LOCUS ADH1A 17622 bp DNA linear PRI 28-FEB-2005 DEFINITION Homo sapiens alcohol dehydrogenase 1A (class I), alpha polypeptide (ADH1A) gene, complete cds. ACCESSION ADH1A VERSION tmp KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 17622) AUTHORS Livingston,R.J., Rieder,M.J., Rajkumar,N., Downing,T.K., Olson,A.N., Nguyen,C.P., Gildersleeve,H., Cassidy,C.M., Johnson,E.J., Swanson,J.E., McFarland,I., Yool,B., Park,C. and Nickerson,D.A. TITLE Direct Submission JOURNAL Submitted (28-FEB-2005) Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195, USA COMMENT To cite this work please use: NIEHS-SNPs, Environmental Genome Project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu). FEATURES Location/Qualifiers source 1..17622 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" variation 106 /frequency="0.01" /replace="G" variation 107 /frequency="0.14" /replace="A" variation 178 /frequency="0.01" /replace="C" variation 261 /frequency="0.01" /replace="T" variation 517 /frequency="0.02" /replace="C" variation 531 /frequency="0.41" /replace="T" misc_feature 647..811 /note="Region not scanned for variation" variation 890 /frequency="0.01" /replace="C" repeat_region 891..999 /rpt_family="MIR" /rpt_type=dispersed repeat_region 1030..1163 /rpt_family="MIR" /rpt_type=dispersed variation 1115 /frequency="0.01" /replace="G" variation 1159 /frequency="0.01" /replace="T" repeat_region 1218..1293 /rpt_family="L2" /rpt_type=dispersed variation 1445 /frequency="0.01" /replace="A" variation 1652 /frequency="0.01" /replace="G" variation 1767 /frequency="0.34" /replace="T" variation 1791 /frequency="0.14" /replace="A" gene 1822..16441 /gene="ADH1A" mRNA join(1822..1910,5142..5243,5819..5957,8004..8091, 8189..8408,10201..10461,12528..12663,13243..13381, 16160..16441) /gene="ADH1A" /product="ADH1A" CDS join(1893..1910,5142..5243,5819..5957,8004..8091, 8189..8408,10201..10461,12528..12663,13243..13381, 16160..16184) /gene="ADH1A" /codon_start=1 /product="alcohol dehydrogenase 1A (class I), alpha polypeptide" /translation="MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAV GICGTDDHVVSGTMVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLAIPQCGKCR ICKNPESNYCLKNDVSNPQGTLQDGTSRFTCRRKPIHHFLGISTFSQYTVVDENAVAK IDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAIMGCKAAGAA RIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTM MASLLCCHEACGTSVIVGVPPDSQNLSMNPMLLLTGRTWKGAILGGFKSKECVPKLVA DFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTILMF" variation 1974 /gene="ADH1A" /frequency="0.01" /replace="G" variation 2178 /gene="ADH1A" /frequency="0.32" /replace="G" variation 2379 /gene="ADH1A" /frequency="0.01" /replace="T" variation 2565 /gene="ADH1A" /frequency="0.19" /replace="G" variation 2571 /gene="ADH1A" /frequency="0.01" /replace="G" variation 2580 /gene="ADH1A" /frequency="0.01" /replace="T" variation 3027 /gene="ADH1A" /frequency="0.02" /replace="A" variation 3117 /gene="ADH1A" /frequency="0.14" /replace="T" repeat_region 3162..3304 /rpt_family="MIR" /rpt_type=dispersed variation 3199 /gene="ADH1A" /frequency="0.01" /replace="G" repeat_region 3395..3530 /rpt_family="MIR" /rpt_type=dispersed repeat_region 3531..3985 /rpt_family="L1" /rpt_type=dispersed variation 3731 /gene="ADH1A" /frequency="0.14" /replace="A" variation 3734 /gene="ADH1A" /frequency="0.01" /replace="A" variation 3844 /gene="ADH1A" /frequency="0.01" /replace="C" variation 3944 /gene="ADH1A" /frequency="0.01" /replace="T" misc_feature 3977..4268 /gene="ADH1A" /note="Region not scanned for variation" misc_feature 4516..4871 /gene="ADH1A" /note="Region not scanned for variation" repeat_region 6017..6075 /rpt_family="MIR" /rpt_type=dispersed