LOCUS BLVRB 20922 bp DNA linear PRI 12-JUL-2003 DEFINITION Homo sapiens BLVRB: biliverdin reductase B (flavin reductase (NADPH)) (BLVRB) gene, complete cds. ACCESSION BLVRB VERSION KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 20922) AUTHORS Rieder,M.J., Livingston,R.J., Daniels,M.R., Chung,M.-W., Miyamoto,K.E., Nguyen,C.P., Nguyen,D.A., Poel,C.L., Robertson,P.D., Schackwitz,W.S., Sherwood,J.K., Witrak,L.A. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (12-JUL-2003) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..20922 /organism="Homo sapiens" /db_xref="taxon:9606" variation 131 /frequency="0.01" /replace="A" variation 135 /frequency="0.05" /replace="T" variation 141 /frequency="0.02" /replace="A" variation 273 /frequency="0.03" /replace="T" variation 547 /frequency="0.01" /replace="T" variation 653 /frequency="0.01" /replace="G" variation 862 /frequency="0.08" /replace="T" variation 955 /frequency="0.01" /replace="T" variation 989 /frequency="0.01" /replace="G" variation 1196 /frequency="0.01" /replace="" variation 1450 /frequency="0.06" /replace="A" variation 1520 /frequency="0.03" /replace="C" variation 1776 /frequency="0.03" /replace="C" gene 1820..19796 /gene="BLVRB" mRNA join(1820..1980,9045..9209,9346..9435,16098..16226, 19544..19796) /gene="BLVRB" /product="BLVRB" CDS join(1902..1980,9045..9209,9346..9435,16098..16226, 19544..19701) /gene="BLVRB" /codon_start=1 /product="BLVRB: biliverdin reductase B (flavin reductase (NADPH))" /translation="MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEG PRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHG VDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLT GAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ" repeat_region 2359..2490 /rpt_family="MIR" /rpt_type=dispersed variation 2462 /gene="BLVRB" /frequency="0.01" /replace="C" variation 2519 /gene="BLVRB" /frequency="0.01" /replace="C" variation 2665 /gene="BLVRB" /frequency="0.01" /replace="T" misc_feature 3108..8619 /gene="BLVRB" /note="Region not scanned for variation" repeat_region 3197..3521 /rpt_family="Alu" /rpt_type=dispersed repeat_region 3524..3818 /rpt_family="Alu" /rpt_type=dispersed repeat_region 3819..3986 /rpt_family="Alu" /rpt_type=dispersed repeat_region 4115..4307 /rpt_family="MIR" /rpt_type=dispersed repeat_region 4320..4465 /rpt_family="MIR" /rpt_type=dispersed repeat_region 4671..4980 /rpt_family="Alu" /rpt_type=dispersed repeat_region 5013..5313 /rpt_family="Alu" /rpt_type=dispersed repeat_region 5414..5555 /rpt_family="MIR" /rpt_type=dispersed repeat_region 5660..5790 /rpt_family="L2" /rpt_type=dispersed repeat_region 5791..6091 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6092..6368 /rpt_family="L2" /rpt_type=dispersed repeat_region 6409..6523 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6563..6898 /rpt_family="Alu" /rpt_type=dispersed repeat_region 6979..7234 /rpt_family="Alu" /rpt_type=dispersed repeat_region 7235..7314 /rpt_family="Alu" /rpt_type=dispersed repeat_region 7720..8015 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8040..8151 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8233..8542 /rpt_family="Alu" /rpt_type=dispersed repeat_region 8638..8905 /rpt_family="Alu" /rpt_type=dispersed variation 8880 /gene="BLVRB" /frequency="0.01" /replace="G" variation 9102 /gene="BLVRB" /frequency="0.01" /replace="A" variation 9157 /gene="BLVRB" /frequency="0.01" /replace="T" variation 9185 /gene="BLVRB" /frequency="0.14" /replace="T" variation 9219 /gene="BLVRB" /frequency="0.01" /replace="A" variation 9225 /gene="BLVRB" /frequency="0.01" /replace="" repeat_region 9538..9823 /rpt_family="L2" /rpt_type=dispersed variation 9595 /gene="BLVRB" /frequency="0.08" /replace="G" repeat_region 9814..9890 /rpt_family="L2" /rpt_type=dispersed variation 9830 /gene="BLVRB" /frequency="0.06" /replace="T" repeat_region 9946..10187 /rpt_family="Alu" /rpt_type=dispersed variation 10200 /gene="BLVRB" /frequency="0.10" /replace="T" misc_feature 10297..14383 /gene="BLVRB" /note="Region not