc 12901 cacctggtat ttgtctcacc acgccctgca ctggtggctg ctcacaccag gtttgttggc 12961 catcagtagt agtagtgatg aggtaatgtc cacaccgaag aggattccta ggtgtaactt 13021 ccttcctagg actggttaaa ggccataagg aatctggaat tagcatgatt taatgctttt 13081 ttttttttcc ccttaccgaa atcttagcct aaagaataag tgaattttta tttggagaac 13141 ttttaacata gtagcctaaa actgctttta agaagaaaat gaggcttggg tgcggtggct 13201 catgcctgta atcctagcac tttgggaggc caaggtgggc ggatcacaag gtcaggaaat 13261 cgagaccatc ctggctaaca gtgaaactcc gtctctacta aaaatagaaa aattagccag 13321 gcatggtggc gggcacctgt agtcccagct acctaggagg ctgaggcagg agaatggcat 13381 gaacccagga ggcggagctt gcagtgtgct gagatcgcgc caccactcca gcctgggcaa 13441 cagagcgaga ctgtct //