repeat_region 6155..6268 /rpt_family="L2" /rpt_type=dispersed variation 6200 /gene="ADH1A" /frequency="0.01" /replace="A" variation 6386 /gene="ADH1A" /frequency="0.01" /replace="A" variation 6386 /gene="ADH1A" /frequency="0.14" /replace="C" variation 6399 /gene="ADH1A" /frequency="0.02" /replace="T" variation 6610..6611 /gene="ADH1A" /frequency="0.01" /replace="" variation 6699 /gene="ADH1A" /frequency="0.04" /replace="C" repeat_region 6766..7044 /rpt_family="Alu" /rpt_type=dispersed variation 7040 /gene="ADH1A" /frequency="0.01" /replace="G" variation 7052 /gene="ADH1A" /frequency="0.17" /replace="G" variation 7149 /gene="ADH1A" /frequency="0.15" /replace="A" variation 7240 /gene="ADH1A" /frequency="0.01" /replace="T" variation 7246 /gene="ADH1A" /frequency="0.15" /replace="G" variation 7253..7256 /gene="ADH1A" /frequency="0.01" /replace="" variation 7318 /gene="ADH1A" /frequency="0.01" /replace="T" misc_feature 7387..7757 /gene="ADH1A" /note="Region not scanned for variation" variation 7844 /gene="ADH1A" /frequency="0.01" /replace="A" variation 8077 /gene="ADH1A" /frequency="0.01" /replace="T" variation 8135 /gene="ADH1A" /frequency="0.14" /replace="C" variation 8145 /gene="ADH1A" /frequency="0.14" /replace="T" variation 8518 /gene="ADH1A" /frequency="0.02" /replace="A" variation 8601 /gene="ADH1A" /frequency="0.01" /replace="G" repeat_region 8700..8805 /rpt_family="L2" /rpt_type=dispersed variation 8736 /gene="ADH1A" /frequency="0.01" /replace="T" variation 8797 /gene="ADH1A" /frequency="0.01" /replace="C" variation 8924 /gene="ADH1A" /frequency="0.01" /replace="C" repeat_region 9073..9169 /rpt_family="MIR" /rpt_type=dispersed variation 9301 /gene="ADH1A" /frequency="0.01" /replace="A" variation 9390 /gene="ADH1A" /frequency="0.03" /replace="T" variation 9584 /gene="ADH1A" /frequency="0.14" /replace="T" variation 9738 /gene="ADH1A" /frequency="0.05" /replace="C" repeat_region 9863..9887 /rpt_family="MIR" /rpt_type=dispersed repeat_region 9888..10040 /rpt_family="MER1_type" /rpt_type=dispersed variation 9982 /gene="ADH1A" /frequency="0.01" /replace="T" repeat_region 10041..10094 /rpt_family="MIR" /rpt_type=dispersed variation 10517 /gene="ADH1A" /frequency="0.17" /replace="G" misc_feature 10691..11003 /gene="ADH1A" /note="Region not scanned for variation" variation 11061..11088 /gene="ADH1A" /frequency="0.01" /replace="" repeat_region 11098..11188 /rpt_family="MIR" /rpt_type=dispersed repeat_region 11190..11347 /rpt_family="Alu" /rpt_type=dispersed variation 11259 /gene="ADH1A" /frequency="0.19" /replace="A" variation 11331 /gene="ADH1A" /frequency="0.01" /replace="A" variation 11358 /gene="ADH1A" /frequency="0.01" /replace="A" variation 11550 /gene="ADH1A" /frequency="0.15" /replace="A" variation 11630 /gene="ADH1A" /frequency="0.02" /replace="A" variation 11771 /gene="ADH1A" /frequency="0.01" /replace="C" variation 11880 /gene="ADH1A" /frequency="0.01" /replace="C" variation 11886 /gene="ADH1A" /frequency="0.15" /replace="G" variation 12095 /gene="ADH1A" /frequency="0.01" /replace="C" variation 12225 /gene="ADH1A" /frequency="0.41" /replace="G" repeat_region 12322..12443 /rpt_family="L2" /rpt_type=dispersed variation 12338 /gene="ADH1A" /frequency="0.19" /replace="" variation 12456 /gene="ADH1A" /frequency="0.01" /replace="G" variation 12487 /gene="ADH1A" /frequency="0.01" /replace="T" variation 12669 /gene="ADH1A" /frequency="0.01" /replace="C" variation 13393 /gene="ADH1A" /frequency="0.97" /replace="" variation 13456 /gene="ADH1A" /frequency="0.40" /replace="A" misc_feature 13529..13673 /gene="ADH1A" /note="Region not scanned for variation" variation 13812 /gene="ADH1A" /frequency="0.19" /replace="A" variation 