scanned for variation" repeat_region 10409..10598 /rpt_family="Alu" /rpt_type=dispersed repeat_region 10637..10983 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11168..11327 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11376..11479 /rpt_family="L1" /rpt_type=dispersed repeat_region 11620..11758 /rpt_family="Alu" /rpt_type=dispersed repeat_region 11869..12160 /rpt_family="Alu" /rpt_type=dispersed repeat_region 12444..12744 /rpt_family="Alu" /rpt_type=dispersed repeat_region 12746..13046 /rpt_family="Alu" /rpt_type=dispersed repeat_region 13109..13158 /rpt_family="MIR" /rpt_type=dispersed repeat_region 13163..13390 /rpt_family="Alu" /rpt_type=dispersed repeat_region 13391..13544 /rpt_family="Alu" /rpt_type=dispersed repeat_region 13586..13880 /rpt_family="Alu" /rpt_type=dispersed repeat_region 14099..14173 /rpt_family="L2" /rpt_type=dispersed repeat_region 14236..14377 /rpt_family="L2" /rpt_type=dispersed repeat_region 14392..14505 /rpt_family="Alu" /rpt_type=dispersed repeat_region 14510..14691 /rpt_family="Alu" /rpt_type=dispersed repeat_region 14696..15007 /rpt_family="Alu" /rpt_type=dispersed misc_feature 14840..15071 /gene="BLVRB" /note="Region not scanned for variation" repeat_region 15061..15284 /rpt_family="Alu" /rpt_type=dispersed variation 15196 /gene="BLVRB" /frequency="0.09" /replace="A" variation 15333 /gene="BLVRB" /frequency="0.01" /replace="T" repeat_region 15335..15710 /rpt_family="L2" /rpt_type=dispersed variation 15485 /gene="BLVRB" /frequency="0.03" /replace="A" variation 15593 /gene="BLVRB" /frequency="0.01" /replace="T" repeat_region 15758..16064 /rpt_family="Alu" /rpt_type=dispersed variation 15763 /gene="BLVRB" /frequency="0.16" /replace="T" repeat_region 16299..16334 /rpt_family="L2" /rpt_type=dispersed variation 16324 /gene="BLVRB" /frequency="0.01" /replace="C" repeat_region 16336..16602 /rpt_family="ERV1" /rpt_type=dispersed misc_feature 16380..19378 /gene="BLVRB" /note="Region not scanned for variation" repeat_region 16612..16695 /rpt_family="Alu" /rpt_type=dispersed repeat_region 16753..17051 /rpt_family="Alu" /rpt_type=dispersed repeat_region 17063..17166 /rpt_family="Alu" /rpt_type=dispersed repeat_region 17167..17366 /rpt_family="Alu" /rpt_type=dispersed repeat_region 17367..17672 /rpt_family="Alu" /rpt_type=dispersed repeat_region 17850..18044 /rpt_family="L1" /rpt_type=dispersed repeat_region 18051..18343 /rpt_family="Alu" /rpt_type=dispersed repeat_region 18390..18495 /rpt_family="L1" /rpt_type=dispersed repeat_region 18497..18780 /rpt_family="Alu" /rpt_type=dispersed repeat_region 18982..19281 /rpt_family="Alu" /rpt_type=dispersed repeat_region 19282..19376 /rpt_family="L2" /rpt_type=dispersed variation 19435 /gene="BLVRB" /frequency="0.07" /replace="A" variation 19783 /gene="BLVRB" /frequency="0.09" /replace="" repeat_region 19912..20216 /rpt_family="Alu" /rpt_type=dispersed misc_feature 20117..20349 /note="Region not scanned for variation" repeat_region 20238..20539 /rpt_family="Alu" /rpt_type=dispersed repeat_region 20543..20821 /rpt_family="Alu" /rpt_type=dispersed variation 20613 /frequency="0.05" /replace="A" variation 20630 /frequency="0.01" /replace="A" variation 20655 /frequency="0.01" /replace="A" variation 20683 /frequency="0.09" /replace="T" BASE COUNT 5122 a 5170 c 5545 g 5085 t ORIGIN 1 tcagaggctt taacccttcc caggccgcgc ctctctccct gcggtccaga cactgcgccc 61 aaggaggggg cctgggaagg acaaggcctg ggggtaagac ccacgcgtgg cgcggaagct 121 agaccgggtg ggggggttgt gggctcgtcc tgccctcgac cctttgcctc cctccagccg 181 gggagacccg gggctccagc catgccccgt gcgcgcggag gagggatgct cgccaggtgg 241 ggacatactt gggggagggg ctgtcggccc ccctagcagc tcacctgggc ccgcggccgc 301 cagcgtcgct gtctccgctg ctcgccgcga ccgaccgccc tccctgtcgg cgtccgctgc 361 ccggcccggc ccggcccggc ccagcccggc tcagctcggc cccgccggcc cgcggctcag 421 ccagatccgc atgcgccgcc gcgcctccct ctctcgcgcc gccgccgcgc tcagcgcgcc 481 cccgggaccc cctcccgccc gcggtccccg cgccccgccg cccgaggccc acgcgcagtc 541 acacccggcc gcggcgtggg gtgcacggct gcactcgcga gggcacggcg gcgtcacgcg 601 ctgcacactc ccacggggtc