13914 /gene="ADH1A" /frequency="0.01" /replace="G" repeat_region 14259..14439 /rpt_family="MIR" /rpt_type=dispersed misc_feature 14414..14538 /gene="ADH1A" /note="Region not scanned for variation" repeat_region 14743..15324 /rpt_family="L1" /rpt_type=dispersed variation 14941 /gene="ADH1A" /frequency="0.02" /replace="" variation 15151 /gene="ADH1A" /frequency="0.01" /replace="A" variation 15406 /gene="ADH1A" /frequency="0.01" /replace="A" variation 15453 /gene="ADH1A" /frequency="0.32" /replace="A" variation 15479 /gene="ADH1A" /frequency="0.04" /replace="G" repeat_region 15639..15840 /rpt_family="MIR" /rpt_type=dispersed variation 15655 /gene="ADH1A" /frequency="0.01" /replace="T" variation 15827 /gene="ADH1A" /frequency="0.01" /replace="C" variation 16327 /gene="ADH1A" /frequency="0.01" /replace="C" variation 16606 /frequency="0.04" /replace="G" variation 16789 /frequency="0.01" /replace="T" variation 17264 /frequency="0.01" /replace="C" repeat_region 17494..17558 /rpt_family="Alu" /rpt_type=dispersed BASE COUNT 5800 a 3177 c 3165 g 5480 t ORIGIN 1 gagggcgaca aaagggaaca gacccaaaac cacaggagag atgctagcat gacagggatg 61 cagagacata aagcacaaca gtgagatgga gttaatatac ctccacgagg gtgaccttgt 121 cctgcatctc aaattttggg taggatttga atgggccaga gggacagaaa agaagagaaa 181 gagcatgatg agcaagggct tgaatgttaa atagattcct ctttggggga ccagggagat 241 acaagcttct aaagcacata cgccctgtat tggagaatgg ggaggagtag atagatgaga 301 aggttgaagc catattacga agccttgaat gctgaacatc agatctgggg ctatattctt 361 accttgatac atttcagaag caactgaaat cgtaggacct tccttgcttc tctattgggt 421 gaatgtttct cagtcttggt gtgagtctca gtgcctacgt agttaaagct tactgaaatg 481 ttccctttac aattctagag agatatgtcc tttatgttga catgttcatg ctgacagact 541 gcatctgatt aaacagctgc ctgtgcaatg cctccaagtg tggataaaag aaaaattaaa 601 ctcataatct tggacagcca tgtgtagact agttacattg atcaaagggc aatagaaatg 661 atccagtgag gatttgtctg aatttcccac aattatttaa aatctacctc aaatacctgt 721 tcatctataa tgcctcccct gaggccttca ttctgaatag tacctctgtc tctgtcccca 781 aagcactaac tgatccctgt gatagcgcac ttcccagcca ggctgatatg tagacttggc 841 tgcctgtgta tcttttcccc atagactgtg agcttccttt tatgaataat aattgtagct 901 agcatttagt agggtgctcc tacctgttaa actctatgat gagtgcttta catagattat 961 atcatttatt cactaaacag tcctttaaaa tggtgctata ttcactaaac agtcctttaa 1021 aatggtgcta tattcactaa acagtcattt aaaatggtat tattcttctt catcttacag 1081 gtaaacaaac taaggcaaaa aaaaaagtga aataataagt gccagtacac agagctagta 1141 aggaataggg tctgccaggt cccaaaaagc atgccatcac ctttgcccca tactgcctct 1201 ggtacagata gaggtaatgt cttatttatc actgccatcc actggaccca gcttagtgcc 1261 tgacacacag aggggctcag tcaatgctga ttggtttgag gtggagcaaa aatgcttagc 1321 agggtgagca cctttgctgt gattgagtat ctgattctct atgaagagaa ggggagtcct 1381 gagccaaaca cattcctctg gctcctggct gtcatcttta tttgcccggc ttctttgctc 1441 ttcctccttc ctaactgcac cgtttggatt caaagctgga gcttaatgca gataaaggga 1501 aaacagaact ttgaatgacc actgtgggac taagagagga gaaacaagaa atttgacaga 1561 tgaggaataa agtgaggaga agagaaaatg attaagcttt atcactttaa cttaatattt 1621 aacctaatga aaacaaaatc ttatttgaaa ttggaaaaat caatgtattg attgctggtt 1681 cattgccctc ttctttatga tttgacagtc tgtgaataat ctaatgggtg tggcttaaag 1741 acctagatca tgtgtggaac tggaatcggg tgttattcaa gcaaaaaaaa taaataaata 1801 cctatgcaat acacctgctt tatgcacttg agcagggaag aaatccacaa ggactcacca 1861 gtctcctggt ctgcagagaa gacagaatca acatgagcac agcaggaaaa gtaagcaaaa 1921 aatatattac tgttggaact atattctcat caatataaca aagaaagtaa tacagtattt 1981 gatgaatcat ttaaaattca tatctaaatt agaaatgata cactgaaata tgatatgcaa 2041 tatatgctat aatatgtaat gtatactgaa ctacagtgga aataagctat tcctaaatac 2101 cttcaaaaag aatgtataga atctgtatct atgaagtgtt tatttcccac attaaagaca 2161 tttgcggtaa agcgataatt tattccaagc taatcatgat taatttgtaa agccaaagtt 2221 agaaatgtct ttcatcaaga agttttcttt atattaaggt accataattt aaatgtatta 2281 ctatttgtat ttatattttt tgtgaataca agaaagttaa gtctgatgaa agttttatga 2341 gaggatttga tttagaagac tttgaaatac ccttttaacc ttaacataaa atagtttaca 2401 aaatgctcat tggtctcaca gcattagaat catcaaggtt aatcaagaca acatcaacat 2461 tcaaattctg atttaaaagg gtctagtagg acacaattca ggcaatttcc agagtaatcc 2521 tatggaacag tatcttcccc atataaaagt caatatggtt ttacagaaaa ttaataatac 2581 aatttgaatc acttattagc actaggaaca cagatatttg gttttgcctt ccataaatat 2641 cttaattgtt caatgtgttt ataggtgcac aaaaatacat gtggtaatac aatataatca 2701 attgatattt taattgccta attacaaaaa tttgtgcaac tatttccagt ccttttttgt 2761 gttaggagtg tattacacag taaaatatct cactatgata actcagttta aaggctctga 2821 ggcttctcta tacactctgt gacaaaacag gttcatatca ataagactgg ttggaaatca 2881 catgggtggc ccattgttac tgttcttatt ccacctcact ttactttcat tcattactga 2941 ttaatatgta cattccacat agaaaacaat tagcaaaaaa attaaattta ccaaactcaa 3001 cttaaaagaa ataatgagtt cctacagcaa aagtataaac caatcatatt aatgaaaata 3061 ataactgatg aaatagacaa ttgcctcccc tcttgggcac aacatcaata acttagcttg 3121 ttgtcagcat ttcatttatg tttatacatc ctgcattata ttttcctcaa atgctaaata 3181 gtgacaatac taacatctat ttcataaagt agttgtgttg tgataattca ataaatgaat 3241 actataaaga acttaaaatt gtatttggga tgtagaaata agtcaataac tattagccac 3301 tattattatt gttgctattt aactttttgc taacttttta ctgacaccga gtagtgaaaa 3361 cataaggcta gattcatctt tattctctgg aaagccagct ttgagacttt agagaaatta 3421 gttaatcact gagtcaatgg atcctcaatt atttcagctg taaaataaag ccaataattc 3481 aatagtactg tcctggtagc atccttatga gattttaaaa taatgcatgt tgtttatagc 3541 agcacaattt gcaattacaa aatacagaac tgacctaaat gcccatcgac aaacgagtag 3601 ataaagaaaa tatggtgtgc atataccatg gaatactact cagccattaa acagaataaa 3661 ataaaataat ggcctttgca gcaacttgga tggagctgga gaccattatt ctaagtaatt 3721 cagaaatgga gaaccaaaca tcatatgttc tcatttataa gagagagtta ggctatgagg 3781 atgcaaaggc atgagaatga tatcatgaac tttgggaact cgagggggaa ggttgaaagg 3841 ggaggtgagg gataaaagac tacatattgg gtgcaatgta cactgcttga gtgaagggtg 3901 caccaaaatc tcagaaatca ccactaaaga acttacccag gtaaccagaa aacacctgca 3961 ccccaaaaac tattgaaatt aaaaataaat tttataaata aatataatgc aaataactca 4021 ccgagcacag gccacaatgt gcctgtcaca tcataggcac ctgataatca ggaactccta 4081 ctattagtac tttacttcca agtattctga tatttatttg gcattgatca tgttgaacat 4141 cctgcaaagt tgaataattt gacaaataaa taatgacaac gaattatcag aagaacaaat 4201 ttcaattgaa tttttatcat aattgcaatt ttgttgattc tctctggaaa gagttttgtg 4261 aattgtacat gcttaaccac aatgaagaca gatattacag ttcactgcca agcactggaa 4321 attatgtgta catcttttat ttttaagaac atctatggat aagatctgct agctagaaat 4381 tcaaacacac agtgtctcca attttgaaat atgtatgtgt aggtctgagt gtatacacac 4441 acacacatac acacacacac acacacacac ccaactctaa cctttgtaat ttggggctca 4501 aatcaaagct ggaaggagtc tctacacata gatcagataa cagtacagcc tctcaaagct 4561 aagttgcaaa tgggtgttgg aacaagtaac acacagaagt ggtggagaga gaaaattaaa 4621 agaggagaat aggaaaagag agagaaagag atgtcatccc aggcaggaag gtaaatatat 4681 ccttataaac tcagatcctt ttggcctaag cagaaaattg agaaagaaaa cagtgtattt 4741 tatgtgaaca gacactgact ctgtcagcaa aatgaaggtg acttagaatt tgatgtacca 4801 gccaataatt gtgggtgaag agacattttc agcatagcat taggaaatgt caggattaaa 4861 caactttgga gaaaaacaac aacaacataa ggatggcctt aatgaatata ttccatttta 4921 tctcagtgtg ttgttatagt taactgttta tctttcctta tgttattgct tttttaaaat 4981 atattttttt ctctttataa atcagaggtg atcatttcta tagagcactt gttaggtacc 5041 agacatggga ttagatgttg tatgtacaaa gatgaaatga cacaatatct gactgcaagc 5101 gtgggagaac actggtgcca tctctctgtt tgcttttcta ggtaatcaaa tgcaaagcag 5161 ctgtgctatg ggagttaaag aaaccctttt ccattgagga ggtggaggtt gcacctccta 5221 aggcccatga agttcgtatt aaggtgaaat acatttttcc atttgtattt aagttttaaa 5281 aactcagaaa agttaaaaaa cggaaacaac