acgctcgcca cgctgccata ctcgcggggg cctcggcgca 661 caaactcacc cccgcatcca cgcgcttgcg cgccgtcact ccctcctgtg gggtctcacg 721 gggtcacacc ctcacgccgt cacacgcggc gtccacactg gaacggtgtc acccaccacc 781 acacaaatcc aatagggtaa ccaccgccca cgcggcgtca cacacaaatg cacctgtcac 841 acacagccgc acactccccg gcagtcacaa acagtgtcat aggcccacac atcacgcaca 901 gcttcacagc cacagtgtca cacactctac acactcgaac cttcatagca gtcgccccgc 961 acatgctgca ccgccgcacc tcacacatca tagtcacagg gggtcacaat gagcagctca 1021 acacagacac ccacagccac acactcgaat ggggtcccgg tgtcacacat ccttacacga 1081 gacatgtggt gtcacacact gtcacagtct aattagtctc acgcttccat gtagcacacc 1141 tcacacgtcc cacaccctat cgtacaggct gacgcagtgt cacccacggt gtcaccacaa 1201 ggtcacaaaa gaacagaatc aatgcctgcc acacgtggtg tcacgcacgt gtagtcacac 1261 tgtaacacgg gatcacactc agaggatgac acaaggtgtc acccacagtc ctgcttgccc 1321 tccgggtcac tgagtcacac agggtcatat aagtgcatag gtacgccgtg acacagtgtc 1381 ttacatccaa gtgcacacac acactctgtc ctcctaactt tctccccttg ctggttctgg 1441 gaggccctgg ggcttagagt gcgccccaga tccgctccag gctccgggag agggggcgtg 1501 agctacgaga ggccgtgggt gaggctcgcc tggccccgcc cctctccggg aggtggagcg 1561 cggaggcagg gcgctgagtg acaagttatc tcggctccgt ccactctatt tgttgctatg 1621 tggaggcgtg gccttctgtg gccccgcctt ccagtctaag tggcgcgcag agagggcggt 1681 gctggacggt gagcgaatgc aagctgacgc ctgccccgcc catccgcgtt aggccccgcc 1741 ccttgacctg agccgcgggc ggagagtctg aggcgtggcc cttcgagcca gctccgcccc 1801 gttgttcctg gcttgagtag ggcagagagc accgcccagc agccagtggg ttcccgcgcg 1861 tgccgagact ctgaggcctt gcacccccac gatcccgtac gatggccgtc aagaagatcg 1921 cgatcttcgg cgccactggc cagaccgggc tcaccaccct ggcgcaggcg gtgcaagcag 1981 gcatgagccg gggcgggcgg ggcatgtcac gggacagacg ggcagaactt taggaagggg 2041 caccatgggg tcgggccgag gctgattggg gccatgagcg ccccagccag gtgtatgagg 2101 actcaggggc caaagcaagt ggccacgggg gcagaaatgg ggaaagatgt gagatccaag 2161 tttatgtgag tccaagccag agaggaattg gccccgggag ccccgggagg actccactgg 2221 cacagtcgtg tgtaagtcca gggctcttat gcaatgcggt tgtcattatt gtggttgtgg 2281 tggtggttgt tcgcactccc agagaggatt tactaagcca agcttgctct gtcgtctctt 2341 cacatgagag ctttcaaaat ggggtgggaa ctagtatcac cctacttgac agatgagaaa 2401 actgagaccc agagagtgac ttgcccaata tcacacagct gttaactgac aggactggga 2461 tttgaactca gctcatgctc ttaaccacca caagtcccca ggctggaaac tgaaaaagtt 2521 ggggggtcag gttgctgcga gtacctaatg ggaaggagtc acagagagac atgagtgaag 2581 acttggggac agcagtcctg ggaaagtcaa tgagggctga aaatttggag ttgccccagg 2641 agagagggca gaaaagggga taaccatccc ccagcactcc ctgcccccac agcccagact 2701 tgaccaactc ccagctgggc ctgggacttc cagatatggg gccccaccct tgcaggcctt 2761 ggggacgctg aagatattga ctatctgcgt gccccaaaag ggtggaggcc aacaggaccc 2821 cactctgctg tctcccttgg agggactctg aaagttcttc tctaggtcca taactctccc 2881 cttccccagg gagaccacgt gaggatcttg acttgtggag aatggggagc tgtgggcctc 2941 tcagtaaaaa ccagtttgct gataagcatt tattcgggag taatggagaa ggaagtaaga 3001 gagagaagtt gagaggcgct gagtcacctg gaaatccact aattccaccg aattccactc 3061 gcccaccctg ctggtcatag ctgggactgc actcagaggg ttaagaactg gagcctaggg 3121 agcttcagag ctgtggctct gaaaaatctc ttcccagctc tcagctttgc tgtccccctc 3181 agcaaaggga agggctggcc aggcacggtg gatcatgcct ataatcccag cactttggga 3241 ggccaaggcg ggaggatggc ttgaggccag gagtttgaga ctagcctggg caacgtagca 3301 agaccccatc tctacaaaaa tacaaaaaaa aaataaatta gctgggcgtg gtgatgcatg 3361 cctgtagtcc cagctactca gaaggctcag gtgggaggat tgcttgagct caggagttca 3421 aggctacagt gagctgtgtt tgcaccactg cactccagcc tgggtgacag ggtgagaccc 3481 tgtctctcaa atttaaaaaa atacataaaa agaaagaaaa agaggctggg tgcggtggct 3541 cacgcctgta atctcagcac tttgggaggc tgaggcaggt ggatcacgag gtcaggagtt 3601 cgagaccagc ctggccaata tagtgaaacc ccgtctctac taaaaatacg aaaaattagc 3661 cgggcatggt ggctggtgcc tgtaatcgca gttacttggc agactgaggc aggagaatag 3721 cttgaatccg ggaggcagag gttgtggtga gccgagatta cgccactgca ttccagcctg 3781 ggcgacaaga gtgaaactct gtctcaaaaa aaaaaaaatt agctgggcac agtggtacgt 3841 gcctgtaatt ccaggtactt gggaggctga ggcacaagaa tcgcttgaac ctgggaggtt 3901 gcagtgagct aagattgcat cactgcacca ctgcactcca gcctgggtga cacagcaaga 3961 tgaaaggaaa gaaggaagga agaaaaggag ggagggatgg agggagggag ggagggaagg 4021 aaagaaggga gggaaggagg