caaattttta tatgatcatc cagaaaatag 5341 aatatacttg ttgtcaagga aaggtataaa tataaatttt taaattttaa aaaagtgcac 5401 acagtgtaat tccagtaaaa tacaaaagaa tttatgtgtt tgtacagaaa gaaaatttca 5461 aagtgatata tatcaagact tcaaaatcaa ttagcattag atatttttat gtattaattt 5521 gcaacttcta cttctatttt ttaaaggcat gcattctttt atattattta agacttaact 5581 atttcaggat cagttacttc acagattatt ctaaactgtt tacttcaaga atggaaggta 5641 gaggagggtt tcagcctggt caaccttgag gataaactga atctttcata cttgggatag 5701 tagggattat tagcaaaacc cttgaaaaca ttttggaagc gcaatttcag ggaactggga 5761 tttttaaatt cacctgagac tcacaatctt ttataaacat cttctcttca ctctgtagat 5821 ggtggctgta ggaatctgtg gcacagatga ccacgtggtt agtggtacca tggtgacccc 5881 acttcctgtg attttaggcc atgaggcagc cggcatcgtg gagagtgttg gagaaggggt 5941 gactacagtc aaaccaggta caggattcac attcaggaaa catgatggtt caccatccta 6001 agatttccca gcctgaatga ggaaacagag gcaaagaggg acgaaagggc ttgaccaagg 6061 tcaccgcgca gccaggactt cagggatttc ctctttccct ctcttcctgc ctgactcaag 6121 catgtatgtc tttaggcacg catgtattct acccttcaac aattatgtac tgagcatctg 6181 ctagatgcca gtcaccaggt tggagcctgg agatatgtga ggatcaaaag ggacacagtg 6241 cctactagtg tggcattcat aatctagtaa cttccgtgtt agtgttggtg aacacggtct 6301 tctgtcaggg cccagacacc tagaaatggg aggagggaaa aaacataagt atggacattg 6361 ttctgtgctg agttcacaaa atggaggcta catggctacg gctgaatgag catgaccttt 6421 tcttaggtga cctatgcagc cccttcacca atttcctctt gcaacgtggt ctctcttcct 6481 gagcaaggaa tcaatgaagc agactaggtg aaaggaaatg aaagaaacat agaaagagcc 6541 atccaccatc aacaatgtct gccttattac tttcagccat gcttaaatgt aactggttac 6601 ggattactaa ttataaaggg agaataacta ggacacttcc atactatcat tttcacataa 6661 attttaccta taaaatgtta tgggccaacc atttttcttg gtcttgtgga atagacagca 6721 taggtaattt aaaataaaaa ttatgtttaa ttctaaaaaa atcacttttt tttttttttt 6781 tttttgagac ggagtctcgc tctgtcgccc aggctggagt gcagtggcgc gatctcagct 6841 cactgcaacc tccacctccc gggttcacgc cattctcctg cctcagccta ccgggtatct 6901 ggggccacag gtgcccgcca ccacacccag ctaatttttt ctgtttttag tagagacagg 6961 gtttcaccat attagccagg atggtctcga tctcctgacc tcgtgatctg cctgcctcgg 7021 cctcccaaag tgctgggatt acagtctaaa aaatcacttt aggcactaga ttggacctgc 7081 cactttacca aatacttatt tgaactgtga acagaaaaat aaaatgaact gtccaatttg 7141 ggtttcagct cctactaatt tctttagtag taataaatta ataactactg aataataact 7201 aataactact aaactactaa taataactac taaataatac taataataac taattagtta 7261 gtaataagtt aataacaaaa tgacaccctt actttttacc catgctccct ccactgtaac 7321 aggaaaagta gataattcac aaattatcag ctaaaaacat ttcaaagtca gttcttatcc 7381 taaaagtgcc taacttattg tggagggttg aaatttccag aggaatttct ggaattgttc 7441 tttgtcccat ttttgatagt tttcctcaaa aaaagaactg agatcatttt aaaagcattc 7501 atttcataat aaagataaac ctagttactt tgaaaagaat tagttcaaaa ttctcatttt 7561 tattgtaaat caaactataa caaaaaacag gtcttaccaa catctagtgg aactattata 7621 ccctactttc aactaaaatt tatatttata cttacagtaa gatttatata gttaaggatt 7681 aaattaaatg tttgtaaagc ctccaggaga aattggtaca ccacatgaaa gtaactgtta 7741 atacagtgga agcaattttt ctaatccatg ttgtttccca tatttgcatg tcctctttag 7801 gaatcttcag gcacttataa acccaaactg gaaacaaggc tgtggcaggc aatgacaaat 7861 gacatatttg tgattggact gtatttcttg gagactttta aagacacatg tttctaatgt 7921 tttaaagaca tgtgagcttt atgtttttgc tctattaata cctggataga aattgtaaaa 7981 gaatttgttt tatccctctc caggtgataa agtcatccca ctcgctattc ctcagtgtgg 8041 aaaatgcaga atttgtaaaa acccggagag caactactgc ttgaaaaacg agtaggtttc 8101 tgatgctctc cctgcgcaga cattgagttt gcacattagt tatggtcctg tctcatgcct 8161 ttgtgtgtct ttgtattgca ctgtccagtg taagcaatcc tcaggggacc ctgcaggatg 8221 gcaccagcag gttcacctgc aggaggaagc ccatccacca cttccttggc atcagcacct 8281 tctcacagta cacagtggtg gatgaaaatg cagtagccaa aattgatgca gcctcgcctc 8341 tagagaaagt ctgtctcatt ggctgtggat tttcaactgg ttatgggtct gcagtcaatg 8401 ttgccaaggt aagaatggca