gagggaggga gggagggagg gagaaggggc ttggattaac 4081 tggagttcac aatggttctg tagggccaag agtcttaaca ggcatgaact ctggtgccag 4141 cctgcccaca ttcaagtcac cagctctgcg gcttacagcc tttgtgacca aatgccttgt 4201 catctgtgta cctagatatg tgtaagatca tgacaaaact ggtagtactt gccctagggc 4261 tcttgggata attaaatgag atcttatata ggaggtactt agactagcat tgaattttgc 4321 agtctctgga tcagacttac ttaggtaaaa attcaacctt ctctacctac tagctgtgtg 4381 atcctggccc ggttgcctaa aattgcctca gtttccccat caatgtggac aggataatga 4441 tacctacctt gcagggttgt tgcaacctga tgcttctcaa actgtgagtt acaatgagat 4501 ctgaaacata tggtcacaac gtgtatcaac aatatagggt aacaaatgat gacatagtat 4561 caaaatgtat cacatgttaa gtattagttt tgtgaaactc attttaatta tatatgtatg 4621 cgtttgtgta caccaggtta ggcaatgaaa ttttttgtat tgatggctga tttttttttt 4681 tttttttttt tttttttgag acaagagtct cactctgccg cccaggctgg agtgcagtgg 4741 cacaatctta gctcactgca agctccgcct cccgagttca gccattctcc tgcttcagcc 4801 tcccaagtag ctgggactac aggcgcctgc caccatgccc agctaatttt ttttgtattt 4861 ttagtaaaga tggggtttca ccatgttaac caggatggtc tccatctcct gacctcatga 4921 tccgcccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc acgcccggcc 4981 aatggctgag attttcaaaa agcttaaaaa gaggccaggc accatggctc acgcctgtaa 5041 tcccagcact ttgggaggcc aaggtgggcg gatcacaagg tcaggagatc gagaccaccc 5101 tggctaacac cgtgaaaccc catctctact aaaaatacaa aaaattcgcc gggtgttgtg 5161 gtgcacacct ataatcccag ctactctgga ggctgaggtg ggagaatcgc ttgaacctgg 5221 gaggcggagg ttgcagtgag ctgagattgc gccactgcac tccagcctgg gcaagagagt 5281 gagacttcat ctcaaaaaaa aaaaaaaaaa gaatgcccat attggcccat gcaagcccct 5341 gctgctcccc catgtgtgag ggcagcacag atcttgtgtc attcccctat gaaaggtggt 5401 cacatagcac ggggaggctg gtgctgtgat cctcacttca gagatgagga agctgaggtc 5461 caatcacgga agaggttgca tgaggttcct cagctggtaa gtggcagagc tggagtttgg 5521 atcaaggtcc ctggggcagt aatgcctgtg cttttgtgtt tacaaaggtt cagggagatg 5581 gcagaaaaca tgacacagtc cctggaccca cagggtgctt ggtttgctgc aggtcagcat 5641 aaagagggct gtgacagagg aagtacaagt tactgggggg accgggtaaa gagggtaaag 5701 ggtgttccag gcagagggca cagcacgtgc aaagtccagg aggcaggaag cagcaccatg 5761 catttgagga actgaaagaa gagcagttgg ggccgggtgc agtggctcat gcctgtaatc 5821 ccaacacttt ggggggctga ggcaggtgga tcacacagtc aggagttcga gaccagcctg 5881 gctaacatcg tgaaacccca tctctactaa aaatacaaaa aaattagcca ggcatggtgg 5941 caggcgcctg taatcacagc tactcaggag gctgaggcag gagaatcgct tgaacccatg 6001 agacggaggt tgcagtgagc cgagactgca ccactgcact ccagactggg caacagagcg 6061 agactccgtc tcagaaaaaa aaaaaaaaaa atgtgctgtg ggtgaagagg gcagaggctt 6121 cagcagagcc tggagaggag aagccagatc ccgaggggcc tggaaggctg gcatgaggag 6181 catgggtttt atcacagggc atttcaggct tgcgggaggc aactgagcag agaggcactt 6241 aaatattact gtggagaact ctgtctggct gctgtgtgga atatggattg gagagggcag 6301 gactgggtcc aggagcccag ggaggaccca ggaaagggac caggaaggag acgtaggcct 6361 ggatcaggcc aggagataaa gttgcaaaat ggttacaagg tgtaataggc cacgctcggt 6421 agctcatgcc tgtaatccca gcactttggg aggccatgcc aggcagatta cttgagtcca 6481 ggagttcgag accagcctgg ccaacatgca aaaccccatc tcttttttta atttttttat 6541 tgtgtctttt tgggtttttt ggttttttat gtttattgtt gttgttgttg tttgttttgt 6601 tttgttttgt tttgtttgag acggagtttc gctcttgttg cccaggctgg cgtgcaatgg 6661 cacaatctca gctgactgca atctctacct cctgggttca agcgattctt ctgcctcagc 6721 ctcccaagta gctgggatta caggcatgca ccaccatgcc tggctaattt tgtattttta 6781 gtagaggcgg ggtttccctg tgttggtcag gctggtcttg gacttccaac ttcaggtgat 6841 ccacctgcct tggcctccca aagtgctggg attacaggcg tgagccatcg cgcccagcac 6901 caggtaactc ttatttctgt gccaggtagt agcctaaact ttttgttaat ttaatttaat 6961 ttaatttaat ttaatttatt tatttatttt tgagacagag tcttgttctg tagcccaggc 7021 tggagtgcag tggtacaatc atagctcact acagcctcag ccacctgagt agctgagact 7081 acaggttgcg ccagcacacc tggctagatt ttttttattt tttttgcaga gacggggttt 7141 cactatgttg cccagtctgg tctcaaactc ctggcctcaa acaatcttcc tgtcttggcc 7201 tcccaaagca ctgggattat aataggcatc agcccaggaa tttgaggtta cagtgagcta 7261 tgattggcgc ccctgcactc cagcctgggc aacagagcaa gaccctgtct ctaaatatat 7321 atatatatat atatatatat atgttgctat tacagtatac ccaaatgtta acatcctttg 7381 ccaatgttta aaacaaagga agaaatatgt tagttgtgaa ctttaaaatg tgtgtgtatg 7441 tgtgtgtgtg ttgaagagaa acaaaattat ccaaaattat tttgggaagg aacatactaa 7501 gacaatatta aaaatcttta atgaccacta aaggagggct gggcttccca gcagtaaggc 7561 tgggcagcag gggctgggac caatcccagc actggtcagt ctgtaggcaa cccatgtccc 7621 cctcagaacc tcagtttctt ccaggaccat ggatgggaga cagagaccag tgcaatgcct 7681 gcattaaccc tttagttgtt agagggtagg gaagttgctg gctgggtaca gtggcttacg 7741 cctgtaatcc tagcactttg ggaggccaag gtgggtggat cacctgaggt taggagttca 7801 agaccagcct ggccaacatg gtaaaaccct atctctacta gaaacacaaa aattagttgg 7861 atgtggtggc atgcgcctgt agtcccagct actcgggagg ctgaggcaaa agaatcgctt 7921 gaacttggga ggcggaggtt gcagtgagct gagatcatgc cactgtgctc cagcctgggc 7981 aacagaggga gactctatct caaaaaaaat aataatgata gccaggtgtg gtggcacgtg 8041 cctgaacccg ggaggcggag gttgcagtga gccgagattg tgccactgca ctctagcctg 8101 ggttacagag tgagattccg tctcaaaaaa taataataat aataaataga aggtaaggaa 8161 tttacagggt gtggtgcttg gaggcttcag ttcagattat ttatgaatta tcatgaaggt 8221 atggtctttt tttttttttt tttttttttt tttttttttt ttgagataga gtctcgcttt 8281 gtcatccagg ctggagtgca ctggtgcaat ctctgctcac tgcaacctcc gcctgtcggg 8341 tcaagtgatt cttttgcctc agcttcccaa gtacttggga ttacaggtat gtgccaccat 8401 gcctggctaa ttttgtattt ttagtggcaa tggggtttca tcatgttgtc caggctggtc 8461 tcaaactcct gacctcaggt gatctgcccg cctcagcctc ccaaagtgtt gagattacag 8521 gcgtgagcca ccatgcctgg ccaaggtatg gtctatttta ataatcagcc caatactaag 8581 catcaactgt aggtatgcca gcaaaaatgt ttgaaggcca cggcgcagtg gctcatgggg 8641 aggctgaggc aggcagatca cctgagccca ggagttcaag accagcctgg gcaacatggc 8701 aaaacccctt ctctacaaaa gattgcaaaa ttagctgggt gtggtggtgc acactgtggt 8761 cccagctact tggggtgctg agatgggagg atcagttgaa ccccggaggt tgaggctgca 8821 gtgagctgtg actgcaccat tgcacagcag cctgggcaag tgagcaagac cctgtctcaa 8881 aaacaaaaca aacaaaaaga aaaaaccaaa aatgtttgaa gaccacttcc ccagaacaga 8941 ggaggggatg gatttgagag ttcatggtgg cttctaggac ccagctcctg gagcccaaga 9001 gtgccagccc actgaccagg ctctctgctc ctctttgccc acaggttacg aagtgacagt 9061 gctggtgcgg gactcctcca ggctgccatc agaggggccc cggccggccc acgtggtagt 9121 gggagatgtt ctgcaggcag ccgatgtgga caagaccgtg gctgggcagg acgctgtcat 9181 cgtgctgctg ggcacccgca atgacctcag tactgagccc cccctctgcc cacggccctc 9241 ccctacacct cggcccccag cgccaccccc gcccccggcc ccgcccctgc cacccctgcc 9301 gccgccgccg cccaccagtg acagccactc tctgtcccct ctaaggtccc acgacagtga 9361 tgtccgaggg cgcccggaac attgtggcag ccatgaaggc tcatggtgtg gacaaggtcg 9421 tggcctgcac ctcgggtggg tggtgggatc atggaggtgg ggctgaactg gggggtactg 9481 gggaggcagc ccaggggcct ctgaaaggtg acgctgaagc cattccatgt tactgtgcat 9541 ttactgaaca ccagctgtgt gcctgaacct tactgggtga tgctggggac acagtggtga 9601 cctgtacagc cctgggccct gctcacacaa ggctcacaga gagaggtggt aaacagatcc 9661 atgatcaaac tgacatccag atcatcggag ctgggatcgg gaggcaggca gaggggatag 9721 ggccacaatg ggagaaacta caggactatg ggagcccaga ggaggcgtcc gacttaggct 9781 gagagaggtc agggtaggcc tcccagagga agtgatagag ctgtggatag acactaggtc 9841 tctgccctca cagagctccc gattatgggg acacagacat taagcaaata gttgccctgt 9901 ataatcattt atttatttat ttatttattt atagttattt tgaggtttgt ttgagataga 9961 gtcttgctct gatgcccagg ctggagtgca gtggcgtgat cttggctccc tgcaacctcc 10021 gcctcccgga ggtggttctc ctgcctcaag tgattctcct gcctctgcct cccaggtagc 10081 tgggactaca ggtgtgcacc accatgccca gctaattttt gtatttttag tagagacagg 10141 gtttcgccat gttggccagg ctagtctcga actcctgacc tcaagtgtgt ttcatgacac 10201 aaattgcctc cctggaaagg gaagtggcat gagggagggc tgcctgatga ttgtaattac 10261 actccaggca gaggacaaag caagcaaaga ggcctggagg ccagacctag ttggagggta 10321 ggaagcaaaa tcatttatgg cttttttcct caagctctga aatggaaaag taatacacga 10381 gtaaacttgc gatttcagaa tggttcactt tttttttttt tttttgagac tttctgtcac 10441 ccaggctgga gtgcagtggt gcaaccatgg ctcactgcag cctcagtctg ggttcaagtg 10501 atcctcccca ctgcagcctc ccaagcggct gggactacag gcatgcacca ccacacctgg 10561 ctaatttttt gatatttttg tagagacaag gtcttacttt tgttcgcaga ttggaatggt 10621 ctgctgttaa ttttagtttt gtttttttct cccatgtctt tttttctttg agatgaagtc 10681 tgactccatt gcccaggctg gagtgcagtg gcgtggtatc agctcactgc aaccgccact 10741 ccacctcccg ggttcatggt gcctgggacc aagatcgtgg cccacagtga ttctcctgcc 10801 ccagcctcct gagtagctgg gattaccggc gcctgccacc