atgggtgata aaaacagtta cacgcagact gtcaggaacc 8461 caaagggaag gaatgtctca caagaatcga agattatttt tgtagatttt gaatgtcgac 8521 taagaataga aacacaatcc agaaagaatt gagagcacat gctagaagtt tcacctgttt 8581 atcagattaa aaagttgttg agagtttaga aaatgtaaag atttcatttt caataattac 8641 tcttctgtat ttgctcttta tgagctcatg aaatattagg cctgagaact catttagtaa 8701 ttcattctac aattagagag cacctacaca tgcttcaggc accataggtt ctgctaggct 8761 ctgacagcaa aagtaaatga aatgaagcgt ttgcccttga ggagcagcta gtctgtggat 8821 cctctactcc cagaattagg atcaacaaca gtagagtcca aaaccttacc tgatgcacct 8881 ccaaaccaag gctcacccac tctgtggatt cttagactga aagtaatgac gcttcagtga 8941 tgcgtaattc actcattatg acatttcact gctaaaacta actcccctgg catgaacaca 9001 cacatatatt cagaagtggt aaatttcaag cagaaattct ttaaaggctt cttatctgag 9061 taggctgaaa atctagtagt atgctttatt ttatgaaacc gaggcccaga gatataaaga 9121 tatttgccca aagtctcact gctggttaat atgagagctg agactaaaat atcttttact 9181 aatctcctgc tgaatcttag atcatgatac ataattatta gcacttttaa atcacagtca 9241 caagccttgt atttttctaa gtaagttaga aaatggtgtt gtcccccata gtattgcata 9301 ccacttggtg aatgaatgaa tgaatgaatg aatagacacc cttaagggaa tataagaatg 9361 agattatttg gaacaggaag agcatgttac gcaaaatgaa ggcggactat gggagactag 9421 gtttaataaa tatcccctgg ccaattaaaa aaatgtagat ggcatctttt ccaaatttct 9481 gtgactttag ctcttagtcc cttgttcaat tgcctcgtct attttaacag gtgatctaag 9541 tgagcctacc caagaacaga agatgaggat actcataaca atagatttta ttattaaaat 9601 atagactaat gtttcattac tgtgttattc actagtgtat tttttaaagc agggatatac 9661 tggtcatgac tactgaacat aaatgaacca aggagttcat tactgagggt ttaagtggaa 9721 tatttttcag tctcctggag tagccttttc cacttatttt gttttccaaa tattgccttt 9781 gtgtatatat gagttactga agctggctat caagggattt cagcaatcga gagtcccttc 9841 aagattgtaa tcactgccat ctggatctca aagatcatcc agtcgcctgg ttcccagcct 9901 gaccttccca ttggagtcac ctggggacta agttccacct gcagagcttc tcatttaatt 9961 ggcatgggct gtgacctgga cagtgggata tttttaaacc tgcccagatg aatccaatat 10021 gcagcagttt gagaaccact caactagttc aactccatga atttaaaaat aaagcaactg 10081 aagccaaaag aggttttgat aacagattga acagaagagt ttgagcagct tttgataaac 10141 actaagcatg gcactttata aagtttttat aatccatttt tgcattttct gaaaacacag 10201 gtcaccccag gctctacctg tgctgtgttt ggcctgggag gggtcggcct atctgctatt 10261 atgggctgta aagcagctgg ggcagccaga atcattgcgg tggacatcaa caaggacaaa 10321 tttgcaaagg ccaaagagtt gggtgccact gaatgcatca accctcaaga ctacaagaaa 10381 cccatccagg aggtgctaaa ggaaatgact gatggaggtg tggatttttc atttgaagtc 10441 atcggtcggc ttgacaccat ggtatgtacc atgacatgcc ctgagatttc tgcctctaca 10501 acttggagga tgcatttagg ctgcagaata tatgttttct gtataaagga tatttttaat 10561 gatgaatgga aatttcccat catctgtttg ttacctggct tgtttaattt attgttatga 10621 ggaatctttt attctatcaa ctatgcaaac gtgtctcaag tcatatttcc tctagaggaa 10681 aagcaaaggg cttgtttttc ttaactgagt gataatagat tactttgtta atttttagtt 10741 aaaaactgta agttaaagta aacataaata atacaagttc tgttctcaaa ttggaatgtt 10801 ttatttttct gccacattct taacaaaaat gatttaataa ttttgcatat gttcttaata 10861 aattccaatt tttttaaaca tattagtatt tggccaaaag aagtaagcaa ttttaggcca 10921 actattgttt tattaacaaa aacatgccct aaggaaagtg aagctcaaat gcattactat 10981 attttatcac agaaactgga cagtacctgg cacaaaacta gagcccaata ctagtaggac 11041 tgaatacttt gaaaagtcaa cagattttta tcacccccca aatttcaaag ctatatactc 11101 atggcattgt ttatagattg catgagacaa tgcatgtaat atacttagca cagtgcagcc 11161 tgtcatatgg taagctccca ataaatgtct tctttttatt tgagacaggg tctcactctg 11221 tcacttaggc tgaagtacag tggcataatt ataactcact acagcctcaa cctcctgggc 11281 tcaagcaaat ctcctacctc accctccaaa aatgctgaga atataggaac gagctaccac 11341 gcccggcctc agttggcgtt attgatatga aatactattt ccaatcttgc agtacttaca 11401 tcatctttgg cttattacat gatattgctt tcaaacagtt acaaatatca aaggcaatgg 11461 gaaacacatc tctagctata tttcacctac ccagaattct