atgccctgct aatttttgta 10861 tttttggtag agacaaggtt ttgccatgtt ggccaggctg atgttgaact cctggcctca 10921 agcagtcctc ccacctcagc cttccaaagt gctgagatta caggtataag ccaccacgtc 10981 cagactctcc catgtcttaa aaaccaattt aactggttaa gttttgcttc catgaaaaag 11041 acaaacctgt aaaattgatt taatttgctt tcttttttct catttttttt tgtttagatt 11101 gttttctaaa tattaaagtc ttaggtgtgc caggattttt tttttcatta aaaaaaaaac 11161 aaacatagag acaaggtctc gctctgtcac ccaggctgga gtgcagtggc ctgatcatag 11221 ctcattgtac ccttgaaccc ctgggctcaa ggaatcccct cactttagcc cctcaaatag 11281 ctggggcaac aggtatgagc cattgagtcc agcttaactt tttatctgga aatgatctta 11341 aacttacaga aaaattgaaa ggacaccagt acacctaccg tcctctgttc acagacacac 11401 aatgtttttt ttctgaccca tttgaagtta gcttacatac atcatggctg cttacttcaa 11461 tgtgtaggtc ctcaatatac tttttaactt tttattataa aaatttttaa acagaaaagt 11521 taatagtcgt gtgaacaacc atattccttt tcttttttta tttttaagtt tgtagctatc 11581 tatctattta tttatttatt ttgagaccgg gttataaggc tggctaattt ttgtattttt 11641 ggtagagata gagtttcgcc atgttgccca ggctggtccc gaactcccgg actcaagcga 11701 tccaccagcc tcagcctccc aaagtgctgg gattacacct gagccactgc acctggccaa 11761 cagccatatt cctgatttta aaattgtgat tgtgttttgt aattggttta tctatgcaca 11821 tacacataca caaatagatt ttgtttttgt tctcctaaac tatttgggtt ttttgtttgt 11881 ttgtttttat ttgagacaga gtctcattct gtcacccagg ccggaataca gtggcgtgat 11941 cttggctcac tgcaacatcc acctcctggg ttcaagggat tctcctgcct cagcctcctg 12001 agtagctggg attacaggtg cctgccacca catctggtta attttgtgtg tgtgtatttt 12061 tagtatagat ggggtttcac catattgggc aggctggtct gacctcaagt gatctggcct 12121 cccaaagtgc tggattacag gcatgagcca ctgcgcccag acttcctaaa ctatttgaaa 12181 tggagttgca cacccacaga caccttcggc aagtcccaag aaaaaggact tttctcttcc 12241 agcaccacag tgctattgtc acactttaat tatcttccag cctctaatta ttagagttta 12301 atcttccctc catattcaaa tgtcaaggta aaagattaga aagatttttg tcatctaagg 12361 agcttggagt ttatccatta gggcttgggg aggattgttt tttatggagg catctgagag 12421 gattagaaag aaacccagag taaggccagg cacagtggct cacgcctgta atcctagcac 12481 tttgagaggc caaggtgggc ggattgcttg cgtccaggag tgcaggacca gtctgggcaa 12541 cacagcaaaa ctccatctct acaaaaaaaa aatacaaaaa attagctggg tgtggtggta 12601 cacacctgtg gtccccaata cttgggaagc ttaggtagga ggatcctttg agcctagaag 12661 gcagaggttg cagtgagccg tgatggcacc actgcactcc agccttggct gcagagcaag 12721 accctgtctc aaaacacaac aaaacagccg ggtgctgtgg ctcacgcctg taatcccagc 12781 actttgggag gccaaggtgg gtggatcacg aggtcaggag attgagacca tcctggctaa 12841 cacagtgaaa caccgtctct actaaaaata caaaaaatta gccaggcgtg gcggcgggtg 12901 cctatagtcc cagctactcg ggaggctgag gcaggagaat ggcgtaaacc cgggaggagg 12961 agcttgcagt gagctgagat cgtgccactg cactccagcc tgggtgacag agcgagactg 13021 cctcaaaaaa aaaaagaaaa aagaaactag gggtaagtta gagactggat ttgagattgt 13081 gaactggaga ctggaggctg cagacaaaaa cccacttcac actctgcacc gcagttttct 13141 catctgtaaa gaggaaatcc tagaccaggc gcagtggctc acgctgtaat cccagcactt 13201 taggaggcta aggcaggtgg atcgcttgag gtcaggagtt cgagaccagc ctggccaaca 13261 tggtgaaacc ccgtctctac caaaaataca aaaactagcc aggtgtggtg gcacacgcct 13321 gtaatcccag ctactcagga ggcttaggca ggagaatcac ttgaaacttg taggtggagg 13381 ttgcagtgag aatgatgtca tcatagctcg ctaccgcctc caactcctag gctcaaggga 13441 tcctcctgag tagctgagac cacaggcatg tgccaccatg cccatctaat ttttaaaatt 13501 tttttgttgc gacagagtct ggctttgttg cccaggctgg tctctgtgac acaccttttt 13561 ataaccacta acattactca aactatttat ttatttcttt ttgttgagac aaggtcttgc 13621 tctgttgtcc aggctggagt gcagcggtgc aatcacagct cactgcagcc tcgaactcct 13681 gagctcaagc gatcctctcg cctcagcctt ctaagcagct aagaccacag gtccccacgc 13741 ctggctaatt ttttaatttt ctgtagagac aggtctcacc atcgtaccca ggtgagtcta 13801 gaactgctgg gctcaactga tcctcctacc tcagcctccc aaagtgctgg gattacaggt 13861 gtgagccact ctgcccagcc tttgaacaat ttatatcatc ccagtttgca catgaggaaa 13921 caagaagctg gccagtggtc gatccagtac ttgactttag gcaaaaccca agctctttaa 13981 ctattcacca aactgctcct aaaaatattt agcatagttc ttggcttgag gtaaaagttc 14041 tataaatgtc agctggtgta gcttggccaa gttatagctt gttgaaagct aattcctgaa 14101 caaatattta gtaagtacct acaatgttcc agatgcttct aagggctggg attggagcag 14161 gaaatgtgat agagtcacag gataactcta gcgtgtggtg gcaggggaag ggtcctaggg 14221 agaaaacaag gccccaagaa aagggattgg taaactgggc tgggggagac aggattttgc 14281 aattttaaac aggacagtca agaaaagctg catggaaagg tgacctttga gcaaagtctg 14341 caaagaaaac agggagccat gtggctacga gagggaaatg gcaaagggtc ctgggtcaca 14401 cctgtaatcg cagcatttta ggaggtcgag atggaaggat cgcttaagcc cgggagttca 14461 aaactagcct gggcaacttg gtaagacctc catcgctaca aaaaaaatgt ttttttcttt 14521 ttcttttgag acggagtctt gctctgtcac ccaggctgga gtgcaatggc acgatctcgg 14581 ctcactgcaa cctctgcctc ccaggttcaa gggattctcc tgcctcagct tcctgagaat 14641 agctgggatt acaggcatgc accacgacac ctggctaatt tttgtgtttt ttttgttttg 14701 ttttgttttg ttctgctttg tttttgagat ggagtcttgc tctgtctccc aagctggagt 14761 gccgtggcgc gatctcagct cactgcaacc tccgcctcaa gggttccagc aattctccag 14821 cttcagcctc ctgagtagct aggactacag gcatgcacca ccatgcccag ctaacttttg 14881 tatttttact agagatgggg tttcaccatg ttggccaggc tggtctcgaa ctcctaacct 14941 caggcgatct ggcctcctca gtctcccaaa gtgctgggat tacaggggtt agccaccaga 15001 cccggcctaa aaaaattttt taaattagcc aggcttggcc ggtatcatgc cattgcactg 15061 cagcctgggt ggcaagaggg aaggaaactc tgtctcaaaa aaaaaaaaaa atagtggggt 15121 ttggtggctc acccctgtgg tcccagctcc tcaggaggct aaggcaggag gatcacttca 15181 gcccagaaag tcaaggctgc agtgagccgt gttcacgcca ctgtcctcca gcctggacaa 15241 cagaatgaga ccctgtctca gagaaaataa aaaagagagg gaaatgcatc aggggcagag 15301 gaatcagaca ttgccaaggc tgggaggcag aacctggctg gagcagaggc gtgtaagaga 15361 gagtggtagg cagagtaggc aaggacgtca gagggctgat ggggccatat caggtggggc 15421 cttgagggct ggccatgggg actttgcttc taccctgagt gagatggagc tatggatgtg 15481 aactgatagg ggtgttcacg ggctccttgg gaggagggaa ggaggggctg agagaccagg 15541 gagtaggctg ctgggctggt ccaggcaaga ggtaacagtg gacaggacca ggcggagtga 15601 gaagaggtca gatttggaat tattgtgatc agcagacagc tcttacctgg ggtgtgaggg 15661 aaagaggagc cccagaggac tcccctgttt ttgcaactgg aaagcaatgg tcagccatgg 15721 cagggttttg tcctggcatc aagacaagcg agcccttggc tgggcacaat ggctcatgcc 15781 tgtaattcca gcactttggg aggtggagga gggtggatca cctgaggtca ggagtttgag 15841 accagcctgg ccaacatggc aaaaccctgt ctgtactaaa aatacaaaaa ttagtcaggc 15901 ctggtggtgt gcacctgtaa tcccagctac tggggaggct gaggcaggag aattgcttga 15961 acccgggagg cagaggttgc agtgagccga gattgcgcca ctgcactcag cctgggtgac 16021 aaagcgacac tctgtctcaa aaaaaaaaaa aaaaagacaa gagagcccag gctgatcctg 16081 ccctgtgttc cctccagctt tcctgctctg ggaccctacc aaggtgcccc cacgactgca 16141 ggctgtgact gatgaccaca tccggatgca caaggtgctg cgggaatcag gcctgaagta 16201 cgtggctgtg atgccgccac acataggtaa gcagggcagg gacctggtgg caccaatgcc 16261 atctgcctgt tccctcctgc cctctgggga gatctgcaag gccttccctg accaccctaa 16321 aattgcaaac cttcctatga tattgtgaca tatatatttg gcctttgtcc ctgtttcctg 16381 gcatacaact cctaaaatcc ttggaatctc caaaatggta aatgtctttt tctatgctaa 16441 tgagttcact gagagctggc agcccctagg cagcttcagg tctggtcacc agaaagacta 16501 aggctggatt acagggttgg gactttcacc tctggggagt ggtgagggat tgaaggttga 16561 ggggattacc actggctaat ggtttaatcc attatgtcta tggattctgg ggcttcagcc 16621 tcctgagtag ctgggattac aggcctgcat caccatgccc cgccatggct tacatttcta 16681 gtatgggaga tagagattag atagatagat agatagatag atagatagat agatagatag 16741 atagatacat aggccaggca tggtggttca cacctgtaat ctcatcactt tgggaagcca 16801 agacgggagg atttcttcag cccaggagtt tgagaccagc ctgggcaaca tagacttatc 16861 tctacaaaaa aaaaaaaaaa ttagctgggc gtcgtggcac acacctgtgg tcccagctac 16921 tgggaggcgg gaggatggct tgagcccagg agatcaaggc tgcaataaac tgttgcccag 16981 gctgctgtac tccagcctgg gtaatagagt gagaccctgt ctaaaaaaaa aaagaaaaag 17041 acaagaaaag atagatatta atggccgggt gcggtggctc acgcctgtaa tcccagcact 17101 ttgagaggcc gaggcgggca gatcacaagg tcaggagatc gagaccatcc tggctaacat 17161 ggtgaaaccc cattctcctg cccagcctcc cgagtagctg ggactacagg cgcccgccac 17221 cacacctggc taattttttg tattttttaa tacagacggg gtttcacagt gttagccagg 17281 atggtctcaa tctcctgacc ttgtgatccg cccgcctcgg cctcccaaag tgctgggatt 17341 acaggcgtga gccactgcgc ctggcttttt tttttttttt tttttttttt ttgagacaga 17401 gtcttgctct gccgccaggc tggagtacag tggtgcgatc ttggctcact gcaacctttt 17461 gcctcctggg ttcaagtgat tctcctgcct cagccccccg aatagctggg actacaggcg 17521 cgtgccacca cgcccagcta atttttgtat ttttagtaga