ctagaatcct actgaaaaag 11521 tctccagaga ccaacacgtt tccattgccg agattttcta gaaggtccag cagtgtgggt 11581 aatggggagc agcaccctga gatcaatgct ctcagcagcc ttgccctggg acaaatgcca 11641 cagatgaatg aagtgtcaag agattccact ttttccaggg ctatagcttt tctcctaatg 11701 ttcttttcct gtatcttcct ccattttctc atgtggaacg ggagtgtacc ttatctcaag 11761 ataccaaata tctgacagcc acatgttctg aggatgtctg gtctcccaaa ggtcagaatc 11821 caaaatcaaa gaactaatca ttacatatct tggggcaatc ctaaaccatt ttctaactat 11881 agaacatgtt cagaaagctc actggaaaag actttctgaa cggtcttttg aggttcccta 11941 ataatcaggg tattttaatg taaaacctat atatatttgg ggagataaaa acaatgttta 12001 aaacatgtcc atttgagaaa tggacagtag aacaggaatc cattacaaaa ggagaccatc 12061 aagtggacaa gagactactt tggtgatata atcatttatc ttgtttccca ttaaaatatg 12121 tggttgaaag taatgggttc aaaataccta tgtaataaat caatgaaaaa tgaattaacc 12181 aactcacaga ttgcctaaga attatgtgat gatgaaattg tatgcttata taaggaactg 12241 gacttaatat atatttgtga tgatatctac cactttattc ctttattagg aaaaattaag 12301 tgcactccaa tttattcatc cattctttca ttaaaaaacc gttttctggg catttcctaa 12361 atccacagca ctatcccgtg caaaaaaggg gactgaagga gcaaaagaca taatctcttc 12421 cctctacaca ctcacaatcc agttaagcct attacatgat attgtgcatt atgaatagga 12481 actatgcgac tccatgttaa gaatgctaag tgttcacttt attccagatg gcttccctgt 12541 tatgttgtca tgaggcatgt ggcacaagtg tcatcgtagg ggtacctcct gattcccaaa 12601 acctctcaat gaaccctatg ctgctactga ctggacgtac ctggaaggga gctattcttg 12661 gtggtatgta gttaggcttc agagccaaat tctcattaac ctcagcatat ctcccctttt 12721 acaagtgaca aggcaaggtt ttgaaaagca gatcaaaaac aaattaaaat tccttttcta 12781 tctacagtct ccaaatcaac tagatatgga actaatgcag gcagaaggtc ccaaaatcga 12841 catttctgat gccaccatta acaaagtctg ttcctcttca tctgttttcg tacttgtaac 12901 tgtgtaaggc atgggaattt ctagtaagac acagaaatct acaacaatat ttcatatcta 12961 cacccaaatt tagacaactg ttaaacttgt tcctttgggc ataacatctg tactatgatt 13021 tctctgtggg agagagaata accagggacc cttgtttatc tgtgattttt ttttaagtct 13081 gagcctgtaa aagcttattg aggtactgta tctcttatta acctcagtcg ttgcagtctg 13141 gaagcagcat cttttctaaa ctttcattta tttggaaaat cttctcttca attctcctac 13201 ttaccctggt tgaatctaac aatgatacca tcttcttttc aggctttaaa agtaaagaat 13261 gtgtcccaaa acttgtggct gattttatgg ctaagaagtt ttcattggat gcattaataa 13321 cccatgtttt accttttgaa aaaataaatg aaggatttga cctgcttcac tctgggaaaa 13381 ggtagatttt tttagttagt tttctgtttt gctttttttt ctaccatagg ggattgtcta 13441 gcagaaaatg aaaaggtgga aggatgagaa aaattagagt gccttggttc ttccattacc 13501 agttcagtct ttacatggag agcttgtaag agaagtttaa aacctctgtg agatgctaaa 13561 aacagttgct ttgcatttcc tattgtgctg aagccaaatt atgttgatta cagcaaatcc 13621 gaatgatcag agacactcag ccttctttaa aagagaacaa tcacctttgc caaaaaaaaa 13681 aaagtctttt taaataacca taattataac atggtgtcat tgaagcctct gcctaccacc 13741 tatataaaac tgacattagg tggctgtata tttaaataat tttcaggaca tcctcaacat 13801 tttcattatt ggagtatgtg aaactatatt tagtttgttt tctaagtaga tattactagt 13861 tttttctttt tccttttttt tcttttgcag tttacaaaaa tttttttatc aataaaagtt 13921 attataaaag agaagtatac taaacactat tgtaaatgtt tggcttactt tttgtctgaa 13981 gcttagaaaa ctaagccaat tctatttcct gtctctaaca cttaactctc acaaccagct 14041 aataaaatga attttgtcac ctgcatttac atgaggcaca actggaaaca ggcagttata 14101 tctaacttct gccttctagc tccagagtct gagacttttc tgctatccca ttcttatttt 14161 cacgagattt tcaactttta atagtgtttc tttggcactc acaaaattat tatagtagat 14221 actttaaccg acaacattct tgaggaggga aagaaactag cacccacaga gcaccagctg 14281 ttctactaag tgtcttacct gcattatctt atgtgattcc caggcaatgc tcggtgtcag 14341 tctcaatctc actatcttag agaagagaaa actgagactc agagaaggca tgacttggtc 14401 aaaatcatca gatggtagga aggagagcca gaattcaaag gtagatcttg ttgttagcaa 14461 atatctcact tctattaaac cacaccgccc ctcaagagcg catggatata tggaacacag 14521 tagccatcaa aggttagtta tcattgtcat cattatcatt gacatcatca tcgtgatcat 14581 catcatcatc ataggattga aaagatgatg gcaaatatag agatgaacaa aaccagaaga 14641 tagtgttgag caacataaga agtcatgaag catgcctaaa ttcactttat gagaatgtca 14701 tatagtaata tgcatatgta aatataatta atcctatcaa taagattaaa aattgtaaca 14761 ctcaatattg gtaagactaa ggtgactagg cactttcatg tactttcagt agtaattgat 14821 acatcctttt gggaaagcaa tttggtaata tgtatcagaa acccttaaaa aaaatggatc 14881 ttttgttcca gcaattccat ttctagaaat ctattctaca gaaataatca actattcaaa 14941 cacacatatg tgtttcagca tgtttacttg tttctgtaat atcaaacatt agaaacattc 15001 taaatttcaa catgaggaaa atgatttaat aaattccaat catctattag aaatgaatga 15061 agccatcaaa aagaaatgac attattggga aattctcatg atataattta ggctcatata 15121 ataaagaata taaattttat atacaatatc gcacattttc aacaacagca gtaaaacttg 15181 tacatatgcc tagtaagaag ttgatagaaa ttcaagtaaa cattgagaat gattgtttct 15241 aggttggggg attatggatt acctttactt tcttctttct gctgtcttgt attctctgaa 15301 ttatgtgcat atatttttct tatatatgca tatgcaaata catatatatt ttaaaaatta 15361 ttaaagagtc acaaagacca tcattttcta aaaatattta ttcatgagaa gttggtttat 15421 agaaagggca ttagttctag tgtaaatgtt ccttttgtaa tcttcacaag aatgaagtat 15481 cttagaatta atacaaatcg actttattct ctacttctaa aaatccttaa acatatctgt 15541 atcaaaggtc ttttaaactt ccagcatggt tttaactttg ttaaattatc agttctttca 15601 ggcaagttat ttatcatctt ataatttgtg caaatttgta tttgagtttt aatcccaaaa 15661 ctctatacta gatatgcgac cagaccaagt tacaaatctt tctaagtctc agtgtttata 15721 atctctaaaa tcaaaataat atgaaaatct acctcctagt gttgatgttt aggttgaagt 15781 ttaagacaga aaatgcatga agaatgtgac aaatagcaaa aacttatcac aagttattat 15841 ccattgttgt tttatattcc ttattataac aggaacgtgg gcacacaaca atgatttttt 15901 gaagatgcta acgtagtatt gaagtctaaa tgacaggcat actcagaatg ttgtgagtga 15961 gcttaaagtt gaagaaaaca caagagaaaa ccaaaaaaga tgagctttcc tttgacttca 16021 cttgacccga atgcatgggg gtgggattag agtggctgag aacagacaga ttttcactaa 16081 gtcatttcaa atgctccttg gactctcaca tggaagcatg tctaaatgct aatacaatgt 16141 ctcttctttc ctattgcagt atccgtacca ttctgatgtt ttgagacaat acagatgttt 16201 tcccttgtgg cagtcttcag cctcctctac cctacatgat ctggagcaac agctgggaaa 16261 tatcattaat tctgctcatc acagatttta tcaataaatt acatttgggg gctttccaaa 16321 gaaatggaaa ttgatgtaaa attatttttc aagcaaatgt ttaaaatcca aatgagaact 16381 aaataaagtg ttgaacatca gctggggaat tgaagccaat aaaccttcct tcttaaccat 16441 tctacttgtg tcatctttgc cattgagaaa agctatttcc tatgacttcc tgcatttttg 16501 gtatcttcat aatctttagt catggaatcc cagtggaggg gacccttcac ttgccctgaa 16561 tatacacatg ctgggctatt gtgcttgtag tctcctgcat ctatctcaat tttcactgtc 16621 ggcattttcg cctttttttt tttttaataa aatataccga attcctaggg taaaagctgt 16681 agtagggtaa aggatatact catatttaca agtggtgaaa gtccaagagt tgtaaatcca 16741 ggaaatttct taggaactca aataaaatgt cacatgtttt cttacagtga aggagaatgt 16801 ttttctgaca tttatactat gtctttatgg tcaatataca attgattttt aaaaataata 16861 gctgatttca tgcttcatat gactaaggta caattactaa ttgcaaaaac tgaactattc 16921 ctggaattat gttcaaaaaa tctataattt ttgctcatga aagtgcttca ttggctaaac 16981 agtattagtt tatggctata aacgattatt tagataattg aaaatgggta taaagtgatt 17041 caaaataata tggtggcttt aagtgtagag atgggatggc aaaagctgtg aacacagaat 17101 gtaaaattgg taactaagaa atggcacaaa caccttaagc aatatatttt cctagtagat 17161 agacatatag acatatatat acacacatat acaaatgtat atttttgcaa aattgttttc 17221 agtctagaac ttttctatta actaccatgt cttaaatcaa gtatacaatc ctagaattag 17281 tttaatattt tgaatatgta aagacttgtg gtgcctattt gttaatgctt tcccactctc 17341 aggggaaaga tttgcatttt gagctttatc tctaaatgtg acatgcaaag gttattcctg 17401 gtaaaggagt tacagctgtc tccaaaaatg ctacttgttg caatatctac attctatttc 17461 atattatgaa agaccttaga tataaagtaa aatagccaaa atcgcgccac cacactccag 17521 cctgggcaac agagcgaaac tccgtctcag ataaaaaaag agacagagag agagagagag 17581 agagacaagg gatagggagg aggctaattc caaaatgttg gc //