gacggggttt caccatattg 17581 gccaagatgg tctcgatctc ttgacctcgt gatctgccca ccttggcctc ccaaagtgct 17641 gggattacag gcgtgagcca ccacgcccag ccaagtgtgt gaaaacttcc acacctcccg 17701 atttgaaagc attaaaggtt tatgaataca cataagccct ttgtttaggt tcaatgctta 17761 gcattttatc ctgttgtctc tccctctctc ctcctctctc tctctccatg aatatatagt 17821 tagattttgc tgaatatatt gtgaaaacat atatgcatat gtatatttgg cttaatcatt 17881 tgagaggaat tgcaacattg tcgcacttaa ctcctaaata cctagacagc catctcctaa 17941 aagaaagata tttgcacaca aaacatgctc acacctaagg aaagtgacat ttactctgtc 18001 atatcattta gtatccactc cgtagtaaaa tttccccaac tgtcaggcca gcgtggtggc 18061 tcacatctgt aatcccagca ctttgggagg ctgaggcggg tggatctctt gaggtcagga 18121 gttcaaaacc agcctggcca acgtggtgag accccgtctc tactaaaaat acaaaaatta 18181 gccaggtgtg gtggcggaca cctgtaatcc cagatactcg ggaggctgag gcacaagaat 18241 tgcttgaacc tgggaggtgg aggttgcagt gagccaagat tgcaccactg tactccagcc 18301 tgggtgacag agcaagactc tatccaaaaa agaaaaaaaa aaattcaacc cactctgccc 18361 tttttcttta agtttctcat aacattaacc aggccaggtg actttaaagg cccacattct 18421 ggatttttct agctgttttg tcacagattc agattaaaca tgttgggcag gaatgccaca 18481 tgggtgaagg tgtgtgttcc tttttttttt ttgagacagg gtctccctct gtagcccagg 18541 ctggagcgca atggcacaat cttggctcac tgcaacctcc gccttctggg ctcaagtgat 18601 tctcctgccc aagtagctgg gactacaggc ataagccacc acactcagcg aatttttgca 18661 ttttttgtag agatgtggtt ttgccatgtt ggctggtctc aaactcctga gctcaagtga 18721 tcctcccacc ttggcctccc gaagtgctga gattacaggc gtgagccact gtgcccagcc 18781 agggcaggag cttcctgtct gctttgtccc aagcaaacac acagccaagg gtgtgtgttc 18841 catactgtgc ataattccag cctgtctctg tttgggtgat ggtacattgt atccctaagt 18901 ttagttggtt actgtcagat agacagatat atatctatct gacaaatata tatatatata 18961 tatatatata tatatatata tttgttgttg ttgttgttag agacaaggtc ttgctctgtc 19021 gtcccggctg gagtgcagtg tcacgatcat ggctcactgt agcttcaact tccctggctc 19081 aagcaattct ccagcctcag cctcctgagt agttgggact acaggggcat gccactgcac 19141 ccggctgatt tttgtatttt tagtggactc agggtctccc tgtgttgccc aggatagttt 19201 caaactcctg ggcttgagtg atactcctgt ctcagcctcc caaagtgcca ggattacagg 19261 catgagccac cgccactggc cagggcaggg gattcctgtc tgctttgtcc cttgcttggg 19321 tgcccagcac ctggccacac aataggtaat caataaggat ttatcgaatg aatgaagcaa 19381 aggatataga tgagcacctg catatggaaa gtccattctt ggctgtgaca ccacccaggc 19441 tggacacaca gtaggcaccc tgggaaggtc tttctggggg tcgaattttg ggggaaggga 19501 aaggtgtctg ctttatccag cccctcttgt ctttacttca taggagacca gccactaact 19561 ggggcgtaca cagtgaccct ggatggacga gggccctcaa gggtcatctc caaacatgac 19621 ctgggccatt tcatgctgcg ctgcctcacc accgatgagt acgacggaca cagcacctac 19681 ccctcccacc agtaccagta gcactctgtc cccatctggg agggtggcat tctgggacat 19741 gaggagcaaa ggaagggggc aataaatgtt gagccaagag cttcaaatta ctctagagaa 19801 accgactgtg tgactcttcc tctctctgcc tctgtctgag tattttggtg tgtctgcctg 19861 cctctgtgta agatttgctt gttatgcatt cattcatttg ttcagtaaca gtttattttt 19921 atttttttat ttttttgaga ccgagtcttg ctctgtcgcc caggctggag tgcagtggcg 19981 caatctggct cactgcaagc tccacctccc aggttcacac cattctcctg cctcagcctc 20041 cccagtagct gggactacag gcgcccacta ccacacccag ctaatttttt tgtattttta 20101 gtagagacag ggtttcaccg tgttagccag gatggtcttg atctcctgac ctcatgatcc 20161 gcctgcctcg cctcccaaag tgctgggatt acaggcgtga gccactgcgc cccgcccagt 20221 aacagtttat tgagtctggc caggcatggt ggctcatgct tggaatccca gcacattggg 20281 aggccgaggc gggtagatca cttgaggtca ggagttcaag accagcctgg cgaacatggt 20341 gaaaccctgt ctctactaaa aatacaaaaa ttacccaggc gtggtgatgc acacttgtaa 20401 tcccagctac ttaggaggct gaggcaggag aatcgcttga acctgggagg tggaggttgc 20461 agtgatccga gattgtgcca ctgcactcca gcctgggtga cagagcgaga ctccatctca 20521 ataataataa taataataac ttagctgggc atggtggtgt gcacctatag tcccagatac 20581 tcaggaagct gaggtgggag gatggcttga agccaggagt ccaggttggg caacatagtg 20641 agaccccatc tctacaaaat aatttttaaa aacttagctg ggcatggtgg tgtgtacctg 20701 tagtcccaga tactcaggag gctgaggcgg gagaatggct tgaggccagg aggtcaaggc 20761 ctggccactg cactccagcc tgtaggacag atccagaccc tgtctctgaa aataaaaaaa 20821 agtttgtgct ttattttgag gatttatgca aggagtggag caccagagaa gtaaggcagg 20881 ggggacagtt gggtgtttta tgaagcttcc tttggctact ct //